Search Results - "HOFFNER, Sven E"

Microevolution of extensively drug-resistant tuberculosis in Russia by Casali, Nicola, Nikolayevskyy, Vladyslav, Balabanova, Yanina, Ignatyeva, Olga, Kontsevaya, Irina, Harris, Simon R, Bentley, Stephen D, Parkhill, Julian, Nejentsev, Sergey, Hoffner, Sven E, Horstmann, Rolf D, Brown, Timothy, Drobniewski, Francis

“…Extensively drug-resistant (XDR) tuberculosis (TB), which is resistant to both first- and second-line antibiotics, is an escalating problem, particularly in…”
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Detection of First- and Second-Line Drug Resistance in Mycobacterium tuberculosis Clinical Isolates by Pyrosequencing by ENGSTRÖM, Anna, MORCILLO, Nora, IMPERIALE, Belen, HOFFNER, Sven E, JUREEN, Pontus

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Challenging a dogma: antimicrobial susceptibility testing breakpoints for Mycobacterium tuberculosis by ÄNGEBY, Kristian, JUREEN, Pontus, KAHLMETER, Gunnar, HOFFNER, Sven E, SCHÖN, Thomas

“…The rise in multidrug-resistant tuberculosis makes it increasingly important that antimicrobial susceptibility testing of Mycobacterium tuberculosis produce…”
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In Vitro Antimycobacterial Spectrum of a Diarylquinoline ATP Synthase Inhibitor by HUITRIC, Emma, VERHASSELT, Peter, ANDRIES, Koen, HOFFNER, Sven E

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Drivers and sites of diversity in the DNA adenine methylomes of 93 Mycobacterium tuberculosis complex clinical isolates by Modlin, Samuel J, Conkle-Gutierrez, Derek, Kim, Calvin, Mitchell, Scott N, Morrissey, Christopher, Weinrick, Brian C, Jacobs, William R, Ramirez-Busby, Sarah M, Hoffner, Sven E, Valafar, Faramarz

“…This study assembles DNA adenine methylomes for 93 complex (MTBC) isolates from seven lineages paired with fully-annotated, finished, de novo assembled…”
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Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis by Thiede, Joshua M, Dillon, Nicholas A, Howe, Michael D, Aflakpui, Ranee, Modlin, Samuel J, Hoffner, Sven E, Valafar, Faramarz, Minato, Yusuke, Baughn, Anthony D

“…Pyrazinamide (PZA) plays a crucial role in first-line tuberculosis drug therapy. Unlike other antimicrobial agents, PZA is active against Mycobacterium…”
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Effect of rpoB Mutations Conferring Rifampin Resistance on Fitness of Mycobacterium tuberculosis by MARIAM, Deneke H, MENGISTU, Yohannes, HOFFNER, Sven E, ANDERSSON, Dan I

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Drug-Susceptible Mycobacterium tuberculosis Beijing Genotype Does Not Develop Mutation-Conferred Resistance to Rifampin at an Elevated Rate by WERNGREN, Jim, HOFFNER, Sven E

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Rapid Detection of Rifampin Resistance in Mycobacterium tuberculosis by Pyrosequencing Technology by Jureen, Pontus, Engstrand, Lars, Eriksson, Solveig, Alderborn, Anders, Krabbe, Margareta, Hoffner, Sven E

“…We developed an assay for rapid detection of rifampin resistance in Mycobacterium tuberculosis based on Pyrosequencing technology, involving a technique for…”
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Rapid and Inexpensive Drug Susceptibility Testing of Mycobacterium tuberculosis with a Nitrate Reductase Assay by ÄNGEBY, K. A, KLINTZ, Lisbeth, HOFFNER, Sven E

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Spread of Drug-Resistant Pulmonary Tuberculosis in Estonia by Krüüner, A, Hoffner, S E, Sillastu, H, Danilovits, M, Levina, K, Svenson, S B, Ghebremichael, S, Koivula, T, Källenius, G

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Molecular diversity of Mycobacterium tuberculosis isolates from patients with tuberculosis in Honduras by Rosales, Senia, Pineda-García, Lelany, Ghebremichael, Solomon, Rastogi, Nalin, Hoffner, Sven E

