Search Results - "HOEGER, Simone"

The Cholinergic Anti-Inflammatory Pathway as a Conceptual Framework to Treat Inflammation-Mediated Renal Injury by Jarczyk, Jonas, Yard, Benito A., Hoeger, Simone

“…Background: The cholinergic anti-inflammatory pathway, positioned at the interface of the nervous and immune systems, is the efferent limb of the “inflammatory…”
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Quantitative renal perfusion measurements in a rat model of acute kidney injury at 3T: testing inter- and intramethodical significance of ASL and DCE-MRI by Zimmer, Fabian, Zöllner, Frank G, Hoeger, Simone, Klotz, Sarah, Tsagogiorgas, Charalambos, Krämer, Bernhard K, Schad, Lothar R

“…To establish arterial spin labelling (ASL) for quantitative renal perfusion measurements in a rat model at 3 Tesla and to test the diagnostic significance of…”
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N-octanoyl dopamine inhibits the expression of a subset of κB regulated genes: potential role of p65 Ser276 phosphorylation by Hottenrott, Maximilia C, Wedel, Johannes, Gaertner, Sophie, Stamellou, Eleni, Kraaij, Tineke, Mandel, Linda, Loesel, Ralf, Sticht, Carsten, Hoeger, Simone, Ait-Hsiko, Lamia, Schedel, Angelika, Hafner, Mathias, Yard, Benito, Tsagogiorgas, Charalambos

“…Catechol containing compounds have anti-inflammatory properties, yet for catecholamines these properties are modest. Since we have previously demonstrated that…”
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UW is Superior Compared with HTK After Prolonged Preservation of Renal Grafts by Hoeger, Simone, Ph.D, Lueg, Georgia, Tsagogiorgas, Charalambos, M.D, Schneider, Michael, Theisinger, Sonja, Ph.D, Theisinger, Bastian, Ph.D, Fontana, Johann, M.D, Waldherr, Ruediger, M.D., Ph.D, Krämer, Bernhard K., M.D., Ph.D, Schnuelle, Peter, M.D., Ph.D, Yard, Benito, Ph.D

“…Background In recent clinical studies, the efficacy of histidine-tryptophan-ketoglutarate (HTK) in kidney transplantation was questioned. This study compares…”
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Oxygen-charged HTK-F6H8 emulsion reduces ischemia–reperfusion injury in kidneys from brain-dead pigs by Asif, Sana, MD, Sedigh, Amir, MD, Nordström, Johan, MD, Brandhorst, Heide, PhD, Jorns, Carl, MD, Lorant, Tomas, PhD, Larsson, Erik, PhD, Magnusson, Peetra U., PhD, Nowak, Greg, PhD, Theisinger, Sonja, PhD, Hoeger, Simone, PhD, Wennberg, Lars, PhD, Korsgren, Olle, PhD, Brandhorst, Daniel, PhD

“…Abstract Background Prolonged cold ischemia is frequently associated with a greater risk of delayed graft function and enhanced graft failure. We hypothesized…”
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Effects of Donor Pre-Treatment With Dopamine on Survival After Heart Transplantation by Benck, Urs, MD, Hoeger, Simone, PhD, Brinkkoetter, Paul T., MD, PhD, Gottmann, Uwe, MD, PhD, Doenmez, Duygu, CandMed, Boesebeck, Detlef, MD, Lauchart, Werner, MD, PhD, Gummert, Jan, MD, PhD, Karck, Matthias, MD, PhD, Lehmkuhl, Hans B., MD, Bittner, Hartmuth B., MD, PhD, Zuckermann, Andreas, MD, PhD, Wagner, Florian, MD, PhD, Schulz, Uwe, MD, Koch, Achim, MD, Bigdeli, Amir K., MD, Bara, Christoph, MD, PhD, Hirt, Stephan, MD, PhD, Berchtold-Herz, Michael, MD, Brose, Stefan, MD, Herold, Ulf, MD, Boehm, Johannes, MD, Welp, Henryk, MD, Strecker, Thomas, MD, PhD, Doesch, Andreas, MD, Birck, Rainer, MD, PhD, Krämer, Bernhard K., MD, PhD, Yard, Benito A., PhD, Schnuelle, Peter, MD, PhD

