Search Results - "HOFFMAN, Brian M."

Mechanism of Nitrogen Fixation by Nitrogenase: The Next Stage by Hoffman, Brian M, Lukoyanov, Dmitriy, Yang, Zhi-Yong, Dean, Dennis R, Seefeldt, Lance C

“…The vital role that nitrogenase plays in sustaining life is examined from a biomolecular perspective. Nitrogen fixation is shown to occur in lightning and the…”
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Particulate methane monooxygenase contains only mononuclear copper centers by Ross, Matthew O, MacMillan, Fraser, Wang, Jingzhou, Nisthal, Alex, Lawton, Thomas J, Olafson, Barry D, Mayo, Stephen L, Rosenzweig, Amy C, Hoffman, Brian M

“…Bacteria that oxidize methane to methanol are central to mitigating emissions of methane, a potent greenhouse gas. The nature of the copper active site in the…”
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Mechanism of Mo-dependent nitrogenase by Seefeldt, Lance C, Hoffman, Brian M, Dean, Dennis R

“…Nitrogen-fixing bacteria catalyze the reduction of dinitrogen (N(2)) to two ammonia molecules (NH(3)), the major contribution of fixed nitrogen to the…”
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Reductive Elimination of H2 Activates Nitrogenase to Reduce the NN Triple Bond: Characterization of the E4(4H) Janus Intermediate in Wild-Type Enzyme by Lukoyanov, Dmitriy, Khadka, Nimesh, Yang, Zhi-Yong, Dean, Dennis R, Seefeldt, Lance C, Hoffman, Brian M

“…We proposed a reductive elimination/oxidative addition (re/oa) mechanism for reduction of N2 to 2NH3 by nitrogenase, based on identification of a…”
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The Elusive 5′-Deoxyadenosyl Radical: Captured and Characterized by Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopies by Yang, Hao, McDaniel, Elizabeth C, Impano, Stella, Byer, Amanda S, Jodts, Richard J, Yokoyama, Kenichi, Broderick, William E, Broderick, Joan B, Hoffman, Brian M

“…The 5′-deoxyadenosyl radical (5′-dAdo·) abstracts a substrate H atom as the first step in radical-based transformations catalyzed by…”
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Structural and spectroscopic characterization of an Fe(VI) bis(imido) complex by Martinez, Jorge L., Lutz, Sean A., Yang, Hao, Xie, Jiaze, Telser, Joshua, Hoffman, Brian M., Carta, Veronica, Pink, Maren, Losovyj, Yaroslav, Smith, Jeremy M.

“…Nitrogen lifts iron to hexavalence The myriad ways that iron can interact with oxygen have been amply studied in biochemical and geochemical contexts. More…”
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Internal dynamics of a supramolecular nanofibre by Ortony, Julia H., Newcomb, Christina J., Matson, John B., Palmer, Liam C., Doan, Peter E., Hoffman, Brian M., Stupp, Samuel I.

“…Variations in the internal conformational dynamics of supramolecular nanostructures may be important for their function, yet such dynamics have been difficult…”
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Mechanism of Nitrogenase H2 Formation by Metal-Hydride Protonation Probed by Mediated Electrocatalysis and H/D Isotope Effects by Khadka, Nimesh, Milton, Ross D, Shaw, Sudipta, Lukoyanov, Dmitriy, Dean, Dennis R, Minteer, Shelley D, Raugei, Simone, Hoffman, Brian M, Seefeldt, Lance C

“…Nitrogenase catalyzes the reduction of dinitrogen (N2) to two ammonia (NH3) at its active site FeMo-cofactor through a mechanism involving reductive…”
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Kinetic Understanding of N2 Reduction versus H2 Evolution at the E4(4H) Janus State in the Three Nitrogenases by Harris, Derek F, Yang, Zhi-Yong, Dean, Dennis R, Seefeldt, Lance C, Hoffman, Brian M

“…The enzyme nitrogenase catalyzes the reduction of N2 to ammonia but also that of protons to H2. These reactions compete at the mechanistically central ‘Janus’…”
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From micelles to bicelles: Effect of the membrane on particulate methane monooxygenase activity by Ro, Soo Y., Ross, Matthew O., Deng, Yue Wen, Batelu, Sharon, Lawton, Thomas J., Hurley, Joseph D., Stemmler, Timothy L., Hoffman, Brian M., Rosenzweig, Amy C.

