Search Results - "HOFFMANN, Erich"

Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection by Salomon, Rachelle, Hoffmann, Erich, Webster, Robert G

“…Because proinflammatory cytokines are markedly elevated during H5N1 influenza virus infection, the "cytokine storm" is hypothesized to be the main cause of…”
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Molecular Basis of Replication of Duck H5N1 Influenza Viruses in a Mammalian Mouse Model by ZEJUN LI, HUALAN CHEN, PEIRONG JIAO, GUOHUA DENG, GUOBIN TIAN, YANBING LI, HOFFMANN, Erich, WEBSTER, Robert G, MATSUOKA, Yumiko, KANGZHEN YU

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Large-Scale Sequence Analysis of Avian Influenza Isolates by Obenauer, John C, Denson, Jackie, Mehta, Perdeep K, Su, Xiaoping, Mukatira, Suraj, Finkelstein, David B, Xu, Xiequn, Wang, Jinhua, Ma, Jing, Fan, Yiping, Rakestraw, Karen M, Webster, Robert G, Hoffmann, Erich, Krauss, Scott, Zheng, Jie, Zhang, Ziwei, Naeve, Clayton W

“…The spread of H5N1 avian influenza viruses (AIVs) from China to Europe has raised global concern about their potential to infect humans and cause a pandemic…”
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A DNA Transfection System for Generation of Influenza a Virus from Eight Plasmids by Hoffmann, Erich, Neumann, Gabriele, Kawaoka, Yoshihiro, Hobom, Gerd, Webster, Robert G.

“…We have developed an eight-plasmid DNA transfection system for the rescue of infectious influenza A virus from cloned cDNA. In this plasmid-based expression…”
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Neuraminidase Inhibitor-Resistant Recombinant A/Vietnam/1203/04 (H5N1) Influenza Viruses Retain Their Replication Efficiency and Pathogenicity In Vitro and In Vivo by YEN, Hui-Ling, ILYUSHINA, Natalia A, SALOMON, Rachelle, HOFFMANN, Erich, WEBSTER, Robert G, GOVORKOVA, Elena A

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The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04 by Salomon, Rachelle, Franks, John, Govorkova, Elena A, Ilyushina, Natalia A, Yen, Hui-Ling, Hulse-Post, Diane J, Humberd, Jennifer, Trichet, Michel, Rehg, Jerold E, Webby, Richard J, Webster, Robert G, Hoffmann, Erich

“…H5N1 influenza viruses transmitted from poultry to humans in Asia cause high mortality and pose a pandemic threat. Viral genes important for cell tropism and…”
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Importance of Neuraminidase Active-Site Residues to the Neuraminidase Inhibitor Resistance of Influenza Viruses by YEN, Hui-Ling, HOFFMANN, Erich, TAYLOR, Garry, SCHOLTISSEK, Christoph, MONTO, Arnold S, WEBSTER, Robert G, GOVORKOVA, Elena A

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Molecular constraints to interspecies transmission of viral pathogens by Webby, Richard, Hoffmann, Erich, Webster, Robert

“…The successful replication of a viral pathogen in a host is a complex process involving many interactions. These interactions develop from the coevolution of…”
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Lethality to Ferrets of H5N1 Influenza Viruses Isolated from Humans and Poultry in 2004 by Govorkova, Elena A, Rehg, Jerold E, Krauss, Scott, Yen, Hui-Ling, Guan, Yi, Peiris, Malik, Nguyen, Tien D, Hanh, Thi H, Puthavathana, Pilipan, Long, Hoang T, Buranathai, Chantanee, Lim, Wilina, Webster, Robert G, Hoffmann, Erich

“…Author's Correction ( vol. 80 , p. 6195 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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Neuraminidase Inhibitor-Resistant Influenza Viruses May Differ Substantially in Fitness and Transmissibility by Yen, Hui-Ling, Herlocher, Louise M, Hoffmann, Erich, Matrosovich, Mikhail N, Monto, Arnold S, Webster, Robert G, Govorkova, Elena A

