Search Results - "HONG, Keelung"

Development of a highly active nanoliposomal irinotecan using a novel intraliposomal stabilization strategy by DRUMMOND, Daryl C, NOBLE, Charles O, ZEXIONG GUO, HONG, Keelung, PARK, John W, KIRPOTIN, Dmitri B

“…Liposome formulations of camptothecins have been actively pursued because of the potential for significant pharmacologic advantages from successful drug…”
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Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo by MAMOT, Christoph, DRUMMOND, Daryl C, NOBLE, Charles O, KALLAB, Verena, ZEXIONG GUO, HONG, Keelung, KIRPOTIN, Dmitri B, PARK, John W

“…We previously reported the development of epidermal growth factor receptor (EGFR)-targeted immunoliposomes that bind and internalize in tumor cells which…”
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Anti-HER2 immunoliposomes: Enhanced efficacy attributable to targeted delivery by PARK, John W, KEELUNG HONG, PAPAHADJOPOULOS, Demetrios, BENZ, Christopher C, KIRPOTIN, Dmitri B, COLBERN, Gail, SHALABY, Refaat, BASELGA, Jose, SHAO, Yvonne, NIELSEN, Ulrik B, MARKS, James D, MOORE, Dan

“…Anti-HER2 immunoliposomes combine the tumor-targeting of certain anti-HER2 monoclonal antibodies (MAbs) with the pharmacokinetic and drug delivery capabilities…”
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Development of a highly stable and targetable nanoliposomal formulation of topotecan by Drummond, Daryl C., Noble, Charles O., Guo, Zexiong, Hayes, Mark E., Connolly-Ingram, Ceirin, Gabriel, Bianca S., Hann, Byron, Liu, Bin, Park, John W., Hong, Keelung, Benz, Christopher C., Marks, James D., Kirpotin, Dmitri B.

“…Topotecan (TPT), a highly active anticancer camptothecin drug, would benefit from nanocarrier-mediated site-specific and intracellular delivery because of a…”
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Epidermal growth factor receptor (EGFR)-targeted immunoliposomes mediate specific and efficient drug delivery to EGFR- and EGFRvIII-overexpressing tumor cells by MAMOT, Christoph, DRUMMOND, Daryl C, GREISER, Udo, KEELUNG HONG, KIRPOTIN, Dmitri B, MARKS, James D, PARK, John W

“…We hypothesized that immunoliposomes (ILs) that target epidermal growth factor receptor (EGFR) and/or its truncated variant EGFRvIII can be constructed to…”
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Improved pharmacokinetics and efficacy of a highly stable nanoliposomal vinorelbine by Drummond, Daryl C, Noble, Charles O, Guo, Zexiong, Hayes, Mark E, Park, John W, Ou, Ching-Ju, Tseng, Yun-Long, Hong, Keelung, Kirpotin, Dmitri B

“…Effective liposomal formulations of vinorelbine (5' nor-anhydro-vinblastine; VRL) have been elusive due to vinorelbine's hydrophobic structure and resulting…”
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Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain by Saito, Ryuta, Krauze, Michal T., Bringas, John R., Noble, Charles, McKnight, Tracy R., Jackson, Pamela, Wendland, Michael F., Mamot, Christoph, Drummond, Daryl C., Kirpotin, Dimitri B., Hong, Keelung, Berger, Mitchel S., Park, John W., Bankiewicz, Krystof S.

“…Drug delivery to brain tumors has long posed a major challenge. Convection-enhanced delivery (CED) has been developed as a drug delivery strategy to overcome…”
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N-isopropylacrylamide copolymers for the preparation of pH-sensitive liposomes and polymeric micelles by Leroux, Jean-Christophe, Roux, Emmanuelle, Le Garrec, Dorothée, Hong, Keelung, Drummond, Daryl C

“…Hydrophobically-modified copolymers of N-isopropylacrylamide bearing a pH-sensitive moiety were investigated for the preparation of pH-responsive liposomes and…”
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Stabilization of cationic liposome-plasmid DNA complexes by polyamines and poly(ethylene glycol)-phospholipid conjugates for efficient in vivo gene delivery by Hong, Keelung, Zheng, Weiwen, Baker, Andrew, Papahadjopoulos, Demetrios

“…Stable complexes of cationic liposomes with plasmid DNA were prepared by (1) including a small amount of poly(ethylene glycol)-phospholipid conjugate or (2)…”
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Sterically Stabilized Anti-HER2 Immunoliposomes:  Design and Targeting to Human Breast Cancer Cells in Vitro by Kirpotin, Dmitri, Park, John W, Hong, Keelung, Zalipsky, Samuel, Li, Wen-Lu, Carter, Paul, Benz, Christopher C, Papahadjopoulos, Demetrios

