Search Results - "HONG, Jenny J"

A simple high-throughput approach identifies actionable drug sensitivities in patient-derived tumor organoids by Phan, Nhan, Hong, Jenny J., Tofig, Bobby, Mapua, Matthew, Elashoff, David, Moatamed, Neda A., Huang, Jin, Memarzadeh, Sanaz, Damoiseaux, Robert, Soragni, Alice

“…Tumor organoids maintain cell–cell interactions, heterogeneity, microenvironment, and drug response of the sample they originate from. Thus, there is…”
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A TCR targeting the HLA-A0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer by Chinnasamy, Nachimuthu, Wargo, Jennifer A, Yu, Zhiya, Rao, Mahadev, Frankel, Timothy L, Riley, John P, Hong, Jenny J, Parkhurst, Maria R, Feldman, Steven A, Schrump, David S, Restifo, Nicholas P, Robbins, Paul F, Rosenberg, Steven A, Morgan, Richard A

“…Adoptive immunotherapy using TCR-engineered PBLs against melanocyte differentiation Ags mediates objective tumor regression but is associated with on-target…”
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Current practices of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the treatment of peritoneal surface malignancies: an international survey of oncologic surgeons by Yoo, Heon Jong, Hong, Jenny J, Ko, Young Bok, Lee, Mina, Kim, Youjin, Han, Hye Young, Song, Yong Jung, Lim, Myong Cheol, Park, Sang-Yoon

“…The goal of the study was to investigate the current clinical practices among oncologic surgeons regarding cytoreductive surgery (CRS) with intraoperative…”
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Phospholipase Cγ1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE by KEQIANG YE, AGHDASI, Bahman, LUO, Hongbo R, MORIARITY, John L, WU, Frederick Y, HONG, Jenny J, HURT, K. Joseph, SUN SIK BAE, SUH, Pann-Ghill, SNYDER, Solomon H

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Preclinical Efficacy of the Antibody-Drug Conjugate CLDN6-23-ADC for the Treatment of CLDN6-Positive Solid Tumors by McDermott, Martina S J, O'Brien, Neil A, Hoffstrom, Benjamin, Gong, KeWei, Lu, Ming, Zhang, Jun, Luo, Tong, Liang, Min, Jia, Weiping, Hong, Jenny J, Chau, Kevin, Davenport, Simon, Xie, Bin, Press, Michael F, Panayiotou, Richard, Handly-Santana, Abram, Brugge, Joan S, Presta, Leonard, Glaspy, John, Slamon, Dennis J

“…Claudin-6 (CLDN6) is expressed at elevated levels in multiple human cancers including ovarian and endometrial malignancies, with little or no detectable…”
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Successful Treatment of Melanoma Brain Metastases with Adoptive Cell Therapy by HONG, Jenny J, ROSENBERG, Steven A, DUDLEY, Mark E, YANG, James C, WHITE, Donald E, BUTMAN, John A, SHERRY, Richard M

“…To determine the objective response rate and response duration of melanoma brain metastases to adoptive cell therapy (ACT) with autologous antitumor…”
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CD8+ Enriched Young Tumor Infiltrating Lymphocytes Can Mediate Regression of Metastatic Melanoma by DUDLEY, Mark E, GROSS, Colin A, RESTIFO, Nicholas P, WUNDERLICH, John R, PRIETO, Peter A, HONG, Jenny J, LANGAN, Russell C, ZLOTT, Daniel A, MORTON, Kathleen E, WHITE, Donald E, LAURENCOT, Carolyn M, ROSENBERG, Steven A, LANGHAN, Michelle M, GARCIA, Marcos R, SHERRY, Richard M, YANG, James C, PHAN, Giao Q, KAMMULA, Udai S, HUGHES, Marybeth S, CITRIN, Deborah E

“…Tumor-infiltrating lymphocytes (TIL) and interleukin (IL)-2 administered following lymphodepletion can cause the durable complete regression of bulky…”
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A platform for rapid patient-derived cutaneous neurofibroma organoid establishment and screening by Nguyen, Huyen Thi Lam, Kohl, Emily, Bade, Jessica, Eng, Stefan E., Tosevska, Anela, Al Shihabi, Ahmad, Tebon, Peyton J., Hong, Jenny J., Dry, Sarah, Boutros, Paul C., Panossian, Andre, Gosline, Sara J.C., Soragni, Alice

“…Localized cutaneous neurofibromas (cNFs) are benign tumors that arise in the dermis of patients affected by neurofibromatosis type 1 syndrome. cNFs are benign…”
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PIKE: A Nuclear GTPase that Enhances PI3Kinase Activity and Is Regulated by Protein 4.1N by Ye, Keqiang, Hurt, K.Joseph, Wu, Frederick Y, Fang, Ming, Luo, Hongbo R, Hong, Jenny J, Blackshaw, Seth, Ferris, Christopher D, Snyder, Solomon H

“…While cytoplasmic PI3Kinase (PI3K) is well characterized, regulation of nuclear PI3K has been obscure. A novel protein, PIKE ( PI 3 K inase E nhancer),…”
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The Calcineurin-Dynamin 1 Complex as a Calcium Sensor for Synaptic Vesicle Endocytosis by Lai, Michael M., Hong, Jenny J., Ruggiero, Alicia M., Burnett, Patrick E., Slepnev, Vladimir I., De Camilli, Pietro, Snyder, Solomon H.

