Search Results - "HOLSON, Edward B"

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate by Sleiman, Sama F, Henry, Jeffrey, Al-Haddad, Rami, El Hayek, Lauretta, Abou Haidar, Edwina, Stringer, Thomas, Ulja, Devyani, Karuppagounder, Saravanan S, Holson, Edward B, Ratan, Rajiv R, Ninan, Ipe, Chao, Moses V

“…Exercise induces beneficial responses in the brain, which is accompanied by an increase in BDNF, a trophic factor associated with cognitive improvement and the…”
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EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression by Renneville, Aline, Van Galen, Peter, Canver, Matthew C., McConkey, Marie, Krill-Burger, John M., Dorfman, David M., Holson, Edward B., Bernstein, Bradley E., Orkin, Stuart H., Bauer, Daniel E., Ebert, Benjamin L.

“…Fetal hemoglobin (HbF, α2γ2) induction is a well-validated strategy for sickle cell disease (SCD) treatment. Using a small-molecule screen, we found that…”
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Hdac3 Is Essential for the Maintenance of Chromatin Structure and Genome Stability by Bhaskara, Srividya, Knutson, Sarah K., Jiang, Guochun, Chandrasekharan, Mahesh B., Wilson, Andrew J., Zheng, Siyuan, Yenamandra, Ashwini, Locke, Kimberly, Yuan, Jia-ling, Bonine-Summers, Alyssa R., Wells, Christina E., Kaiser, Jonathan F., Washington, M. Kay, Zhao, Zhongming, Wagner, Florence F., Sun, Zu-Wen, Xia, Fen, Holson, Edward B., Khabele, Dineo, Hiebert, Scott W.

“…Hdac3 is essential for efficient DNA replication and DNA damage control. Deletion of Hdac3 impaired DNA repair and greatly reduced chromatin compaction and…”
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Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia by Wagner, Florence F, Benajiba, Lina, Campbell, Arthur J, Weïwer, Michel, Sacher, Joshua R, Gale, Jennifer P, Ross, Linda, Puissant, Alexandre, Alexe, Gabriela, Conway, Amy, Back, Morgan, Pikman, Yana, Galinsky, Ilene, DeAngelo, Daniel J, Stone, Richard M, Kaya, Taner, Shi, Xi, Robers, Matthew B, Machleidt, Thomas, Wilkinson, Jennifer, Hermine, Olivier, Kung, Andrew, Stein, Adam J, Lakshminarasimhan, Damodharan, Hemann, Michael T, Scolnick, Edward, Zhang, Yan-Ling, Pan, Jen Q, Stegmaier, Kimberly, Holson, Edward B

“…Glycogen synthase kinase 3 (GSK3), a key regulatory kinase in the wingless-type MMTV integration site family (WNT) pathway, is a therapeutic target of interest…”
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In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs by Wang, Changning, Schroeder, Frederick A, Wey, Hsiao-Ying, Borra, Ronald, Wagner, Florence F, Reis, Surya, Kim, Sung Won, Holson, Edward B, Haggarty, Stephen J, Hooker, Jacob M

“…Epigenetic enzymes are now targeted to treat the underlying gene expression dysregulation that contribute to disease pathogenesis. Histone deacetylases (HDACs)…”
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Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy by Ferguson, Bradley S., Harrison, Brooke C., Jeong, Mark Y., Reid, Brian G., Wempe, Michael F., Wagner, Florence F., Holson, Edward B., McKinsey, Timothy A.

“…Cardiac hypertrophy is a strong predictor of morbidity and mortality in patients with heart failure. Small molecule histone deacetylase (HDAC) inhibitors have…”
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Small Molecule Inhibitors of Zinc-dependent Histone Deacetylases by Wagner, Florence F., Weїwer, Michel, Lewis, Michael C., Holson, Edward B.

“…Lysine acetylation is an ancient, evolutionarily conserved, reversible post-translational modification. A multitude of diverse cellular functions are regulated…”
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A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests by Schroeder, Frederick A, Lewis, Michael C, Fass, Daniel M, Wagner, Florence F, Zhang, Yan-Ling, Hennig, Krista M, Gale, Jennifer, Zhao, Wen-Ning, Reis, Surya, Barker, Douglas D, Berry-Scott, Erin, Kim, Sung Won, Clore, Elizabeth L, Hooker, Jacob M, Holson, Edward B, Haggarty, Stephen J, Petryshen, Tracey L

“…Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade…”
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Selective HDAC inhibition for the disruption of latent HIV-1 infection by Barton, Kirston M, Archin, Nancie M, Keedy, Kara S, Espeseth, Amy S, Zhang, Yan-ling, Gale, Jennifer, Wagner, Florence F, Holson, Edward B, Margolis, David M

“…Selective histone deacetylase (HDAC) inhibitors have emerged as a potential anti-latency therapy for persistent human immunodeficiency virus type 1 (HIV-1)…”
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Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries by Lowe, Jason T, Lee, Maurice D, Akella, Lakshmi B, Davoine, Emeline, Donckele, Etienne J, Durak, Landon, Duvall, Jeremy R, Gerard, Baudouin, Holson, Edward B, Joliton, Adrien, Kesavan, Sarathy, Lemercier, Berenice C, Liu, Haibo, Marié, Jean-Charles, Mulrooney, Carol A, Muncipinto, Giovanni, Welzel-O’Shea, Morgan, Panko, Laura M, Rowley, Ann, Suh, Byung-Chul, Thomas, Meryl, Wagner, Florence F, Wei, Jingqiang, Foley, Michael A, Marcaurelle, Lisa A

“…The synthesis and diversification of a densely functionalized azetidine ring system to gain access to a wide variety of fused, bridged, and spirocyclic ring…”
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HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury by Aufhauser, David D., Hernandez, Paul, Concors, Seth J., O’Brien, Ciaran, Wang, Zhonglin, Murken, Douglas R., Samanta, Arabinda, Beier, Ulf H., Krumeich, Lauren, Bhatti, Tricia R., Wang, Yanfeng, Ge, Guanghui, Wang, Liqing, Cheraghlou, Shayan, Wagner, Florence F., Holson, Edward B., Kalin, Jay H., Cole, Philip A., Hancock, Wayne W., Levine, Matthew H.

