Search Results - "HOELSCHER, Michael"

Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany by Rothe, Camilla, Schunk, Mirjam, Sothmann, Peter, Bretzel, Gisela, Froeschl, Guenter, Wallrauch, Claudia, Zimmer, Thorbjörn, Thiel, Verena, Janke, Christian, Guggemos, Wolfgang, Seilmaier, Michael, Drosten, Christian, Vollmar, Patrick, Zwirglmaier, Katrin, Zange, Sabine, Wölfel, Roman, Hoelscher, Michael

“…In this report, investigators in Germany detected the spread of the novel coronavirus (2019-nCoV) from a person who had recently traveled from China to Germany…”
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Host-directed therapies for infectious diseases: current status, recent progress, and future prospects by Zumla, Alimuddin, Prof, Rao, Martin, PhD, Wallis, Robert S, Prof, Kaufmann, Stefan H E, Prof, Rustomjee, Roxana, PhD, Mwaba, Peter, PhD, Vilaplana, Cris, PhD, Yeboah-Manu, Dorothy, Prof, Chakaya, Jeremiah, PhD, Ippolito, Giuseppe, Prof, Azhar, Esam, PhD, Hoelscher, Michael, Prof, Maeurer, Markus, Prof

“…Summary Despite extensive global efforts in the fight against killer infectious diseases, they still cause one in four deaths worldwide and are important…”
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Accelerating the transition of new tuberculosis drug combinations from Phase II to Phase III trials: New technologies and innovative designs by Davies, Geraint, Boeree, Martin, Hermann, Dave, Hoelscher, Michael

“…Geraint Davies and colleagues discuss the potential for innovative early-phase clinical trial methods and technologies to reduce risk and speed up drug…”
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Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test by Lawn, Stephen D, FRCP, Mwaba, Peter, FRCP, Bates, Matthew, PhD, Piatek, Amy, MS, Alexander, Heather, PhD, Marais, Ben J, Prof, Cuevas, Luis E, Prof, McHugh, Timothy D, Prof, Zijenah, Lynn, Prof, Kapata, Nathan, MMed, Abubakar, Ibrahim, Prof, McNerney, Ruth, PhD, Hoelscher, Michael, Prof, Memish, Ziad A, Prof, Migliori, Giovanni Battista, Prof, Kim, Peter, MD, Maeurer, Markus, Prof, Schito, Marco, PhD, Zumla, Alimuddin, Prof

“…Summary Rapid progress has been made in the development of new diagnostic assays for tuberculosis in recent years. New technologies have been developed and…”
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Tuberculosis—advances in development of new drugs, treatment regimens, host-directed therapies, and biomarkers by Wallis, Robert S, Prof, Maeurer, Markus, Prof, Mwaba, Peter, FRCP, Chakaya, Jeremiah, MD, Rustomjee, Roxana, FRCP, Migliori, Giovanni Battista, Prof, Marais, Ben, Prof, Schito, Marco, PhD, Churchyard, Gavin, Prof, Swaminathan, Soumya, MD, Hoelscher, Michael, Prof, Zumla, Alimuddin, Prof

“…Summary Tuberculosis is the leading infectious cause of death worldwide, with 9·6 million cases and 1·5 million deaths reported in 2014. WHO estimates 480 000…”
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Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled trial by Theron, Grant, PhD, Zijenah, Lynn, Prof, Chanda, Duncan, MD, Clowes, Petra, MD, Rachow, Andrea, MD, Lesosky, Maia, PhD, Bara, Wilbert, MD, Mungofa, Stanley, MD, Pai, Madhukar, MD, Hoelscher, Michael, Prof, Dowdy, David, PhD, Pym, Alex, PhD, Mwaba, Peter, Prof, Mason, Peter, Prof, Peter, Jonny, MBChB, Dheda, Keertan, Prof

“…Summary Background The Xpert MTB/RIF test for tuberculosis is being rolled out in many countries, but evidence is lacking regarding its implementation outside…”
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Post-tuberculosis lung impairment: systematic review and meta-analysis of spirometry data from 14 621 people by Ivanova, Olena, Hoffmann, Verena Sophia, Lange, Christoph, Hoelscher, Michael, Rachow, Andrea

