Search Results - "HOETELMANS, Richard"

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    Clinical Pharmacokinetics and Pharmacodynamics of Etravirine by Schöller-Gyüre, Monika, Kakuda, Thomas N., Raoof, Araz, De Smedt, Goedele, Hoetelmans, Richard M. W.

    Published in Clinical pharmacokinetics (01-01-2009)
    “…Etravirine is a next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) developed for the treatment of HIV-1 infection. It has a high genetic…”
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    Journal Article
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    Pharmacokinetic Interactions between Etravirine and Non-Antiretroviral Drugs by Kakuda, Thomas N., Schöller-Gyüre, Monika, Hoetelmans, Richard M. W.

    Published in Clinical pharmacokinetics (2011)
    “…Etravirine (formerly TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) with activity against wild-type and NNRTI-resistant strains of HIV-1…”
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    Mechanistic Model Describing the Time Course of Humoral Immunity Following Ad26.COV2.S Vaccination in Non-Human Primates by Dari, Anna, Solforosi, Laura, Roozendaal, Ramon, Hoetelmans, Richard M W, Pérez-Ruixo, Juan-José, Boulton, Muriel

    “…Mechanistic modeling can be used to describe the time course of vaccine-induced humoral immunity and to identify key biological drivers in antibody production…”
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    Impact of Food and Different Meal Types on the Pharmacokinetics of Rilpivirine by Crauwels, Herta M., van Heeswijk, Rolf P.G., Buelens, Annemie, Stevens, Marita, Boven, Katia, Hoetelmans, Richard M.W.

    Published in Journal of clinical pharmacology (01-08-2013)
    “…The objective of the study was to determine the impact of food and different meal types on the pharmacokinetics of rilpivirine, a nonnucleoside reverse…”
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    The Effect of Different Meal Types on the Pharmacokinetics of Darunavir (TMC114)/Ritonavir in HIV-Negative Healthy Volunteers by Sekar, Vanitha, Kestens, Dries, Spinosa-Guzman, Sabrina, De Pauw, Martine, De Paepe, Els, Vangeneugden, Tony, Lefebvre, Eric, Hoetelmans, Richard M. W.

    Published in Journal of clinical pharmacology (01-04-2007)
    “…This open‐label, randomized, crossover study investigated the bioavailability, short‐term safety, and tolerability of darunavir (TMC114) coadministered with…”
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    Pharmacokinetics and pharmacodynamics of boosted once-daily darunavir by Kakuda, Thomas N, Brochot, Anne, Tomaka, Frank L, Vangeneugden, Tony, Van De Casteele, Tom, Hoetelmans, Richard M W

    Published in Journal of antimicrobial chemotherapy (01-10-2014)
    “…The ability to dose antiretroviral agents once daily simplifies the often complex therapeutic regimens required for the successful treatment of HIV infection…”
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    The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects by Kakuda, Thomas N., Van Solingen-Ristea, Rodica M., Onkelinx, Joelle, Stevens, Tanja, Aharchi, Fatima, De Smedt, Goedele, Peeters, Monika, Leopold, Lorant, Hoetelmans, Richard M.W.

    Published in Journal of clinical pharmacology (01-04-2014)
    “…The effect of etravirine on cytochrome P450 (CYP) enzymes and P‐glycoprotein were evaluated in two randomized, crossover trials in healthy subjects. A modified…”
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    Darunavir : pharmacokinetics and drug interactions by BACK, David, SEKAR, Vanitha, HOETELMANS, Richard M. W

    Published in Antiviral therapy (2008)
    “…Darunavir (TMC114) is a new HIV protease inhibitor that has demonstrated substantial antiretroviral activity against wild-type HIV-1 virus and…”
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    Bioequivalence of a darunavir/cobicistat fixed-dose combination tablet versus single agents and food effect in healthy volunteers by Kakuda, Thomas N, Van De Casteele, Tom, Petrovic, Romana, Neujens, Mark, Salih, Hiba, Opsomer, Magda, Hoetelmans, Richard Mw

    Published in Antiviral therapy (01-01-2014)
    “…Darunavir requires pharmacokinetic enhancement to increase its bioavailability. Cobicistat is potentially an alternative pharmacokinetic booster to ritonavir…”
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    Pharmacokinetics of Multiple-Dose Darunavir in Combination with Low-Dose Ritonavir in Individuals with Mild-to-Moderate Hepatic Impairment by Sekar, Vanitha, Spinosa-Guzman, Sabrina, De Paepe, Els, Stevens, Tanja, Tomaka, Frank, De Pauw, Martine, Hoetelmans, Richard M. W.

    Published in Clinical pharmacokinetics (01-05-2010)
    “…Background and Objective The pharmacokinetics of some HIV protease inhibitors are altered in patients with hepatic impairment. The TMC114-C134 study assessed…”
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    The effect of rilpivirine on the pharmacokinetics of methadone in HIV-negative volunteers by Crauwels, Herta M., van Heeswijk, Rolf P.G., Vandevoorde, Ann, Buelens, Annemie, Stevens, Marita, Hoetelmans, Richard M.W.

    Published in Journal of clinical pharmacology (01-02-2014)
    “…Antiretrovirals may influence methadone exposure in HIV‐1‐infected patients receiving methadone for opiate addiction. Rilpivirine is a non‐nucleoside reverse…”
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    Pharmacokinetic evaluation of the interaction between etravirine and rifabutin or clarithromycin in HIV-negative, healthy volunteers: results from two Phase 1 studies by Kakuda, Thomas N, Woodfall, Brian, De Marez, Tine, Peeters, Monika, Vandermeulen, Kati, Aharchi, Fatima, Hoetelmans, Richard M W

    Published in Journal of antimicrobial chemotherapy (01-03-2014)
    “…Drug-drug interactions between etravirine and rifabutin or clarithromycin were examined in two separate open-label, randomized, two-period, crossover trials in…”
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    Pharmacokinetic interaction between TMC114/ritonavir and tenofovir disoproxil fumarate in healthy volunteers by Hoetelmans, Richard M. W., Mariën, Kris, De Pauw, Martine, Hill, Andrew, Peeters, Monika, Sekar, Vanitha, De Doncker, Piet, Woodfall, Brian, Lefebvre, Eric

    Published in British journal of clinical pharmacology (01-11-2007)
    “…What is already known about this subject • Tenofovir disoproxil fumarate and some of the HIV protease inhibitors show drug–drug interactions that cannot be…”
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