Search Results - "HOFMANN, Ute"

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity by Moriyama, Takaya, Nishii, Rina, Perez-Andreu, Virginia, Yang, Wenjian, Klussmann, Federico Antillon, Zhao, Xujie, Lin, Ting-Nien, Hoshitsuki, Keito, Nersting, Jacob, Kihira, Kentaro, Hofmann, Ute, Komada, Yoshihiro, Kato, Motohiro, McCorkle, Robert, Li, Lie, Koh, Katsuyoshi, Najera, Cesar Rolando, Kham, Shirley Kow-Yin, Isobe, Tomoya, Chen, Zhiwei, Chiew, Edwynn Kean-Hui, Bhojwani, Deepa, Jeffries, Cynthia, Lu, Yan, Schwab, Matthias, Inaba, Hiroto, Pui, Ching-Hon, Relling, Mary V, Manabe, Atsushi, Hori, Hiroki, Schmiegelow, Kjeld, Yeoh, Allen E J, Evans, William E, Yang, Jun J

“…Jun Yang and colleagues perform targeted sequencing of NUDT15 and identify loss-of-function variants associated with thiopurine intolerance. Functionally, they…”
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Tri‐Allelic Haplotypes Determine and Differentiate Functionally Normal Allele CYP2D62 and Impaired Allele CYP2D641 by Zanger, Ulrich M., Momoi, Kyoko, Hofmann, Ute, Schwab, Matthias, Klein, Kathrin

“…CYP2D6 metabolizes 20–25% of all clinically used drugs and its complex genetic polymorphism is a major determinant of drug safety and efficacy. We investigated…”
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Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours by Nwosu, Zeribe C, Battello, Nadia, Rothley, Melanie, Piorońska, Weronika, Sitek, Barbara, Ebert, Matthias P, Hofmann, Ute, Sleeman, Jonathan, Wölfl, Stefan, Meyer, Christoph, Megger, Dominik A, Dooley, Steven

“…Although metabolism is profoundly altered in human liver cancer, the extent to which experimental models, e.g. cell lines, mimic those alterations is…”
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Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood by Ghallab, Ahmed, Hofmann, Ute, Sezgin, Selahaddin, Vartak, Nachiket, Hassan, Reham, Zaza, Ayham, Godoy, Patricio, Schneider, Kai Markus, Guenther, Georgia, Ahmed, Yasser A., Abbas, Aya A., Keitel, Verena, Kuepfer, Lars, Dooley, Steven, Lammert, Frank, Trautwein, Christian, Spiteller, Michael, Drasdo, Dirk, Hofmann, Alan F., Jansen, Peter L.M., Hengstler, Jan G., Reif, Raymond

“…Bile duct ligation (BDL) is an experimental procedure that mimics obstructive cholestatic disease. One of the early consequences of BDL in rodents is the…”
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A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and HepaRG cells by Klein, Marcus, Thomas, Maria, Hofmann, Ute, Seehofer, Daniel, Damm, Georg, Zanger, Ulrich M

“…Inflammatory processes are associated with compromised metabolism and elimination of drugs in the liver, largely mediated by proinflammatory cytokines, such as…”
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Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs) by Nies, Anne T, Hofmann, Ute, Resch, Claudia, Schaeffeler, Elke, Rius, Maria, Schwab, Matthias

“…Metformin, an oral insulin-sensitizing drug, is actively transported into cells by organic cation transporters (OCT) 1, 2, and 3 (encoded by SLC22A1, SLC22A2,…”
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Inflammation-associated microRNA-130b down-regulates cytochrome P450 activities and directly targets CYP2C9 by Rieger, Jessica K, Reutter, Sandra, Hofmann, Ute, Schwab, Matthias, Zanger, Ulrich M

“…Expression of genes involved in absorption, distribution, metabolism, and excretion (ADME) of drugs is impaired in pathophysiologic conditions such as…”
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Progesterone receptor membrane component 1 regulates lipid homeostasis and drives oncogenic signaling resulting in breast cancer progression by Asperger, Hannah, Stamm, Nadia, Gierke, Berthold, Pawlak, Michael, Hofmann, Ute, Zanger, Ulrich M, Marton, Annamaria, Katona, Robert L, Buhala, Andrea, Vizler, Csaba, Cieslik, Jan-Philipp, Ruckhäberle, Eugen, Niederacher, Dieter, Fehm, Tanja, Neubauer, Hans, Ludescher, Marina

“…PGRMC1 (progesterone receptor membrane component 1) is a highly conserved heme binding protein, which is overexpressed especially in hormone receptor-positive…”
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Comparative analysis of 3D culture methods on human HepG2 cells by Luckert, Claudia, Schulz, Christina, Lehmann, Nadja, Thomas, Maria, Hofmann, Ute, Hammad, Seddik, Hengstler, Jan G., Braeuning, Albert, Lampen, Alfonso, Hessel, Stefanie

“…Human primary hepatocytes represent a gold standard in in vitro liver research. Due to their low availability and high costs alternative liver cell models with…”
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Role of Genetic and Nongenetic Factors for Fluorouracil Treatment-Related Severe Toxicity: A Prospective Clinical Trial by the German 5-FU Toxicity Study Group by SCHWAB, Matthias, ZANGER, Ulrich M, BOKEMEYER, Carsten, EICHELBAUM, Michel, MARX, Claudia, SCHAEFFELER, Elke, KLEIN, Kathrin, DIPPON, Jürgen, KERB, Reinhold, BLIEVERNICHT, Julia, FISCHER, Joachim, HOFMANN, Ute

“…To assess the predictive value of polymorphisms in dihydropyrimidine dehydrogenase (DPYD ), thymidylate synthase (TYMS ), and methylene tetrahydrofolate…”
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Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells by Heintze, Tamara, Klein, Kathrin, Hofmann, Ute, Zanger, Ulrich M.