“…A substantial proportion of tuberculosis patients remain with pulmonary symptoms and reduced physical capacity despite successful treatment. We performed a…”
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High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial by Boeree, Martin J, PhD, Heinrich, Norbert, MD, Aarnoutse, Rob, PhD, Diacon, Andreas H, PhD, Dawson, Rodney, PhD, Rehal, Sunita, MSc, Kibiki, Gibson S, Prof, Churchyard, Gavin, Prof, Sanne, Ian, FRCP, Ntinginya, Nyanda E, MD, Minja, Lilian T, MD, Hunt, Robert D, BSc, Charalambous, Salome, PhD, Hanekom, Madeleine, PhD, Semvua, Hadija H, PhD, Mpagama, Stellah G, PhD, Manyama, Christina, MD, Mtafya, Bariki, MSc, Reither, Klaus, MD, Wallis, Robert S, Prof, Venter, Amour, NatDipMicr, Narunsky, Kim, MD, Mekota, Anka, PhD, Henne, Sonja, MSc, Colbers, Angela, PhD, van Balen, Georgette Plemper, PhD, Gillespie, Stephen H, Prof, Phillips, Patrick P J, PhD, Hoelscher, Michael, Prof

“…Summary Background Tuberculosis is the world's leading infectious disease killer. We aimed to identify shorter, safer drug regimens for the treatment of…”
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Prevalence and antibiotic susceptibility pattern of CTX-M type extended-spectrum β-lactamases among clinical isolates of gram-negative bacilli in Jimma, Ethiopia by Zeynudin, Ahmed, Pritsch, Michael, Schubert, Sören, Messerer, Maxim, Liegl, Gabriele, Hoelscher, Michael, Belachew, Tefara, Wieser, Andreas

“…The prevalence of extended-spectrum β-lactamases (ESBLs) have been reported in clinical isolates obtained from various hospitals in Ethiopia. However, there is…”
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Effect on mortality of point-of-care, urine-based lipoarabinomannan testing to guide tuberculosis treatment initiation in HIV-positive hospital inpatients: a pragmatic, parallel-group, multicountry, open-label, randomised controlled trial by Peter, Jonny G, PhD, Zijenah, Lynn S, PhD, Chanda, Duncan, MD, Clowes, Petra, MD, Lesosky, Maia, PhD, Gina, Phindile, MD, Mehta, Nirja, MSc, Calligaro, Greg, MD, Lombard, Carl J, PhD, Kadzirange, Gerard, MD, Bandason, Tsitsi, PhD, Chansa, Abidan, MD, Liusha, Namakando, MD, Mangu, Chacha, MD, Mtafya, Bariki, MD, Msila, Henry, MD, Rachow, Andrea, PhD, Hoelscher, Michael, PhD, Mwaba, Peter, MD, Theron, Grant, PhD, Dheda, Keertan, Dr

“…Summary Background HIV-associated tuberculosis is difficult to diagnose and results in high mortality. Frequent extra-pulmonary presentation, inability to…”
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Evaluation of the Xpert MTB/RIF Assay for the Diagnosis of Pulmonary Tuberculosis in a High HIV Prevalence Setting by THERON, Grant, PETER, Jonny, PAI, Madhukar, WARREN, Robin, DHEDA, Keertan, VAN ZYL-SMIT, Richard, MISHRA, Hridesh, STREICHER, Elizabeth, MURRAY, Samuel, DAWSON, Rodney, WHITELAW, Andrew, HOELSCHER, Michael, SHARMA, Surendra

“…Xpert MTB/RIF is a novel automated molecular diagnostic recently endorsed by the World Health Organization. However, performance-related data from high HIV…”
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New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects by Zumla, Alimuddin I, Prof, Gillespie, Stephen H, Prof, Hoelscher, Michael, Prof, Philips, Patrick P J, PhD, Cole, Stewart T, Prof, Abubakar, Ibrahim, Prof, McHugh, Timothy D, Prof, Schito, Marco, PhD, Maeurer, Markus, Prof, Nunn, Andrew J, Prof

“…Summary About 1·3 million people died of tuberculosis in 2012, despite availability of effective drug treatment. Barriers to improvements in outcomes include…”
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Modelling of a triage scoring tool for SARS-COV-2 PCR testing in health-care workers: data from the first German COVID-19 Testing Unit in Munich by Hohl, Hannah Tuulikki, Froeschl, Guenter, Hoelscher, Michael, Heumann, Christian

“…Abstract Background Numerous scoring tools have been developed for assessing the probability of SARS-COV-2 test positivity, though few being suitable or…”
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Knowledge, attitudes and practices towards viral haemorrhagic fevers amongst healthcare workers in urban and rural public healthcare facilities in the N'zérékoré prefecture, Guinea: a cross-sectional study by Raab, Manuel, Pfadenhauer, Lisa M, Millimouno, Tamba Jacques, Hoelscher, Michael, Froeschl, Guenter

“…The 2013-2016 Ebola epidemic in West Africa began in Guinea's Forest region, a region now considered to be at high risk for future epidemics of viral…”
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Xpert MTB/RIF Ultra assay for the diagnosis of pulmonary tuberculosis in children: a multicentre comparative accuracy study by Sabi, Issa, Rachow, Andrea, Mapamba, Daniel, Clowes, Petra, Ntinginya, Nyanda E., Sasamalo, Mohamed, Kamwela, Lujeko, Haraka, Frederick, Hoelscher, Michael, Paris, Daniel H., Saathoff, Elmar, Reither, Klaus

