Search Results - "HOLCZBAUER, Agnes"

MYC and MET cooperatively drive hepatocellular carcinoma with distinct molecular traits and vulnerabilities by Sequera, Celia, Grattarola, Margherita, Holczbauer, Agnes, Dono, Rosanna, Pizzimenti, Stefania, Barrera, Giuseppina, Wangensteen, Kirk J., Maina, Flavio

“…Enhanced activation of the transcription factor MYC and of the receptor tyrosine kinase MET are among the events frequently occurring in hepatocellular…”
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Evolutionary conservation of the fidelity of transcription by Chung, Claire, Verheijen, Bert M., Navapanich, Zoe, McGann, Eric G., Shemtov, Sarah, Lai, Guan-Ju, Arora, Payal, Towheed, Atif, Haroon, Suraiya, Holczbauer, Agnes, Chang, Sharon, Manojlovic, Zarko, Simpson, Stephen, Thomas, Kelley W., Kaplan, Craig, van Hasselt, Peter, Timmers, Marc, Erie, Dorothy, Chen, Lin, Gout, Jean-Franćois, Vermulst, Marc

“…Accurate transcription is required for the faithful expression of genetic information. However, relatively little is known about the molecular mechanisms that…”
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Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling by Kitade, Mitsuteru, Factor, Valentina M, Andersen, Jesper B, Tomokuni, Akira, Kaji, Kosuke, Akita, Hirofumi, Holczbauer, Agnes, Seo, Daekwan, Marquardt, Jens U, Conner, Elizabeth A, Lee, Seung-Bum, Lee, Yun-Han, Thorgeirsson, Snorri S

“…The relative contribution of hepatocyte growth factor (HGF)/MET and epidermal growth factor (EGF)/EGF receptor (EGFR), two key signal transduction systems in…”
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Distinct Claudin Expression Profiles of Hepatocellular Carcinoma and Metastatic Colorectal and Pancreatic Carcinomas by Holczbauer, Ágnes, Gyöngyösi, Benedek, Lotz, Gábor, Szijártó, Attila, Kupcsulik, Péter, Schaff, Zsuzsa, Kiss, András

“…Tight junction proteins, including claudins, are often dysregulated during carcinogenesis and tumor progression. Moreover, the claudin expression pattern…”
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Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways by Marquardt, Jens U., Raggi, Chiara, Andersen, Jesper B., Seo, Daekwan, Avital, Itzhak, Geller, David, Lee, Yun‐Han, Kitade, Mitsuteru, Holczbauer, Agnes, Gillen, Matthew C., Conner, Elizabeth A., Factor, Valentina M., Thorgeirsson, Snorri S.

“…Epigenetic mechanisms play critical roles in stem cell biology by maintaining pluripotency of stem cells and promoting differentiation of more mature…”
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Contribution of Hepatic Lineage Stage-Specific Donor Memory to the Differential Potential of Induced Mouse Pluripotent Stem Cells by Lee, Seung Bum, Seo, Daekwan, Choi, Dongho, Park, Kye-Yoon, Holczbauer, Agnes, Marquardt, Jens U., Conner, Elizabeth A., Factor, Valentina M., Thorgeirsson, Snorri S.

“…Recent studies suggested that induced pluripotent stem cells (iPSCs) retain a residual donor cell gene expression, which may impact their capacity to…”
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Claudin-1 and claudin-2 differentiate fetal and embryonal components in human hepatoblastoma by Halász, Judit, Holczbauer, Ágnes, Páska, Csilla, Kovács, Margit, Benyó, Gábor, Verebély, Tibor, Schaff, Zsuzsa, Kiss, András

“…Claudins (CLDNs), a family of transmembrane proteins, are major constituents of tight junctions (TJs). They have been shown to be differentially regulated in…”
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Modeling Pathogenesis of Primary Liver Cancer in Lineage-Specific Mouse Cell Types by Holczbauer, Ágnes, Factor, Valentina M, Andersen, Jesper B, Marquardt, Jens U, Kleiner, David E, Raggi, Chiara, Kitade, Mitsuteru, Seo, Daekwan, Akita, Hirofumi, Durkin, Marian E, Thorgeirsson, Snorri S

“…Background & Aims Human primary liver cancer is classified into biologically distinct subgroups based on cellular origin. Liver cancer stem cells (CSCs) have…”
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Claudin expression in Barrett's esophagus and adenocarcinoma by Gyõrffy, Hajnalka, Holczbauer, Agnes, Nagy, Pál, Szabó, Zsuzsa, Kupcsulik, Péter, Páska, Csilla, Papp, János, Schaff, Zsuzsa, Kiss, András

