Search Results - "HOGAN, Quinn H"

Piezo2 mechanosensitive ion channel is located to sensory neurons and nonneuronal cells in rat peripheral sensory pathway: implications in pain by Shin, Seung Min, Moehring, Francie, Itson-Zoske, Brandon, Fan, Fan, Stucky, Cheryl L., Hogan, Quinn H., Yu, Hongwei

“…Piezo2 mechanotransduction channel is a crucial mediator of sensory neurons for sensing and transducing touch, vibration, and proprioception. We here…”
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Peripheral sensory neurons and non-neuronal cells express functional Piezo1 channels by Shin, Seung Min, Itson-Zoske, Brandon, Fan, Fan, Gani, Uarda, Rahman, Mahmudur, Hogan, Quinn H., Yu, Hongwei

“…Here, we present evidence showing Piezo1 protein expression in the primary sensory neurons (PSNs) and non-neuronal cells of rat peripheral nervous system…”
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Selective block of sensory neuronal T-type/Cav3.2 activity mitigates neuropathic pain behavior in a rat model of osteoarthritis pain by Itson-Zoske, Brandon, Shin, Seung Min, Xu, Hao, Qiu, Chensheng, Fan, Fan, Hogan, Quinn H, Yu, Hongwei

“…Peripheral and central nociceptive sensitization is a critical pathogenetic component in osteoarthritis (OA) chronic pain. T-type calcium channel 3.2 (Ca 3.2)…”
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Intraganglionic AAV6 results in efficient and long-term gene transfer to peripheral sensory nervous system in adult rats by Yu, Hongwei, Fischer, Gregory, Ferhatovic, Lejla, Fan, Fan, Light, Alan R, Weihrauch, Dorothee, Sapunar, Damir, Nakai, Hiroyuki, Park, Frank, Hogan, Quinn H

“…We previously demonstrated safe and reliable gene transfer to the dorsal root ganglion (DRG) using a direct microinjection procedure to deliver recombinant…”
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Thrombospondin-4 divergently regulates voltage-gated Ca2+ channel subtypes in sensory neurons after nerve injury by Pan, Bin, Guo, Yuan, Wu, Hsiang-En, Park, John, Trinh, Van Nancy, Luo, Z. David, Hogan, Quinn H.

“…Loss of high-voltage-activated (HVA) calcium current (ICa) and gain of low-voltage-activated (LVA) ICa after painful peripheral nerve injury cause elevated…”
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Permeability of injured and intact peripheral nerves and dorsal root ganglia by ABRAM, Stephen E, JOHNNY YI, FUCHS, Andreas, HOGAN, Quinn H

“…Nerve injury that produces behavioral changes of allodynia and hyperalgesia in animals is associated with electrophysiologic changes in dorsal root ganglion…”
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Failure of action potential propagation in sensory neurons: mechanisms and loss of afferent filtering in C‐type units after painful nerve injury by Gemes, Geza, Koopmeiners, Andrew, Rigaud, Marcel, Lirk, Philipp, Sapunar, Damir, Bangaru, Madhavi Latha, Vilceanu, Daniel, Garrison, Sheldon R., Ljubkovic, Marko, Mueller, Samantha J., Stucky, Cheryl L., Hogan, Quinn H.

“…Key points The peripheral terminals of sensory neurons encode physical and chemical signals into trains of action potentials (APs) and transmit these trains to…”
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Store-operated Ca2+ entry in sensory neurons: functional role and the effect of painful nerve injury by Gemes, Geza, Bangaru, Madhavi Latha Yadav, Wu, Hsiang-En, Tang, Qingbo, Weihrauch, Dorothee, Koopmeiners, Andrew S, Cruikshank, James M, Kwok, Wai-Meng, Hogan, Quinn H

“…Painful nerve injury disrupts levels of cytoplasmic and stored Ca(2+) in sensory neurons. Since influx of Ca(2+) may occur through store-operated Ca(2+) entry…”
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Repetitive Mild Traumatic Brain Injury in Rats Impairs Cognition, Enhances Prefrontal Cortex Neuronal Activity, and Reduces Pre-synaptic Mitochondrial Function by Feng, Yin, Li, Keguo, Roth, Elizabeth, Chao, Dongman, Mecca, Christina M, Hogan, Quinn H, Pawela, Christopher, Kwok, Wai-Meng, Camara, Amadou K S, Pan, Bin

“…A major hurdle preventing effective interventions for patients with mild traumatic brain injury (mTBI) is the lack of known mechanisms for the long-term…”
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Spinal nerve ligation in mouse upregulates TRPV1 heat function in injured IB4-positive nociceptors by Vilceanu, Daniel, Honore, Prisca, Hogan, Quinn H, Stucky, Cheryl L

