Search Results - "HONGBING WANG"

Mechanisms of xenobiotic receptor activation: Direct vs. indirect by Mackowiak, Bryan, Wang, Hongbing

“…The so-called xenobiotic receptors (XRs) have functionally evolved into cellular sensors for both endogenous and exogenous stimuli by regulating the…”
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The Roles of Xenobiotic Receptors: Beyond Chemical Disposition by Mackowiak, Bryan, Hodge, Jessica, Stern, Sydney, Wang, Hongbing

“…Over the past 20 years, the ability of the xenobiotic receptors to coordinate an array of drug-metabolizing enzymes and transporters in response to endogenous…”
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Socially dominant mice in C57BL6 background show increased social motivation by Kunkel, Thaddeus, Wang, Hongbing

“…A series of behavioral tests measuring social dominance, social motivation, and non-social motivation are examined in adult male C57BL6 mice. By using the…”
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Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR by Tolson, Antonia H., Wang, Hongbing

“…Drug-metabolizing enzymes (DMEs) and transporters play pivotal roles in the disposition and detoxification of numerous foreign and endogenous chemicals. To…”
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Metformin Actions on the Liver: Protection Mechanisms Emerging in Hepatocytes and Immune Cells against NASH-Related HCC by Zhang, Yueqi, Wang, Hongbing, Xiao, Hua

“…Nonalcoholic fatty liver disease (NAFLD) is strongly linked to the global epidemic of obesity and type 2 diabetes mellitus (T2DM). Notably, NAFLD can progress…”
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Enhancement of the electrical properties of MXene Ti3C2 nanosheets by post-treatments of alkalization and calcination by Wang, Hongbing, Wu, Yuping, Zhang, Jianfeng, Li, Gaiye, Huang, Huajie, Zhang, Xin, Jiang, Quanguo

“…Two-dimensional (2D) MXene Ti3C2 nanosheets are prepared by liquid phase exfoliation of layered Ti3AlC2 in aqueous solution of HF, followed by alkalization and…”
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Behavioral analysis of male and female Fmr1 knockout mice on C57BL/6 background by Ding, Qi, Sethna, Ferzin, Wang, Hongbing

“…•We examined multiple behavioral phenotypes in Fmr1 KO mice on the C57BL/6 background.•Both male and female Fmr1 KO mice displayed significant audiogenic…”
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Ca2+-stimulated ADCY1 and ADCY8 regulate distinct aspects of synaptic and cognitive flexibility by Zhang, Ming, Wang, Hongbing

“…The type 1 and 8 adenylyl cyclase (ADCY1 and ADCY8) exclusively account for Ca 2+ -stimulated cyclic AMP (cAMP) production and regulate activity-dependent…”
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H3K27ac-activated EGFR-AS1 promotes cell growth in cervical cancer through ACTN4-mediated WNT pathway by Li, Jingyan, Wang, Hongbing

“…Recently, extensive studies unveiled that lncRNAs exert critical function in the development and progression of cervical cancer (CC). EGFR-AS1 is a novel…”
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Signaling control of the constitutive androstane receptor (CAR) by Yang, Hui, Wang, Hongbing

“…The constitutive androstane receptor (CAR, NR1I3) plays a crucial role in the regulation of drug metabolism, energy homeostasis, and cancer development through…”
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Insights into CYP2B6-mediated drug–drug interactions by Hedrich, William D, Hassan, Hazem E, Wang, Hongbing

“…Mounting evidence demonstrates that CYP2B6 plays a much larger role in human drug metabolism than was previously believed.The discovery of multiple important…”
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The controlling nutritional status score as a new prognostic predictor in patients with cervical cancer receiving radiotherapy: a propensity score matching analysis by Fu, Juan, Xu, Xintian, Tian, Mengxing, Wang, Hongbing, Jin, Xin

“…As assessment tools of nutritional status, the controlling nutritional status (CONUT) and modified controlling nutritional status (mCONUT) score are associated…”
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CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme by Wang, Hongbing, Tompkins, Leslie M

“…Human CYP2B6 has been thought to account for a minor portion (<1%) of total hepatic cytochrome P450 (CYP) content and to have a minor function in human drug…”
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Hippocampal dysfunctions caused by cranial irradiation: A review of the experimental evidence by Son, Yeonghoon, Yang, Miyoung, Wang, Hongbing, Moon, Changjong

“…Highlights • Cranial irradiation is commonly used for the brain tumor therapy, but may cause hippocampal injury and dysfunctions. • This article reviews…”
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Preservation of vision after CaMKII-mediated protection of retinal ganglion cells by Guo, Xinzheng, Zhou, Jing, Starr, Christopher, Mohns, Ethan J., Li, Yidong, Chen, Earnest P., Yoon, Yonejung, Kellner, Christopher P., Tanaka, Kohichi, Wang, Hongbing, Liu, Wei, Pasquale, Louis R., Demb, Jonathan B., Crair, Michael C., Chen, Bo

“…Retinal ganglion cells (RGCs) are the sole output neurons that transmit visual information from the retina to the brain. Diverse insults and pathological…”
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Weld Defect Cascaded Detection Model Based on Bidirectional Multi-scale Feature Fusion and Shape Pre-classification by Yang, Haoying, Wang, Hongbing, Li, Haihua, Song, Xiaoping

“…Object detection algorithms like Faster R-CNN have been widely used in the field of industrial defect detection. For weld defect detection, its detection…”
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Antibody–Drug Conjugates: Pharmacokinetic/Pharmacodynamic Modeling, Preclinical Characterization, Clinical Studies, and Lessons Learned by Hedrich, William D., Fandy, Tamer E., Ashour, Hossam M., Wang, Hongbing, Hassan, Hazem E.

“…Antibody–drug conjugates are an emerging class of biopharmaceuticals changing the landscape of targeted chemotherapy. These conjugates combine the target…”
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Ribosome heterogeneity in development and disease by Gao, Yuen, Wang, Hongbing

“…Traditionally viewed as a fixed and homogeneous machinery for protein synthesis, the ribosome is increasingly recognized for its heterogeneity, as indicated by…”
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Adaptive strategies in architecture and allocation for the asymmetric growth of camphor tree (Cinnamomum camphora L.) by Guo, Chenbing, Hu, Yonghong, Qin, Jun, Wu, Duorun, Leng, Hanbing, Wang, Hongbing

“…The stability-related asymmetry in roots, trunk, and crown is always found as a typical effect of biomechanical design under heterogeneous stimulus…”
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Carbamazepine Restores Neuronal Signaling, Protein Synthesis, and Cognitive Function in a Mouse Model of Fragile X Syndrome by Ding, Qi, Zhang, Fan, Feng, Yue, Wang, Hongbing

“…Fragile X syndrome (FXS) is a leading genetic disorder of intellectual disability caused by the loss of the functional fragile X mental retardation protein…”
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