Search Results - "HOLMANS, P. A"

Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia by Lips, E S, Cornelisse, L N, Toonen, R F, Min, J L, Hultman, C M, Holmans, P A, O'Donovan, M C, Purcell, S M, Smit, A B, Verhage, M, Sullivan, P F, Visscher, P M, Posthuma, D

“…Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of ∼1%. Previous studies have implicated…”
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The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia by Green, E K, Grozeva, D, Jones, I, Jones, L, Kirov, G, Caesar, S, Gordon-Smith, K, Fraser, C, Forty, L, Russell, E, Hamshere, M L, Moskvina, V, Nikolov, I, Farmer, A, McGuffin, P, Holmans, P A, Owen, M J, O'Donovan, M C, Craddock, N

“…Molecular genetic analysis offers opportunities to advance our understanding of the nosological relationship between psychiatric diagnostic categories in…”
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Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept by Hamshere, M. L., Green, E. K., Jones, I. R., Jones, L., Moskvina, V., Kirov, G., Grozeva, D., Nikolov, I., Vukcevic, D., Caesar, S., Gordon-Smith, K., Fraser, C., Russell, E., Breen, G., Clair, D. St, Collier, D. A., Young, A. H., Ferrier, I. N., Farmer, A., McGuffin, P., Holmans, P. A., Owen, M. J., O'Donovan, M. C., Craddock, N.

“…Psychiatric phenotypes are currently defined according to sets of descriptive criteria. Although many of these phenotypes are heritable, it would be useful to…”
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No consistent evidence for association between mtDNA variants and Alzheimer disease by HUDSON, G, SIMS, R, THOMAS, C, STRETTON, A, HOLMANS, P. A, O'DONOVAN, M. C, OWEN, M. J, WILLIAMS, J, CHINNER, P. F, HAROLD, D, CHAPMAN, J, HOLLINGWORTH, P, GERRISH, A, RUSSO, G, HAMSHERE, M, MOSKVINA, V, JONES, N

“…Although several studies have described an association between Alzheimer disease (AD) and genetic variation of mitochondrial DNA (mtDNA), each has implicated…”
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Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms by Holmans, P A, Riley, B, Pulver, A E, Owen, M J, Wildenauer, D B, Gejman, P V, Mowry, B J, Laurent, C, Kendler, K S, Nestadt, G, Williams, N M, Schwab, S G, Sanders, A R, Nertney, D, Mallet, J, Wormley, B, Lasseter, V K, O'Donovan, M C, Duan, J, Albus, M, Alexander, M, Godard, S, Ribble, R, Liang, K Y, Norton, N, Maier, W, Papadimitriou, G, Walsh, D, Jay, M, O'Neill, A, Lerer, F B, Dikeos, D, Crowe, R R, Silverman, J M, Levinson, D F

“…A genomewide linkage scan was carried out in eight clinical samples of informative schizophrenia families. After all quality control checks, the analysis of…”
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Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis by Hollingworth, P., Hamshere, M.L., Holmans, P.A., O'Donovan, M.C., Sims, Rebecca, Powell, J., Lovestone, S., Myers, A., DeVrieze, F.W., Hardy, J., Goate, A., Owen, M., Williams, J.

“…Psychotic symptoms are common in Alzheimer's disease (AD) and are associated with increased cognitive impairment and earlier institutionalization. One study…”
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Multicenter linkage study of schizophrenia loci on chromosome 22q by MOWRY, B. J, HOLMANS, P. A, OWEN, M. J, WORMLEY, B, SANDERS, A. R, NESTADT, G, LIANG, K. Y, DUAN, J, RIBBLE, R, NORTON, N, SOUBIGOU, S, MAIER, W, PULVER, A. E, EWEN-WHITE, K. R, DEMARCHI, N, CARPENTER, B, WALSH, D, WILLIAMS, H, JAY, M, ALBUS, M, NERTNEY, D. A, PAPADIMITRIOU, G, O'NEILL, A, GEJMAN, P. V, O'DONOVAN, M. C, DELEUZE, J.-F, LERER, F. B, DIKEOS, D, KENDLER, K. S, MALLET, J, SILVERMAN, J. M, CROWE, R. R, LEVINSON, D. F, RILEY, B, WILLIAMS, N. M, LAURENT, C, SCHWAB, S. G, WILDENAUER, D. B, BAUCHE, S

