Search Results - "HOHL, Tobias M"

Immune responses to human fungal pathogens and therapeutic prospects by Lionakis, Michail S., Drummond, Rebecca A., Hohl, Tobias M.

“…Pathogenic fungi have emerged as significant causes of infectious morbidity and death in patients with acquired immunodeficiency conditions such as HIV/AIDS…”
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Serious Infections in Patients Receiving Ibrutinib for Treatment of Lymphoid Cancer by Varughese, Tilly, Taur, Ying, Cohen, Nina, Palomba, M Lia, Seo, Susan K, Hohl, Tobias M, Redelman-Sidi, Gil

“…Abstract Background Ibrutinib is a Bruton tyrosine kinase inhibitor that is used for the treatment of lymphoid cancers, including chronic lymphocytic leukemia,…”
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Interleukin 23 Production by Intestinal CD103+CD11b+ Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense by Kinnebrew, Melissa A., Buffie, Charlie G., Diehl, Gretchen E., Zenewicz, Lauren A., Leiner, Ingrid, Hohl, Tobias M., Flavell, Richard A., Littman, Dan R., Pamer, Eric G.

“…Microbial penetration of the intestinal epithelial barrier triggers inflammatory responses that include induction of the bactericidal C-type lectin RegIIIγ…”
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Bone Marrow Mesenchymal Stem and Progenitor Cells Induce Monocyte Emigration in Response to Circulating Toll-like Receptor Ligands by Shi, Chao, Jia, Ting, Mendez-Ferrer, Simon, Hohl, Tobias M., Serbina, Natalya V., Lipuma, Lauren, Leiner, Ingrid, Li, Ming O., Frenette, Paul S., Pamer, Eric G.

“…Inflammatory (Ly6C hi CCR2 +) monocytes provide defense against infections but also contribute to autoimmune diseases and atherosclerosis. Monocytes originate…”
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High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis by Zhai, Bing, Ola, Mihaela, Rolling, Thierry, Tosini, Nicholas L., Joshowitz, Sari, Littmann, Eric R., Amoretti, Luigi A., Fontana, Emily, Wright, Roberta J., Miranda, Edwin, Veelken, Charlotte A., Morjaria, Sejal M., Peled, Jonathan U., van den Brink, Marcel R. M., Babady, N. Esther, Butler, Geraldine, Taur, Ying, Hohl, Tobias M.

“…The intestinal microbiota is a complex community of bacteria, archaea, viruses, protists and fungi 1 , 2 . Although the composition of bacterial constituents…”
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Inflammatory monocytes are detrimental to the host immune response during acute infection with Cryptococcus neoformans by Heung, Lena J, Hohl, Tobias M

“…Cryptococcus neoformans is a leading cause of invasive fungal infections among immunocompromised patients. However, the cellular constituents of the innate…”
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Inflammatory monocytes orchestrate innate antifungal immunity in the lung by Espinosa, Vanessa, Jhingran, Anupam, Dutta, Orchi, Kasahara, Shinji, Donnelly, Robert, Du, Peicheng, Rosenfeld, Jeffrey, Leiner, Ingrid, Chen, Chiann-Chyi, Ron, Yacov, Hohl, Tobias M, Rivera, Amariliz

“…Aspergillus fumigatus is an environmental fungus that causes invasive aspergillosis (IA) in immunocompromised patients. Although -CC-chemokine receptor-2…”
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Monocyte-mediated defense against microbial pathogens by Serbina, Natalya V, Jia, Ting, Hohl, Tobias M, Pamer, Eric G

“…Circulating blood monocytes supply peripheral tissues with macrophage and dendritic cell (DC) precursors and, in the setting of infection, also contribute…”
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Rapid transcriptional and metabolic adaptation of intestinal microbes to host immune activation by Becattini, Simone, Sorbara, Matthew T., Kim, Sohn G., Littmann, Eric L., Dong, Qiwen, Walsh, Gavin, Wright, Roberta, Amoretti, Luigi, Fontana, Emily, Hohl, Tobias M., Pamer, Eric G.

“…The gut microbiota produces metabolites that regulate host immunity, thereby impacting disease resistance and susceptibility. The extent to which commensal…”
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Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression by Ryder, Mabel, Gild, Matti, Hohl, Tobias M, Pamer, Eric, Knauf, Jeff, Ghossein, Ronald, Joyce, Johanna A, Fagin, James A

“…Advanced human thyroid cancers are densely infiltrated with tumor-associated macrophages (TAMs) and this correlates with a poor prognosis. We used BRAF-induced…”
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Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses by Panea, Casandra, Farkas, Adam M., Goto, Yoshiyuki, Abdollahi-Roodsaz, Shahla, Lee, Carolyn, Koscsó, Balázs, Gowda, Kavitha, Hohl, Tobias M., Bogunovic, Milena, Ivanov, Ivaylo I.