“…Objectives We determined the outcome of cardiac allografts from multiorgan donors enrolled in a randomized trial of donor pre-treatment with dopamine…”
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N-octanoyl-dopamine is an agonist at the capsaicin receptor TRPV1 and mitigates ischemia-induced [corrected] acute kidney injury in rat by Tsagogiorgas, Charalambos, Wedel, Johannes, Hottenrott, Maximilia, Schneider, Michael O, Binzen, Uta, Greffrath, Wolfgang, Treede, Rolf-Detlef, Theisinger, Bastian, Theisinger, Sonja, Waldherr, Rüdiger, Krämer, Bernhard K, Thiel, Manfred, Schnuelle, Peter, Yard, Benito A, Hoeger, Simone

“…Since stimulation of transient receptor potential channels of the vanilloid receptor subtype 1 (TRPV1) mitigates acute kidney injury (AKI) and endogenous…”
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Effects of Donor Pretreatment With Dopamine on Graft Function After Kidney Transplantation: A Randomized Controlled Trial by Schnuelle, Peter, Gottmann, Uwe, Hoeger, Simone, Boesebeck, Detlef, Lauchart, Werner, Weiss, Christel, Fischereder, Michael, Jauch, Karl-Walter, Heemann, Uwe, Zeier, Martin, Hugo, Christian, Pisarski, Przemyslaw, Krämer, Bernhard K, Lopau, Kai, Rahmel, Axel, Benck, Urs, Birck, Rainer, Yard, Benito Antonio

“…CONTEXT Kidney graft function after transplantation can be improved through pharmacological donor pretreatment to limit organ injury from cold preservation…”
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Impact of different emulsifiers on biocompatibility and inflammatory potential of Perfluorohexyloctane by Hoeger, Simone, Beck, Grietje, Breedijk, Annette, Yard, Benito, Anger, Friedrich, Tsagogiorgas, Charalambos

“…Background: Emulsions on the basis of Perfluorohexyloctane (F6H8), a semifluorinated alkane (SFA), have shown to dissolve and transport highly lipophilic…”
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Impact of different emulsifiers on biocompatibility and inflammatory potential of Perfluorohexyloctane (F6H8) emulsions for new intravenous drug delivery systems by Tsagogiorgas, Charalambos, Anger, Friedrich, Beck, Grietje, Breedijk, Annette, Yard, Benito, Hoeger, Simone

“…Emulsions on the basis of Perfluorohexyloctane (F6H8), a semifluorinated alkane (SFA), have shown to dissolve and transport highly lipophilic compounds. It is…”
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Renal perfusion in acute kidney injury with DCE-MRI: Deconvolution analysis versus two-compartment filtration model by Zöllner, Frank G, Zimmer, Fabian, Klotz, Sarah, Hoeger, Simone, Schad, Lothar R

“…Abstract Purpose To investigate the results of different pharmacokinetic models of a quantitative analysis of renal blood flow (RBF) in acute kidney injury…”
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Dopamine and lipophilic derivates protect cardiomyocytes against cold preservation injury by Vettel, Christiane, Hottenrott, Maximilia C, Spindler, Rahel, Benck, Urs, Schnuelle, Peter, Tsagogiorgas, Charalambos, Krämer, Bernhard K, Hoeger, Simone, El-Armouche, Ali, Wieland, Thomas, Yard, Benito A

“…Donor heart allografts are extremely susceptible to prolonged static cold storage. Because donor treatment with low-dose dopamine improves clinical outcome…”
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N-Octanoyl Dopamine for Donor Treatment in a Brain-death Model of Kidney and Heart Transplantation by Spindler, Rahel S, Schnuelle, Peter, Nickels, Lukas, Jarczyk, Jonas, Waldherr, Rüdiger, Theisinger, Sonja, Theisinger, Bastian, Klotz, Sarah, Tsagogiorgas, Charalambos, Göttmann, Uwe, Krämer, Bernhard K, Yard, Benito A, Hoeger, Simone

“…BACKGROUNDThis study investigated the potential use of N-octanoyl dopamine (NOD) in donor management to ameliorate the damage caused by brain death and…”
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Effects of Donor Pre-Treatment With Dopamine on Survival After Heart Transplantation: A Cohort Study of Heart Transplant Recipients Nested in a Randomized Controlled Multicenter Trial by BENCK, Urs, HOEGER, Simone, BITTNER, Hartmuth B, ZUCKERMANN, Andreas, WAGNER, Florian, SCHULZ, Uwe, KOCH, Achim, BIGDELI, Amir K, BARA, Christoph, HIRT, Stephan, BERCHTOLD-HERZ, Michael, BROSE, Stefan, BRINKKOETTER, Paul T, HEROLD, Ulf, BOEHM, Johannes, WELP, Henryk, STRECKER, Thomas, DOESCH, Andreas, BIRCK, Rainer, KRÄMER, Bernhard K, YARD, Benito A, SCHNUELLE, Peter, GOTTMANN, Uwe, DOENMEZ, Duygu, BOESEBECK, Detlef, LAUCHART, Werner, GUMMERT, Jan, KARCK, Matthias, LEHMKUHL, Hans B