“…Claudins (CLDNs) are key molecules in cell adhesion, polarity, and control of paracellular solute transport. Several studies suggested that changes in claudin…”
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Cellular origins of regenerating liver and hepatocellular carcinoma by Holczbauer, Ágnes, Wangensteen, Kirk J., Shin, Soona

“…Hepatocellular carcinoma (HCC) is the predominant primary cancer arising from the liver and is one of the major causes of cancer-related mortality worldwide…”
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Expression of Matrilin-2 in Liver Cirrhosis and Hepatocellular Carcinoma by Szabó, Erzsébet, Korpos, Éva, Batmunkh, Enkhjargal, Lotz, Gábor, Holczbauer, Ágnes, Kovalszky, Ilona, Deák, Ferenc, Kiss, Ibolya, Schaff, Zsuzsa, Kiss, András

“…The recently described matrilin protein family is part of the extracellular matrix, their pathophysiological role as well as distribution in liver diseases,…”
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P-A2 Towards curtailing HIV latency by combinatorial unblocking viral transcription by Arya, Suresh, Holczbauer, Agnes

“…The idea that it may be possible to "cure" AIDS is beginning to be accepted. Whether that is realistic or a pipe dream remains to be seen. The impediment is…”
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P-A2 Towards curtailing HIV latency by combinatorial unblocking viral transcription by Arya, Suresh, Holczbauer, Agnes

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Comparison of the expression of agrin, a basement membrane heparan sulfate proteoglycan, in cholangiocarcinoma and hepatocellular carcinoma by Batmunkh, Enkhjargal, MD, Tátrai, Péter, MSc, Szabó, Erzsébet, MSc, Lódi, Csaba, MD, Holczbauer, Ágnes, MD, Páska, Csilla, PhD, Kupcsulik, Péter, MD, PhD, DSc, Kiss, András, MD, PhD, Schaff, Zsuzsa, MD, PhD, DSc, Kovalszky, Ilona, MD, PhD, DSc

“…Summary Heparan sulfate proteoglycans mediate cell adhesion and control the activities of numerous growth and motility factors. They play a critical role in…”
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PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies by Basavaraja, Raghavendra, Zhang, Hongru, Holczbauer, Ágnes, Lu, Zhen, Radaelli, Enrico, Assenmacher, Charles-Antoine, George, Subin S., Nallamala, Vamshidhar C., Beiting, Daniel P., Meyer-Ficca, Mirella L., Meyer, Ralph G., Guo, Wei, Fan, Yi, Modzelewski, Andrew J., Spiegelman, Vladimir S., Cohen, Michael S., Fuchs, Serge Y.

“…Tumor-infiltrating regulatory T cells (TI-Tregs) elicit immunosuppressive effects in the tumor microenvironment (TME) leading to accelerated tumor growth and…”
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Increased Expression of Claudin-1 and Claudin-7 in Liver Cirrhosis and Hepatocellular Carcinoma by Holczbauer, Ágnes, Gyöngyösi, Benedek, Lotz, Gábor, Törzsök, Péter, Kaposi-Novák, Pál, Szijártó, Attila, Tátrai, Péter, Kupcsulik, Péter, Schaff, Zsuzsa, Kiss, András

“…Claudins have been reported to be differentially regulated in malignancies and implicated in the process of carcinogenesis and tumor progression. Claudin-1 has…”
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MYC and MET cooperatively drive hepatocellular carcinoma with distinct molecular traits and vulnerabilities by Sequera, Célia, Grattarola, Margherita, Holczbauer, Agnes, Dono, Rosanna, Pizzimenti, Stefania, Barrera, Giuseppina, Wangensteen, Kirk, Maina, Flavio

“…Abstract Enhanced activation of the transcription factor MYC and of the receptor tyrosine kinase MET are among events frequently occurring in hepatocellular…”
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HIV Latency: Activating Virus Expression with Combined Genetic and Chemical Tools by Arya, Suresh K, Holczbauer, Agnes

“…One difficulty in curing HIV/AIDS is the tendency of the virus to enter into latency, where minimal or no viral gene expression occurs. The sequestered virus…”
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Epigenetic reprogramming modulates malignant properties of human liver cancer by Raggi, Chiara, Factor, Valentina M., Seo, Daekwan, Holczbauer, Agnes, Gillen, Matthew C., Marquardt, Jens U., Andersen, Jesper B., Durkin, Marian, Thorgeirsson, Snorri S.

“…Reversal of DNA hypermethylation and associated gene silencing is an emerging cancer therapy approach. Here we addressed the impact of epigenetic alterations…”
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Down regulating HIV latency by transcription activation by Arya, Suresh K, Holczbauer, Agnes

“…One difficulty in curing HIV/AIDS is the tendency of the virus to enter into latency, where minimal or no viral gene expression occurs. The sequestered virus…”
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