Search Results - "HOLLMAN, Peter C"

Potential Health Impact of Environmentally Released Micro- and Nanoplastics in the Human Food Production Chain: Experiences from Nanotoxicology by Bouwmeester, Hans, Hollman, Peter C. H, Peters, Ruud J. B

“…High concentrations of plastic debris have been observed in the oceans. Much of the recent concern has focused on microplastics in the marine environment…”
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Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: a randomized, double-blind, placebo-controlled, crossover trial by Dower, James I, Geleijnse, Johanna M, Gijsbers, Lieke, Zock, Peter L, Kromhout, Daan, Hollman, Peter CH

“…Background: Prospective cohort studies showed inverse associations between the intake of flavonoid-rich foods (cocoa and tea) and cardiovascular disease (CVD)…”
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Supplementation of the Pure Flavonoids Epicatechin and Quercetin Affects Some Biomarkers of Endothelial Dysfunction and Inflammation in (Pre)Hypertensive Adults: A Randomized Double-Blind, Placebo-Controlled, Crossover Trial by Dower, James I, Geleijnse, Johanna M, Gijsbers, Lieke, Schalkwijk, Casper, Kromhout, Daan, Hollman, Peter C

“…Consumption of flavonoid-rich foods such as cocoa and tea may reduce cardiovascular disease risk. The flavonoids epicatechin (in cocoa and tea) and quercetin…”
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The biological relevance of direct antioxidant effects of polyphenols for cardiovascular health in humans is not established by Hollman, Peter C H, Cassidy, Aedin, Comte, Blandine, Heinonen, Marina, Richelle, Myriam, Richling, Elke, Serafini, Mauro, Scalbert, Augustin, Sies, Helmut, Vidry, Stéphane

“…Human studies provide evidence for beneficial effects of polyphenol-rich foods on cardiovascular health. The antioxidant activity of polyphenols potentially…”
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Polyphenols and disease risk in epidemiologic studies by Arts, Ilja C.W, Hollman, Peter C.H

“…Plant polyphenols, a large group of natural antioxidants, are serious candidates in explanations of the protective effects of vegetables and fruits against…”
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Dietary flavonol intake may lower stroke risk in men and women by Hollman, Peter C H, Geelen, Anouk, Kromhout, Daan

“…Flavonols are strong antioxidants in plant foods and tea is a major dietary source. There is evidence from prospective cohort studies that tea and flavonols…”
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Procyanidin Dimers Are Metabolized by Human Microbiota with 2-(3,4-Dihydroxyphenyl)acetic Acid and 5-(3,4-Dihydroxyphenyl)-γ-valerolactone as the Major Metabolites by Appeldoorn, Maaike M, Vincken, Jean-Paul, Aura, Anna-Marja, Hollman, Peter C. H, Gruppen, Harry

“…Procyanidins (PCs) are highly abundant phenolic compounds in the human diet and might be responsible for the health effects of chocolate and wine. Due to low…”
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Pure flavonoid epicatechin and whole genome gene expression profiles in circulating immune cells in adults with elevated blood pressure: A randomised double-blind, placebo-controlled, crossover trial by Esser, Diederik, Geleijnse, Johanna M, Matualatupauw, Juri C, Dower, James I, Kromhout, Daan, Hollman, Peter C H, Afman, Lydia A

“…Cocoa consumption has beneficial cardiometabolic effects, but underlying mechanisms remain unclear. Epicatechin, the cocoa major monomeric flavan-3-ol, is…”
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Procyanidin dimers A1, A2, and B2 are absorbed without conjugation or methylation from the small intestine of rats by Appeldoorn, Maaike M, Vincken, Jean-Paul, Gruppen, Harry, Hollman, Peter C H

“…Intervention studies with procyanidin (PC)-rich extracts and products such as cocoa and wine suggest protective effects of PC against cardiovascular diseases…”
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Quercetin induces hepatic lipid omega-oxidation and lowers serum lipid levels in mice by Hoek-van den Hil, Elise F, Keijer, Jaap, Bunschoten, Annelies, Vervoort, Jacques J M, Stankova, Barbora, Bekkenkamp, Melissa, Herreman, Laure, Venema, Dini, Hollman, Peter C H, Tvrzicka, Eva, Rietjens, Ivonne M C M, van Schothorst, Evert M

