Search Results - "HOLLENBERG, Morley D"

A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan by Mohammed, Ibrahim, Hollenberg, Morley D, Ding, Hong, Triggle, Chris R

“…The numerous beneficial health outcomes associated with the use of metformin to treat patients with type 2 diabetes (T2DM), together with data from…”
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Oxytocin: much more than childbirth and milk letdown by Hollenberg, Morley D

“…This commentary deals with the new observations that dendritic cell (DC) oxytocin receptors play a role in the inflammatory response generated in murine animal…”
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Targeting proteinase-activated receptors: therapeutic potential and challenges by Ramachandran, Rithwik, Noorbakhsh, Farshid, DeFea, Kathryn, Hollenberg, Morley D.

“…Key Points Proteinase-activated receptors are seven-transmembrane G protein-coupled receptors with an unusual mechanism of activation involving the proteolytic…”
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Repurposing Metformin for Vascular Disease by Triggle, Chris R, Marei, Isra, Ye, Kevin, Ding, Hong, Anderson, Todd J, Hollenberg, Morley D, Hill, Michael A

“…Metformin has been used as an oral anti-hyperglycaemic drug since the late 1950s; however, following the release in 1998 of the findings of the 20-year United…”
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Structure, function and pathophysiology of protease activated receptors by Adams, Mark N, Ramachandran, Rithwik, Yau, Mei-Kwan, Suen, Jacky Y, Fairlie, David P, Hollenberg, Morley D, Hooper, John D

“…Discovered in the 1990s, protease activated receptors(1) (PARs) are membrane-spanning cell surface proteins that belong to the G protein coupled receptor…”
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Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress by El-Daly, Mahmoud, Pulakazhi Venu, Vivek Krishna, Saifeddine, Mahmoud, Mihara, Koichiro, Kang, Sean, Fedak, Paul W.M., Alston, Laurie A., Hirota, Simon A., Ding, Hong, Triggle, Chris R., Hollenberg, Morley D.

“…Hyperglycaemia is a major contributor to diabetic cardiovascular disease with hyperglycaemia-induced endothelial dysfunction recognized as the initiating…”
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Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro by Carr, Brittany J, Mihara, Koichiro, Ramachandran, Rithwik, Saifeddine, Mahmoud, Nathanson, Neil M, Stell, William K, Hollenberg, Morley D

“…Myopia is a refractive disorder that degrades vision. It can be treated with atropine, a muscarinic acetylcholine receptor (mAChR) antagonist, but the…”
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Thrombin-Mediated Direct Activation of Proteinase-Activated Receptor-2: Another Target for Thrombin Signaling by Mihara, Koichiro, Ramachandran, Rithwik, Saifeddine, Mahmoud, Hansen, Kristina K, Renaux, Bernard, Polley, Danny, Gibson, Stacy, Vanderboor, Christina, Hollenberg, Morley D

“…Thrombin is known to signal to cells by cleaving/activating a G-protein-coupled family of proteinase-activated receptors (PARs). The signaling mechanism…”
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Granzyme K initiates IL-6 and IL-8 release from epithelial cells by activating protease-activated receptor 2 by Kaiserman, Dion, Zhao, Peishen, Rowe, Caitlin Lorraine, Leong, Andrea, Barlow, Nicholas, Joeckel, Lars Thomas, Hitchen, Corinne, Stewart, Sarah Elizabeth, Hollenberg, Morley D, Bunnett, Nigel, Suhrbier, Andreas, Bird, Phillip Ian

“…Granzyme K (GzmK) is a tryptic member of the granzyme family of chymotrypsin-like serine proteases produced by cells of the immune system. Previous studies…”
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TRPM8 activation attenuates inflammatory responses in mouse models of colitis by Ramachandran, Rithwik, Hyun, Eric, Zhao, Liena, Lapointe, Tamia K., Chapman, Kevin, Hirota, Christina L., Ghosh, Subrata, McKemy, David D., Vergnolle, Nathalie, Beck, Paul L., Altier, Christophe, Hollenberg, Morley D.

