Search Results - "HOFFMAN, Robert L"

Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19 by Hoffman, Robert L, Kania, Robert S, Brothers, Mary A, Davies, Jay F, Ferre, Rose A, Gajiwala, Ketan S, He, Mingying, Hogan, Robert J, Kozminski, Kirk, Li, Lilian Y, Lockner, Jonathan W, Lou, Jihong, Marra, Michelle T, Mitchell, Lennert J, Murray, Brion W, Nieman, James A, Noell, Stephen, Planken, Simon P, Rowe, Thomas, Ryan, Kevin, Smith, George J, Solowiej, James E, Steppan, Claire M, Taggart, Barbara

“…The novel coronavirus disease COVID-19 that emerged in 2019 is caused by the virus SARS CoV-2 and named for its close genetic similarity to SARS CoV-1 that…”
Get full text

Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer by Freeman-Cook, Kevin D, Hoffman, Robert L, Behenna, Douglas C, Boras, Britton, Carelli, Jordan, Diehl, Wade, Ferre, Rose Ann, He, You-Ai, Hui, Andrea, Huang, Buwen, Huser, Nanni, Jones, Rhys, Kephart, Susan E, Lapek, John, McTigue, Michele, Miller, Nichol, Murray, Brion W, Nagata, Asako, Nguyen, Lisa, Niessen, Sherry, Ninkovic, Sacha, O’Doherty, Inish, Ornelas, Martha A, Solowiej, James, Sutton, Scott C, Tran, Khanh, Tseng, Elaine, Visswanathan, Ravi, Xu, Meirong, Zehnder, Luke, Zhang, Qin, Zhang, Cathy, Dann, Stephen

“…Control of the cell cycle through selective pharmacological inhibition of CDK4/6 has proven beneficial in the treatment of breast cancer. Extending this level…”
Get full text

Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib by Huang, Qinhua, Johnson, Ted W, Bailey, Simon, Brooun, Alexei, Bunker, Kevin D, Burke, Benjamin J, Collins, Michael R, Cook, Andrew S, Cui, J. Jean, Dack, Kevin N, Deal, Judith G, Deng, Ya-Li, Dinh, Dac, Engstrom, Lars D, He, Mingying, Hoffman, Jacqui, Hoffman, Robert L, Johnson, Patrick S, Kania, Robert S, Lam, Hieu, Lam, Justine L, Le, Phuong T, Li, Qiuhua, Lingardo, Laura, Liu, Wei, Lu, Melissa West, McTigue, Michele, Palmer, Cynthia L, Richardson, Paul F, Sach, Neal W, Shen, Hong, Smeal, Tod, Smith, Graham L, Stewart, Albert E, Timofeevski, Sergei, Tsaparikos, Konstantinos, Wang, Hui, Zhu, Huichun, Zhu, Jinjiang, Zou, Helen Y, Edwards, Martin P

“…Crizotinib (1), an anaplastic lymphoma kinase (ALK) receptor tyrosine kinase inhibitor approved by the U.S. Food and Drug Administration in 2011, is…”
Get full text

Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility by Martinez, Ricardo, Blasina, Alessandra, Hallin, Jill F, Hu, Wenyue, Rymer, Isha, Fan, Jeffery, Hoffman, Robert L, Murphy, Sean, Marx, Matthew, Yanochko, Gina, Trajkovic, Dusko, Dinh, Dac, Timofeevski, Sergei, Zhu, Zhou, Sun, Peiquing, Lappin, Patrick B, Murray, Brion W

“…Cell cycle checkpoint intervention is an effective therapeutic strategy for cancer when applied to patients predisposed to respond and the treatment is…”
Get full text

Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations by Johnson, Ted W, Richardson, Paul F, Bailey, Simon, Brooun, Alexei, Burke, Benjamin J, Collins, Michael R, Cui, J Jean, Deal, Judith G, Deng, Ya-Li, Dinh, Dac, Engstrom, Lars D, He, Mingying, Hoffman, Jacqui, Hoffman, Robert L, Huang, Qinhua, Kania, Robert S, Kath, John C, Lam, Hieu, Lam, Justine L, Le, Phuong T, Lingardo, Laura, Liu, Wei, McTigue, Michele, Palmer, Cynthia L, Sach, Neal W, Smeal, Tod, Smith, Graham L, Stewart, Albert E, Timofeevski, Sergei, Zhu, Huichun, Zhu, Jinjiang, Zou, Helen Y, Edwards, Martin P

“…Although crizotinib demonstrates robust efficacy in anaplastic lymphoma kinase (ALK)-positive non-small-cell lung carcinoma patients, progression during…”
Get full text

Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor by Freeman-Cook, Kevin, Hoffman, Robert L., Miller, Nichol, Almaden, Jonathan, Chionis, John, Zhang, Qin, Eisele, Koleen, Liu, Chaoting, Zhang, Cathy, Huser, Nanni, Nguyen, Lisa, Costa-Jones, Cinthia, Niessen, Sherry, Carelli, Jordan, Lapek, John, Weinrich, Scott L., Wei, Ping, McMillan, Elizabeth, Wilson, Elizabeth, Wang, Tim S., McTigue, Michele, Ferre, Rose Ann, He, You-Ai, Ninkovic, Sacha, Behenna, Douglas, Tran, Khanh T., Sutton, Scott, Nagata, Asako, Ornelas, Martha A., Kephart, Susan E., Zehnder, Luke R., Murray, Brion, Xu, Meirong, Solowiej, James E., Visswanathan, Ravi, Boras, Britton, Looper, David, Lee, Nathan, Bienkowska, Jadwiga R., Zhu, Zhou, Kan, Zhengyan, Ding, Ying, Mu, Xinmeng Jasmine, Oderup, Cecilia, Salek-Ardakani, Shahram, White, Michael A., VanArsdale, Todd, Dann, Stephen G.

“…The CDK4/6 inhibitor, palbociclib (PAL), significantly improves progression-free survival in HR+/HER2− breast cancer when combined with anti-hormonals. We…”
Get full text

Lipophilic efficiency: the most important efficiency metric in medicinal chemistry by Freeman-Cook, Kevin D, Hoffman, Robert L, Johnson, Ted W

Get more information

Impacts of a Gape Limited Brook Trout, Salvelinus Fontinalis, on Larval Northwestern Salamander, Ambystoma Gracile, Growth: A Field Enclosure Experiment by Currens, Christopher R, Liss, William J, Hoffman, Robert L

“…The formation of amphibian population structure is directly affected by predation. Although aquatic predators have been shown to have direct negative effects…”
Get full text

Asymmetric Synthesis of Cis-Fused Bicyclic Pyrrolidines and Pyrrolidinones via Chiral Polycyclic Lactams by Ennis, Michael D, Hoffman, Robert L, Ghazal, Nabil B, Old, David W, Mooney, Pamela A

“…Condensation of racemic keto-ester 2 and 1.1 equiv of (R)-(−)-phenylglycinol in toluene with azeotropic removal of water and methanol gave rise to a…”
Get full text

Heteroatom-linked indanylpyrazines are corticotropin releasing factor type-1 receptor antagonists by Corbett, Jeffrey W., Rauckhorst, Mark R., Qian, Fang, Hoffman, Robert L., Knauer, Christopher S., Fitzgerald, Lawrence W.