“…Elevated circulating lipid levels are known risk factors for cardiovascular diseases (CVD). In order to examine the effects of quercetin on lipid metabolism,…”
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Distribution, Elimination, and Toxicity of Silver Nanoparticles and Silver Ions in Rats after 28-Day Oral Exposure by van der Zande, Meike, Vandebriel, Rob J, Van Doren, Elke, Kramer, Evelien, Herrera Rivera, Zahira, Serrano-Rojero, Cecilia S, Gremmer, Eric R, Mast, Jan, Peters, Ruud J. B, Hollman, Peter C. H, Hendriksen, Peter J. M, Marvin, Hans J. P, Peijnenburg, Ad A. C. M, Bouwmeester, Hans

“…We report the results of a 28-day oral exposure study in rats, exposed to <20 nm noncoated, or <15 nm PVP-coated silver nanoparticles ([Ag] = 90 mg/kg body…”
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Does epicatechin contribute to the acute vascular function effects of dark chocolate? A randomized, crossover study by Dower, James I., Geleijnse, Johanna M., Kroon, Paul A., Philo, Mark, Mensink, Marco, Kromhout, Daan, Hollman, Peter C. H.

“…Scope Cocoa, rich in flavan‐3‐ols, improves vascular function, but the contribution of specific flavan‐3‐ols is unknown. We compared the effects of pure…”
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Lignan contents of Dutch plant foods: a database including lariciresinol, pinoresinol, secoisolariciresinol and matairesinol by Milder, Ivon E. J., Arts, Ilja C. W., Putte, Betty van de, Venema, Dini P., Hollman, Peter C. H.

“…Enterolignans (enterodiol and enterolactone) can potentially reduce the risk of certain cancers and cardiovascular diseases. Enterolignans are formed by the…”
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Direct comparison of metabolic health effects of the flavonoids quercetin, hesperetin, epicatechin, apigenin and anthocyanins in high-fat-diet-fed mice by Hoek-van den Hil, Elise F, van Schothorst, Evert M, van der Stelt, Inge, Swarts, Hans J M, van Vliet, Marjanne, Amolo, Tom, Vervoort, Jacques J M, Venema, Dini, Hollman, Peter C H, Rietjens, Ivonne M C M, Keijer, Jaap

“…Dietary flavonoid intake is associated with reduced risk of cardiovascular diseases, possibly by affecting metabolic health. The relative potency of different…”
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Tissue distribution of quercetin in pigs after long-term dietary supplementation by Bieger, Juliane, Cermak, Rainer, Blank, Ralf, de Boer, Vincent C J, Hollman, Peter C H, Kamphues, Joseph, Wolffram, Siegfried

“…Although the flavonol quercetin is intensively investigated, our knowledge about its bioavailability and possible target organs is far from being complete. The…”
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Some Phenolic Compounds Increase the Nitric Oxide Level in Endothelial Cells in Vitro by Appeldoorn, Maaike M, Venema, Dini P, Peters, Theodorus H. F, Koenen, Marjorie E, Arts, Ilja C. W, Vincken, Jean-Paul, Gruppen, Harry, Keijer, Jaap, Hollman, Peter C. H

“…The vasorelaxing properties of chocolate and wine might relate to the presence of phenolic compounds. One of the potential mechanisms involved is stimulation…”
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The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides by Arts, Ilja C. W., Sesink, Aloys L. A., Faassen-Peters, Maria, Hollman, Peter C. H.

“…Quercetin is an important dietary flavonoid with putative beneficial effects in the prevention of cancer and CVD. The in vivo bioactivity of quercetin depends…”
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SIRT1 stimulation by polyphenols is affected by their stability and metabolism by de Boer, Vincent C.J., de Goffau, Marcus C., Arts, Ilja C.W., Hollman, Peter C.H., Keijer, Jaap

“…Silent information regulator two ortholog 1 (SIRT1) is the human ortholog of the yeast sir2 protein; one of the most important regulators of lifespan extension…”
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Effects of sodium and potassium supplementation on endothelial function: a fully controlled dietary intervention study by Gijsbers, Lieke, Dower, James I., Schalkwijk, Casper G., Kusters, Yvo H. A. M., Bakker, Stephan J. L., Hollman, Peter C. H., Geleijnse, Johanna M.

“…High Na and low K intakes have adverse effects on blood pressure, which increases the risk for CVD. The role of endothelial dysfunction and inflammation in…”
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Evidence for health benefits of plant phenols: local or systemic effects? by Hollman, Peter C H

“…Plant phenols are mostly products of the phenylpropanoid pathway and comprise a large variety of compounds: cinnamic acids, benzoic acids, flavonoids,…”
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