Search Results - "HOFFMANN, THOMAS K"

Clinical Significance of PD-L1 + Exosomes in Plasma of Head and Neck Cancer Patients by Theodoraki, Marie-Nicole, Yerneni, Saigopalakrishna S, Hoffmann, Thomas K, Gooding, William E, Whiteside, Theresa L

“…The microenvironment of head and neck squamous cell carcinomas (HNSCC) is highly immunosuppressive. HNSCCs expressing elevated levels of PD-L1 have especially…”
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Total Laryngectomy-Still Cutting-Edge? by Hoffmann, Thomas K

“…Surgical removal of the larynx (total laryngectomy) offers a curative approach to patients with advanced laryngeal and hypopharyngeal (squamous cell) cancer…”
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A Randomized Trial of Icatibant in ACE-Inhibitor–Induced Angioedema by Baş, Murat, Greve, Jens, Stelter, Klaus, Havel, Miriam, Strassen, Ulrich, Rotter, Nicole, Veit, Johannes, Schossow, Beate, Hapfelmeier, Alexander, Kehl, Victoria, Kojda, Georg, Hoffmann, Thomas K

“…Thirty patients with ACE-inhibitor–induced angioedema were assigned to receive icatibant or standard therapy with intravenous prednisolone plus clemastine. The…”
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Evidence for epithelial-mesenchymal transition in cancer stem cells of head and neck squamous cell carcinoma by Chen, Chao, Wei, Yan, Hummel, Michael, Hoffmann, Thomas K, Gross, Manfred, Kaufmann, Andreas M, Albers, Andreas E

“…Initiation, growth, recurrence, and metastasis of head and neck squamous cell carcinomas (HNSCC) have been related to the behavior of cancer stem cells (CSC)…”
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The Emerging Role of Exosomes in Diagnosis, Prognosis, and Therapy in Head and Neck Cancer by Hofmann, Linda, Ludwig, Sonja, Vahl, Julius M, Brunner, Cornelia, Hoffmann, Thomas K, Theodoraki, Marie-Nicole

“…Exosomes, the smallest group of extracellular vesicles, carry proteins, miRNA, mRNA, DNA, and lipids, which they efficiently deliver to recipient cells,…”
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Angioedema in the emergency department: a practical guide to differential diagnosis and management by Bernstein, Jonathan A., Cremonesi, Paolo, Hoffmann, Thomas K., Hollingsworth, John

“…Background Angioedema is a common presentation in the emergency department (ED). Airway angioedema can be fatal; therefore, prompt diagnosis and correct…”
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NF-κB and Its Role in Checkpoint Control by Betzler, Annika C, Theodoraki, Marie-Nicole, Schuler, Patrick J, Döscher, Johannes, Laban, Simon, Hoffmann, Thomas K, Brunner, Cornelia

“…Nuclear factor-κB (NF-κB) has been described as one of the most important molecules linking inflammation to cancer. More recently, it has become clear that…”
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A clinical evaluation of patients with known mutations (plasminogen and factor XII) with a focus on prophylactic treatment by Lochbaum, Robin, Trainotti, Susanne, Hoffmann, Thomas K, Greve, Jens, Hahn, Janina

“…Hereditary angioedema with normal C1-inhibitor (HAE-nC1-INH) is a rare genetic disease. The symptoms can resemble other forms of hereditary angioedema (HAE),…”
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Polymorphonuclear granulocytes in human head and neck cancer: Enhanced inflammatory activity, modulation by cancer cells and expansion in advanced disease by Trellakis, Sokratis, Bruderek, Kirsten, Dumitru, Claudia A., Gholaman, Hossein, Gu, Xiang, Bankfalvi, Agnes, Scherag, André, Hütte, Jan, Dominas, Nina, Lehnerdt, Götz F., Hoffmann, Thomas K., Lang, Stephan, Brandau, Sven

“…The progression of epithelial cancer is associated with an intense immunological interaction between the tumor cells and immune cells of the host. However,…”
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Therapeutic Efficacy of Icatibant in Angioedema Induced by Angiotensin-Converting Enzyme Inhibitors: A Case Series by Bas, Murat, MD, Greve, Jens, MD, Stelter, Klaus, MD, Bier, Henning, MD, Stark, Thomas, MD, Hoffmann, Thomas K., MD, Kojda, Georg, PharmD, PhD

“…Study objective The pathophysiology of angiotensin-converting enzyme inhibitor (ACEi)–induced angioedema most likely resembles that of hereditary angioedema,…”
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CD44v3 protein-carrying tumor-derived exosomes in HNSCC patients' plasma as potential noninvasive biomarkers of disease activity by Theodoraki, Marie-Nicole, Matsumoto, Akihiro, Beccard, Inga, Hoffmann, Thomas K., Whiteside, Theresa L.

