Search Results - "HOLLIS, D"

Recent Progress in the Discovery and Development of 2-Nitroimidazooxazines and 6-Nitroimidazooxazoles to Treat Tuberculosis and Neglected Tropical Diseases by Showalter, Hollis D

“…Nitroimidazole drugs have a long history as therapeutic agents to treat bacterial and parasitic diseases. The discovery in 1989 of a bicyclic nitroimidazole…”
Get full text

Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer by Madak, Joseph T., Bankhead, Armand, Cuthbertson, Christine R., Showalter, Hollis D., Neamati, Nouri

“…Identified as a hallmark of cancer, metabolic reprogramming allows cancer cells to rapidly proliferate, resist chemotherapies, invade, metastasize, and survive…”
Get full text

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release by Shen, Dongbiao, Wang, Xiang, Li, Xinran, Zhang, Xiaoli, Yao, Zepeng, Dibble, Shannon, Dong, Xian-ping, Yu, Ting, Lieberman, Andrew P., Showalter, Hollis D., Xu, Haoxing

“…Lysosomal lipid accumulation, defects in membrane trafficking and altered Ca 2+ homoeostasis are common features in many lysosomal storage diseases. Mucolipin…”
Get full text

Progress in the Synthesis of Canthine Alkaloids and Ring-Truncated Congeners by Showalter, H. D. Hollis

“…The canthines represent a fairly large subclass of β-carboline alkaloids, with the first members described 75 years ago. Over the last 60 years, many members…”
Get full text

Prevalence of Disabilities and Health Care Access by Disability Status and Type Among Adults — United States, 2016 by Okoro, Catherine A., Hollis, NaTasha D., Cyrus, Alissa C., Griffin-Blake, Shannon

“…Persons with disabilities face greater barriers to health care than do those without disabilities (1). To identify characteristics of noninstitutionalized…”
Get full text

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia by Grembecka, Jolanta, He, Shihan, Shi, Aibin, Purohit, Trupta, Muntean, Andrew G, Sorenson, Roderick J, Showalter, Hollis D, Murai, Marcelo J, Belcher, Amalia M, Hartley, Thomas, Hess, Jay L, Cierpicki, Tomasz

“…MLL fusion genes often encode leukemogenic proteins that depend on interaction with menin, a component of the MLL SET1-like histone methyltransferase complex…”
Get full text

Spectrum of hot methane in astronomical objects using a comprehensive computed line list by Yurchenko, Sergei N., Tennyson, Jonathan, Bailey, Jeremy, Hollis, Morgan D. J., Tinetti, Giovanna

“…Hot methane spectra are important in environments ranging from flames to the atmospheres of cool stars and exoplanets. A new spectroscopic line list, 10to10,…”
Get full text

A concise synthesis of 3-substituted-7-amino-6-carboxyl-8-azachromones by Gan, Xinmin, Showalter, Hollis D.

“…[Display omitted] •Amlexanox is an approved drug currently under clinical evaluation to treat obesity.•A concise synthesis of truncated analogues…”
Get full text

Ambient noise multimode Rayleigh and Love wave tomography to determine the shear velocity structure above the Groningen gas field by Chmiel, M, Mordret, A, Boué, P, Brenguier, F, Lecocq, T, Courbis, R, Hollis, D, Campman, X, Romijn, R, Van der Veen, W

“…SUMMARY The Groningen gas field is one of the largest gas fields in Europe. The continuous gas extraction led to an induced seismic activity in the area. In…”
Get full text

Racial and Ethnic Disparities in Incidence of SARS-CoV-2 Infection, 22 US States and DC, January 1-October 1, 2020 by Hollis, NaTasha D, Li, Wen, Van Dyke, Miriam E, Njie, Gibril J, Scobie, Heather M, Parker, Erin M, Penman-Aguilar, Ana, Clarke, Kristie E N

“…We examined disparities in cumulative incidence of severe acute respiratory syndrome coronavirus 2 by race/ethnicity, age, and sex in the United States during…”
Get full text

Train Traffic as a Powerful Noise Source for Monitoring Active Faults With Seismic Interferometry by Brenguier, F., Boué, P., Ben‐Zion, Y., Vernon, F., Johnson, C.W., Mordret, A., Coutant, O., Share, P.‐E., Beaucé, E., Hollis, D., Lecocq, T.

