Search Results - "HOLMBERG, Anders R"

Poly-guanidine shows high cytotoxicity in glioma cell cultures and glioma stem cells by Márquez, Marcela, Olausson, Karl Holmberg, Alaiya, Ayodele, Nilsson, Sten, Meurling, Lennart, Holmberg, Anders R.

“…Glioblastoma multiforme (GBM) is a malignant CNS tumor with a poor prognosis. GBM shows aberrant glycosylation with hypersialylation. This property is a…”
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The novel cytotoxic polybisphosphonate osteodex decreases bone resorption by enhancing cell death of mature osteoclasts without affecting osteoclastogenesis of RANKL-stimulated mouse bone marrow macrophages by Henning, Petra, Westerlund, Anna, Movérare-Skrtic, Sofia, Lindholm, Catharina, Márquez-Méndez, Marcela, Nilsson, Sten, Holmberg, Anders R., Lerner, Ulf H.

“…Summary It has previously been demonstrated that the polybisphosphonate osteodex (ODX) inhibits bone resorption in organ-cultured mouse calvarial bone. In this…”
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Cytotoxicity of poly-guanidine in medulloblastoma cell lines by Gallo-Oller, Gabriel, de Ståhl, Teresita Díaz, Alaiya, Ayodele, Nilsson, Sten, Holmberg, Anders R., Márquez-Méndez, Marcela

“…Summary Medulloblastoma (MB) is the most common pediatric brain tumor. The therapy frequently causes serious side effects, and new selective therapies are…”
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Charge-dependent Targeting: Results in Six Tumor Cell Lines by MARQUEZ, Marcela, NILSSON, Sten, LENNARTSSON, Lena, ZHAOXU LIU, TAMMELA, Teuvo, RAITANEN, Mika, HOLMBERG, Anders R

“…Background: Many previous studies show that cell surface sialylation of malignant cells is enhanced compared to normal tissue. The carboxyl group of the sialic…”
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Synthesis and Binding of a Novel PSMA-specific Conjugate by Holmberg, Anders R, Marquez, Marcela, Lennartsson, Lena, Meurling, Lennart, Nilsson, Sten

“…Prostate-specific membrane antigen (PSMA) is emerging as a target for treatment of castration-resistant prostate cancer (CRPC) while its up-regulated in the…”
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Bone-targeted Novel Cytotoxic Polybisphosphonate Conjugate in Castration-resistant Prostate Cancer: A Multicenter Phase 1 Study by Thellenberg-Karlsson, Camilla, Nyman, Claes, Nilsson, Sten, Blom, René, Márquez, Marcela, Castellanos, Enrique, Holmberg, Anders R

“…Osteodex (ODX) is a cytotoxic bone-targeting polybisphosphonate, intended for treatment of bone metastasis from castration-resistant prostate cancer (CRPC)…”
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Efficacy of a novel cytotoxic polybisphosphonate for treatment of bone metastasis in castration-resistant prostate cancer (CRPC) by Nilsson, Sten, Lindberg, Henriette, Thellenberg-Karlsson, Camilla, Nyman, Claes, Marquez, Marcela, Lennartsson, Lena, Blom, René, Castellanos, Enrique, Holmberg, Anders R

“…Abstract only 236 Background: A cytostatic polybisphosphonate was developed for Tx of mCRPC. It has a) anti-resorptive effects, osteoclast inhib., b) tum. cell…”
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Proteomic analysis of soft tissue tumor implants treated with a novel polybisphosphonate by Alaiya, Ayodele, Fox, Jonathan, Bobis, Steve, Matic, Goran, Shinwari, Zakia, Barhoush, Eman, Márquez, Marcela, Nilsson, Sten, Holmberg, Anders R

“…Osteodex is a novel bi-functional macromolecular polybisphosphonate developed for treatment of bone metastases in prostate and breast cancer. High efficacy of…”
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Polymer-conjugated guanidine is a potentially useful anti-tumor agent by MEURLING, Lennart, MARQUEZ, Marcela, NILSSON, Sten, HOLMBERG, Anders R

“…Guanidine compounds have important biochemical properties. Aminoguanidine, as an example, is an anti-oxidant, a nitric oxide synthase inhibitor (NOS) which…”
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Treatment of Bone Metastasis in Prostate Cancer: Efficacy of a Novel Polybisphosphonate by DAUBINE, Florence, LE BOT, Ronan, MARQUEZ, Marcela, NILSSON, Sten, SCHRÖDER, Torbjörn, HOLMBERG, Anders R

