Search Results - "HOLMES, EDWARD C."

A Genomic Perspective on the Origin and Emergence of SARS-CoV-2 by Zhang, Yong-Zhen, Holmes, Edward C.

“…The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous global concern. We and others in China were involved in the initial genome…”
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The Ecology and Evolution of Influenza Viruses by Wille, Michelle, Holmes, Edward C

“…The patterns and processes of influenza virus evolution are of fundamental importance, underpinning such traits as the propensity to emerge in new host species…”
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The Evolution of Endogenous Viral Elements by Holmes, Edward C.

“…Endogenous retroviruses are a common component of the eukaryotic genome, and their evolution and potential function have attracted considerable interest. More…”
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Using Metagenomics to Characterize an Expanding Virosphere by Zhang, Yong-Zhen, Shi, Mang, Holmes, Edward C.

“…We know less about viruses than any other lifeform. Fortunately, metagenomics has led to a massive expansion in the known diversity of the virosphere. Here, we…”
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The evolution of Ebola virus: Insights from the 2013–2016 epidemic by Holmes, Edward C., Dudas, Gytis, Rambaut, Andrew, Andersen, Kristian G.

“…The 2013–2016 epidemic of Ebola virus disease in West Africa was of unprecedented magnitude and changed our perspective on this lethal but sporadically…”
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A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein by Zhou, Hong, Chen, Xing, Hu, Tao, Li, Juan, Song, Hao, Liu, Yanran, Wang, Peihan, Liu, Di, Yang, Jing, Holmes, Edward C., Hughes, Alice C., Bi, Yuhai, Shi, Weifeng

“…The unprecedented pandemic of pneumonia caused by a novel coronavirus, SARS-CoV-2, in China and beyond has had major public health impacts on a global scale…”
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Comparative analysis estimates the relative frequencies of co-divergence and cross-species transmission within viral families by Geoghegan, Jemma L, Duchêne, Sebastián, Holmes, Edward C

“…The cross-species transmission of viruses from one host species to another is responsible for the majority of emerging infections. However, it is unclear…”
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After the pandemic: perspectives on the future trajectory of COVID-19 by Telenti, Amalio, Arvin, Ann, Corey, Lawrence, Corti, Davide, Diamond, Michael S., García-Sastre, Adolfo, Garry, Robert F., Holmes, Edward C., Pang, Phillip S., Virgin, Herbert W.

“…There is a realistic expectation that the global effort in vaccination will bring the pandemic caused by severe acute respiratory syndrome coronavirus 2…”
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Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses by Zhou, Hong, Ji, Jingkai, Chen, Xing, Bi, Yuhai, Li, Juan, Wang, Qihui, Hu, Tao, Song, Hao, Zhao, Runchu, Chen, Yanhua, Cui, Mingxue, Zhang, Yanyan, Hughes, Alice C., Holmes, Edward C., Shi, Weifeng

“…Despite the discovery of animal coronaviruses related to SARS-CoV-2, the evolutionary origins of this virus are elusive. We describe a meta-transcriptomic…”
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How accurately can we assess zoonotic risk? by Wille, Michelle, Geoghegan, Jemma L, Holmes, Edward C

“…Identifying the animal reservoirs from which zoonotic viruses will likely emerge is central to understanding the determinants of disease emergence…”
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A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology by Rambaut, Andrew, Holmes, Edward C., O’Toole, Áine, Hill, Verity, McCrone, John T., Ruis, Christopher, du Plessis, Louis, Pybus, Oliver G.

“…The ongoing pandemic spread of a new human coronavirus, SARS-CoV-2, which is associated with severe pneumonia/disease (COVID-19), has resulted in the…”
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The evolutionary history of vertebrate RNA viruses by Shi, Mang, Lin, Xian-Dan, Chen, Xiao, Tian, Jun-Hua, Chen, Liang-Jun, Li, Kun, Wang, Wen, Eden, John-Sebastian, Shen, Jin-Jin, Liu, Li, Holmes, Edward C., Zhang, Yong-Zhen

“…Our understanding of the diversity and evolution of vertebrate RNA viruses is largely limited to those found in mammalian and avian hosts and associated with…”
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Large-Scale Phylogenomic Analysis Reveals the Complex Evolutionary History of Rabies Virus in Multiple Carnivore Hosts by Troupin, Cécile, Dacheux, Laurent, Tanguy, Marion, Sabeta, Claude, Blanc, Hervé, Bouchier, Christiane, Vignuzzi, Marco, Duchene, Sebastián, Holmes, Edward C, Bourhy, Hervé

“…The natural evolution of rabies virus (RABV) provides a potent example of multiple host shifts and an important opportunity to determine the mechanisms that…”
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What Does Virus Evolution Tell Us about Virus Origins? by HOLMES, Edward C

“…Author's Correction ( vol. 85 , p. 9655 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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High-Resolution Metatranscriptomics Reveals the Ecological Dynamics of Mosquito-Associated RNA Viruses in Western Australia by Shi, Mang, Neville, Peter, Nicholson, Jay, Eden, John-Sebastian, Imrie, Allison, Holmes, Edward C

“…Mosquitoes harbor a high diversity of RNA viruses, including many that impact human health. Despite a growing effort to describe the extent and nature of the…”
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S1 gene-based phylogeny of infectious bronchitis virus: An attempt to harmonize virus classification by Valastro, Viviana, Holmes, Edward C., Britton, Paul, Fusaro, Alice, Jackwood, Mark W., Cattoli, Giovanni, Monne, Isabella

“…Infectious bronchitis virus (IBV) is the causative agent of a highly contagious disease that results in severe economic losses to the global poultry industry…”
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Predicting virus emergence amid evolutionary noise by Geoghegan, Jemma L., Holmes, Edward C.

“…The study of virus disease emergence, whether it can be predicted and how it might be prevented, has become a major research topic in biomedicine. Here we show…”
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The origins of SARS-CoV-2: A critical review by Holmes, Edward C., Goldstein, Stephen A., Rasmussen, Angela L., Robertson, David L., Crits-Christoph, Alexander, Wertheim, Joel O., Anthony, Simon J., Barclay, Wendy S., Boni, Maciej F., Doherty, Peter C., Farrar, Jeremy, Geoghegan, Jemma L., Jiang, Xiaowei, Leibowitz, Julian L., Neil, Stuart J.D., Skern, Tim, Weiss, Susan R., Worobey, Michael, Andersen, Kristian G., Garry, Robert F., Rambaut, Andrew

“…Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest…”
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Evolutionary Virology at 40 by Geoghegan, Jemma L, Holmes, Edward C

“…RNA viruses are diverse, abundant, and rapidly evolving. Genetic data have been generated from virus populations since the late 1970s and used to understand…”
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Rates of evolutionary change in viruses: patterns and determinants by Holmes, Edward C, Duffy, Siobain, Shackelton, Laura A

“…Key Points Viral mutation rates vary over five orders of magnitude, whereas viral substitution rates vary over six orders of magnitude. Instead of simplifying…”
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