“…The hypothesis of the existence of one or more schizophrenia susceptibility loci on chromosome 22q is supported by reports of genetic linkage and association,…”
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Exome arrays capture polygenic rare variant contributions to schizophrenia by Richards, A L, Leonenko, G, Walters, J T, Kavanagh, D H, Rees, E G, Evans, A, Chambert, K D, Moran, J L, Goldstein, J, Neale, B M, McCarroll, S A, Pocklington, A J, Holmans, P A, Owen, M J, O'Donovan, M C

“…Schizophrenia is a highly heritable disorder. Genome-wide association studies based largely on common alleles have identified over 100 schizophrenia risk loci,…”
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Polygenic dissection of the bipolar phenotype by Hamshere, M L, O'Donovan, M C, Jones, I R, Jones, L, Kirov, G, Green, E K, Moskvina, V, Grozeva, D, Bass, N, McQuillin, A, Gurling, H, St Clair, D, Young, A H, Ferrier, I N, Farmer, A, McGuffin, P, Sklar, P, Purcell, S, Holmans, P A, Owen, M J, Craddock, N

“…Recent data provide strong support for a substantial common polygenic contribution (i.e. many alleles each of small effect) to genetic susceptibility for…”
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Meta-analysis of 32 genome-wide linkage studies of schizophrenia by Ng, M Y M, Levinson, D F, Faraone, S V, Suarez, B K, DeLisi, L E, Arinami, T, Riley, B, Paunio, T, Pulver, A E, Irmansyah, Holmans, P A, Escamilla, M, Wildenauer, D B, Williams, N M, Laurent, C, Mowry, B J, Brzustowicz, L M, Maziade, M, Sklar, P, Garver, D L, Abecasis, G R, Lerer, B, Fallin, M D, Gurling, H M D, Gejman, P V, Lindholm, E, Moises, H W, Byerley, W, Wijsman, E M, Forabosco, P, Tsuang, M T, Hwu, H-G, Okazaki, Y, Kendler, K S, Wormley, B, Fanous, A, Walsh, D, O'Neill, F A, Peltonen, L, Nestadt, G, Lasseter, V K, Liang, K Y, Papadimitriou, G M, Dikeos, D G, Schwab, S G, Owen, M J, O'Donovan, M C, Norton, N, Hare, E, Raventos, H, Nicolini, H, Albus, M, Maier, W, Nimgaonkar, V L, Terenius, L, Mallet, J, Jay, M, Godard, S, Nertney, D, Alexander, M, Crowe, R R, Silverman, J M, Bassett, A S, Roy, M-A, Mérette, C, Pato, C N, Pato, M T, Roos, J Louw, Kohn, Y, Amann-Zalcenstein, D, Kalsi, G, McQuillin, A, Curtis, D, Brynjolfson, J, Sigmundsson, T, Petursson, H, Sanders, A R, Duan, J, Jazin, E, Myles-Worsley, M, Karayiorgou, M, Lewis, C M

“…A genome scan meta-a nalysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases…”
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Factor-derived subsyndromes of schizophrenia and familial morbid risks by Cardno, Alastair G., Holmans, Peter A., Harvey, Ian, Williams, Maureen B., Owen, Michael J., McGuffin, Peter

“…Factor analysis was performed on OPCRIT checklist ratings from 66 patients with RDC schizophrenia. Eight substantive factors were found, characterised…”
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No Major Schizophrenia Locus Detected on Chromosome 1q in a Large Multicenter Sample by Levinson, Douglas F., Holmans, Peter A., Laurent, Claudine, Riley, Brien, Pulver, Ann E., Gejman, Pablo V., Schwab, Sibylle G., Williams, Nigel M., Owen, Michael J., Wildenauer, Dieter B., Sanders, Alan R., Nestadt, Gerald, Mowry, Bryan J., Wormley, Brandon, Bauché, Stéphanie, Soubigou, Stéphane, Ribble, Robert, Nertney, Deborah A., Liang, Kung Yee, Martinolich, Laura, Maier, Wolfgang, Norton, Nadine, Williams, Hywel, Albus, Margot, Carpenter, Eric B., deMarchi, Nicola, Ewen-White, Kelly R., Walsh, Dermot, Jay, Maurice, Deleuze, Jean-François, O'Neill, F. Anthony, Papadimitriou, George, Weilbaecher, Ann, Lerer, Bernard, O'Donovan, Michael C., Dikeos, Dimitris, Silverman, Jeremy M., Kendler, Kenneth S., Mallet, Jacques, Crowe, Raymond R., Walters, Marilyn

“…Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of…”
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A genomewide linkage study of age at onset in schizophrenia by Cardno, Alastair G., Holmans, Peter A., Rees, Mark I., Jones, Lisa A., McCarthy, Geraldine M., Hamshere, Marian L., Williams, Nigel M., Norton, Nadine, Williams, Hywel J., Fenton, Iain, Murphy, Kieran C., Sanders, Robert D., Gray, Marion Y., O'Donovan, Michael C., McGuffin, Peter, Owen, Michael J.