“…Transient Receptor Potential Melastatin–8 (TRPM8), a recently identified member of the transient receptor potential (TRP) family of ion channels, is activated…”
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Active thrombin produced by the intestinal epithelium controls mucosal biofilms by Motta, Jean-Paul, Denadai-Souza, Alexandre, Sagnat, David, Guiraud, Laura, Edir, Anissa, Bonnart, Chrystelle, Sebbag, Mireille, Rousset, Perrine, Lapeyre, Ariane, Seguy, Carine, Mathurine-Thomas, Noa, Galipeau, Heather J., Bonnet, Delphine, Alric, Laurent, Buret, Andre G., Wallace, John L., Dufour, Antoine, Verdu, Elena F., Hollenberg, Morley D., Oswald, Eric, Serino, Matteo, Deraison, Celine, Vergnolle, Nathalie

“…Proteolytic homeostasis is important at mucosal surfaces, but its actors and their precise role in physiology are poorly understood. Here we report that…”
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Granulocyte-colony–stimulating factor (G-CSF) signaling in spinal microglia drives visceral sensitization following colitis by Basso, Lilian, Lapointe, Tamia K., Iftinca, Mircea, Marsters, Candace, Hollenberg, Morley D., Kurrasch, Deborah M., Altier, Christophe

“…Pain is a main symptom of inflammatory diseases and often persists beyond clinical remission. Although we have a good understanding of the mechanisms of…”
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Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation by Melo, Helvira, Basso, Lilian, Iftinca, Mircea, MacNaughton, Wallace K., Hollenberg, Morley D., McKay, Derek M., Altier, Christophe

“…Opioids remain the gold standard for the treatment of moderate to severe pain. However, their analgesic properties come with important side effects, including…”
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Dihydromyricetin protects against high glucose-induced endothelial dysfunction: Role of HIF-1α/ROR2/NF-κB by Awad, Eman M., Ahmed, Al-Shaimaa F., El-Daly, Mahmoud, Amin, Ali H., El-Tahawy, Nashwa F.G., Wagdy, AlShimaa, Hollenberg, Morley D., Taye, Ashraf

“…Dihydromyricetin (DHM), a natural flavonoid isolated from vine tea with anti-inflammatory activity was evaluated for its ability to prevent vascular…”
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The RGS-RhoGEFs control the amplitude of YAP1 activation by serum by Lane, Brandon S., Heller, Brigitte, Hollenberg, Morley D., Wells, Clark D.

“…Actin-dependent mechanisms drive the nuclear translocation of Yap1 to enable its co-activation of transcription factors that induce pro-growth and survival…”
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Platelet-Mediated NET Release Amplifies Coagulopathy and Drives Lung Pathology During Severe Influenza Infection by Kim, Seok-Joo, Carestia, Agostina, McDonald, Braedon, Zucoloto, Amanda Z, Grosjean, Heidi, Davis, Rachelle P, Turk, Madison, Naumenko, Victor, Antoniak, Silvio, Mackman, Nigel, Abdul-Cader, Mohamed Sarjoon, Abdul-Careem, Mohamed Faizal, Hollenberg, Morley D, Jenne, Craig N

“…The influenza A virus (IAV) causes a respiratory tract infection with approximately 10% of the population infected by the virus each year. Severe IAV infection…”
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Proteinase-Activated Receptors: Transducers of Proteinase-Mediated Signaling in Inflammation and Immune Response by Steinhoff, Martin, Buddenkotte, Jörg, Shpacovitch, Victoria, Rattenholl, Anke, Moormann, Corinna, Vergnolle, Nathalie, Luger, Thomas A, Hollenberg, Morley D

“…Serine proteinases such as thrombin, mast cell tryptase, trypsin, or cathepsin G, for example, are highly active mediators with diverse biological activities…”
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Proteinase-activated Receptor 2 (PAR2) Decreases Apoptosis in Colonic Epithelial Cells by Iablokov, Vadim, Hirota, Christina L., Peplowski, Michael A., Ramachandran, Rithwik, Mihara, Koichiro, Hollenberg, Morley D., MacNaughton, Wallace K.

“…Mucosal biopsies from inflamed colon of inflammatory bowel disease patients exhibit elevated epithelial apoptosis compared with those from healthy individuals,…”
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Proteinase-Mediated Macrophage Signaling in Psoriatic Arthritis by Abji, Fatima, Rasti, Mozhgan, Gómez-Aristizábal, Alejandro, Muytjens, Carla, Saifeddine, Mahmoud, Mihara, Koichiro, Motahhari, Majid, Gandhi, Rajiv, Viswanathan, Sowmya, Hollenberg, Morley D, Oikonomopoulou, Katerina, Chandran, Vinod

“…Multiple proteinases are present in the synovial fluid (SF) of an arthritic joint. We aimed to identify inflammatory cell populations present in psoriatic…”
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Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production by Holani, Ravi, Babbar, Anshu, Blyth, Graham A. D., Lopes, Fernando, Jijon, Humberto, McKay, Derek M., Hollenberg, Morley D., Cobo, Eduardo R.

“…We hypothesized that the antimicrobial peptide cathelicidin has a physiological role in regulating gut inflammatory homeostasis. We determined that…”
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