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Inefficient Transmission of H5N1 Influenza Viruses in a Ferret Contact Model by YEN, Hui-Ling, LIPATOV, Aleksandr S, HOFFMANN, Erich, WEBSTER, Robert G, ILYUSHINA, Natalia A, GOVORKOVA, Elena A, FRANKS, John, YILMAZ, Neziha, DOUGLAS, Alan, HAY, Alan, KRAUSS, Scott, REHG, Jerold E

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Generation of Influenza A Viruses Entirely from Cloned cDNAs by Neumann, Gabriele, Watanabe, Tokiko, Ito, Hiroshi, Watanabe, Shinji, Goto, Hideo, Gao, Peng, Hughes, Mark, Perez, Daniel R., Donis, Ruben, Hoffmann, Erich, Hobom, Gerd, Kawaoka, Yoshihiro

“…We describe a new reverse-genetics system that allows one to efficiently generate influenza A viruses entirely from cloned cDNAs. Human embryonic kidney cells…”
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Amantadine-oseltamivir combination therapy for H5N1 influenza virus infection in mice by Ilyushina, Natalia A, Hoffmann, Erich, Salomon, Rachelle, Webster, Robert G, Govorkova, Elena A

“…The clinical management of H5N1 influenza virus infection in humans remains unclear. Combination chemotherapy with drugs that target different viral proteins…”
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Role of Specific Hemagglutinin Amino Acids in the Immunogenicity and Protection of H5N1 Influenza Virus Vaccines by Hoffmann, Erich, Lipatov, Aleksandr S., Webby, Richard J., Govorkova, Elena A., Webster, Robert G.

“…If H5N1 influenza viruses become transmissible among humans, vaccination will offer the most effective option to limit their spread. Two human vaccine…”
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Rescue of Influenza B Virus from Eight Plasmids by Hoffmann, Erich, Mahmood, Kutubuddin, Yang, Chin-Fen, Webster, Robert G., Greenberg, Harry B., Kemble, George

“…Influenza B virus causes a significant amount of morbidity and mortality, yet the systems to produce high yield inactivated vaccines for these viruses have…”
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Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade by Marjuki, Henju, Yen, Hui-Ling, Franks, John, Webster, Robert G, Pleschka, Stephan, Hoffmann, Erich

“…Influenza viruses replicate within the nucleus of infected cells. Viral genomic RNA, three polymerase subunits (PB2, PB1, and PA), and the nucleoprotein (NP)…”
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Contribution of H7 haemagglutinin to amantadine resistance and infectivity of influenza virus by Ilyushina, Natalia A, Govorkova, Elena A, Russell, Charles J, Hoffmann, Erich, Webster, Robert G

“…1 Division of Virology, Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, TN 38105, USA 2 The D. I. Ivanovsky Institute of…”
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Multiple Gene Segments Control the Temperature Sensitivity and Attenuation Phenotypes of ca B/Ann Arbor/1/66 by Hoffmann, Erich, Mahmood, Kutubuddin, Chen, Zhongying, Yang, Chin-Fen, Spaete, Joshua, Greenberg, Harry B, Herlocher, M Louise, Jin, Hong, Kemble, George

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Characterization of the Influenza A Virus Gene Pool in Avian Species in Southern China: Was H6N1 a Derivative or a Precursor of H5N1? by Hoffmann, E, Stech, J, Leneva, I, Krauss, S, Scholtissek, C, Chin, P S, Peiris, M, Shortridge, K F, Webster, R G

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Mx1 Gene Protects Mice Against the Highly Lethal Human H5N1 Influenza Virus by Salomon, Rachelle, Staeheli, Peter, Kochs, Georg, Yen, Hui-Ling, Franks, John, Rehg, Jerold E., Webster, Robert G., Hoffmann, Erich

“…We investigated the importance of the host Mx1 gene in protection against highly pathogenic H5N1 avian influenza virus. Mice expressing the Mx1 gene survived…”
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