Search Results - "HOFLER, Heinz"

Protein Expression Profiling in Esophageal Adenocarcinoma Patients Indicates Association of Heat-Shock Protein 27 Expression and Chemotherapy Response by Langer, Rupert, Ott, Katja, Specht, Katja, Becker, Karen, Lordick, Florian, Burian, Maria, Herrmann, Ken, Schrattenholz, Andre, Cahill, Michael A, Schwaiger, Markus, Hofler, Heinz, Wester, Hans-Jurgen

“…Purpose: To identify pretherapeutic predictive biomarkers in tumor biopsies of patients with locally advanced esophageal adenocarcinomas treated with…”
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Different mechanisms of cyclin D1 overexpression in multiple myeloma revealed by fluorescence in situ hybridization and quantitative analysis of mRNA levels by Specht, Katja, Haralambieva, Eugenia, Bink, Karin, Kremer, Marcus, Mandl-Weber, Sonja, Koch, Ina, Tomer, Raju, Hofler, Heinz, Schuuring, Ed, Kluin, Philip M., Fend, Falko, Quintanilla-Martinez, Leticia

“…The t(11;14)(q13;q32) is the most common translocation in multiple myeloma (MM), resulting in up-regulation of cyclin D1. We used a segregation fluorescence in…”
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Classification of HER2 Receptor Status in Breast Cancer Tissues by MALDI Imaging Mass Spectrometry by Rauser, Sandra, Marquardt, Claudio, Balluff, Benjamin, Deininger, Sören-Oliver, Albers, Christian, Belau, Eckhard, Hartmer, Ralf, Suckau, Detlev, Specht, Katja, Ebert, Matthias Philip, Schmitt, Manfred, Aubele, Michaela, Höfler, Heinz, Walch, Axel

“…Clinical laboratory testing for HER2 status in breast cancer tissues is critically important for therapeutic decision making. Matrix-assisted laser…”
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Rapamycin extends murine lifespan but has limited effects on aging by Neff, Frauke, Flores-Dominguez, Diana, Ryan, Devon P, Horsch, Marion, Schröder, Susanne, Adler, Thure, Afonso, Luciana Caminha, Aguilar-Pimentel, Juan Antonio, Becker, Lore, Garrett, Lillian, Hans, Wolfgang, Hettich, Moritz M, Holtmeier, Richard, Hölter, Sabine M, Moreth, Kristin, Prehn, Cornelia, Puk, Oliver, Rácz, Ildikó, Rathkolb, Birgit, Rozman, Jan, Naton, Beatrix, Ordemann, Rainer, Adamski, Jerzy, Beckers, Johannes, Bekeredjian, Raffi, Busch, Dirk H, Ehninger, Gerhard, Graw, Jochen, Höfler, Heinz, Klingenspor, Martin, Klopstock, Thomas, Ollert, Markus, Stypmann, Jörg, Wolf, Eckhard, Wurst, Wolfgang, Zimmer, Andreas, Fuchs, Helmut, Gailus-Durner, Valérie, Hrabe de Angelis, Martin, Ehninger, Dan

“…Aging is a major risk factor for a large number of disorders and functional impairments. Therapeutic targeting of the aging process may therefore represent an…”
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Nucleic acids from long-term preserved FFPE tissues are suitable for downstream analyses by Ludyga, Natalie, Grünwald, Barbara, Azimzadeh, Omid, Englert, Sonja, Höfler, Heinz, Tapio, Soile, Aubele, Michaela

“…Tissues used for clinical diagnostics are mostly formalin-fixed and paraffin-embedded (FFPE) which provides many advantages. However, the quality of the…”
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MALDI imaging mass spectrometry in cancer research: Combining proteomic profiling and histological evaluation by Schöne, Cédrik, Höfler, Heinz, Walch, Axel

“…Despite the tendency to regard tumors as a simple mass of cancer cells, tumors have a high degree of complexity that is difficult to access with most…”
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PET to assess early metabolic response and to guide treatment of adenocarcinoma of the oesophagogastric junction: the MUNICON phase II trial by Lordick, Florian, Dr, Ott, Katja, MD, Krause, Bernd-Joachim, Prof, Weber, Wolfgang A, MD, Becker, Karen, MD, Stein, Hubert J, Prof, Lorenzen, Sylvie, MD, Schuster, Tibor, MS, Wieder, Hinrich, MD, Herrmann, Ken, MD, Bredenkamp, Rainer, BSc, Höfler, Heinz, Prof, Fink, Ulrich, Prof, Peschel, Christian, Prof, Schwaiger, Markus, Prof, Siewert, Jörg R, Prof