“…HepaRG cells are increasingly accepted as model for human drug metabolism and other hepatic functions. We used lentiviral transduction of undifferentiated…”
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Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells by Goedtke, Lisa, Sprenger, Heike, Hofmann, Ute, Schmidt, Felix F, Hammer, Helen S, Zanger, Ulrich M, Poetz, Oliver, Seidel, Albrecht, Braeuning, Albert, Hessel-Pras, Stefanie

“…Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants produced by incomplete combustion of organic matter. They induce their own metabolism by…”
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Hepatobiliary Thyroid Hormone Deficiency Impacts Bile Acid Hydrophilicity and Aquaporins in Cholestatic C57BL/6J Mice by Kube, Irina, Kowalczyk, Manuela, Hofmann, Ute, Ghallab, Ahmed, Hengstler, Jan Georg, Führer, Dagmar, Zwanziger, Denise

“…Women are more prone to develop either hypothyroidism or cholesterol gallstones than men. However, a male predominance in cholesterol gallstones under…”
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Intestinal absorption, metabolism, and excretion of (–)-epicatechin in healthy humans assessed by using an intestinal perfusion technique by Actis-Goretta, Lucas, Lévèques, Antoine, Rein, Maarit, Teml, Alexander, Schäfer, Christian, Hofmann, Ute, Li, Hequn, Schwab, Matthias, Eichelbaum, Michel, Williamson, Gary

“…Background: (–)-Epicatechin is a dietary flavonoid present in many foods that affects vascular function, but its action is limited by incomplete absorption,…”
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Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage by Schenk, Arne, Ghallab, Ahmed, Hofmann, Ute, Hassan, Reham, Schwarz, Michael, Schuppert, Andreas, Schwen, Lars Ole, Braeuning, Albert, Teutonico, Donato, Hengstler, Jan G., Kuepfer, Lars

“…Diseases and toxins may lead to death of active liver tissue, resulting in a loss of total clearance capacity at the whole-body level. However, it remains…”
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Attenuated lipotoxicity and apoptosis is linked to exogenous and endogenous augmenter of liver regeneration by different pathways by Weiss, Thomas S, Lupke, Madeleine, Ibrahim, Sara, Buechler, Christa, Lorenz, Julia, Ruemmele, Petra, Hofmann, Ute, Melter, Michael, Dayoub, Rania

“…Nonalcoholic fatty liver disease (NAFLD) covers a spectrum from simple steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Free fatty acids (FFA)…”
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Gastrointestinal absorption and metabolism of hesperetin‐7‐O‐rutinoside and hesperetin‐7‐O‐glucoside in healthy humans by Actis‐Goretta, Lucas, Dew, Tristan P, Lévèques, Antoine, Pereira‐Caro, Gema, Rein, Maarit, Teml, Alexander, Schäfer, Christian, Hofmann, Ute, Schwab, Matthias, Eichelbaum, Michel, Crozier, Alan, Williamson, Gary

“…SCOPE: Hesperetin‐7‐O‐rutinoside (hesperidin) reduces blood pressure in healthy volunteers but its intestinal absorption and metabolism are not fully…”
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Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy by Nishii, Rina, Moriyama, Takaya, Janke, Laura J., Yang, Wenjian, Suiter, Chase C., Lin, Ting-Nien, Li, Lie, Kihira, Kentaro, Toyoda, Hidemi, Hofmann, Ute, Schwab, Matthias, Takagi, Masatoshi, Morio, Tomohiro, Manabe, Atsushi, Kham, Shirley, Jiang, Nan, Rabin, Karen R., Kato, Motohiro, Koh, Katsuyoshi, Yeoh, Allen Eng-Juh, Hori, Hiroki, Yang, Jun J.

“…Thiopurines (eg, 6-mercaptopurine [MP]) are highly efficacious antileukemic agents, but they are also associated with dose-limiting toxicities. Recent studies…”
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Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue by Godoy, Patricio, Widera, Agata, Schmidt-Heck, Wolfgang, Campos, Gisela, Meyer, Christoph, Cadenas, Cristina, Reif, Raymond, Stöber, Regina, Hammad, Seddik, Pütter, Larissa, Gianmoena, Kathrin, Marchan, Rosemarie, Ghallab, Ahmed, Edlund, Karolina, Nüssler, Andreas, Thasler, Wolfgang E., Damm, Georg, Seehofer, Daniel, Weiss, Thomas S., Dirsch, Olaf, Dahmen, Uta, Gebhardt, Rolf, Chaudhari, Umesh, Meganathan, Kesavan, Sachinidis, Agapios, Kelm, Jens, Hofmann, Ute, Zahedi, René P., Guthke, Reinhard, Blüthgen, Nils, Dooley, Steven, Hengstler, Jan G.

“…It is well known that isolation and cultivation of primary hepatocytes cause major gene expression alterations. In the present genome-wide, time-resolved study…”
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Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis by Heintze, Tamara, Wilhelm, Denise, Schmidlin, Thierry, Hofmann, Ute, Zanger, Ulrich M., Schwab, Matthias, Klein, Kathrin

“…NADPH:cytochrome P450 oxidoreductase (POR) is the obligate electron donor for microsomal cytochrome P450 (CYP) enzymes involved in the biosynthesis of…”
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