“…The molecular cargo of tumor-cell-derived exosomes (TEX) mimics that of parental tumor cells. Thus, TEX could potentially serve as noninvasive biomarkers of…”
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The Potential of CD16 on Plasma-Derived Exosomes as a Liquid Biomarker in Head and Neck Cancer by Hofmann, Linda, Ludwig, Sonja, Schuler, Patrick J, Hoffmann, Thomas K, Brunner, Cornelia, Theodoraki, Marie-Nicole

“…Head and neck squamous cell carcinomas (HNSCC) are highly immune suppressive and aggressive malignancies. As part of the tumor microenvironment, exosomes…”
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Type 2-like polarization and elevated CXCL4 secretion of monocyte derived macrophages upon internalization of plasma-derived exosomes from head and neck cancer patients by Theodoraki, Marie-Nicole, Huber, Diana, Hofmann, Linda, Werner, Lotte, Idel, Christian, Fleckner, Jonas, Plötze-Martin, Kirstin, Schütt, Lutz, Brunner, Cornelia, Depping, Reinhard, Hoffmann, Thomas K, Bruchhage, Karl-Ludwig, Pries, Ralph

“…Exosomes are closely associated with different aspects of tumor-progression in patients with head and neck squamous cell carcinoma (HNSCC), such as…”
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The HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination by Mühlenbruch, Lena, Abou-Kors, Tsima, Dubbelaar, Marissa L., Bichmann, Leon, Kohlbacher, Oliver, Bens, Martin, Thomas, Jaya, Ezić, Jasmin, Kraus, Johann M., Kestler, Hans A., von Witzleben, Adrian, Mytilineos, Joannis, Fürst, Daniel, Engelhardt, Daphne, Doescher, Johannes, Greve, Jens, Schuler, Patrick J., Theodoraki, Marie-Nicole, Brunner, Cornelia, Hoffmann, Thomas K., Rammensee, Hans-Georg, Walz, Juliane S., Laban, Simon

“…Background The immune peptidome of OPSCC has not previously been studied. Cancer-antigen specific vaccination may improve clinical outcome and efficacy of…”
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Partial recovery of peripheral blood monocyte subsets in head and neck squamous cell carcinoma patients upon radio(chemo)therapy is associated with decreased plasma CXCL11 by Idel, Christian, Fleckner, Jonas, Plötze-Martin, Kirstin, Werner, Lotte, Rades, Dirk, Theodoraki, Marie-Nicole, Hofmann, Linda, Huber, Diana, Leichtle, Anke, Hoffmann, Thomas K, Bruchhage, Karl-Ludwig, Pries, Ralph

“…Head and neck squamous cell carcinoma (HNSCC) represents a common and heterogeneous malignancy of the oral cavity, pharynx and larynx. Surgery and…”
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Thrombosis of the internal jugular vein in the ENT-department — Prevalence, causes and therapy: A retrospective analysis by Hahn, Janina, Nordmann-Kleiner, Melanie, Hoffmann, Thomas K., Greve, Jens

“…Less than 5% of deep vein thrombosis is due to thrombosis of the internal jugular vein. Genetic, malignant or inflammatory underlying diseases as well as…”
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Characterization and Differentiation of the Tumor Microenvironment (TME) of Orthotopic and Subcutaneously Grown Head and Neck Squamous Cell Carcinoma (HNSCC) in Immunocompetent Mice by Brand, Matthias, Laban, Simon, Theodoraki, Marie-Nicole, Doescher, Johannes, Hoffmann, Thomas K, Schuler, Patrick J, Brunner, Cornelia

“…For the development and evaluation of new head and neck squamous cell carcinoma (HNSCC) therapeutics, suitable, well-characterized animal models are needed…”
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T Cell Specific BOB.1/OBF.1 Expression Promotes Germinal Center Response and T Helper Cell Differentiation by Betzler, Annika C, Ezić, Jasmin, Abou Kors, Tsima, Hoffmann, Thomas K, Wirth, Thomas, Brunner, Cornelia

“…The transcriptional co-activator BOB.1/OBF.1 is expressed in both B and T cells. The main characteristic of conventional BOB.1/OBF.1 deficient mice is the…”
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Immune Checkpoint Expression on Immune Cells of HNSCC Patients and Modulation by Chemo- and Immunotherapy by Puntigam, Lisa K, Jeske, Sandra S, Götz, Marlies, Greiner, Jochen, Laban, Simon, Theodoraki, Marie-Nicole, Doescher, Johannes, Weissinger, Stephanie E, Brunner, Cornelia, Hoffmann, Thomas K, Schuler, Patrick J

“…Endogenous control mechanisms, including immune checkpoints and immunosuppressive cells, are exploited in the process of tumorigenesis to weaken the anti-tumor…”
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Influence of Bruton’s Tyrosine Kinase (BTK) on Epithelial–Mesenchymal Transition (EMT) Processes and Cancer Stem Cell (CSC) Enrichment in Head and Neck Squamous Cell Carcinoma (HNSCC) by Leichtle, Franziska, Betzler, Annika C., Eizenberger, Carlotta, Lesakova, Kristina, Ezić, Jasmin, Drees, Robert, Greve, Jens, Schuler, Patrick J., Laban, Simon, Hoffmann, Thomas K., Cordes, Nils, Lavitrano, Marialuisa, Grassilli, Emanuela, Brunner, Cornelia

“…Constitutively active kinases play a crucial role in carcinogenesis, and their inhibition is a common target for molecular tumor therapy. We recently…”
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