“…Summary Background In patients with locally advanced adenocarcinoma of the oesophagogastric junction (AEG), early metabolic response defined by…”
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Tissue-based proteomics reveals FXYD3, S100A11 and GSTM3 as novel markers for regional lymph node metastasis in colon cancer by Meding, Stephan, Balluff, Benjamin, Elsner, Mareike, Schöne, Cédrik, Rauser, Sandra, Nitsche, Ulrich, Maak, Matthias, Schäfer, Alexander, Hauck, Stefanie M, Ueffing, Marius, Langer, Rupert, Höfler, Heinz, Friess, Helmut, Rosenberg, Robert, Walch, Axel

“…Regional lymph node metastasis negatively affects prognosis in colon cancer patients. The molecular processes leading to regional lymph node metastasis are…”
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Tumor Classification of Six Common Cancer Types Based on Proteomic Profiling by MALDI Imaging by Meding, Stephan, Nitsche, Ulrich, Balluff, Benjamin, Elsner, Mareike, Rauser, Sandra, Schöne, Cédrik, Nipp, Martin, Maak, Matthias, Feith, Marcus, Ebert, Matthias P, Friess, Helmut, Langer, Rupert, Höfler, Heinz, Zitzelsberger, Horst, Rosenberg, Robert, Walch, Axel

“…In clinical diagnostics, it is of outmost importance to correctly identify the source of a metastatic tumor, especially if no apparent primary tumor is…”
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MALDI imaging mass spectrometry for direct tissue analysis: a new frontier for molecular histology by Walch, Axel, Rauser, Sandra, Deininger, Sören-Oliver, Höfler, Heinz

“…Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a powerful tool for investigating the distribution of proteins and small…”
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MALDI imaging mass spectrometry for direct tissue analysis: technological advancements and recent applications by Balluff, Benjamin, Schöne, Cedrik, Höfler, Heinz, Walch, Axel

“…Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a method that allows the investigation of the molecular content of…”
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Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics by Nicholson, George, Selloum, Mohammed, Morgan, Hugh, Ramirez-Solis, Ramiro, Sorg, Tania, Wells, Sara, Fuchs, Helmut, Fray, Martin, Adams, David J, Adler, Thure, Aguilar-Pimentel, Antonio, Ali-Hadji, Dalila, Amann, Gregory, André, Philippe, Auburtin, Aurelie, Ayadi, Abdel, Becker, Julien, Birling, Marie-Christine, Blake, Andrew, Bottomley, Joanna, Bowl, Michael R, Busch, Dirk H, Cater, Heather, Champy, Marie-France, Charles, Philippe, Chevalier, Claire, Chiani, Francesco, Combe, Roy, Cox, Roger, Dalloneau, Emilie, Di Fenza, Armida, Eickelberg, Oliver, Esapa, Chris T, Fertak, Lahcen El, Feigel, Tanja, Emelyanova, Irina, Flenniken, Ann, Gates, Hilary, Gerdin, Anna-Karin, Gkoutos, George, Greenaway, Simon, Goetz, Patrice, Da Cruz, Isabelle Goncalves, Graw, Jochen, Guimond, Alain, Hans, Wolfgang, Höfler, Heinz, Hancock, John M, Hoehndorf, Robert, Hurt, Anja, Jacobs, Hughes, Jones, Nora, Karp, Natasha A, Katus, Hugo A, Klein-Rodewald, Tanja, Lalanne, Valerie, Leblanc, Sophie, le Marchand, Elise, McKerlie, Colin, Mark, Manuel, Meziane, Hamid, Mittelhauser, Christophe, Monassier, Laurent, Moulaert, David, Muller, Stéphanie, Naton, Beatrix, Neff, Frauke, Nolan, Patrick M, Nutter, Lauryl M J, Ollert, Markus, Pavlovic, Guillaume, Pellegata, Natalia S, Peter, Emilie, Petit-Demoulière, Benoit, Pickard, Amanda, Potter, Paul, Pouilly, Laurent, Puk, Oliver, Rousseau, Stephane, Quwailid, Mohamed M, Rathkolb, Birgit, Rossant, Janet, Rozman, Jan, Schrewe, Anja, Schulz, Holger, Steinkamp, Ralf, Stewart, Michelle, Stöger, Tobias, Sun, Minxuan, Sunter, David, Teboul, Lydia, Tocchini-Valentini, Glauco P, Wagner, Christelle, Wattenhofer-Donze, Marie, Weber, Bruno, Wood, Joe, Yildirim, Ali Önder, Zeh, Ramona, Zimmer, Andreas, Zimprich, Annemarie