“…•Xpert Ultra detects tuberculosis in children with a superior sensitivity compared to Xpert.•The sensitivity of Xpert Ultra is considerably lower in children…”
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Morbidity profile and sociodemographic characteristics of unaccompanied refugee minors seen by paediatric practices between October 2014 and February 2016 in Bavaria, Germany by Kloning, Teresa, Nowotny, Thomas, Alberer, Martin, Hoelscher, Michael, Hoffmann, Axel, Froeschl, Guenter

“…This study aimed to investigate the morbidity profile and the sociodemographic characteristics of unaccompanied refugee minors (URM) arriving in the region of…”
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In Vivo Dearomatization of the Potent Antituberculosis Agent BTZ043 via Meisenheimer Complex Formation by Kloss, Florian, Krchnak, Viktor, Krchnakova, Anna, Schieferdecker, Sebastian, Dreisbach, Julia, Krone, Volker, Möllmann, Ute, Hoelscher, Michael, Miller, Marvin J.

“…Nitrobenzothiazinones are among the most potent antituberculosis agents. Herein, we disclose an unprecedented in vivo reduction process that affords…”
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Tuberculosis comorbidity with communicable and non-communicable diseases: integrating health services and control efforts by Marais, Ben J, FCPaed, Lönnroth, Knut, PhD, Lawn, Stephen D, FRCP, Migliori, Giovanni Battista, Prof, Mwaba, Peter, FRCP, Glaziou, Philippe, MD, Bates, Matthew, PhD, Colagiuri, Ruth, GCHPM, Zijenah, Lynn, Prof, Swaminathan, Soumya, MD, Memish, Ziad A, Prof, Pletschette, Michel, FRCP, Hoelscher, Michael, Prof, Abubakar, Ibrahim, Prof, Hasan, Rumina, FRCPath, Zafar, Afia, FRCPath, Pantaleo, Guiseppe, PhD, Craig, Gill, PhD, Kim, Peter, MD, Maeurer, Markus, Prof, Schito, Marco, PhD, Zumla, Alimuddin, Prof

“…Summary Recent data for the global burden of disease reflect major demographic and lifestyle changes, leading to a rise in non-communicable diseases. Most…”
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Assessment of the novel T-cell activation marker–tuberculosis assay for diagnosis of active tuberculosis in children: a prospective proof-of-concept study by Portevin, Damien, PhD, Moukambi, Felicien, MSc, Clowes, Petra, MD, Bauer, Asli, PhD, Chachage, Mkunde, PhD, Ntinginya, Nyanda E, MD, Mfinanga, Elirehema, MD, Said, Khadija, MD, Haraka, Frederick, MD, Rachow, Andrea, MD, Saathoff, Elmar, PhD, Mpina, Maximilian, MSc, Jugheli, Levan, PhD, Lwilla, Fred, PhD, Marais, Ben J, Prof, Hoelscher, Michael, Prof, Daubenberger, Claudia, Prof, Reither, Klaus, Dr, Geldmacher, Christof, Dr

“…Summary Background The diagnosis of paediatric tuberculosis is complicated by non-specific symptoms, difficult specimen collection, and the paucibacillary…”
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Drug-resistant tuberculosis: time for visionary political leadership by Abubakar, Ibrahim, Prof, Zignol, Matteo, MD, Falzon, Dennis, MD, Raviglione, Mario, Prof, Ditiu, Lucica, MD, Masham, Susan, Baroness, Adetifa, Ifedayo, PhD, Ford, Nathan, PhD, Cox, Helen, PhD, Lawn, Stephen D, FRCP, Marais, Ben J, FCPaed, McHugh, Timothy D, Prof, Mwaba, Peter, FRCP, Bates, Matthew, PhD, Lipman, Marc, FRCP, Zijenah, Lynn, Prof, Logan, Simon, MSc, McNerney, Ruth, PhD, Zumla, Adam, MD, Sarda, Krishna, MD, Nahid, Payam, MD, Hoelscher, Michael, Prof, Pletschette, Michel, FRCP, Memish, Ziad A, Prof, Kim, Peter, MD, Hafner, Richard, MD, Cole, Stewart, Prof, Migliori, Giovanni Battista, Prof, Maeurer, Markus, Prof, Schito, Marco, PhD, Zumla, Alimuddin, Prof

“…Summary Two decades ago, WHO declared tuberculosis a global emergency, and invested in the highly cost-effective directly observed treatment short-course…”
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