“…To investigate the in vivo efficacy of a novel polybisphosphonate (ODX) in the treatment of bone metastasis from prostate cancer. A rat prostatic carcinoma…”
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Development of a novel poly bisphosphonate conjugate for treatment of skeletal metastasis and osteoporosis by HOLMBERG, Anders R, LERNER, Ulf H, ALAYIA, Ayodele A, AL-MOHANNA, Mai, ADRA, Chaker, MARQUEZ, Marcela, MEURLING, Lennart, NILSSON, Sten

“…Advanced stage prostate and breast cancer frequently metastasize to the skeleton (approximately 75%). An additional complication in these patients, that…”
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Application of accelerator mass spectrometry to macromolecules: preclinical pharmacokinetic studies on a polybisphosphonate by Salehpour, Mehran, Håkansson, Karl, Höglund, Urban, Grahn-Westin, Annika, Nilsson, Sten, Márquez, Marcela, Possnert, Göran, Holmberg, Anders R.

“…Data on the use of accelerator mass spectrometry (AMS) in conjunction with in vivo studies of macromolecular drugs are scarce. The present study shows the…”
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Incubation with somatostatin, 5-aza decitabine and trichostatin up-regulates somatostatin receptor expression in prostate cancer cells by ZHAOXU LIU, MARQUEZ, Marcela, NILSSON, Sten, HOLMBERG, Anders R

“…Somatostatin (SMS), binds to its specific receptors (SSTRs) and transduces growth inhibitory, anti-secretory and apoptotic signals. Several human cancers…”
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The use of Butea superba (Roxb.) compared to sildenafil for treating erectile dysfunction by Cortés‐González, Jeff R., Arratia‐Maqueo, Jorge A., Gómez‐Guerra, Lauro S., Holmberg, Anders R.

“…Study Type – Therapy (case control) Level of Evidence 3b OBJECTIVE To evaluate the effect of an extract of Butea superba (Roxb.) (BS) compared to sildenafil…”
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Comparison of protein expression in two prostate cancer cell-lines, LNCaP and DU145, after treatment with somatostatin by ZHAOXU LIU, MARQUEZ, Marcela, NILSSON, Sten, HOLMBERG, Anders R

“…The mechanisms underlying prostate cancer progression are poorly understood. Proteins responsive to androgens may be involved in the development and…”
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Somatostatin effects on the proteome of the LNCaP cell-line by ZHAOXU LIU, BENGTSSON, Sofia, KROGH, Morten, MARQUEZ, Marcela, NILSSON, Sten, JAMES, Peter, ALIAYA, Ayodele, HOLMBERG, Anders R

“…Some clinical results indicate that somatostatin (sms) might be useful in the treatment of advanced prostate cancer (HRPC). Because of its transient in vivo…”
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Prostate cancer cell lines lack amplification: overexpression of HER2 by Ullén, Anders, Lennartsson, Lena, Harmenberg, Ulrika, Lennernäs, Bo, Majumder, Khairul, Holmberg, Anders R, Nilsson, Sten, Elmberger, Göran P

“…The potential overexpression of HER2 in prostate cancer cells has attended significant interest during the past few years, both as potential target for HER2…”
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A novel somatostatin conjugate with a high affinity to all five somatostatin receptor subtypes by Wulbrand, Ulrich, Feldman, Martin, Pfestroff, Andreas, Fehman, Hans‐Cristophe, Du, Jin, Hiltunen, Jukka, Marquez, Marcela, Arnold, Rudolf, Westlin, Jan‐Erik, Nilsson, Sten, Holmberg, Anders R.

“…BACKGROUND Somatostatin receptors (SRS, five subtypes) are expressed in a variety of human tumors, including most tumors of neuroendocrine origin, breast…”
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Technetium-99m labelling of glycosylated somatostatin-14 by Du, Jin, Hiltunen, Jukka, Marquez, Marcela, Nilsson, Sten, Holmberg, Anders R

“…This study presents a technetium-99m labelling method based on organometallic chemistry. It describes the simple mixing of a 99mTc(I)–carbonyl compound […”
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Proteomic Analysis of a Human Prostate Cancer Cell Line after Incubation with a Novel Somatostatin14 Derivative by ZHAOXU LIU, MARCELA MRQUEZ, STEN NILSSON, ANDERS R. HOLMBERG, AYODELE ALAIYA

“…Background: Derivatives of somatostatin (sms) are sometimes used in the treatment of hormone-refractory prostatic cancer, in spite of modest results in…”
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