Search Results - "HOLLAND, H"

Benchmark and integration of resources for the estimation of human transcription factor activities by Garcia-Alonso, Luz, Holland, Christian H, Ibrahim, Mahmoud M, Turei, Denes, Saez-Rodriguez, Julio

“…The prediction of transcription factor (TF) activities from the gene expression of their targets (i.e., TF regulon) is becoming a widely used approach to…”
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Transfer of regulatory knowledge from human to mouse for functional genomics analysis by Holland, Christian H., Szalai, Bence, Saez-Rodriguez, Julio

“…Transcriptome profiling followed by differential gene expression analysis often leads to lists of genes that are hard to analyze and interpret. Functional…”
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Reconstruction of the ancestral metazoan genome reveals an increase in genomic novelty by Paps, Jordi, Holland, Peter W. H.

“…Understanding the emergence of the Animal Kingdom is one of the major challenges of modern evolutionary biology. Many genomic changes took place along the…”
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Disabling Immune Tolerance by Programmed Death-1 Blockade With Pidilizumab After Autologous Hematopoietic Stem-Cell Transplantation for Diffuse Large B-Cell Lymphoma: Results of an International Phase II Trial by ARMAND, Philippe, NAGLER, Arnon, FAY, Joseph W, RIZZIERI, David A, HOSING, Chitra M, BALL, Edward D, UBERTI, Joseph P, LAZARUS, Hillard M, MAPARA, Markus Y, GREGORY, Stephanie A, TIMMERMAN, John M, ANDORSKY, David, WELLER, Edie A, OR, Reuven, WALLER, Edmund K, ROTEM-YEHUDAR, Rinat, GORDON, Leo I, DEVINE, Steven M, AVIGAN, David E, CHEN, Yi-Bin, KAMINSKI, Mark S, KENT HOLLAND, H, WINTER, Jane N, MASON, James R

“…The Programmed Death-1 (PD-1) immune checkpoint pathway may be usurped by tumors, including diffuse large B-cell lymphoma (DLBCL), to evade immune…”
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Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment by Schneider, Kai Markus, Mohs, Antje, Gui, Wenfang, Galvez, Eric J. C., Candels, Lena Susanna, Hoenicke, Lisa, Muthukumarasamy, Uthayakumar, Holland, Christian H., Elfers, Carsten, Kilic, Konrad, Schneider, Carolin Victoria, Schierwagen, Robert, Strnad, Pavel, Wirtz, Theresa H., Marschall, Hanns-Ulrich, Latz, Eicke, Lelouvier, Benjamin, Saez-Rodriguez, Julio, de Vos, Willem, Strowig, Till, Trebicka, Jonel, Trautwein, Christian

“…Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, and therapeutic options for advanced HCC are limited. Here, we observe…”
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Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data by Holland, Christian H, Tanevski, Jovan, Perales-Patón, Javier, Gleixner, Jan, Kumar, Manu P, Mereu, Elisabetta, Joughin, Brian A, Stegle, Oliver, Lauffenburger, Douglas A, Heyn, Holger, Szalai, Bence, Saez-Rodriguez, Julio

“…Many functional analysis tools have been developed to extract functional and mechanistic insight from bulk transcriptome data. With the advent of single-cell…”
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T-Cell–Replete HLA-Haploidentical Hematopoietic Transplantation for Hematologic Malignancies Using Post-Transplantation Cyclophosphamide Results in Outcomes Equivalent to Those of Contemporaneous HLA-Matched Related and Unrelated Donor Transplantation by BASHEY, Asad, XU ZHANG, SIZEMORE, Connie A, MANION, Karen, BROWN, Stacey, HOLLAND, H. Kent, MORRIS, Lawrence E, SOLOMON, Scott R

“…T-cell-replete grafts from haploidentical donors using post-transplantation cyclophosphamide may represent a solution for patients who require allogeneic…”
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New genes from old: asymmetric divergence of gene duplicates and the evolution of development by Holland, Peter W. H., Marlétaz, Ferdinand, Maeso, Ignacio, Dunwell, Thomas L., Paps, Jordi

“…Gene duplications and gene losses have been frequent events in the evolution of animal genomes, with the balance between these two dynamic processes…”
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Letermovir prophylaxis lowers the incidence of Non-CMV infections after allogeneic hematopoietic cell transplantation by Bashey, Saffiya Z., Solomon, Scott R., Zhang, Xu, Morris, Lawrence E., Kent Holland, H., Bachier, Lizamarie, Solh, Melhem M.

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Evolution of homeobox genes by Holland, Peter W H

“…Many homeobox genes encode transcription factors with regulatory roles in animal and plant development. Homeobox genes are found in almost all eukaryotes, and…”
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CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation by Bashey, Asad, Medina, Bridget, Corringham, Sue, Pasek, Mildred, Carrier, Ewa, Vrooman, Linda, Lowy, Israel, Solomon, Scott R., Morris, Lawrence E., Holland, H. Kent, Mason, James R., Alyea, Edwin P., Soiffer, Robert J., Ball, Edward D.