“…There is strong evidence for a genetic contribution to age at onset of schizophrenia, which probably involves both susceptibility loci for schizophrenia and…”
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Strong genetic evidence for a selective influence of GABA receptors on a component of the bipolar disorder phenotype

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Rheumatoid arthritis association at 6q23 by Worthington, Jane, Thomson, Wendy, Barton, Anne, Ke, Xiayi, Eyre, Steve, Hinks, Anne, Bowes, John, Donn, Rachelle, Symmons, Deborah, Hider, Samantha, Bruce, Ian N, Wilson, Anthony G, Marinou, Ioanna, Morgan, Ann, Emery, Paul, Carter, Angela, Steer, Sophia, Hocking, Lynne, Reid, David M, Wordsworth, Paul, Harrison, Pille, Strachan, David

“…The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 × 10−5 − 5 × 10−7 in a…”
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Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder by Liu, Y, Blackwood, D H, Caesar, S, de Geus, E J C, Farmer, A, Ferreira, M A R, Ferrier, I N, Fraser, C, Gordon-Smith, K, Green, E K, Grozeva, D, Gurling, H M, Hamshere, M L, Heutink, P, Holmans, P A, Hoogendijk, W J, Hottenga, J J, Jones, L, Jones, I R, Kirov, G, Lin, D, McGuffin, P, Moskvina, V, Nolen, W A, Perlis, R H, Posthuma, D, Scolnick, E M, Smit, A B, Smit, J H, Smoller, J W, St Clair, D, van Dyck, R, Verhage, M, Willemsen, G, Young, A H, Zandbelt, T, Boomsma, D I, Craddock, N, O'Donovan, M C, Owen, M J, Penninx, B W J H, Purcell, S, Sklar, P, Sullivan, P F

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Schizophrenia genetic variants are not associated with intelligence by van Scheltinga, A F Terwisscha, Bakker, S C, van Haren, N E M, Derks, E M, Buizer-Voskamp, J E, Cahn, W, Ripke, S, Ophoff, R A, Kahn, R S

“…Schizophrenia is associated with lower pre-morbid intelligence (IQ) in addition to (pre-morbid) cognitive decline. Both schizophrenia and IQ are highly…”
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Genome-wide association study identifies five new schizophrenia loci by Ripke, Stephan, Sanders, Alan R, Kendler, Kenneth S, Levinson, Douglas F, Sklar, Pamela, Holmans, Peter A, Lin, Dan-Yu, Duan, Jubao, Ophoff, Roel A, Andreassen, Ole A, Scolnick, Edward, Cichon, Sven, St Clair, David, Corvin, Aiden, Gurling, Hugh, Werge, Thomas, Rujescu, Dan, Blackwood, Douglas H R, Pato, Carlos N, Malhotra, Anil K, Purcell, Shaun, Dudbridge, Frank, Neale, Benjamin M, Rossin, Lizzy, Visscher, Peter M, Posthuma, Danielle, Ruderfer, Douglas M, Fanous, Ayman, Stefansson, Hreinn, Steinberg, Stacy, Mowry, Bryan J, Golimbet, Vera, De Hert, Marc, Jonsson, Erik G, Bitter, Istvan, Pietilaeinen, Olli P H, Collier, David A, Tosato, Sarah, Agartz, Ingrid, Albus, Margot, Alexander, Madeline, Amdur, Richard L, Amin, Farooq, Bass, Nicholas, Bergen, Sarah E, Black, Donald W, Boerglum, Anders D, Brown, Matthew A, Bruggeman, Richard, Buccola, Nancy G

“…We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856…”
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Toxins, genetics, and Parkinson's disease: the role of N-acetyltransferase 2 by Bandmann, O, Vaughan, J, Holmans, P A, Marsden, C D, Wood, N W

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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder by Purcell, Shaun M, Wray, Naomi R, Stone, Jennifer L, Visscher, Peter M, O'Donovan, Michael C, Sullivan, Patrick F, Sklar, Pamela

“…Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with…”
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