Search Results - "HOLMES, Amie L"

Chronic Exposure to Particulate Chromate Induces Premature Centrosome Separation and Centriole Disengagement in Human Lung Cells by Martino, Julieta, Holmes, Amie L, Xie, Hong, Wise, Sandra S, Wise, Sr, John Pierce

“…Particulate hexavalent chromium (Cr(VI)) is a well-established human lung carcinogen. Lung tumors are characterized by structural and numerical chromosome…”
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The cytotoxicity and genotoxicity of soluble and particulate cobalt in human lung epithelial cells by Xie, Hong, Smith, Leah J., Holmes, Amie L., Zheng, Tongzhang, Pierce Wise Sr, John

“…Cobalt is a toxic metal used in various industrial applications leading to adverse lung effects by inhalation. Cobalt is considered a possible human carcinogen…”
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Chronic Exposure to Zinc Chromate Induces Centrosome Amplification and Spindle Assembly Checkpoint Bypass in Human Lung Fibroblasts by Holmes, Amie L, Wise, Sandra S, Pelsue, Stephen C, Aboueissa, AbouEl-Makarim, Lingle, Wilma, Salisbury, Jeffery, Gallagher, Jamie, Wise, John Pierce

“…Hexavalent chromium (Cr(VI)) compounds are known human lung carcinogens. Solubility plays an important role in its carcinogenicity with the particulate or…”
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Mechanisms of metal-induced centrosome amplification by Holmes, Amie L, Wise, John Pierce

“…Exposure to toxic and carcinogenic metals is widespread; however, their mechanisms of action remain largely unknown. One potential mechanism for metal-induced…”
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Neoplastic Transformation of Human Bronchial Cells by Lead Chromate Particles by Xie, Hong, Holmes, Amie L, Wise, Sandra S, Huang, Shouping, Peng, Cheng, Wise, John Pierce, Sr

“…Particulate hexavalent chromium (Cr(VI)) is a well-established human lung carcinogen with widespread exposure among people in occupational settings and the…”
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The cytotoxicity and genotoxicity of hexavalent chromium in Steller sea lion lung fibroblasts compared to human lung fibroblasts by Wise, John Pierce, Wise, Sandra S., Holmes, Amie L., LaCerte, Carolyne, Shaffiey, Fariba, Aboueissa, AbouEl-Makarim

“…In this study we directly compared soluble and particulate chromate cytotoxicity and genotoxicity in human ( Homo sapiens) and sea lion ( Eumetopias jubatus)…”
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Chromium is the proximate clastogenic species for lead chromate-induced clastogenicity in human bronchial cells by Wise, Sandra S., Holmes, Amie L., Ketterer, Michael E., Hartsock, Wendy J., Fomchenko, Elena, Katsifis, Spiros, Thompson, W.Douglas, Wise, John Pierce

“…Hexavalent chromium (Cr(VI)) is a well-established human lung carcinogen with potentially widespread exposure. Solubility is a key factor in the…”
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Hexavalent chromium induces chromosome instability in human urothelial cells by Wise, Sandra S., Holmes, Amie L., Liou, Louis, Adam, Rosalyn M., Wise Sr, John Pierce

“…Numerous metals are well-known human bladder carcinogens. Despite the significant occupational and public health concern of metals and bladder cancer, the…”
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Chronic Exposure to Particulate Nickel Induces Neoplastic Transformation in Human Lung Epithelial Cells by Holmes, Amie, The, Therry, Thompson, Kelsey, Mason, Michael, Kandpal, Sanjeev, Zheng, Tongzhang, Wise, John

“…Nickel is a well-known human lung carcinogen with the particulate form being the most potent; however, the carcinogenic mechanism remains largely unknown. Few…”
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Homologous recombination repair signaling in chemical carcinogenesis: prolonged particulate hexavalent chromium exposure suppresses the Rad51 response in human lung cells by Qin, Qin, Xie, Hong, Wise, Sandra S, Browning, Cynthia L, Thompson, Kelsey N, Holmes, Amie L, Wise, Sr, John Pierce

“…The aim of this study was to focus on hexavalent chromium, [Cr(VI)], a chemical carcinogen and major public health concern, and consider its ability to impact…”
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The cytotoxicity and genotoxicity of soluble and particulate cobalt in human lung fibroblast cells by Smith, Leah J., Holmes, Amie L., Kandpal, Sanjeev Kumar, Mason, Michael D., Zheng, Tongzhang, Wise, John Pierce

