Search Results - "HOLLENBERG, Paul F"

Oxidation of the endogenous cannabinoid arachidonoyl ethanolamide by the cytochrome P450 monooxygenases: physiological and pharmacological implications by Snider, Natasha T, Walker, Vyvyca J, Hollenberg, Paul F

“…Arachidonoyl ethanolamide (anandamide) is an endogenous amide of arachidonic acid and an important signaling mediator of the endocannabinoid system. Given its…”
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Heme Modification Contributes to the Mechanism-Based Inactivation of Human Cytochrome P450 2J2 by Two Terminal Acetylenic Compounds by Lin, Hsia-Lien, Zhang, Haoming, Walker, Vyvyca J, D'Agostino, Jaime, Hollenberg, Paul F

“…The mechanism-based inactivation of human CYP2J2 by three terminal acetylenic compounds: -(methylsulfonyl)-6-(2-propargyloxyphenyl)hexanamide (MS),…”
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Mechanism-Based Inactivation of Human Cytochromes P450s: Experimental Characterization, Reactive Intermediates, and Clinical Implications by Hollenberg, Paul F, Kent, Ute M, Bumpus, Namandjé N

“…The P450 type cytochromes are responsible for the metabolism of a wide variety of xenobiotics and endogenous compounds. Although P450-catalyzed reactions are…”
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Mechanism-Based Inactivation of Human Cytochrome P450 2B6 by Chlorpyrifos by D’Agostino, Jaime, Zhang, Haoming, Kenaan, Cesar, Hollenberg, Paul F

“…Chlorpyrifos (CPS) is a commonly used pesticide which is metabolized by P450s into the toxic metabolite chlorpyrifos-oxon (CPO). Metabolism also results in the…”
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Polymorphic variants of cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) exhibit altered rates of metabolism for bupropion and efavirenz: a charge-reversal mutation in the K139E variant (CYP2B6.8) impairs formation of a functional cytochrome p450-reductase complex by Zhang, Haoming, Sridar, Chitra, Kenaan, Cesar, Amunugama, Hemali, Ballou, David P, Hollenberg, Paul F

“…In this study, metabolism of bupropion, efavirenz, and 7-ethoxy-4-trifluoromethylcoumarin (7-EFC) by CYP2B6 wild type (CYP2B6.1) and six polymorphic variants…”
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The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivation by Yoshigae, Yasushi, Sridar, Chitra, Kent, Ute M, Hollenberg, Paul F

“…Phenethylisothiocyanate (PEITC), a naturally occurring isothiocyanate and potent cancer chemopreventive agent, works by multiple mechanisms, including the…”
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Inhibition of bupropion metabolism by selegiline: mechanism-based inactivation of human CYP2B6 and characterization of glutathione and peptide adducts by Sridar, Chitra, Kenaan, Cesar, Hollenberg, Paul F

“…Selegiline, the R-enantiomer of deprenyl, is used in the treatment of Parkinson's disease. Bupropion, an antidepressant, often used to treat patients in…”
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Uncovering the Role of Hydrophobic Residues in Cytochrome P450−Cytochrome P450 Reductase Interactions by Kenaan, Cesar, Zhang, Haoming, Shea, Erin V, Hollenberg, Paul F

“…Cytochrome P450 (CYP or P450)-mediated drug metabolism requires the interaction of P450s with their redox partner, cytochrome P450 reductase (CPR). In this…”
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A cytochrome P450-derived epoxygenated metabolite of anandamide is a potent cannabinoid receptor 2-selective agonist by Snider, Natasha T, Nast, James A, Tesmer, Laura A, Hollenberg, Paul F

“…Oxidation of the endocannabinoid anandamide by cytochrome P450 (P450) enzymes has the potential to affect signaling pathways within the endocannabinoid system…”
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Formation of the thiol conjugates and active metabolite of clopidogrel by human liver microsomes by Zhang, Haoming, Lau, Wei C, Hollenberg, Paul F

“…We reported previously the formation of a glutathionyl conjugate of the active metabolite (AM) of clopidogrel and the covalent modification of a cysteinyl…”
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Multiple mechanisms and multiple oxidants in P450-catalyzed hydroxylations by Newcomb, Martin, Hollenberg, Paul F, Coon, Minor J

“…Cytochrome P450 enzymes catalyze a number of oxidations in nature including the difficult hydroxylations of unactivated positions in an alkyl group. The…”
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SILYBIN INACTIVATES CYTOCHROMES P450 3A4 AND 2C9 AND INHIBITS MAJOR HEPATIC GLUCURONOSYLTRANSFERASES by SRIDAR, Chitra, GOOSEN, Theunis C, KENT, Ute M, WILLIAMS, J. Andrew, HOLLENBERG, Paul F

“…Silybin, a major constituent of the milk thistle, is used to treat several liver disorders. Silybin inactivated purified, recombinant cytochromes P450 (P450)…”
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The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6 by Snider, Natasha T, Sikora, Matthew J, Sridar, Chitra, Feuerstein, Thomas J, Rae, James M, Hollenberg, Paul F

“…Members of the cytochrome P450 (P450) family of drug-metabolizing enzymes are present in the human brain, and they may have important roles in the oxidation of…”
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Anandamide metabolism by human liver and kidney microsomal cytochrome p450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides by Snider, Natasha T, Kornilov, Andrei M, Kent, Ute M, Hollenberg, Paul F

“…The endocannabinoid anandamide is an arachidonic acid derivative that is found in most tissues where it acts as an important signaling mediator in…”
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Role of the Highly Conserved Threonine in Cytochrome P450 2E1: Prevention of H2O2‑Induced Inactivation during Electron Transfer by Yoshigae, Yasushi, Kent, Ute M, Hollenberg, Paul F

“…A highly conserved threonine in the I-helix of cytochrome P450s has been suggested to play an important role in dioxygen activation, a critical step for…”
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Gender Dimorphic Formation of Mouse Mallory–Denk Bodies and the Role of Xenobiotic Metabolism and Oxidative Stress by Hanada, Shinichiro, Snider, Natasha T, Brunt, Elizabeth M, Hollenberg, Paul F, Omary, M. Bishr

“…Background & Aims Mallory–Denk bodies (MDBs) are keratin (K)-rich cytoplasmic hepatocyte inclusions commonly associated with alcoholic steatohepatitis. Given…”
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Characteristics and common properties of inhibitors, inducers, and activators of CYP enzymes by Hollenberg, Paul F.

“…Many inhibitors of the CYP enzymes have been identified and although some are inhibitory for a number of different CYPs, a fair number are very selective for…”
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The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5 by Lin, Hsia-lien, Kent, Ute M, Hollenberg, Paul F

“…Bergamottin (BG), a component of grapefruit juice, is a mechanism-based inactivator of cytochromes P450 (P450) 2B6 and 3A5 in the reconstituted system. The…”
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Effect of Conformational Dynamics on Substrate Recognition and Specificity as Probed by the Introduction of a de Novo Disulfide Bond into Cytochrome P450 2B1 by Zhang, Haoming, Kenaan, Cesar, Hamdane, Djemel, Hoa, Gaston Hui Bon, Hollenberg, Paul F.

“…The conformational dynamics of cytochrome P450 2B1 (CYP2B1) were investigated through the introduction of a disulfide bond to link the I- and K-helices by…”
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Cross-linking of human cytochrome P450 2B6 to NADPH-cytochrome P450 reductase: Identification of a potential site of interaction by Bumpus, Namandjé N., Hollenberg, Paul F.

“…Isotopic labeling of cross-linked peptides coupled with mass spectrometry was used to identify P450 2B6 residues that potentially interact with…”
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