“…Generation of different CD4 T cell responses to commensal and pathogenic bacteria is crucial for maintaining a healthy gut environment, but the associated…”
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In vivo hypoxia and a fungal alcohol dehydrogenase influence the pathogenesis of invasive pulmonary aspergillosis by Grahl, Nora, Puttikamonkul, Srisombat, Macdonald, Jeffrey M, Gamcsik, Michael P, Ngo, Lisa Y, Hohl, Tobias M, Cramer, Robert A

“…Currently, our knowledge of how pathogenic fungi grow in mammalian host environments is limited. Using a chemotherapeutic murine model of invasive pulmonary…”
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During Aspergillus Infection, Monocyte-Derived DCs, Neutrophils, and Plasmacytoid DCs Enhance Innate Immune Defense through CXCR3-Dependent Crosstalk by Guo, Yahui, Kasahara, Shinji, Jhingran, Anupam, Tosini, Nicholas L., Zhai, Bing, Aufiero, Mariano A., Mills, Kathleen A.M., Gjonbalaj, Mergim, Espinosa, Vanessa, Rivera, Amariliz, Luster, Andrew D., Hohl, Tobias M.

“…Aspergillus fumigatus, a ubiquitous mold, is a common cause of invasive aspergillosis (IA) in immunocompromised patients. Host defense against IA relies on…”
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Inflammatory Monocytes Mediate Early and Organ-Specific Innate Defense During Systemic Candidiasis by Ngo, Lisa Y., Kasahara, Shinji, Kumasaka, Debra K., Knoblaugh, Sue E., Jhingran, Anupam, Hohl, Tobias M.

“…Candida albicans is a commensal fungus that can cause systemic disease in patients with breaches in mucosal integrity, indwelling catheters, and defects in…”
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Compartment-specific and sequential role of MyD88 and CARD9 in chemokine induction and innate defense during respiratory fungal infection by Jhingran, Anupam, Kasahara, Shinji, Shepardson, Kelly M, Junecko, Beth A Fallert, Heung, Lena J, Kumasaka, Debra K, Knoblaugh, Sue E, Lin, Xin, Kazmierczak, Barbara I, Reinhart, Todd A, Cramer, Robert A, Hohl, Tobias M

“…Aspergillus fumigatus forms ubiquitous airborne conidia that humans inhale on a daily basis. Although respiratory fungal infection activates the adaptor…”
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Essential Role for Neutrophils but not Alveolar Macrophages at Early Time Points following Aspergillus fumigatus Infection by Mircescu, Monica M., Lipuma, Lauren, van Rooijen, Nico, Pamer, Eric G., Hohl, Tobias M.

“…Alveolar macrophages and neutrophils mediate innate immune defense against the opportunistic fungal pathogen Aspergillus fumigatus and are believed to be…”
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Heterogeneity among Isolates Reveals that Fitness in Low Oxygen Correlates with Aspergillus fumigatus Virulence by Kowalski, Caitlin H, Beattie, Sarah R, Fuller, Kevin K, McGurk, Elizabeth A, Tang, Yi-Wei, Hohl, Tobias M, Obar, Joshua J, Cramer, Jr, Robert A

“…Previous work has shown that environmental and clinical isolates of Aspergillus fumigatus represent a diverse population that occupies a variety of niches, has…”
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Candida albicans Isolates 529L and CHN1 Exhibit Stable Colonization of the Murine Gastrointestinal Tract by McDonough, Liam D, Mishra, Animesh A, Tosini, Nicholas, Kakade, Pallavi, Penumutchu, Swathi, Liang, Shen-Huan, Maufrais, Corrine, Zhai, Bing, Taur, Ying, Belenky, Peter, Bennett, Richard J, Hohl, Tobias M, Koh, Andrew Y, Ene, Iuliana V

“…Candida albicans is a pathobiont that colonizes multiple niches in the body including the gastrointestinal (GI) tract but is also responsible for both mucosal…”
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Mitochondrial Reactive Oxygen Species Enhance Alveolar Macrophage Activity against Aspergillus fumigatus but Are Dispensable for Host Protection by Shlezinger, Neta, Hohl, Tobias M

“…Aspergillus fumigatus is the most common cause of mold pneumonia worldwide, and a significant cause of infectious morbidity and mortality in immunocompromised…”
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Systematic Analysis of Copy Number Variations in the Pathogenic Yeast Candida parapsilosis Identifies a Gene Amplification in RTA3 That is Associated with Drug Resistance by Bergin, Sean A, Zhao, Fang, Ryan, Adam P, Müller, Carolin A, Nieduszynski, Conrad A, Zhai, Bing, Rolling, Thierry, Hohl, Tobias M, Morio, Florent, Scully, Jillian, Wolfe, Kenneth H, Butler, Geraldine

“…We analyzed the genomes of 170 C. parapsilosis isolates and identified multiple copy number variations (CNVs). We identified two genes, ( ) and ( ), each of…”
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