“…Tuberculosis persists as a public health problem in Honduras. A better knowledge of the molecular characteristics of Mycobacterium tuberculosis strains will…”
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Atypical Genetic Basis of Pyrazinamide Resistance in Monoresistant Mycobacterium tuberculosis by Modlin, Samuel J, Marbach, Tyler, Werngren, Jim, Mansjö, Mikael, Hoffner, Sven E, Valafar, Faramarz

“…Pyrazinamide (PZA) is a widely used antitubercular chemotherapeutic. Typically, PZA resistance (PZA-R) emerges in strains with existing resistance to isoniazid…”
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Pattern recognition and cellular immune responses to novel Mycobacterium tuberculosis-antigens in individuals from Belarus by Ahmed, Raija K, Rohava, Zoyia, Balaji, Kithiganahalli N, Hoffner, Sven E, Gaines, Hans, Magalhaes, Isabelle, Zumla, Alimuddin, Skrahina, Alena, Maeurer, Markus J

“…Tuberculosis (TB) is an enduring health problem worldwide and the emerging threat of multidrug resistant (MDR) TB and extensively drug resistant (XDR) TB is of…”
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Drug resistance-related mutations in multidrug-resistant Mycobacterium tuberculosis isolates from diverse geographical regions by Rosales-Klintz, Senia, Jureen, Pontus, Zalutskayae, Aksana, Skrahina, Alena, Xu, Biao, Hu, Yi, Pineda-Garcia, Lelany, Merza, Muayad Aghali, Muntean, Ionela, Bwanga, Freddie, Joloba, Moses, Hoffner, Sven E

“…Abstract Background Drug resistance in Mycobacterium tuberculosis is associated with chromosomal mutations in selected genes. These mutations can be screened…”
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Distribution of Common and Rare Genetic Markers of Second-Line-Injectable-Drug Resistance in Mycobacterium tuberculosis Revealed by a Genome-Wide Association Study by Conkle-Gutierrez, Derek, Kim, Calvin, Ramirez-Busby, Sarah M, Modlin, Samuel J, Mansjö, Mikael, Werngren, Jim, Rigouts, Leen, Hoffner, Sven E, Valafar, Faramarz

“…Point mutations in the gene and the promoter are known to confer resistance to the second-line injectable drugs (SLIDs) amikacin (AMK), capreomycin (CAP), and…”
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Pyrazinamide-resistant Tuberculosis Obscured From Common Targeted Molecular Diagnostics by Modlin, Samuel J., Mansjö, Mikael, Werngren, Jim, Ejike, Chidera M., Hoffner, Sven E., Valafar, Faramarz

“…Here, we describe a clinical case of pyrazinamide-resistant (PZA-R) tuberculosis (TB) reported as PZA-susceptible (PZA-S) by common molecular diagnostics…”
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Evaluation of a Novel Kit for Use with the BacT/ALERT 3D System for Drug Susceptibility Testing of Mycobacterium tuberculosis by Werngren, Jim, Klintz, Lisbeth, Hoffner, Sven E

“…We evaluated a new protocol for the BacT/ALERT MB susceptibility test (bioMérieux Inc., Durham, NC) using 80 Mycobacterium tuberculosis WHO challenge panel…”
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Evaluation of the line probe assay (LiPA) for rapid detection of rifampicin resistance in Mycobacterium tuberculosis by Juréen, Pontus, Werngren, Jim, Hoffner, Sven E

“…Resistant Mycobacterium tuberculosis has become a serious threat to public health. In order to inhibit spreading and give effective treatment, it is of great…”
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Use of Molecular Techniques to Distinguish between Treatment Failure and Exogenous Reinfection with Mycobacterium tuberculosis by Krüüner, Annika, Pehme, Lea, Ghebremichael, Solomon, Koivula, Tuija, Hoffner, Sven E., Mikelsaar, Marika

“…We investigated the means by which drug resistance emerges among drug-susceptible Mycobacterium tuberculosis strains during antituberculosis therapy. Patients…”
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