“…Laboratory experiments report that detectable seismic velocity changes should occur in the vicinity of fault zones prior to earthquakes. However, operating…”
Get full text

Is the ocean surface a source of nitrous acid (HONO) in the marine boundary layer? by Crilley, Leigh R, Kramer, Louisa J, Pope, Francis D, Reed, Chris, Lee, James D, Carpenter, Lucy J, Hollis, Lloyd D. J, Ball, Stephen M, Bloss, William J

“…Nitrous acid, HONO, is a key net photolytic precursor to OH radicals in the atmospheric boundary layer. As OH is the dominant atmospheric oxidant, driving the…”
Get full text

A Randomized Controlled Trial using Brief Educational Messages Directed to Adults with Intellectual Disability and Hypertension or their Helpers Reduces Hospital Stays by Zhang, Wanfang, McDermott, Suzanne, Salzberg, Deborah C., Hollis, NaTasha D., Hardin, James

“…Purpose We assessed an educational intervention to reduce the number of emergency department (ED) and inpatient stays for cardiovascular diagnoses, among South…”
Get full text

Design, Synthesis, and Characterization of Brequinar Conjugates as Probes to Study DHODH Inhibition by Madak, Joseph T., Cuthbertson, Christine R., Chen, Wenmin, Showalter, Hollis D., Neamati, Nouri

“…Brequinar, a potent dihydroorotate dehydrogenase (DHODH) inhibitor, has been evaluated in multiple clinical trials as a potential treatment for cancer. To…”
Get full text

Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies by Peterson, Luke F., Sun, Hanshi, Liu, Yihong, Potu, Harish, Kandarpa, Malathi, Ermann, Monika, Courtney, Stephen M., Young, Matthew, Showalter, Hollis D., Sun, Duxin, Jakubowiak, Andrzej, Malek, Sami N., Talpaz, Moshe, Donato, Nicholas J.

“…Usp9x was recently shown to be highly expressed in myeloma patients with short progression-free survival and is proposed to enhance stability of the survival…”
Get full text

The application of digital volume correlation (DVC) to study the microstructural behaviour of trabecular bone during compression by Gillard, F., Boardman, R., Mavrogordato, M., Hollis, D., Sinclair, I., Pierron, F., Browne, M.

“…Digital Volume Correlation (DVC) has been emerged recently as an innovative approach to full volume (i.e. internal) displacement and strain field measurement…”
Get full text

Design, Synthesis, and Biological Evaluation of 4‑Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase by Madak, Joseph T, Cuthbertson, Christine R, Miyata, Yoshinari, Tamura, Shuzo, Petrunak, Elyse M, Stuckey, Jeanne A, Han, Yanyan, He, Miao, Sun, Duxin, Showalter, Hollis D, Neamati, Nouri

“…We pursued a structure-guided approach toward the development of improved dihydroorotate dehydrogenase (DHODH) inhibitors with the goal of forming new…”
Get full text

Quaternary Diamines as Mass Spectrometry Cleavable Crosslinkers for Protein Interactions by Clifford-Nunn, Billy, Showalter, H. D. Hollis, Andrews, Philip C.

“…Mapping protein interactions and their dynamics is crucial to defining physiologic states, building effective models for understanding cell function, and to…”
Get full text

A novel synthesis of substituted 3‐amino and 3‐thio pyrimido[5,4‐e]‐1,2,4‐triazine‐5,7(1H,6H)‐diones by Xu, Hao, Powelson, Ian A., Jin, Yafei, Showalter, Hollis D.

“…Fervenulin is a natural product that has been extensively studied due to its molecular features and breadth of biological activities. Published studies have…”
Get full text

J-Integral Calculation by Finite Element Processing of Measured Full-Field Surface Displacements by Barhli, S.M., Mostafavi, M., Cinar, A.F., Hollis, D., Marrow, T.J.

“…A novel method has been developed based on the conjoint use of digital image correlation to measure full field displacements and finite element simulations to…”
Get full text