“…Particulate methane monooxygenase (pMMO) is a copper-dependent integral membrane metalloenzyme that converts methane to methanol in methanotrophic bacteria…”
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Electron Transfer within Nitrogenase: Evidence for a Deficit-Spending Mechanism by Danyal, Karamatullah, Dean, Dennis R, Hoffman, Brian M, Seefeldt, Lance C

“…The reduction of substrates catalyzed by nitrogenase utilizes an electron transfer (ET) chain comprised of three metalloclusters distributed between the two…”
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Ultrafast Excited State Relaxation of a Metalloporphyrin Revealed by Femtosecond X‑ray Absorption Spectroscopy by Shelby, Megan L, Lestrange, Patrick J, Jackson, Nicholas E, Haldrup, Kristoffer, Mara, Michael W, Stickrath, Andrew B, Zhu, Diling, Lemke, Henrik T, Chollet, Matthieu, Hoffman, Brian M, Li, Xiaosong, Chen, Lin X

“…Photoexcited Nickel­(II) tetramesitylporphyrin (NiTMP), like many open-shell metalloporphyrins, relaxes rapidly through multiple electronic states following an…”
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On reversible H₂ loss upon N₂ binding to FeMo-cofactor of nitrogenase by Yang, Zhi-Yong, Khadka, Nimesh, Lukoyanov, Dmitriy, Hoffman, Brian M, Dean, Dennis R, Seefeldt, Lance C

“…Nitrogenase is activated for N ₂ reduction by the accumulation of four electrons/protons on its active site FeMo-cofactor, yielding a state, designated as E ₄,…”
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Electron transfer precedes ATP hydrolysis during nitrogenase catalysis by Duval, Simon, Danyal, Karamatullah, Shaw, Sudipta, Lytle, Anna K., Dean, Dennis R., Hoffman, Brian M., Antony, Edwin, Seefeldt, Lance C.

“…The biological reduction of N ₂ to NH ₃ catalyzed by Mo-dependent nitrogenase requires at least eight rounds of a complex cycle of events associated with…”
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A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis by Park, Yun Ji, Jodts, Richard J, Slater, Jeffrey W, Reyes, Reyvin M, Winton, Valerie J, Montaser, Rana A, Thomas, Paul M, Dowdle, William B, Ruiz, Anahi, Kelleher, Neil L, Bollinger, Jr, J Martin, Krebs, Carsten, Hoffman, Brian M, Rosenzweig, Amy C

“…SignificanceMethanobactins (Mbns), copper-binding peptidic compounds produced by some bacteria, are candidate therapeutics for human diseases of copper…”
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Characterization of a long overlooked copper protein from methane- and ammonia-oxidizing bacteria by Fisher, Oriana S., Kenney, Grace E., Ross, Matthew O., Ro, Soo Y., Lemma, Betelehem E., Batelu, Sharon, Thomas, Paul M., Sosnowski, Victoria C., DeHart, Caroline J., Kelleher, Neil L., Stemmler, Timothy L., Hoffman, Brian M., Rosenzweig, Amy C.

“…Methane-oxidizing microbes catalyze the oxidation of the greenhouse gas methane using the copper-dependent enzyme particulate methane monooxygenase (pMMO)…”
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Crystal Structure and Characterization of Particulate Methane Monooxygenase from Methylocystis species Strain M by Smith, Stephen M, Rawat, Swati, Telser, Joshua, Hoffman, Brian M, Stemmler, Timothy L, Rosenzweig, Amy C

“…Particulate methane monooxygenase (pMMO) is an integral membrane metalloenzyme that oxidizes methane to methanol in methanotrophic bacteria. Previous…”
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Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis by Dong, Min, Kathiresan, Venkatesan, Fenwick, Michael K, Torelli, Andrew T, Zhang, Yang, Caranto, Jonathan D, Dzikovski, Boris, Sharma, Ajay, Lancaster, Kyle M, Freed, Jack H, Ealick, Steven E, Hoffman, Brian M, Lin, Hening

“…Diphthamide biosynthesis involves a carbon-carbon bond-forming reaction catalyzed by a radical S-adenosylmethionine (SAM) enzyme that cleaves a carbon-sulfur…”
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Why Nature Uses Radical SAM Enzymes so Widely: Electron Nuclear Double Resonance Studies of Lysine 2,3-Aminomutase Show the 5′-dAdo• “Free Radical” Is Never Free by Horitani, Masaki, Byer, Amanda S, Shisler, Krista A, Chandra, Tilak, Broderick, Joan B, Hoffman, Brian M

“…Lysine 2,3-aminomutase (LAM) is a radical S-adenosyl-l-methionine (SAM) enzyme and, like other members of this superfamily, LAM utilizes radical-generating…”
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Identification of the Valence and Coordination Environment of the Particulate Methane Monooxygenase Copper Centers by Advanced EPR Characterization by Culpepper, Megen A, Cutsail III, George E, Gunderson, William A, Hoffman, Brian M, Rosenzweig, Amy C

“…Particulate methane monooxygenase (pMMO) catalyzes the oxidation of methane to methanol in methanotrophic bacteria. As a copper-containing enzyme, pMMO has…”
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