Search Results - "HOFMANN, Clemens"

The genetics of Pak by Hofmann, Clemens, Shepelev, Mikhail, Chernoff, Jonathan

“…p21-activated kinases (Paks) are a highly conserved family of enzymes that bind to and are activated by small GTPases of the Cdc42 and Rac families. With the…”
Get full text

p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics by Allen, Jayme D., Jaffer, Zahara M., Park, Su-Jung, Burgin, Sarah, Hofmann, Clemens, Sells, Mary Ann, Chen, Shi, Derr-Yellin, Ethel, Michels, Elizabeth G., McDaniel, Andrew, Bessler, Waylan K., Ingram, David A., Atkinson, Simon J., Travers, Jeffrey B., Chernoff, Jonathan, Clapp, D. Wade

“…Mast cells are key participants in allergic diseases via activation of high-affinity IgE receptors (FcϵRI) resulting in release of proinflammatory mediators…”
Get full text

Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases by Van den Broeke, Céline, Radu, Maria, Deruelle, Matthias, Nauwynck, Hans, Hofmann, Clemens, Jaffer, Zahara M, Chernoff, Jonathan, Favoreel, Herman W

“…The US3 protein is a viral serine/threonine kinase that is conserved among all members of the ALPHAHERPESVIRINAE: The US3 protein of different…”
Get full text

Role of Group A p21-activated Kinases in Activation of Extracellular-regulated Kinase by Growth Factors by Beeser, Alexander, Jaffer, Zahara M., Hofmann, Clemens, Chernoff, Jonathan

“…The canonical extracellular-regulated kinase (ERK) signaling cascade, consisting of the Ras-Raf-Mek-ERK module, is critically important to many cellular…”
Get full text

Direct Observation of Tiers in the Energy Landscape of a Chromoprotein: A Single-Molecule Study by Hofmann, Clemens, Aartsma, Thijs J., Michel, Hartmut, Köhler, Jürgen

“…Single-molecule spectroscopic techniques were applied to individual pigments embedded in a chromoprotein. A sensitive tool to monitor structural fluctuations…”
Get full text

Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/− mast cells by McDaniel, Andrew S., Allen, Jayme D., Park, Su-Jung, Jaffer, Zahara M, Michels, Elizabeth G., Burgin, Sarah J., Chen, Shi, Bessler, Waylan K., Hofmann, Clemens, Ingram, David A., Chernoff, Jonathan, Clapp, D. Wade

“…Neurofibromatosis type 1 (NF1) is a common genetic disorder caused by mutations in the NF1 locus, which encodes neurofibromin, a negative regulator of Ras…”
Get full text

Energetic disorder and the B850-exciton states of individual light-harvesting 2 complexes from Rhodopseudomonas acidophila by Hofmann, Clemens, Aartsma, Thijs J., Köhler, Jürgen

“…We have studied the spectroscopic properties of the B850 excitations of the peripheral light-harvesting complex (LH2) from Rhodopseudomonas acidophila…”
Get full text

Multivariate analysis of single-molecule spectra : Surpassing spectral diffusion by HOFMANN, Clemens, MICHEL, Hartmut, VAN HEEL, Marin, KÖHLER, Jürgen

“…The full exploitation of single-molecule spectroscopy in disordered systems is often hampered by spectral diffusion processes of the optical transitions due to…”
Get full text

Effect of the venous catheter site on transpulmonary thermodilution measurement variables by Schmidt, Sven, Westhoff, Timm H, Hofmann, Clemens, Schaefer, Juergen-Heiner, Zidek, Walter, Compton, Friederike, van der Giet, Markus

“…OBJECTIVE:Transpulmonary thermodilution is increasingly used for hemodynamic monitoring of critically ill patients. Injection of a cold saline bolus in the…”
Get full text

Adenosine triphosphate–induced oxygen radical production and CD11b up-regulation: Ca++ mobilization and actin reorganization in human eosinophils by Dichmann, Stefan, Idzko, Marco, Zimpfer, Ulrich, Hofmann, Clemens, Ferrari, Davide, Luttmann, Werner, Virchow, Christian, Di Virgilio, Francesco, Norgauer, Johannes

