Search Results - "HOLTRICH, Uwe"

Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis by Verma, Nandini, Müller, Anna-Katharina, Kothari, Charu, Panayotopoulou, Effrosini, Kedan, Amir, Selitrennik, Michael, Mills, Gordon B, Nguyen, Lan K, Shin, Sungyoung, Karn, Thomas, Holtrich, Uwe, Lev, Sima

“…Triple-negative breast cancer (TNBC) is a highly aggressive, heterogeneous disease with poor prognosis and no effective targeted therapies. EGFR is highly…”
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Association Between Genomic Metrics and Immune Infiltration in Triple-Negative Breast Cancer by Karn, Thomas, Jiang, Tingting, Hatzis, Christos, Sänger, Nicole, El-Balat, Ahmed, Rody, Achim, Holtrich, Uwe, Becker, Sven, Bianchini, Giampaolo, Pusztai, Lajos

“…Why some triple-negative breast cancers (TNBCs) have high and others have low immune cell infiltration is unknown. Understanding how immune surveillance shapes…”
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Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer by Ruckhäberle, Eugen, Rody, Achim, Engels, Knut, Gaetje, Regine, von Minckwitz, Gunter, Schiffmann, Susanne, Grösch, Sabine, Geisslinger, Gerd, Holtrich, Uwe, Karn, Thomas, Kaufmann, Manfred

“…Beside their structural role for the cell membrane the family of sphingolipids act as effector molecules in signal transduction with links to various aspects…”
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The Influence of Host Factors on the Prognosis of Breast Cancer: Stroma and Immune Cell Components as Cancer Biomarkers by Karn, Thomas, Pusztai, Lajos, Rody, Achim, Holtrich, Uwe, Becker, Sven

“…In this paper, we will review the data on stromal components and immunological parameters in the cancer microenvironment as prognostic and predictive markers…”
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Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signatures by Karn, Thomas, Pusztai, Lajos, Holtrich, Uwe, Iwamoto, Takayuki, Shiang, Christine Y, Schmidt, Marcus, Müller, Volkmar, Solbach, Christine, Gaetje, Regine, Hanker, Lars, Ahr, Andre, Liedtke, Cornelia, Ruckhäberle, Eugen, Kaufmann, Manfred, Rody, Achim

“…Current prognostic gene signatures for breast cancer mainly reflect proliferation status and have limited value in triple-negative (TNBC) cancers. The…”
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Histotype-specific analysis of acid ceramidase expression in ovarian cancer by El-Balat, Ahmed, Karn, Thomas, Holtrich, Uwe, Becker, Sven, Kommoss, Stefan, Győrffy, Balázs, Anglesio, Michael S., Huntsman, David G., Drosos, Zacharias, Rody, Achim, Gevensleben, Heidrun, Hanker, Lars C.

“…Acid ceramidase (ASAH1) is a key player in sphingolipid metabolism and signaling. It has prognostic value for several cancers, but histotype-specific analyses…”
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Molecular differences between younger versus older ER-positive and HER2-negative breast cancers by Qing, Tao, Karn, Thomas, Rozenblit, Mariya, Foldi, Julia, Marczyk, Michal, Shan, Naing Lin, Blenman, Kim, Holtrich, Uwe, Kalinsky, Kevin, Meric-Bernstam, Funda, Pusztai, Lajos

“…The RxPONDER and TAILORx trials demonstrated benefit from adjuvant chemotherapy in patients age ≤ 50 with node-positive breast cancer and Recurrence Score (RS)…”
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Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers by Bianchini, Giampaolo, Pusztai, Lajos, Karn, Thomas, Iwamoto, Takayuki, Rody, Achim, Kelly, Catherine, Müller, Volkmar, Schmidt, Schmidt, Qi, Yuan, Holtrich, Uwe, Becker, Sven, Santarpia, Libero, Fasolo, Angelica, Del Conte, Gianluca, Zambetti, Milvia, Sotiriou, Christos, Haibe-Kains, Benjamin, Symmans, W Fraser, Gianni, Luca

“…We examined if a combination of proliferation markers and estrogen receptor (ER) activity could predict early versus late relapses in ER-positive breast cancer…”
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Melanoma antigen family A identified by the bimodality index defines a subset of triple negative breast cancers as candidates for immune response augmentation by Karn, Thomas, Pusztai, Lajos, Ruckhäberle, Eugen, Liedtke, Cornelia, Müller, Volkmar, Schmidt, Marcus, Metzler, Dirk, Wang, Jing, Coombes, Kevin R, Gätje, Regine, Hanker, Lars, Solbach, Christine, Ahr, Andre, Holtrich, Uwe, Rody, Achim, Kaufmann, Manfred

“…Abstract Background Molecular markers displaying bimodal expression distribution can reveal distinct disease subsets and may serve as prognostic or predictive…”
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Characterization of WNT7A expression in human endometrium and endometriotic lesions by Gaetje, Regine, M.D, Holtrich, Uwe, Ph.D, Karn, Thomas, Ph.D, Cikrit, Eva, Engels, Knut, M.D, Rody, Achim, M.D, Kaufmann, Manfred, M.D

