Search Results - "HOLLERAN, W. M"

Omega-Hydroxyceramides are Required for Corneocyte Lipid Envelope (CLE) Formation and Normal Epidermal Permeability Barrier Function by Behne, Martin, Uchida, Yoshikazu, Seki, Taisuke, de Montellano, Paul Ortiz, Elias, Peter M., Holleran, Walter M.

“…Omega-hydroxyceramides (ω-OHCer) are the predominant lipid species of the corneocyte lipid envelope in the epidermis. Moreover, their ω-esterified-derivatives…”
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Processing of epidermal glucosylceramides is required for optimal mammalian cutaneous permeability barrier function by HOLLERAN, W. M, TAKAGI, Y, MENON, G. K, LEGLER, G, FEINGOLD, K. R, ELIAS, P. M

“…The interstices of the mammalian stratum corneum contain lipids in a system of continuous membrane bilayers critical for the epidermal permeability barrier…”
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Barrier function regulates epidermal lipid and DNA synthesis by Proksch, E, Holleran, W M, Menon, G K, Elias, P M, Feingold, K R

“…The stratum corneum, the permeability barrier between the internal milieu and the environment, is composed of fibrous protein-enriched corneocytes and a…”
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Structural and biochemical basis for the UVB-induced alterations in epidermal barrier function by Holleran, W M, Uchida, Y, Halkier-Sorensen, L, Haratake, A, Hara, M, Epstein, J H, Elias, P M

“…Ultraviolet light (UVR) induces a myriad of cutaneous changes, including delayed disruption of the permeability barrier with higher doses. To investigate the…”
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Endotoxin and Cytokines Increase Hepatic Sphingolipid Biosynthesis and Produce Lipoproteins Enriched in Ceramides and Sphingomyelin by Memon, Riaz A, Holleran, Walter M, Moser, Arthur H, Seki, Taisuke, Uchida, Yoshikazu, Fuller, John, Shigenaga, Judy K, Grunfeld, Carl, Feingold, Kenneth R

“…Alterations in triglyceride and cholesterol metabolism often accompany inflammatory diseases and infections. We studied the effects of endotoxin…”
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Regulation of epidermal sphingolipid synthesis by permeability barrier function by Holleran, WM, Feingold, KR, Man, MQ, Gao, WN, Lee, JM, Elias, PM

“…A mixture of sphingolipids, cholesterol, and free fatty acids forms the intercellular membrane bilayers of the stratum corneum which are presumed to regulate…”
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Skin abnormalities as an early predictor of neurologic outcome in Gaucher disease by Holleran, WM, Ziegler, SG, Goker-Alpan, O, Eblan, MJ, Elias, PM, Schiffmann, R, Sidransky, E

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Epidermal sphingomyelins are precursors for selected stratum corneum ceramides by Uchida, Y, Hara, M, Nishio, H, Sidransky, E, Inoue, S, Otsuka, F, Suzuki, A, Elias, P M, Holleran, W M, Hamanaka, S

“…Epidermal ceramides (Cer) comprise a heterogeneous family of seven species, including two unique omega-hydroxylated Cer, that are key components of the stratum…”
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Permeability Barrier Disruption Coordinately Regulates mRNA Levels for Key Enzymes of Cholesterol, Fatty Acid, and Ceramide Synthesis in the Epidermis by Harris, Ian R., Farrell, Angela M., Grunfeld, Carl, Holleran, Walter M., Elias, Peter M., Feingold, Kenneth R.

