Search Results - "HOEY, Timothy"

Drug resistance, epigenetics, and tumor cell heterogeneity by Hoey, Timothy

“…The resistance of cancer cells to various therapeutic agents and modalities is a crucial issue in clinical oncology. A recent Cell paper highlights how changes…”
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Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors by Gurney, Austin, Axelrod, Fumiko, Bond, Christopher J, Cain, Jennifer, Chartier, Cecile, Donigan, Lucas, Fischer, Marcus, Chaudhari, Aurélie, Ji, May, Kapoun, Ann M, Lam, Andrew, Lazetic, Sasha, Ma, Shirley, Mitra, Satyajit, Park, In-Kyung, Pickell, Kellie, Sato, Aaron, Satyal, Sanjeev, Stroud, Michelle, Tran, Hoang, Yen, Wan-Ching, Lewicki, John, Hoey, Timothy

“…The Wnt/β-catenin pathway, which signals through the Frizzled (Fzd) receptor family and several coreceptors, has long been implicated in cancer. Here we…”
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Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis by YAQING ZHANG, MORRIS, John P, WEI YAN, SCHOFIELD, Heather K, GURNEY, Austin, SIMEONE, Diane M, MILLAR, Sarah E, HOEY, Timothy, HEBROK, Matthias, DI MAGLIANO, Marina Pasca

“…Wnt ligand expression and activation of the Wnt/β-catenin pathway have been associated with pancreatic ductal adenocarcinoma, but whether Wnt activity is…”
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Phenotypic Characterization of Human Colorectal Cancer Stem Cells by Dalerba, Piero, Dylla, Scott J., Park, In-Kyung, Liu, Rui, Wang, Xinhao, Cho, Robert W., Hoey, Timothy, Gurney, Austin, Huang, Emina H., Simeone, Diane M., Shelton, Andrew A., Parmiani, Giorgio, Castelli, Chiara, Clarke, Michael F.

“…Recent observations indicate that, in several types of human cancer, only a phenotypic subset of cancer cells within each tumor is capable of initiating tumor…”
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The Prognostic Role of a Gene Signature from Tumorigenic Breast-Cancer Cells by Liu, Rui, Wang, Xinhao, Chen, Grace Y, Dalerba, Piero, Gurney, Austin, Hoey, Timothy, Sherlock, Gavin, Lewicki, John, Shedden, Kerby, Clarke, Michael F

“…A small population of distinctive breast-cancer cells can recapitulate an entire breast cancer when injected into immunodeficient mice. These cells express a…”
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DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency by Hoey, Timothy, Yen, Wan-Ching, Axelrod, Fumiko, Basi, Jesspreet, Donigian, Lucas, Dylla, Scott, Fitch-Bruhns, Maureen, Lazetic, Sasha, Park, In-Kyung, Sato, Aaron, Satyal, Sanjeev, Wang, Xinhao, Clarke, Michael F., Lewicki, John, Gurney, Austin

“…Previous studies have shown that blocking DLL4 signaling reduced tumor growth by disrupting productive angiogenesis. We developed selective anti-human and…”
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Targeting HDAC6 to treat heart failure with preserved ejection fraction in mice by Ranjbarvaziri, Sara, Zeng, Aliya, Wu, Iris, Greer-Short, Amara, Farshidfar, Farshad, Budan, Ana, Xu, Emma, Shenwai, Reva, Kozubov, Matthew, Li, Cindy, Van Pell, Melissa, Grafton, Francis, MacKay, Charles E, Song, Xiaomei, Priest, James R, Argast, Gretchen, Mandegar, Mohammad A., Hoey, Timothy, Yang, Jin

“…Heart failure with preserved ejection fraction (HFpEF) poses therapeutic challenges due to the limited treatment options. Building upon our previous research…”
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Author Correction: Targeting HDAC6 to treat heart failure with preserved ejection fraction in mice by Ranjbarvaziri, Sara, Zeng, Aliya, Wu, Iris, Greer-Short, Amara, Farshidfar, Farshad, Budan, Ana, Xu, Emma, Shenwai, Reva, Kozubov, Matthew, Li, Cindy, Van Pell, Melissa, Grafton, Francis, MacKay, Charles E, Song, Xiaomei, Priest, James R, Argast, Gretchen, Mandegar, Mohammad A., Hoey, Timothy, Yang, Jin

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Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs by Zhang, Mingjun, Haughey, Michael, Wang, Nai-Yu, Blease, Kate, Kapoun, Ann M, Couto, Suzana, Belka, Igor, Hoey, Timothy, Groza, Matthew, Hartke, James, Bennett, Brydon, Cain, Jennifer, Gurney, Austin, Benish, Brent, Castiglioni, Paola, Drew, Clifton, Lachowicz, Jean, Carayannopoulos, Leon, Nathan, Steven D, Distler, Jorg, Brenner, David A, Hariharan, Kandasamy, Cho, Ho, Xie, Weilin

“…The Wnt/β-catenin signaling pathway has been implicated in human proliferative diseases such as cancer and fibrosis. The functions of β-catenin and several…”
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COP1, a negative regulator of photomorphogenesis, positively regulates plant disease resistance via double-stranded RNA binding proteins by Lim, Gah-Hyun, Hoey, Timothy, Zhu, Shifeng, Clavel, Marion, Yu, Keshun, Navarre, Duroy, Kachroo, Aardra, Deragon, Jean-Marc, Kachroo, Pradeep