“…Low nanomolar corticotropin releasing factor type-1 (CRF 1) receptor antagonists containing unique indanylamines were identified from the heteroatom-linked…”
Get full text

Effects of Simulated Solar UVB Radiation on Early Developmental Stages of the Northwestern Salamander (Ambystoma gracile) from Three Lakes by Calfee, Robin D, Little, Edward E, Pearl, Christopher A, Hoffman, Robert L

“…Solar ultraviolet radiation (UV) has received much attention as a factor that could play a role in amphibian population declines. UV can be hazardous to some…”
Get full text

Predicting Secchi disk depth from average beam attenuation in a deep, ultra-clear lake by Larson, Gary L, Hoffman, Robert L, Hargreaves, Bruce R, Collier, Robert W

“…Issue Title: Theme: Long-term Limnological Research and Monitoring at Crater Lake, Oregon We addressed potential sources of error in estimating the water…”
Get full text

Thermal, chemical, and optical properties of Crater Lake, Oregon by Larson, Gary L., Hoffman, Robert L., McIntire, David C., Buktenica, Mark W., Girdner, Scott F.

“…Issue Title: Theme: Long-term Limnological Research and Monitoring at Crater Lake, Oregon Crater Lake covers the floor of the Mount Mazama caldera that formed…”
Get full text

Responses of Ambystoma gracile to the Removal of Introduced Nonnative Fish from a Mountain Lake by Hoffman, Robert L, Larson, Gary L, Samora, Barbara

“…Introduced, nonnative brook trout (Salvelinus fontinalis) were removed from a mountain lake in Mount Rainier National Park, Washington, to examine the capacity…”
Get full text

Structure-Activity Relationships in the 8-Amino-6,7,8,9-tetrahydro-3H-benz[e]indole Ring System. Part 2: Effect of 8-Amino Nitrogen Substitution on Serotonin Receptor Binding and Pharmacology by Ennis, Michael D, Stjernloef, Peter, Hoffman, Robert L, Ghazal, Nabil B, Smith, Martin W, Svensson, Kjell, Wikstroem, Haakan, Haadsma-Svensson, Susanne R, Lin, Chiu-Hong

Get full text

Isochroman-6-carboxamides as Highly Selective 5-HT1D Agonists:  Potential New Treatment for Migraine without Cardiovascular Side Effects by Ennis, Michael D, Ghazal, Nabil B, Hoffman, Robert L, Smith, Martin W, Schlachter, Siusaidh K, Lawson, Charles F, Im, Wha Bin, Pregenzer, Jeffrey F, Svensson, Kjell A, Lewis, Richard A, Hall, Edward D, Sutter, Dorothy M, Harris, Lorri T, McCall, Robert B

Get full text

2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: New templates for 5-HT2C agonists by ENNIS, Michael D, HOFFMAN, Robert L, SVENSSON, Kjell A, MCCALL, Robert B, HABER, Christopher L, KAGEY, Michelle L, DINH, Dac M, GHAZAL, Nabil B, OLSON, Rebecca M, KNAUER, Christopher S, CHIO, Chris L, HYSLOP, Deborah K, CAMPBELL, Jeffery E, FITZGERALD, Lawrence W, NICHOLS, Nanette F

Get full text

Observations of the Distributions of Five Fish Species in a Small Appalachian Stream by Larson, Gary L., Hoffman, Robert L., Moore, Stephen E.

“…The notion has been growing that resident stream fishes exhibit a greater capacity for movement than was previously thought. In this study, we recorded the…”
Get full text

Habitat Segregation of Ambystoma gracile and Ambystoma macrodactylum in Mountain Ponds and Lakes, Mount Rainier National Park, Washington, USA by Hoffman, Robert L, Larson, Gary L, Brokes, Brendan J

“…Ambystoma gracile (Baird) and Ambystoma macrodactylum Baird are common salamander species occupying key trophic positions in mountain ponds and lakes of Mount…”
Get full text

Persistence of an unusual pelagic zooplankton assemblage in a clear, mountain lake by LARSON, Gary L, HOFFMAN, Robert L, MCINTIRE, C. David

“…The planktonic zooplankton assemblage in Mowich Lake, Mount Rainier National Park (MORA), was composed almost entirely of rotifers in 1966 and 1967. Adult…”
Get full text