“…Relapse of malignancy after allogeneic hematopoietic cell transplantation (allo-HCT) remains a therapeutic challenge. Blockade of the CTLA4 molecule can…”
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Lineage-specific rediploidization is a mechanism to explain time-lags between genome duplication and evolutionary diversification by Robertson, Fiona M, Gundappa, Manu Kumar, Grammes, Fabian, Hvidsten, Torgeir R, Redmond, Anthony K, Lien, Sigbjørn, Martin, Samuel A M, Holland, Peter W H, Sandve, Simen R, Macqueen, Daniel J

“…The functional divergence of duplicate genes (ohnologues) retained from whole genome duplication (WGD) is thought to promote evolutionary diversification…”
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Evidence from oyster suggests an ancient role for Pdx in regulating insulin gene expression in animals by Xu, Fei, Marlétaz, Ferdinand, Gavriouchkina, Daria, Liu, Xiao, Sauka-Spengler, Tatjana, Zhang, Guofan, Holland, Peter W. H.

“…Hox and ParaHox genes encode transcription factors with similar expression patterns in divergent animals. The Pdx ( Xlox ) homeobox gene, for example, is…”
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HLA evolutionary divergence (HED) informs the effect of HLA-B mismatch on outcomes after haploidentical transplantation by Solh, Melhem, Aubrey, Michael T., Zhang, Xu, Bashey, Asad, Freed, Brian M., Roark, Christina L., Bachier-Rdriguez, Lizamarie, Morris, Lawrence E., Kent Holland, H., Solomon, Scott R.

“…Graft versus tumor relies on tumor-associated antigens (TAAs) that are presented to donor T cells via human leukocyte antigens (HLAs). The HLA evolutionary…”
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decoupleR: ensemble of computational methods to infer biological activities from omics data by Badia-I-Mompel, Pau, Vélez Santiago, Jesús, Braunger, Jana, Geiss, Celina, Dimitrov, Daniel, Müller-Dott, Sophia, Taus, Petr, Dugourd, Aurelien, Holland, Christian H, Ramirez Flores, Ricardo O, Saez-Rodriguez, Julio

“…Many methods allow us to extract biological activities from omics data using information from prior knowledge resources, reducing the dimensionality for…”
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Dating the rise of atmospheric oxygen by Bekker, A, Holland, H. D, Wang, P.-L, Rumble, D, Stein, H. J, Hannah, J. L, Coetzee, L. L, Beukes, N. J

“…Several lines of geological and geochemical evidence indicate that the level of atmospheric oxygen was extremely low before 2.45 billion years (Gyr) ago, and…”
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Jellyfish genomes reveal distinct homeobox gene clusters and conservation of small RNA processing by Nong, Wenyan, Cao, Jianquan, Li, Yiqian, Qu, Zhe, Sun, Jin, Swale, Thomas, Yip, Ho Yin, Qian, Pei Yuan, Qiu, Jian-Wen, Kwan, Hoi Shan, Bendena, William, Tobe, Stephen, Chan, Ting Fung, Yip, Kevin Y., Chu, Ka Hou, Ngai, Sai Ming, Tsim, Karl Yk, Holland, Peter W. H., Hui, Jerome H. L.

“…The phylum Cnidaria represents a close outgroup to Bilateria and includes familiar animals including sea anemones, corals, hydroids, and jellyfish. Here we…”
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Early life stress disrupts social behavior and prefrontal cortex parvalbumin interneurons at an earlier time-point in females than in males by Holland, Freedom H., Ganguly, Prabarna, Potter, David N., Chartoff, Elena H., Brenhouse, Heather C.

“…•We examined divergent sex profiles in early-life stress (ELS) exposed rats.•ELS females showed social interaction deficits earlier in development than…”
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Functional Uncoupling NMDAR NR2A Subunit from PSD-95 in the Prefrontal Cortex: Effects on Behavioral Dysfunction and Parvalbumin Loss after Early-Life Stress by Ganguly, Prabarna, Holland, Freedom H, Brenhouse, Heather C

“…Exposure to early-life stress increases vulnerability to psychiatric disorders, including depression, schizophrenia, and anxiety. Growing evidence implicates…”
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Dynamic Molecular Evolution of Mammalian Homeobox Genes: Duplication, Loss, Divergence and Gene Conversion Sculpt PRD Class Repertoires by Lewin, Thomas D., Royall, Amy H., Holland, Peter W. H.

“…The majority of homeobox genes are highly conserved across animals, but the eutherian-specific ETCHbox genes, embryonically expressed and highly divergent…”
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