“…Steve Brown and colleagues report an analysis of 20 phenotyping tests, including 413 data parameters, across 449 mutant mouse alleles. They identify widespread…”
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De novo discovery of phenotypic intratumour heterogeneity using imaging mass spectrometry by Balluff, Benjamin, Frese, Christian K, Maier, Stefan K, Schöne, Cédrik, Kuster, Bernhard, Schmitt, Manfred, Aubele, Michaela, Höfler, Heinz, Deelder, André M, Heck, Albert JR, Hogendoorn, Pancras CW, Morreau, Johannes, Maarten Altelaar, AF, Walch, Axel, McDonnell, Liam A

“…An essential and so far unresolved factor influencing the evolution of cancer and the clinical management of patients is intratumour clonal and phenotypic…”
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Intraductal papillary neoplasms of the bile duct: stepwise progression to carcinoma involves common molecular pathways by Schlitter, Anna Melissa, Born, Diana, Bettstetter, Marcus, Specht, Katja, Kim-Fuchs, Corina, Riener, Marc-Oliver, Jeliazkova, Petia, Sipos, Bence, Siveke, Jens T, Terris, Benoit, Zen, Yoh, Schuster, Tibor, Höfler, Heinz, Perren, Aurel, Klöppel, Günter, Esposito, Irene

“…Intraductal papillary neoplasms of the bile duct are still poorly characterized regarding (1) their molecular alterations during the development to invasive…”
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Prevalence and Topography of Lymph Node Metastases in Early Esophageal and Gastric Cancer by Gertler, Ralf, Stein, Hubert J, Schuster, Tibor, Rondak, Ina-Christine, Höfler, Heinz, Feith, Marcus

“…OBJECTIVE:To determine the prevalence and localization of lymph node metastases in patients with pT1 carcinoma of the esophagus, esophagogastric junction, and…”
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Differential Expression of the Epithelial-Mesenchymal Transition Regulators Snail, SIP1, and Twist in Gastric Cancer by Rosivatz, Erika, Becker, Ingrid, Specht, Katja, Fricke, Elena, Luber, Birgit, Busch, Raymonde, Höfler, Heinz, Becker, Karl-Friedrich

“…Epithelial-mesenchymal transition (EMT) involving down-regulation of E-cadherin is thought to play a fundamental role during early steps of invasion and…”
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Prognostic Implications of the Seventh Edition of the International Union Against Cancer Classification for Patients With Gastric Cancer: The Western Experience of Patients Treated in a Single-Center European Institution by REIM, Daniel, LOOS, Martin, FRIESS, Helmut, SCHUHMACHER, Christoph, VOGL, Fabian, NOVOTNY, Alexander, SCHUSTER, Tibor, LANGER, Rupert, BECKER, Karen, HÖFLER, Heinz, SIVEKE, Jens, BASSERMANN, Florian

“…Validity of the seventh edition of the American Joint Committee on Cancer/International Union Against Cancer (AJCC/UICC) staging systems for gastric cancer has…”
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Aurora Kinase A Messenger RNA Overexpression Is Correlated with Tumor Progression and Shortened Survival in Head and Neck Squamous Cell Carcinoma by REITER, Rudolf, GAIS, Peter, WALCH, Axel, JÜTTING, Uta, STEUER-VOGT, Miriam K, PICKHARD, Anja, BINK, Karin, RAUSER, Sandra, LASSMANN, Silke, HÖFLER, Heinz, WERNER, Martin

“…Purpose: Aurora kinase A (AURKA/STK15/BTAK) encodes a serine/threonine kinase associated with chromosomal distribution and its up-regulation induces…”
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Expression profiling of stem cell-related genes in neoadjuvant-treated gastric cancer: a NOTCH2, GSK3B and β-catenin gene signature predicts survival by Bauer, Lukas, Langer, Rupert, Becker, Karen, Hapfelmeier, Alexander, Ott, Katja, Novotny, Alexander, Höfler, Heinz, Keller, Gisela

“…Cancer stem cell (CSC) based gene expression signatures are associated with prognosis in various tumour types and CSCs are suggested to be particularly drug…”
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Expression of EpCam and villin in Barrett's esophagus and in gastric cardia by Anders, Mario, Sarbia, Mario, Grotzinger, Carsten, Meining, Alexander, Hofler, Heinz, Wiedenmann, Bertram, Rosch, Thomas

“…In the current study we aimed to clarify the potential of EpCAM and villin as in vivo biomarkers for both Barrett esophagus (BE)-associated neoplasia and BE…”
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