Search Results - "HONESS, D"

Measurement of Tumor Oxygenation: In Vivo Comparison of a Luminescence Fiber-optic Sensor and a Polarographic Electrode in the P22 Tumor by Seddon, Beatrice M., Honess, Davina J., Vojnovic, Borivoj, Tozer, Gillian M., Workman, Paul

“…Seddon, B. M., Honess, D. J., Vojnovic, B., Tozer, G. M. and Workman, P. Measurement of Tumor Oxygenation: In Vivo Comparison of a Luminescence Fiber-optic…”
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Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours by PATTERSON, A. V, WILLIAMS, K. J, STRATFORD, I. J, COWEN, R. L, JAFFAR, M, TELFER, B. A, SAUNDERS, M, AIRLEY, R, HONESS, D, VAN DER KOGEL, A. J, WOLF, C. R

“…Overwhelming clinical and experimental data demonstrate that tumour hypoxia is associated with aggressive disease and poor treatment outcome as hypoxic cells…”
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Changes in oxygenation during radiotherapy in carcinoma of the cervix by Cooper, R A, West, C M, Logue, J P, Davidson, S E, Miller, A, Roberts, S, Statford, I J, Honess, D J, Hunter, R D

“…The aim of this study was to investigate changes in tumor oxygenation, assessed by polarographic needle electrode measurements, following fractionated external…”
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Perfusion changes in the RIF-1 tumour and normal tissues after carbogen and nicotinamide, individually and combined by HONESS, D. J, BLEEHEN, N. M

“…The strategy of combining carbogen breathing and nicotinamide to overcome chronic and acute hypoxia respectively is being evaluated clinically. The effects of…”
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305 ORAL Mapping of interstitial fluid pressure in solid tumours using dynamic contrast enhanced MRI – dream or reality? by Dani, M, Maxwell, R, Honess, D, Wilson, I, Vonjovic, B, Mitchell, I, Padhani, A, Glynne-Jones, R

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Pentoxifylline: its pharmacokinetics and ability to improve tumour perfusion and radiosensitivity in mice by Honess, D J, Dennis, I F, Bleehen, N M

“…The pharmacokinetics of pentoxifylline and its three major metabolites were measured after intraperitoneal administration of 10 mg/g or 100 mg/kg of drug in…”
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Nicotinamide and pentoxifylline increase human leucocyte filterability: a possible mechanism for reduction of acute hypoxia by Honess, D J, Kitamoto, Y, Rampling, M R, Bleehen, N M

“…Transient plugging of microcapillaries by leucocytes is a possible reason for the occurrence of acute hypoxia in tumours. We compared the abilities of…”
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Comparative effects of hydralazine on perfusion of KHT tumor, kidney and liver and on renal function in mice by Honess, D J, Bleehen, N M

“…Hydralazine has been widely used to reduce tumor blood flow in mice. It has an application in the deliberate creation of reducing environments within tumors…”
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Preclinical evaluation of the novel hypoxic marker 99mTc-HL91 (Prognox) in murine and xenograft systems in vivo by Honess, D J, Hill, S A, Collingridge, D R, Edwards, B, Brauers, G, Powell, N A, Chaplin, D J

“…The 99mTc-labelled amine oxime 99mTc-HL91 (Prognox) is under investigation as a potential noninvasive clinical marker of tumour hypoxia whose uptake can be…”
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Tumour concentrations of flavone acetic acid (FAA) in human melanoma: comparison with mouse data by MAUGHAN, T. S, WARD, R, DENNIS, I, HONESS, D. J, WORKMAN, P, BLEEHEN, N. M

“…Flavone acetic acid (FAA) showed impressive effects against murine solid tumours but no activity in clinical studies. The mechanism of action in mice may…”
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Nicotinamide pharmacokinetics in humans and mice: a comparative assessment and the implications for radiotherapy by Horsman, M R, Høyer, M, Honess, D J, Dennis, I F, Overgaard, J

“…Healthy human volunteers orally ingested escalating doses of up to 6 g nicotinamide in capsule form on an empty stomach. Some side-effects were seen although…”
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BW12C: effects on tumour hypoxia, tumour thermosensitivity and relative tumour and normal tissue perfusion in C3H mice by HONESS, D. J, DU, D. E, BLEEHEN, N. M

“…BW12C (5-[2-formyl-3-hydroxypenoxyl] pentanoic acid) is an agent which stabilises oxyhaemoglobin and thus reduces oxygen delivery to tissues. It is of interest…”
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Effects of calcium channel blockers on renal function in mice by Honess, D J, Bleehen, N M

“…Tumor blood flow modification is currently under investigation as a possible means of optimizing current cancer therapies, with particular respect to improving…”
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Pentoxifylline increases RIF-1 tumour pO2 in a manner compatible with its ability to increase relative tumour perfusion by Honess, D J, Andrews, M S, Ward, R, Bleehen, N M

“…The time course and dose response of 600 mm3 subcutaneous RIF-1 tumours to pentoxifylline was measured in terms of relative tumour perfusion, assayed by 86Rb…”
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A study of the mechanism of hydralazine enhancement of thermal damage in the KHT tumour by Honess, D J, Hu, D E, Bleehen, N M

“…The mechanism of the potentiation of thermal damage by hydralazine (HDZ) has been investigated. Using the KHT sarcoma in the leg of C3H mice, it was shown that…”
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Effects of two tumor blood flow modifiers, hydralazine and flavone acetic acid, on KHT tumours and normal tissues in mice by Honess, D J, Bleehen, N M

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Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1 by Williams, Kaye J., Telfer, Brian A., Xenaki, Dia, Sheridan, Mary R., Desbaillets, Isabelle, Peters, Hans J.W., Honess, Davina, Harris, Adrian L., Dachs, Gabi U., Kogel, Albert van der, Stratford, Ian J.

“…To test the hypothesis that deficiency in expression of the transcription factor, HIF-1, renders tumours more radioresponsive than HIF-1 proficient tumours…”
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In vitro and in vivo studies using BW12C: toxicity, haemoglobin modification and effects on the radiosensitivity of normal marrow and RIF-1 tumours in mice by Honess, D J, Nethersell, A B, Bleehen, N M

“…BW12C binds to haemoglobin, shifting the oxygen saturation curve to the left, and is under investigation as an inducer of tumour hypoxia. The intrinsic…”
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The effect of systemic hyperthermia on melphalan pharmacokinetics in mice by HONESS, D. J, DONALDSON, J, WORKMAN, P, BLEEHEN, N. M

“…The effect of 45 min systemic heating at 41 degrees C on plasma and RIF-1 tumour pharmacokinetics of intraperitoneally administered melphalan (MEL) was studied…”
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Thermochemotherapy with cis-platinum, CCNU, BCNU, chlorambucil and melphalan on murine marrow and two tumours: therapeutic gain for melphalan only by Honess, D J, Bleehen, N M

“…The magnitude of potentiation by whole body hyperthermia (45 min at 41 degrees C) of cis-platinum (DDP), CCNU, BCNU, chlorambucil and melphalan (Mel) on two…”
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