“…The E3 ubiquitin ligase COP1 (Constitutive Photomorphogenesis 1) is a well known component of the light-mediated plant development that acts as a repressor of…”
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NOTCH3 Signaling Regulates MUSASHI-1 Expression in Metastatic Colorectal Cancer Cells by PASTO, Anna, SERAFIN, Valentina, PINAZZA, Marica, AGOSTINI, Marco, NITTI, Donato, AMADORI, Alberto, INDRACCOLO, Stefano, PILOTTO, Giorgia, LAGO, Claudia, BELLIO, Chiara, TRUSOLINO, Livio, BERTOTTI, Andrea, HOEY, Timothy, PLATEROTI, Michelina, ESPOSITO, Giovanni

“…MUSASHI-1 (MSI-1) is a well-established stem cell marker in both normal and malignant colon cells and it acts by positively regulating the NOTCH pathway…”
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RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations by Fischer, Marcus M., Yeung, V. Pete, Cattaruzza, Fiore, Hussein, Rajaa, Yen, Wan-Ching, Murriel, Christopher, Evans, James W., O’Young, Gilbert, Brunner, Alayne L., Wang, Min, Cain, Jennifer, Cancilla, Belinda, Kapoun, Ann, Hoey, Timothy

“…Activating mutations in the Wnt pathway are a characteristic feature of colorectal cancer (CRC). The R-spondin (RSPO) family is a group of secreted proteins…”
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G Protein-Coupled Lysophosphatidic Acid Receptors Stimulate Proliferation of Colon Cancer Cells through the β-Catenin Pathway by Yang, Ming, Zhong, Wendy W., Srivastava, Neelam, Slavin, Anthony, Yang, Jianxin, Hoey, Timothy, An, Songzhu, Goeddel, David V.

“…Recent studies suggest that lysophosphatidic acid (LPA) and its G protein-coupled receptors (GPCRs) LPA1, LPA2, or LPA3may play a role in the development of…”
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AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy by Wu, Iris, Zeng, Aliya, Greer-Short, Amara, Aycinena, J. Alex, Tefera, Anley E., Shenwai, Reva, Farshidfar, Farshad, Van Pell, Melissa, Xu, Emma, Reid, Chris, Rodriguez, Neshel, Lim, Beatriz, Chung, Tae Won, Woods, Joseph, Scott, Aquilla, Jones, Samantha, Dee-Hoskins, Cristina, Gutierrez, Carolina G., Madariaga, Jessie, Robinson, Kevin, Hatter, Yolanda, Butler, Renee, Steltzer, Stephanie, Ho, Jaclyn, Priest, James R., Song, Xiaomei, Jing, Frank, Green, Kristina, Ivey, Kathryn N., Hoey, Timothy, Yang, Jin, Yang, Zhihong Jane

“…Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with ventricular arrhythmias and an increased risk…”
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Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers by Herter, Sylvia, Piper, Derek E, Aaron, Wade, Gabriele, Timothy, Cutler, Gene, Cao, Ping, Bhatt, Ami S, Choe, Youngchool, Craik, Charles S, Walker, Nigel, Meininger, David, Hoey, Timothy, Austin, Richard J

“…Hepsin is a membrane-anchored, trypsin-like serine protease with prominent expression in the human liver and tumours of the prostate and ovaries. To better…”
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Discovery of Fully Human Anti-MET Monoclonal Antibodies with Antitumor Activity against Colon Cancer Tumor Models In Vivo by van der Horst, Edward Htun, Chinn, Lawrence, Wang, Min, Velilla, Timothy, Tran, Hoang, Madrona, Yarrow, Lam, Andrew, Ji, May, Hoey, Timothy C., Sato, Aaron K.

“…The receptor tyrosine kinase MET is a major component controlling the invasive growth program in embryonic development and in invasive malignancies. The…”
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Oncogenic Potential of TASK3 (Kcnk9) Depends on K+Channel Function by Pei, Lin, Wiser, Ofer, Slavin, Anthony, Mu, David, Powers, Scott, Jan, Lily Yeh, Hoey, Timothy

“…TASK3 gene (Kcnk9) is amplified and overexpressed in several types of human carcinomas. In this report, we demonstrate that a point mutation (G95E) within the…”
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Metastatic Properties and Genomic Amplification of the Tyrosine Kinase Gene ACK1 by Edward Htun van der Horst, Yan Y. Degenhardt, Strelow, Astrid, Slavin, Anthony, Lawrence Chinn, Jessica Orf, Rong, Minqing, Li, Shyun, Lei-Hoon See, Ken Q. C. Nguyen, Hoey, Timothy, Wesche, Holger, Powers, Scott, McKnight, Steven L.

“…Metastasis of primary tumors leads to a very poor prognosis for patients suffering from cancer. Although it is well established that not every tumor will…”
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Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23 by Powers, Scott, Li, Jing, Yang, Ying, Peng, Yue, Austin, Richard J, van Eyndhoven, Winfried G, Nguyen, Ken C. Q, Gabriele, Tim, McCurrach, Mila E, Marks, Jeffrey R, Hoey, Timothy, Lowe, Scott W

“…We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We…”
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Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene by Mu, David, Chen, Liyun, Zhang, Xiping, See, Lei-Hoon, Koch, Christina M, Yen, Clifford, Tong, James Jiayuan, Spiegel, Lori, Nguyen, Ken C.Q, Servoss, Allyson, Peng, Yue, Pei, Lin, Marks, Jeffrey R, Lowe, Scott, Hoey, Timothy, Jan, Lily Yeh, McCombie, W.Richard, Wigler, Michael H, Powers, Scott

“…Representational difference analysis (RDA) of human breast cancer was used to discover a novel amplicon located at chromosomal region 8q24.3. We examined a…”
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