“…Histone/protein deacetylases (HDAC) 1 and 2 are typically viewed as structurally and functionally similar enzymes present within various co-regulatory…”
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AKT Kinase Activity Is Required for Lithium to Modulate Mood-Related Behaviors in Mice by PAN, Jen Q, LEWIS, Michael C, NEVE, Rachael L, BIECHELE, Travis L, MOON, Randall T, SCOLNICK, Edward M, PETRYSHEN, Tracey L, HAGGARTY, Stephen J, KETTERMAN, Josh K, CLORE, Elizabeth L, RILEY, Misha, RICHARDS, Keenan R, BERRY-SCOTT, Erin, XIULIN LIU, WAGNER, Florence F, HOLSON, Edward B

“…Bipolar disorder (BP) is a debilitating psychiatric disorder, affecting ∼2% of the worldwide population, for which the etiological basis, pathogenesis, and…”
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Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition by Sleiman, Sama F, Olson, David E, Bourassa, Megan W, Karuppagounder, Saravanan S, Zhang, Yan-Ling, Gale, Jennifer, Wagner, Florence F, Basso, Manuela, Coppola, Giovanni, Pinto, John T, Holson, Edward B, Ratan, Rajiv R

“…Histone deacetylase (HDAC) inhibition improves function and extends survival in rodent models of a host of neurological conditions, including stroke, and…”
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Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells by Kubicek, Stefan, Gilbert, Joshua C, Fomina-Yadlin, Dina, Gitlin, Alexander D, Yuan, Yuan, Wagner, Florence F, Holson, Edward B, Luo, Tuoping, Lewis, Timothy A, Taylor, Bradley, Gupta, Supriya, Shamji, Alykhan F, Wagner, Bridget K, Clemons, Paul A, Schreiber, Stuart L

“…Under the instruction of cell-fate–determining, DNA-binding transcription factors, chromatin-modifying enzymes mediate and maintain cell states throughout…”
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Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases by Karnib, Nabil, El-Ghandour, Rim, El Hayek, Lauretta, Nasrallah, Patrick, Khalifeh, Mohamad, Barmo, Nour, Jabre, Vanessa, Ibrahim, Pascale, Bilen, Maria, Stephan, Joseph S, Holson, Edward B, Ratan, Rajiv R, Sleiman, Sama F

“…Chronic stress promotes depression in some individuals, but has no effect in others. Susceptible individuals exhibit social avoidance and anxious behavior and…”
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Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes by Dirice, Ercument, Ng, Raymond W.S., Martinez, Rachael, Hu, Jiang, Wagner, Florence F., Holson, Edward B., Wagner, Bridget K., Kulkarni, Rohit N.

“…Preservation of insulin-secreting β-cells is an important goal for therapies aimed at restoring normoglycemia in patients with diabetes. One approach, the…”
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Diastereoselective Synthesis of the C(17)−C(28) Fragment (The C−D Spiroketal Unit) of Spongistatin 1 (Altohyrtin A) via a Kinetically Controlled Iodo-Spiroketalization Reaction by Holson, Edward B, Roush, William R

“…A convergent and stereocontrolled synthesis of spiroketal 15 corresponding to the C−D fragment of spongistatin 1 has been accomplished by a sequence utilizing…”
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Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome by McCamphill, Patrick K, Stoppel, Laura J, Senter, Rebecca K, Lewis, Michael C, Heynen, Arnold J, Stoppel, David C, Sridhar, Vinay, Collins, Katie A, Shi, Xi, Pan, Jen Q, Madison, Jon, Cottrell, Jeffrey R, Huber, Kimberly M, Scolnick, Edward M, Holson, Edward B, Wagner, Florence F, Bear, Mark F

“…Fragile X syndrome is caused by gene silencing and loss of the encoded fragile X mental retardation protein (FMRP), which binds to mRNA and regulates…”
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Potent and Selective Inhibition of Histone Deacetylase 6 (HDAC6) Does Not Require a Surface-Binding Motif by Wagner, Florence F, Olson, David E, Gale, Jennifer P, Kaya, Taner, Weïwer, Michel, Aidoud, Nadia, Thomas, Méryl, Davoine, Emeline L, Lemercier, Bérénice C, Zhang, Yan-Ling, Holson, Edward B

“…Hydroxamic acids were designed, synthesized, and evaluated for their ability to selectively inhibit human histone deacetylase 6 (HDAC6). Several inhibitors,…”
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Discovery of the First Histone Deacetylase 6/8 Dual Inhibitors by Olson, David E, Wagner, Florence F, Kaya, Taner, Gale, Jennifer P, Aidoud, Nadia, Davoine, Emeline L, Lazzaro, Fanny, Weïwer, Michel, Zhang, Yan-Ling, Holson, Edward B

“…We disclose the first small molecule histone deacetylase (HDAC) inhibitor (3, BRD73954) capable of potently and selectively inhibiting both HDAC6 and HDAC8…”
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