“…Liposomes (70−100 nm) of 1-palmitoyl-2-oleoylphosphatidylcholine, cholesterol, and poly(ethylene glycol) (PEG)-modified phosphatidylethanolamine (PEG-DSPE)…”
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Cationic Liposomes Coated with Polyethylene Glycol As Carriers for Oligonucleotides by Meyer, O, Kirpotin, D, Hong, K, Sternberg, B, Park, J W, Woodle, M C, Papahadjopoulos, D

“…Modification of liposome surface with polyethylene glycol was used to improve oligodeoxyribonucleotide (ODN) loading, stability of the resulting complexes, and…”
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Preclinical Manufacture of an Anti-HER2 scFv-PEG-DSPE, Liposome-Inserting Conjugate. 1. Gram-Scale Production and Purification by Nellis, David F., Ekstrom, Denise L., Kirpotin, Dmitri B., Zhu, Jianwei, Andersson, Robert, Broadt, Trevor L., Ouellette, Timothy F., Perkins, Shelley C., Roach, John M., Drummond, Daryl C., Hong, Keelung, Marks, James D., Park, John W., Giardina, Steven L.

“…A GMP‐compliant process is described for producing F5cys‐PEG‐lipid conjugate. This material fuses with preformed, drug‐loaded liposomes, to form…”
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Preclinical Manufacture of Anti-HER2 Liposome-Inserting, scFv-PEG-Lipid Conjugate. 2. Conjugate Micelle Identity, Purity, Stability, and Potency Analysis by Nellis, David F., Giardina, Steven L., Janini, George M., Shenoy, Shilpa R., Marks, James D., Tsai, Richard, Drummond, Daryl C., Hong, Keelung, Park, John W., Ouellette, Thomas F., Perkins, Shelley C., Kirpotin, Dmitri B.

“…Analytical methods optimized for micellar F5cys‐MP‐PEG(2000)‐DPSE protein‐lipopolymer conjugate are presented. The apparent micelle molecular weight,…”
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Cochlear gene delivery through an intact round window membrane in mouse by Jero, J, Mhatre, A N, Tseng, C J, Stern, R E, Coling, D E, Goldstein, J A, Hong, K, Zheng, W W, Hoque, A T, Lalwani, A K

“…Cochlear gene transfer studies in animal models have utilized mainly two delivery methods: direct injection through the round window membrane (RWM) or…”
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In vitro characterization of a novel polymeric-based pH-sensitive liposome system by Zignani, Monia, Drummond, Daryl Clark, Meyer, Olivier, Hong, Keelung, Leroux, Jean-Christophe

“…This study demonstrates rapid and pH-sensitive release of a highly water-soluble fluorescent aqueous content marker, pyranine, from egg phosphatidylcholine…”
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Ultrastructural characterization of cationic liposome-DNA complexes showing enhanced stability in serum and high transfection activity in vivo by Sternberg, Brigitte, Hong, Keelung, Zheng, Weiwen, Papahadjopoulos, Demetrios

“…We have investigated the morphology and transfection activity of cationic liposome-DNA complexes (CLDC) under conditions relevant to both in vivo and in vitro…”
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Thermosensitive sterically stabilized liposomes : formulation and in vitro studies on mechanism of doxorubicin release by bovine serum and human plasma by GABER, M. H, KEELUNG HONG, SHI KUN HUANG, PAPAHADJOPOULOS, D

“…To formulate thermosensitive sterically stabilized liposomes and to study the effects of plasma and serum components in vitro. The rate of release of…”
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Liposomes and hyperthermia in mice : increased tumor uptake and therapeutic efficacy of doxorubicin in sterically stabilized liposomes by SHI KUN HUANG, STAUFFER, P. R, KEELUNG HONG, GUO, J. W. H, PHILLIPS, T. L, HUANG, A, PAPAHADJOPOULOS, D

“…We have shown that sterically stabilized (Stealth) liposomes (SL), can accumulate in the extracellular space within tumors, and may improve pharmacokinetics…”
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Cationic liposome mediated transgene expression in the guinea pig cochlea by Wareing, Michael, Mhatre, Anand N, Pettis, Robert, Han, Jay J, Haut, Terry, Pfister, Markus H.F, Hong, Keelung, Zheng, Wei Wen, Lalwani, Anil K

“…Sensorineural hearing loss affects nearly 10% of the American population that is refractory to conventional therapy. Gene therapy represents an intervention…”
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Liposome targeting to tumors using vitamin and growth factor receptors by Drummond, Daryl C., Hong, Keelung, Park, John W., Benz, Christopher C., Kirpgtin, Dmitri B.

“…Liposome-encapsulated anticancer drugs reveal their potential for increased therapeutic efficacy and decreased nonspecific toxicities due to their ability to…”
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