“…Exocytosis of synaptic vesicles is calcium-dependent, with synaptotagmin serving as the calcium sensor. Endocytosis of synaptic vesicles has also been…”
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The Calcineurin-binding Protein Cain Is a Negative Regulator of Synaptic Vesicle Endocytosis by Lai, Michael M., Luo, Hongbo R., Burnett, Patrick E., Hong, Jenny J., Snyder, Solomon H.

“…During neurotransmitter release, exocytosed neurotransmitter vesicles are recycled by endocytosis, which involves the assembly of a complex of endocytic…”
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Abstract 4915: Sensitivity to NAMPT inhibition: In vitro and in vivo characterization in ovarian cancer by Hong, Jenny J., McDermott, Martina S., O'Brien, Neil A., Guandique, Enrique, Luo, Tong, Slamon, Dennis J.

“…Previous in vitro work on determining the unique sensitivities of various cancers to nicotinamide phosphoribosyltransferase inhibitors (NAMPTis) has…”
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Abstract 2336: Pan-cancer analysis of NAMPT inhibitors reveals unique sensitivities to multiple NAMPT inhibitors in several cancer types by Hong, Jenny J., McDermott, Martina S., Ng, Jewel K., Pandya, Prita, Slamon, Dennis J.

“…Nicotinamide phosphoribosyltransferase (NAMPT) plays a critical role in cellular metabolism and as such has been an active target for cancer drug therapy…”
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Abstract 196: A platform for rapid patient-derived cutaneous neurofibroma organoid establishment and screening by Nguyen, Huyen T., Kohl, Emily, Bade, Jessica, Eng, Stefan E., Tosevska, Anela, Shihabi, Ahmad Al, Hong, Jenny J., Dry, Sarah, Boutros, Paul C., Panossian, Andre, Gosline, Sara, Soragni, Alice

“…Localized cutaneous neurofibromas (cNFs) are benign tumors that arise in the dermis of patients affected by Neurofibromatosis Type 1 syndrome, a common…”
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Abstract 4044: Development of UCT-01-097, a novel orally available ERK1/2 inhibitor for the treatment of ERK1/2 dependent cancers by O'Brien, Neil A., McDermott, Martina S., O'Boyle, Brendan M., Reeves, Corey M., Bartberger, Michael, Loson, Oliver, Chau, Kevin, Hong, Jenny J., Jia, Weiping, Kamranpour, Naeimeh, Luo, Tong, Ayala, Raul, Madrid, Athena M., Glaspy, John A., Stoltz, Brian M., Slamon, Dennis J.

“…The MAPK signaling pathway is the most commonly mutated and/or dysregulated pathway in cancer. Strategies to target it have yielded some success with…”
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Abstract 342: Development and characterization of a novel anti-CLDN6 antibody drug conjugate for the treatment of CLDN6 positive cancers by McDermott, Martina S., Gong, Ke Wei, O'Brien, Neil A., Conklin, Dylan, Hoffstrom, Benjamin, Lu, Ming, Zhang, Jun, Luo, Tong, Jia, Weiping, Hong, Jenny J., Chau, Kevin, Davenport, Simon, Press, Michael F., Handly-Santana, Abram, Brugge, Joan S., Drapkin, Ronny, Glaspy, John A., Presta, Leonard, Slamon, Dennis J.

“…Background: Claudin 6 (CLDN6), a member of the claudin family of tight junction proteins, is expressed at high levels in multiple human malignancies including…”
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Image of the month. Cystic parathyroid adenoma by Hong, Jenny J, Schrump, David S, Hughes, Marybeth S

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Phospholipase C γ 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE by Snyder, Solomon H, Ye, Keqiang, Aghdasi, Bahman, Luo, Hongbo R, Moriarity, John L, Wu, Frederick Y, Hong, Jenny J, Hurt, K. Joseph, Bae, Sun Sik, Suh, Pann-Ghill

“…Phospholipase Cγ1 (PLC-γ1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. PLC-γ1…”
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PIKE by Ye, Keqiang, Hurt, K.Joseph, Wu, Frederick Y, Fang, Ming, Luo, Hongbo R, Hong, Jenny J, Blackshaw, Seth, Ferris, Christopher D, Snyder, Solomon H

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