Search Results - "HOLLINS, Andrew J"

Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function by Davies, Vanessa J., Hollins, Andrew J., Piechota, Malgorzata J., Yip, Wanfen, Davies, Jennifer R., White, Kathryn E., Nicols, Phillip P., Boulton, Michael E., Votruba, Marcela

“…OPA1 is a ubiquitously expressed, nuclear dynamin-related GTPase, targeted to the inner mitochondrial membrane, which plays a role in mitochondrial fusion…”
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3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors by Badder, Luned M, Hollins, Andrew J, Herpers, Bram, Yan, Kuan, Ewan, Kenneth B, Thomas, Mairian, Shone, Jennifer R, Badder, Delyth A, Naven, Marc, Ashelford, Kevin E, Hargest, Rachel, Clarke, Alan R, Esdar, Christina, Buchstaller, Hans-Peter, Treherne, J. Mark, Boj, Sylvia, Ramezanpour, Bahar, Wienke, Dirk, Price, Leo S, Shaw, Paul H, Dale, Trevor C

“…Aberrant activation of the Wnt signalling pathway is required for tumour initiation and survival in the majority of colorectal cancers. The development of…”
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Toxicogenomics of Non-viral Vectors for Gene Therapy: A Microarray Study of Lipofectin- and Oligofectamine-induced Gene Expression Changes in Human Epithelial Cells by Omidi, Yadollah, Hollins, Andrew J., Benboubetra, Mustapha, Drayton, Ross, Benter, Ibrahim F., Akhtar, Saghir

“…Of the non-viral vectors, cationic lipid (CL) formulations are the most widely studied for the delivery of genes, antisense oligonucleotides and gene silencing…”
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Early inhibition of EGFR signaling prevents diabetes-induced up-regulation of multiple gene pathways in the mesenteric vasculature by Benter, Ibrahim F, Benboubetra, Mustapha, Hollins, Andrew J, Yousif, Mariam H.M, Canatan, Halit, Akhtar, Saghir

“…Abstract Diabetes mellitus is associated with vascular complications including an impairment of vascular function and alterations in the reactivity of blood…”
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Constitutive expression of p-glycoprotein in normal lung alveolar epithelium and functionality in primary alveolar epithelial cultures by Campbell, Lee, Abulrob, Abedel-Nasser G, Kandalaft, Lana E, Plummer, Steven, Hollins, Andrew J, Gibbs, Alan, Gumbleton, Mark

“…The multidrug resistant (MDR) transporter P-glycoprotein (P-gp) is constitutively expressed in normal tissues, where its spatial distribution defines it as an…”
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Modeling colorectal cancer: A bio‐resource of 50 patient‐derived organoid lines by Engel, Rebekah M, Jardé, Thierry, Oliva, Karen, Kerr, Genevieve, Chan, Wing Hei, Hlavca, Sara, Nickless, David, Archer, Stuart K, Yap, Raymond, Ranchod, Pravin, Bell, Stephen, Niap, Ann, Koulis, Christine, Chong, Ashley, Wilkins, Simon, Dale, Trevor C, Hollins, Andrew J, McMurrick, Paul J, Abud, Helen E

“…Background and Aim Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. To improve outcomes for these patients, we need to develop…”
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Toxicogenomics of drug delivery systems: Exploiting delivery system-induced changes in target gene expression to enhance siRNA activity by Hollins, Andrew J., Omidi, Yadollah, Benter, Ibrahim F., Akhtar, Saghir

“…Synthetic siRNAs are typically formulated with drug delivery systems (DDS) that improve cellular uptake for optimal gene silencing activity. Here, we show that…”
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Long-Term Culture of Intestinal Cell Progenitors: An Overview of Their Development, Application, and Associated Technologies by Hollins, Andrew J., Parry, Lee

“…Purpose of Review Long-term culture of adult progenitor cells in 3D is a recently emerging technology that inhabits the space between 2D cell lines and organ…”
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A novel anionic dendrimer for improved cellular delivery of antisense oligonucleotides by Hussain, Majad, Shchepinov, Mikhail, Sohail, Muhammad, Benter, Ibrahim F., Hollins, Andrew J., Southern, Edwin M., Akhtar, Saghir

“…The optimal design of hybridisation-competent antisense oligonucleotides (ODNs) coupled with an efficient delivery system appear to be important prerequisites…”
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Evaluation of generation 2 and 3 poly(propylenimine) dendrimers for the potential cellular delivery of antisense oligonucleotides targeting the epidermal growth factor receptor by Hollins, Andrew J, Benboubetra, Mustapha, Omidi, Yadollah, Zinselmeyer, Bernd H, Schatzlein, Andreas G, Uchegbu, Ijeoma F, Akhtar, Saghir

