Search Results - "HOFER, Michal"

Brief Story on Prostaglandins, Inhibitors of their Synthesis, Hematopoiesis, and Acute Radiation Syndrome by Hofer, Michal, Hoferová, Zuzana, Falk, Martin

“…Prostaglandins and inhibitors of their synthesis (cyclooxygenase (COX) inhibitors, non-steroidal anti-inflammatory drugs) were shown to play a significant role…”
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Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome-A Concise Review by Hofer, Michal, Hoferová, Zuzana, Depeš, Daniel, Falk, Martin

“…The goal of combined pharmacological approaches in the treatment of the acute radiation syndrome (ARS) is to obtain an effective therapy producing a minimum of…”
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Two New Faces of Amifostine: Protector from DNA Damage in Normal Cells and Inhibitor of DNA Repair in Cancer Cells by Hofer, Michal, Falk, Martin, Komůrková, Denisa, Falková, Iva, Bačíková, Alena, Klejdus, Bořivoj, Pagáčová, Eva, Štefančíková, Lenka, Weiterová, Lenka, Angelis, Karel J, Kozubek, Stanislav, Dušek, Ladislav, Galbavý, Štefan

“…Amifostine protects normal cells from DNA damage induction by ionizing radiation or chemotherapeutics, whereas cancer cells typically remain uninfluenced…”
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Modulation of animal and human hematopoiesis by β-glucans: a review by Hofer, Michal, Pospíšil, Milan

“…β-glucans are cell wall constituents of bacteria, yeast, fungi, and plants. They are not expressed in mammalian cells, but they are recognized by mammalian…”
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Granulocyte colony-stimulating factor in the treatment of acute radiation syndrome: a concise review by Hofer, Michal, Pospíšil, Milan, Komůrková, Denisa, Hoferová, Zuzana

“…This article concisely summarizes data on the action of one of the principal and best known growth factors, the granulocyte colony-stimulating factor (G-CSF),…”
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The role of adenosine receptor agonists in regulation of hematopoiesis by Hofer, Michal, Pospisil, Milan, Weiterova, Lenka, Hoferova, Zuzana

“…The review summarizes data evaluating the role of adenosine receptor signaling in murine hematopoietic functions. The studies carried out utilized either…”
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Stimulatory action of cyclooxygenase inhibitors on hematopoiesis: a review by Hofer, Michal, Pospíšil, Milan, Hoferová, Zuzana, Weiterová, Lenka, Komůrková, Denisa

“…The presented review summarizes experimental data obtained with a mouse model when investigating the relationship between inhibition of prostaglandin…”
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Combined pharmacological therapy of the acute radiation disease using a cyclooxygenase-2 inhibitor and an adenosine A3 receptor agonist by Hofer Michal, Pospíšil Milan, Dušek Ladislav, Hoferová Zuzana, Komůrková Denisa

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Trends in pharmacological stimulation of regeneration of ionizing radiation-damaged mammalian organism by Hofer, Michal

“…Many different substances with varying mechanisms of effects have been tested both in animal experiments, as well as verified in clinical studies as potential…”
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Stimulated recovery of perturbed haematopoiesis by inhibition of prostaglandin production — promising therapeutic strategy by Hofer Michal, Pospíšil Milan

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Adenosine A3 receptor agonist acts as a homeostatic regulator of bone marrow hematopoiesis by Hofer, Michal, Pospíšil, Milan, Znojil, Vladimír, Holá, Jiřina, Vacek, Antonín, Štreitová, Denisa

“…Abstract The present study was performed to define the optimum conditions of the stimulatory action of the adenosine A3 receptor agonist, N6…”
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Administration of nitro-oleic acid mitigates radiation-induced hematopoietic injury in mice by Perecko, Tomas, Hoferova, Zuzana, Hofer, Michal, Pereckova, Jana, Falk, Martin

“…Limited number of agents that provide protection against hematopoietic acute radiation syndrome led us to the evaluation of nitro-oleic acid (NO2OA) as a…”
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Pharmacological Modulation of Radiation Damage. Does It Exist a Chance for Other Substances than Hematopoietic Growth Factors and Cytokines? by Hofer, Michal, Hoferová, Zuzana, Falk, Martin

“…In recent times, cytokines and hematopoietic growth factors have been at the center of attention for many researchers trying to establish pharmacological…”
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Hochwasserrückhaltebecken Krems-Au: Konzeption – Planung – Bauausführung by Mayr, Norbert, Hofer, Michael, Somogyi, Wilhelm, Schellenhuber, Klaus, Hueber, Dietmar

“…Zusammenfassung Das Hochwasserrückhaltebecken Krems-Au ist einer der wichtigsten Bestandteile des Hochwasserschutzes im oberösterreichischen Kremstal, der nach…”
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DNA-damage response in chromatin of ribosomal genes and the surrounding genome by Foltánková, Veronika, Legartová, Soňa, Kozubek, Stanislav, Hofer, Michal, Bártová, Eva

“…DNA repair events have functional significance especially for genome stability. Although the DNA damage response within the whole genome has been extensively…”
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Lack of adenosine A3 receptors causes defects in mouse peripheral blood parameters by Hofer, Michal, Pospíšil, Milan, Dušek, Ladislav, Hoferová, Zuzana, Komůrková, Denisa

“…The role of the adenosine A 3 receptor in hematopoiesis was studied using adenosine A 3 receptor knockout (A 3 AR KO) mice. Hematological parameters of…”
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Agonist of the adenosine A3 receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of γ-irradiated mice by Hofer, Michal, Pospíšil, Milan, Dušek, Ladislav, Hoferová, Zuzana, Komůrková, Denisa

“…There exists a requirement for drugs which would be useful in therapy of an acute radiation damage of a mammalian organism. The aim of the study was to…”
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Inhibition of cyclooxygenase-2 promotes the stimulatory action of adenosine A 3 receptor agonist on hematopoiesis in sublethally γ-irradiated mice by Hofer, Michal, Pospíšil, Milan, Dušek, Ladislav, Hoferová, Zuzana, Weiterová, Lenka

“…Mouse hematopoiesis, suppressed by a sublethal dose of ionizing radiation, was the target for combined therapy with a cyclooxygenase-2 (COX-2) inhibitor…”
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Enhanced survival of lethally irradiated adenosine A3 receptor knockout mice. A role for hematopoietic growth factors? by Hofer, Michal, Pospíšil, Milan, Dušek, Ladislav, Hoferová, Zuzana, Komůrková, Denisa

“…Adenosine A 3 receptor knockout (A 3 AR KO) mice and their wild-type (WT) counterparts were compared from the point of view of their abilities to survive…”
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Agonist of the adenosine A^sub 3^ receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of [gamma]-irradiated mice by Hofer, Michal, Pospísil, Milan, Dusek, Ladislav, Hoferová, Zuzana, Komrková, Denisa

“…There exists a requirement for drugs which would be useful in therapy of an acute radiation damage of a mammalian organism. The aim of the study was to…”
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