“…Objective To characterize the expression of WNT7A in human eutopic and ectopic endometrium. Design Experimental study using real-time polymerase chain…”
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Poor Outcome in Estrogen Receptor–Positive Breast Cancers Predicted by Loss of Plexin B1 by RODY, Achim, HOLTRICH, Uwe, AHR, Andre, SOLBACH, Christine, KARN, Thomas, KAUFMANN, Manfred, GAETJE, Regine, GEHRMANN, Mathias, ENGELS, Knut, VON MINCKWITZ, Gunter, LOIBL, Sibylle, DIALLO-DANEBROCK, Raihanatou, RUCKHÄBERLE, Eugen, METZLER, Dirk

“…Purpose: A common characteristic of mammary carcinomas is an inverse relationship between the estrogen receptor (ER) status and the proliferative activity of…”
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Identification of high risk breast-cancer patients by gene expression profiling by Ahr, André, Karn, Thomas, Solbach, Christine, Seiter, Tanja, Strebhardt, Klaus, Holtrich, Uwe, Kaufmann, Manfred

“…We previously used DNA array analyses in the molecular profiling of breast cancers. By cluster analysis of 55 patients, we identified a subpopulation of breast…”
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Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer by WOLF, G, ELEZ, R, DOERMER, A, HOLTRICH, U, ACKERMANN, H, STUTTE, H. J, ALTMANNSBERGER, H.-M, RÜBSAMEN-WAIGMANN, H, STREBHARDT, K

“…Our previous data indicate that the expression of the PLK gene which codes for a serine/threonine kinase is restricted to proliferating cells. In Northern blot…”
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Endometriosis may be generated by mimicking the ontogenetic development of the female genital tract by Gaetje, Regine, M.D, Holtrich, Uwe, Ph.D, Engels, Knut, M.D, Kissler, Stefan, M.D, Rody, Achim, M.D, Karn, Thomas, Ph.D, Kaufmann, Manfred, M.D

“…Objective To compare the expression of genes playing a decisive role during the embryonic development of the female genital tract ( WNT4, WNT5A, WNT7A, PAX8 )…”
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Control of dataset bias in combined Affymetrix cohorts of triple negative breast cancer by Karn, Thomas, Rody, Achim, Müller, Volkmar, Schmidt, Marcus, Becker, Sven, Holtrich, Uwe, Pusztai, Lajos

“…Heterogenous subtypes of breast cancer need to be analyzed separately. Pooling of datasets can provide reasonable sample sizes but dataset bias is an important…”
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PDZ-Domain-Mediated Interaction of the Eph-Related Receptor Tyrosine Kinase EphB3 and the Ras-Binding Protein AF6 Depends on the Kinase Activity of the Receptor by Hock, Bjorn, Bohme, Beatrix, Karn, Thomas, Yamamoto, Takaharu, Kaibuchi, Kozo, Holtrich, Uwe, Holland, Sacha, Pawson, Tony, Rubsamen-Waigmann, Helga, Strebhardt, Klaus

“…Eph-related receptor tyrosine kinases (RTKs) have been implicated in intercellular communication during embryonic development. To elucidate their signal…”
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Molecular classification of breast cancer patients by gene expression profiling by Ahr, André, Holtrich, Uwe, Solbach, Christine, Scharl, Anton, Strebhardt, Klaus, Karn, Thomas, Kaufmann, Manfred

“…For many tumuors, pathological subclasses exist which have to be further defined by genetic markers to improve therapy and follow‐up strategies. In this study,…”
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FSCN1 as prognostic marker in borderline tumors of the ovary by El-Balat, Ahmed, Holtrich, Uwe, Karn, Thomas, Becker, Sven

“…Abstract only e18061 Background: Risk factors for invasive recurrence of borderline tumours (BOT) of the ovary are needed. The actin-bundling protein Fascin-1…”
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Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages by HOLTRICH, Uwe, WOLF, Georg, KUHL, Dietmar, STREBHARDT, Klaus, JUPING YUAN, BEREITER-HAHN, Jürgen, KARN, Thomas, WEILER, Markus, KAUSELMANN, Gunther, REHLI, Michael, ANDREESEN, Reinhard, KAUFMANN, Manfred

“…Members of the polo subfamily of protein kinases play crucial roles in cell proliferation. To study the function of this family in more detail, we isolated the…”
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T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers by Rody, Achim, Holtrich, Uwe, Pusztai, Laos, Liedtke, Cornelia, Gaetje, Regine, Ruckhaeberle, Eugen, Solbach, Christine, Hanker, Lars, Ahr, Andre, Metzler, Dirk, Engels, Knut, Karn, Thomas, Kaufmann, Manfred

“…Lymphocyte infiltration (LI) is often seen in breast cancer but its importance remains controversial. A positive correlation of human epidermal growth factor…”
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