“…We determined the outcome of cardiac allografts from multiorgan donors enrolled in a randomized trial of donor pre-treatment with dopamine. Treatment of the…”
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N-octanoyl dopamine treatment exerts renoprotective properties in acute kidney injury but not in renal allograft recipients by Klotz, Sarah, Pallavi, Prama, Tsagogiorgas, Charalambos, Zimmer, Fabian, Zöllner, Frank G, Binzen, Uta, Greffrath, Wolfgang, Treede, Rolf-Detlef, Walter, Jakob, Harmsen, Martin C, Krämer, Bernhard K, Hafner, Mathias, Yard, Benito A, Hoeger, Simone

“…N-octanoyl dopamine (NOD) treatment improves renal function when applied to brain dead donors and in the setting of warm ischaemia-induced acute kidney injury…”
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N-octanoyl-Dopamine Is an Agonist at the Capsaicin Receptor TRPV1 and Mitigates Is Chemia-Induced Acute Kidney Injury in Rat by Tsagogiorgas, Charalambos, Wedel, Johannes, Hottenrott, Maximilia, Schneider, Michael O, Binzen, Uta, Greffrath, Wolfgang, Treede, Rolf-Detlef, Theisinger, Bastian, Theisinger, Sonja, Waldherr, Rüdiger, Krämer, Bernhard K, Thiel, Manfred, Schnuelle, Peter, Yard, Benito A, Hoeger, Simone

“…Since stimulation of transient receptor potential channels of the vanilloid receptor subtype 1 (TRPV1) mitigates acute kidney injury (AKI) and endogenous…”
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Vagal stimulation in brain dead donor rats decreases chronic allograft nephropathy in recipients by Hoeger, Simone, Fontana, Johann, Jarczyk, Jonas, Selhorst, Jochen, Waldherr, Rüdiger, Krämer, Bernhard K, Schnuelle, Peter, Yard, Benito A

“…Although it has been shown that a vagus nerve stimulation of brain dead (BD) donors leads to an improvement of renal function in recipients in an acute…”
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Long-term Treatment with Suberythropoietic Epo is Vaso- and Neuroprotective in Experimental Diabetic Retinopathy by Wang, Qian, Gorbey, Stefan, Pfister, Frederick, Höger, Simone, Dorn-Beineke, Andrea, Krügel, Katja, Berrone, Elena, Wu, Liang, Korff, Thomas, Lin, Jihong, Busch, Stefanie, Reichenbach, Andreas, Feng, Yuxi, Hammes, Hans-Peter

“…Background/Aims: Diabetic retinopathy is characterized by pericyte loss and vasoregression both in the clinic and in animal models. A mild neurodegeneration…”
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Targeting complement activation in brain-dead donors improves renal function after transplantation by Damman, Jeffrey, Hoeger, Simone, Boneschansker, Leo, Theruvath, Ashok, Waldherr, Ruediger, Leuvenink, Henri G, Ploeg, Rutger J, Yard, Benito A, Seelen, Marc A

“…Abstract Kidneys recovered from brain-dead donors have inferior outcomes after transplantation compared to kidneys from living donors. Since complement…”
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Inhibition of VCAM-1 expression in endothelial cells by CORM-3: The role of the ubiquitin–proteasome system, p38, and mitochondrial respiration by Bergstraesser, Claudia, Hoeger, Simone, Song, Hui, Ermantraut, Linda, Hottenrot, Maxi, Czymai, Tobias, Schmidt, Marc, Goebeler, Matthias, Ponelies, Norbert, Stich, Carsten, Loesel, Ralf, Molema, Grietje, Seelen, Marc, van Son, Willem, Yard, Benito A., Rafat, Neysan

“…Carbon monoxide (CO) abrogates TNF-α-mediated inflammatory responses in endothelial cells, yet the underlying mechanism thereof is still elusive. We have…”
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