“…The extracellular lipids of the stratum corneum, which are comprised mainly of cholesterol, fatty acids, and ceramides, are essential for epidermal…”
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beta-Glucocerebrosidase activity in murine epidermis: characterization and localization in relation to differentiation by Holleran, WM, Takagi, Y, Imokawa, G, Jackson, S, Lee, JM, Elias, PM

“…The intercellular lipids of the stratum corneum, which are highly enriched in ceramides, are critical for the mammalian epidermal permeability barrier. During…”
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Permeability barrier requirements regulate epidermal beta-glucocerebrosidase by Holleran, W M, Takagi, Y, Menon, G K, Jackson, S M, Lee, J M, Feingold, K R, Elias, P M

“…The intercellular spaces of the outermost layers of the epidermis (stratum corneum, SC) of terrestrial mammals contain a mixture of lipids, enriched in…”
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Intrinsically Aged Epidermis Displays Diminished UVB-Induced Alterations in Barrier Function Associated with Decreased Proliferation by Haratake, Akinori, Uchida, Yoshikazu, Mimura, Kunio, Elias, Peter M., Holleran, Walter M.

“…Ultraviolet (UV) irradiation of the skin induces a variety of responses in the epidermis, including sunburn cell Formation, epidermal hyperplasia, and a…”
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Consequences of β-glucocerebrosidase deficiency in epidermis : ultrastructure and permeability barrier alterations in Gaucher disease by HOLLERAN, W. M, GINNS, E. I, MENON, G. K, GRUNDMAN, J.-U, FARTASCH, M, MCKINNEY, C. E

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Glucosylceramides stimulate mitogenesis in aged murine epidermis by MARCHELL, N. L, UCHIDA, Y, BROWN, B. E, ELIAS, P. M, HOLLERAN, W. M

“…Glucosylceramides (GlcCer) and ceramides (Cer) appear to have opposite effects on epidermal growth and differentiation. Whereas Cer inhibit mitosis and induce…”
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Sphingolipids are required for mammalian epidermal barrier function. Inhibition of sphingolipid synthesis delays barrier recovery after acute perturbation by Holleran, W M, Man, M Q, Gao, W N, Menon, G K, Elias, P M, Feingold, K R

“…Stratum corneum lipids comprise an approximately equimolar mixture of sphingolipids, cholesterol, and free fatty acids, arranged as intercellular membrane…”
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Water extract of gromwell (Lithospermum erythrorhizon) enhances migration of human keratinocytes and dermal fibroblasts with increased lipid synthesis in an in vitro wound scratch model by Kim, H, Kim, J, Park, J, Kim, S H, Uchida, Y, Holleran, W M, Cho, Y

“…Although organic extracts of gromwell (Lithospermum erythrorhizon) have been shown to promote wound healing, the wound healing effects of water extracts of…”
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Epidermal abnormalities may distinguish type 2 from type 1 and type 3 of Gaucher disease by SIDRANSKY, E, FARTASCH, M, LEE, R. E, METLAY, L. A, ABELLA, S, ZIMRAN, A, GAO, W, ELIAS, P. M, GINNS, E. I, HOLLERAN, W. M

“…A major clinical challenge in Gaucher disease is the early and presymptomatic discrimination of type 2 (acute neuronopathic) from milder type 1 and type 3…”
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Localization of epidermal sphingolipid synthesis and serine palmitoyl transferase activity : alterations imposed by permeability barrier requirements by HOLLERAN, W. M, GAO, W. N, FEINGOLD, K. R, ELIAS, P. M

“…Sphingolipids, the predominant lipid species in mammalian stratum corneum play, a central role in permeability barrier homeostatis. Prior studies have shown…”
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Glucosylceramide metabolism is regulated during normal and hormonally stimulated epidermal barrier development in the rat by Hanley, K, Jiang, Y, Holleran, W M, Elias, P M, Williams, M L, Feingold, K R

“…Glucosylceramides, delivered to the stratum corneum interstices by exocytosis of lamellar body contents, are enzymatically hydrolyzed to ceramides, which are…”
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Serine-palmitoyl transferase activity in cultured human keratinocytes by Holleran, W M, Williams, M L, Gao, W N, Elias, P M

“…Sphingolipids comprise approximately 25% of the stratum corneum lipids and are considered critical constituents of the epidermal permeability barrier. Whether…”
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