“…Eosinophils are major effector cells in cellular inflammatory conditions such as parasitic infections, atopic diseases, bullous dermatoses, and vasculitis…”
Get full text

Energy transfer in a single self-aggregated photosynthetic unit by Hofmann, Clemens, Francia, Francesco, Venturoli, Giovanni, Oesterhelt, Dieter, Köhler, Jürgen

“…The primary events of bacterial photosynthesis rely on the interplay of various specialized protein complexes organized in a supramolecular structure commonly…”
Get full text

Spectroscopy on Individual Light-Harvesting 1 Complexes of Rhodopseudomonas acidophila by Ketelaars, Martijn, Hofmann, Clemens, Köhler, Jürgen, Howard, Tina D., Cogdell, Richard J., Schmidt, Jan, Aartsma, Thijs J.

“…In this paper the fluorescence-excitation spectra of individual LH1-RC complexes ( Rhodopseudomonas acidophila) at 1.2 K are presented. All spectra show a…”
Get full text

Four-Level Optical Line Shape of a Single Molecule Coupled to a Single Tunneling Two-Level System by Hofmann, Clemens, Orrit, Michel

“…We propose a density-matrix theory for the four-level system consisting of a single optical two-level system (OTLS) coupled to a single two-level system…”
Get full text

Is There Elliptic Distortion in the Light Harvesting Complex 2 of Purple Bacteria? by Jang, Seogjoo, Silbey, Robert J, Kunz, Ralf, Hofmann, Clemens, Köhler, Jürgen

“…Single molecule spectroscopy (SMS) revealed an unusually large Gap between two major exciton peaks of the B850 unit of light harvesting complex 2 (LH2), which…”
Get full text

Single Dibenzoterrylene Molecules in an Anthracene Crystal: Spectroscopy and Photophysics by Nicolet, Aurélien A. L., Hofmann, Clemens, Kol'chenko, Mikhail A., Kozankiewicz, Boleslaw, Orrit, Michel

“…We study single dibenzoterrylene molecules in an anthracene single crystal at 1.4 K in two insertion sites at 785.1 and 794.3 nm. The single‐molecule…”
Get full text

Single Dibenzoterrylene Molecules in an Anthracene Crystal: Main Insertion Sites by Nicolet, Aurélien A. L., Bordat, Patrice, Hofmann, Clemens, Kol'chenko, Mikhail A., Kozankiewicz, Boleslaw, Brown, Ross, Orrit, Michel

“…We present a spectroscopic study of the properties of the two principal insertion sites (at 785.1 and 794.3 nm) of single dibenzoterrylene molecules in…”
Get full text

Single-molecule study of the electronic couplings in a circular array of molecules: light-harvesting-2 complex from Rhodospirillum molischianum by Hofmann, Clemens, Ketelaars, Martijn, Matsushita, Michio, Michel, Hartmut, Aartsma, Thijs J, Köhler, Jürgen

“…Applying single-molecule spectroscopic techniques allowed us to determine the mutual angles between the transition-dipole moments associated with optical…”
Get full text

Stretched Polyethylene Films Probed by Single Molecules by Wirtz, Alexander C., Hofmann, Clemens, Groenen, Edgar J. J.

“…Stretched films of low‐density polyethylene (LDPE) doped with 2.3,8.9‐dibenzanthanthrene (DBATT) were studied using polarization‐selective single‐molecule…”
Get full text

Towards nanoprobes for conduction in molecular crystals: Dibenzoterrylene in anthracene crystals by Hofmann, Clemens, Nicolet, Aurélien, Kol’chenko, Mikhail A., Orrit, Michel

“…The miniaturization of electronic devices and structures brings along the quest for instruments that operate on mesoscopic and nanometric scales. In these…”
Get full text

Spectral dynamics in the B800 band of LH2 from Rhodospirillum molischianum: a single-molecule study by Hofmann, Clemens, Aartsma, Thijs J, Michel, Hartmut, Köhler, Jürgen

“…The BChl a absorptions in the B800 spectrum of individual LH2 complexes from Rhodospirillum molischianum show sudden, reversible spectral jumps between a…”
Get full text