“…To evaluate low generation, G2 and G3, poly(propylenimine) dendrimers for the potential cellular delivery of antisense oligonucleotides (ODNs) targeting the…”
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Delivery strategies for siRNA-mediated gene silencing by Gilmore, Ian R, Fox, Stephen P, Hollins, Andrew J, Akhtar, Saghir

“…RNA interference (RNAi) represents a promising new gene silencing technology for functional genomics and a potential therapeutic strategy for a variety of…”
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A missense mutation in the murine Opa3 gene models human Costeff syndrome by Davies, Vanessa J., Powell, Kate A., White, Kathryn E., Yip, Wanfen, Hogan, Vanessa, Hollins, Andrew J., Davies, Jennifer R., Piechota, Malgorzata, Brownstein, David G., Moat, Stuart J., Nichols, Philip P., Wride, Michael A., Boulton, Michael E., Votruba, Marcela

“…Opa3 mRNA is expressed in all tissues examined to date, but currently the function of the OPA3 protein is unknown. Intriguingly, various mutations in the OPA3…”
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The Design and Exogenous Delivery of siRNA for Post-transcriptional Gene Silencing by Gilmore, Ian R., Fox, Stephen P., Hollins, Andrew J., Sohail, Muhammad, Akhtar, Saghir

“…RNA interference (RNAi) is a natural cellular process that effects post-transcriptional gene silencing in eukaryotic systems. Small interfering RNA (siRNA)…”
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Cell selective glucocorticoid induction of caveolin-1 and caveolae in differentiating pulmonary alveolar epithelial cell cultures by Barar, Jaleh, Campbell, Lee, Hollins, Andrew J., Thomas, Nicholas P.B., Smith, Mathew W., Morris, Christopher J., Gumbleton, Mark

“…Increased caveolin-1 expression is a marker of the differentiation of lung alveolar epithelial type II cells into a type I phenotype. Here, we show in both a…”
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Caveolin-1 Expression and Caveolae Biogenesis during Cell Transdifferentiation in Lung Alveolar Epithelial Primary Cultures by Campbell, Lee, Hollins, Andrew J., Al-Eid, Ahmed, Newman, Geoff R., von Ruhland, Chris, Gumbleton, Mark

“…Caveolae are omega-shaped invaginations of the plasmalemma possessing a cytoplasmic membrane protein coat of caveolin. Caveolae are present in the in vivo…”
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Targeting caveolae for vesicular drug transport by Gumbleton, Mark, Hollins, Andrew J., Omidi, Yadollah, Campbell, Lee, Taylor, Glyn

“…Caveolae are morphologically evident as omega-shaped invaginations of the plasma membrane with a diameter of 50–100 nm. They may also exist in a variety of…”
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Gene Silencing Nucleic Acids Designed by Scanning Arrays: Anti-EGFR Activity of siRNA, Ribozyme and DNA Enzymes Targeting a Single Hybridization-accessible Region using the Same Delivery System by Beale, Gary, Hollins, Andrew J., Benboubetra, Mustapha, Sohail, Muhammad, Fox, Stephen P., Benter, Ibrahim, Akhtar, Saghir

“…Gene silencing nucleic acids such as ribozymes, DNA enzymes (DNAzymes), antisense oligonucleotides (ODNs), and small interfering (si)RNA rely on hybridization…”
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Diabetes-induced renal vascular dysfunction is normalized by inhibition of epidermal growth factor receptor tyrosine kinase by Benter, Ibrahim F, Yousif, Mariam H M, Hollins, Andrew J, Griffiths, Sioned M, Akhtar, Saghir

“…Contribution of receptor tyrosine kinase activation to development of diabetes-induced renal artery dysfunction is not known. We investigated the ability of a…”
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Caveolin expression during chondrogenesis in the avian limb by Hollins, Andrew J., Campbell, Lee, Gumbleton, Mark, Evans, Darrell J.R.

“…Caveolin is the principal component and critical structural and functional element of caveolae, omega‐shaped plasmalemmal invaginations, which have been…”
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A missense mutation in the murine Opa3 gene models human Costeff syndrome. Commentary by ZEVIANI, Massimo, DAVIES, Vanessa J, MOAT, Stuart J, NICHOLS, Philip P, WRIDE, Michael A, BOULTON, Michael E, VOTRUBA, Marcela, POWELL, Kate A, WHITE, Kathryn E, YIP, Wanfen, HOGAN, Vanessa, HOLLINS, Andrew J, DAVIES, Jennifer R, PIECHOTA, Malgorzata, BROWNSTEIN, David G

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