“…Peripheral nerve injury leads to neuropathic pain, but the underlying mechanisms are not clear. The TRPV1 channel expressed by nociceptors is one receptor for…”
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Anandamide in the dorsal periaqueductal gray inhibits sensory input without a correlation to sympathoexcitation by Roberts, Christopher J., Hopp, Francis A., Hogan, Quinn H., Dean, Caron

“…•Accumulating evidence suggests that cannabinoids are potential analgesics.•Cannabinoids in the dorsal periaqueductal gray (dPAG) elicit sensory…”
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Primary sensory neuron-specific interference of TRPV1 signaling by adeno-associated virus-encoded TRPV1 peptide aptamer attenuates neuropathic pain by Xiang, Hongfei, Liu, Zhen, Wang, Fei, Xu, Hao, Roberts, Christopher, Fischer, Gregory, Stucky, Cheryl L, Dean, Caron, Pan, Bin, Hogan, Quinn H, Yu, Hongwei

“…Background TRPV1 (transient receptor potential vanilloid subfamily member 1) is a pain signaling channel highly expressed in primary sensory neurons. Attempts…”
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Distinct membrane effects of spinal nerve ligation on injured and adjacent dorsal root ganglion neurons in rats by SAPUNAR, Damir, LJUBKOVIC, Marko, LIRK, Philipp, MCCALLUM, J. Bruce, HOGAN, Quinn H

“…Painful peripheral nerve injury results in disordered sensory neuron function that contributes to the pathogenesis of neuropathic pain. However, the relative…”
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Quantification of Gene Expression after Painful Nerve Injury: Validation of Optimal Reference Genes by Bangaru, Madhavi Latha Yadav, Park, Frank, Hudmon, Andy, McCallum, J. Bruce, Hogan, Quinn H.

“…Stably expressed housekeeping genes (HKGs) are necessary for standardization of transcript measurement by quantitative real-time polymerase chain reaction…”
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Painful peripheral nerve injury decreases calcium current in axotomized sensory neurons by MCCALLUM, J. Bruce, KWOK, Wai-Meng, SAPUNAR, Damir, FUCHS, Andreas, HOGAN, Quinn H

“…Reports of Ca(2+) current I(Ca) loss after injury to peripheral sensory neurons do not discriminate between axotomized and spared neurons. The spinal nerve…”
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Nitric Oxide Activates ATP-Sensitive Potassium Channels in Mammalian Sensory Neurons: Action by Direct S-Nitrosylation by Kawano, Takashi, Zoga, Vasiliki, Kimura, Masakazu, Liang, Mei-Ying, Wu, Hsiang-En, Gemes, Geza, McCallum, J Bruce, Kwok, Wai-Meng, Hogan, Quinn H, Sarantopoulos, Constantine D

“…Background ATP-sensitive potassium (KATP) channels in neurons regulate excitability, neurotransmitter release and mediate protection from cell-death…”
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Axotomy Depletes Intracellular Calcium Stores in Primary Sensory Neurons by RIGAUD, Marcel, GEMES, Geza, WEYKER, Paul D, CRUIKSHANK, James M, KAWANO, Takashi, WU, Hsiang-En, HOGAN, Quinn H

“…The cellular mechanisms of neuropathic pain are inadequately understood. Previous investigations have revealed disrupted Ca signaling in primary sensory…”
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Heterogeneity in patterns of pain development after nerve injury in rats and the influence of sex by Sherman, Katherine, Woyach, Victoria, Eisenach, James C., Hopp, Francis A., Cao, Freddy, Hogan, Quinn H., Dean, Caron

“…•Modeling highlights heterogeneity in hyperalgesia after uniform nerve injury.•Sex differences are apparent in the temporal phenotypes.•Changes in autonomic…”
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Lentiviral Gene Transfer into the Dorsal Root Ganglion of Adult Rats by Yu, gwei, Fischer, Greg, Jia, Guangfu, Reiser, Jakob, Park, Frank, Hogan, Quinn H

“…Background: Lentivector-mediated gene delivery into the dorsal root ganglion (DRG) is a promising method for exploring pain pathophysiology and for genetic…”
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AAV-encoded CaV2.2 peptide aptamer CBD3A6K for primary sensory neuron-targeted treatment of established neuropathic pain by Yu, Hongwei, Shin, Seung Min, Xiang, Hongfei, Chao, Dongman, Cai, Yongsong, Xu, Hao, Khanna, Rajesh, Pan, Bin, Hogan, Quinn H.

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