“…Cobalt exposure is increasing as cobalt demand rises worldwide due to its use in enhancing rechargeable battery efficiency, super-alloys, and magnetic…”
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Comparative Genotoxicity and Cytotoxicity of Four Hexavalent Chromium Compounds in Human Bronchial Cells by Wise, Sandra S, Holmes, Amie L, Qin, Qin, Xie, Hong, Katsifis, Spiros P, Thompson, W. Douglas, Wise, John Pierce

“…Hexavalent chromium (Cr(VI)) compounds are well-established human lung carcinogens. Solubility plays an important role in their carcinogenicity with the…”
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Human Skin Cells Are More Sensitive than Human Lung Cells to the Cytotoxic and Cell Cycle Arresting Impacts of Particulate and Soluble Hexavalent Chromium by Xie, Hong, Holmes, Amie L, Wise, Sandra S, Young, Jamie L, Wise, James T. F, Wise, John Pierce, Sr

“…Hexavalent chromium Cr(VI) is a known human lung carcinogen, with solubility playing an important role in its carcinogenic potency. Dermal exposure to Cr(VI)…”
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Carcinogenic lead chromate induces DNA double-strand breaks in human lung cells by Xie, Hong, Wise, Sandra S., Holmes, Amie L., Xu, Bo, Wakeman, Timothy P., Pelsue, Stephen C., Singh, Narendra P., Wise, John Pierce

“…Hexavalent chromium (Cr(VI)) is a widespread environmental contaminant and a known human carcinogen, generally causing bronchial cancer. Recent studies have…”
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Particulate and soluble hexavalent chromium are cytotoxic and genotoxic to human lung epithelial cells by Wise, Sandra S., Holmes, Amie L., Wise, John Pierce

“…Particulate hexavalent chromium (Cr(VI)) is a well-established human lung carcinogen. It is currently a major public health concern, there is widespread…”
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Chronic exposure to lead chromate causes centrosome abnormalities and aneuploidy in human lung cells by HOLMES, Amie L, WISE, Sandra S, SANDVICK, Sarah J, LINGLE, Wilma L, NEGRON, Vivian C, THOMPSON, W. Douglas, WISE, John Pierce

“…Hexavalent chromium [Cr(VI)] compounds are established human lung carcinogens. The carcinogenicity of Cr(VI) is related to its solubility, with the most potent…”
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Zinc chromate induces chromosome instability and DNA double strand breaks in human lung cells by Xie, Hong, Holmes, Amie L., Young, Jamie L., Qin, Qin, Joyce, Kellie, Pelsue, Stephen C., Peng, Cheng, Wise, Sandra S., Jeevarajan, Antony S., Wallace, William T., Hammond, Dianne, Wise, John Pierce

“…Hexavalent chromium Cr(VI) is a respiratory toxicant and carcinogen, with solubility playing an important role in its carcinogenic potential. Zinc chromate, a…”
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Lead Chromate-Induced Chromosome Damage Requires Extracellular Dissolution to Liberate Chromium Ions but Does Not Require Particle Internalization or Intracellular Dissolution by Xie, Hong, Holmes, Amie L, Wise, Sandra S, Gordon, Nancy, Wise, John Pierce

“…Hexavalent chromium [Cr(VI)] is a well-established human lung carcinogen. Water solubility has proven to be a key factor in the carcinogenicity of Cr(VI), with…”
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Chronic Exposure to Particulate Chromate Induces Spindle Assembly Checkpoint Bypass in Human Lung Cells by Wise, Sandra S, Holmes, Amie L, Xie, Hong, Thompson, W. Douglas, Wise, John Pierce

“…One of the hallmarks of lung cancer is chromosome instability (CIN), particularly a tetraploid phenotype, which is normally prevented by the spindle assembly…”
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The clastogenic effects of chronic exposure to particulate and soluble Cr(VI) in human lung cells by Holmes, Amie L., Wise, Sandra S., Sandwick, Sarah J., Wise, John Pierce

“…Hexavalent chromium (Cr(VI)) is a well-designated human lung carcinogen, with solubility playing an important role in its carcinogenic potential. Although it…”
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