Search Results - "HODGES, Emily"

Role of circadian rhythms in pathogenesis of acute CNS injuries: Insights from experimental studies by Hetman, Michal, Slomnicki, Lukasz P., Hodges, Emily R., Saraswat Ohri, Sujata, Whittemore, Scott R.

“…A wide range of physiological processes show circadian oscillations that are critical for organismal homeostasis. Consequently, disruption of such rhythmicity…”
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Limited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day by Slomnicki, Lukasz P, Wei, George, Burke, Darlene A, Hodges, Emily R, Myers, Scott A, Yarberry, Christine D, Morehouse, Johnny R, Whittemore, Scott R, Saraswat Ohri, Sujata, Hetman, Michal

“…The circadian gene expression rhythmicity drives diurnal oscillations of physiological processes that may determine the injury response. While outcomes of…”
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Cross-tissue patterns of DNA hypomethylation reveal genetically distinct histories of cell development by Scott, Timothy J, Hansen, Tyler J, McArthur, Evonne, Hodges, Emily

“…Establishment of DNA methylation (DNAme) patterns is essential for balanced multi-lineage cellular differentiation, but exactly how these patterns drive…”
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Sperm Methylation Profiles Reveal Features of Epigenetic Inheritance and Evolution in Primates by Molaro, Antoine, Hodges, Emily, Fang, Fang, Song, Qiang, McCombie, W. Richard, Hannon, Gregory J., Smith, Andrew D.

“…During germ cell and preimplantation development, mammalian cells undergo nearly complete reprogramming of DNA methylation patterns. We profiled the methylomes…”
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Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis by Erlich, Yaniv, Edvardson, Simon, Hodges, Emily, Zenvirt, Shamir, Thekkat, Pramod, Shaag, Avraham, Dor, Talya, Hannon, Gregory J, Elpeleg, Orly

“…Whole exome sequencing has become a pivotal methodology for rapid and cost-effective detection of pathogenic variations in Mendelian disorders. A major…”
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Site identification in high-throughput RNA―protein interaction data by UREN, Philip J, BAHRAMI-SAMANI, Emad, BURNS, Suzanne C, MEI QIAO, KARGINOV, Fedor V, HODGES, Emily, HANNON, Gregory J, SANFORD, Jeremy R, PENALVA, Luiz O. F, SMITH, Andrew D

“…Post-transcriptional and co-transcriptional regulation is a crucial link between genotype and phenotype. The central players are the RNA-binding proteins, and…”
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Directional DNA Methylation Changes and Complex Intermediate States Accompany Lineage Specificity in the Adult Hematopoietic Compartment by Hodges, Emily, Molaro, Antoine, Dos Santos, Camila O., Thekkat, Pramod, Song, Qiang, Uren, Philip J., Park, Jin, Butler, Jason, Rafii, Shahin, McCombie, W. Richard, Smith, Andrew D., Hannon, Gregory J.

“…DNA methylation has been implicated as an epigenetic component of mechanisms that stabilize cell-fate decisions. Here, we have characterized the methylomes of…”
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Enhancer-promoter activation by the Kaposi sarcoma-associated herpesvirus episome maintenance protein LANA by Ye, Xiang, Guerin, Lindsey N., Chen, Ziche, Rajendren, Suba, Dunker, William, Zhao, Yang, Zhang, Ruilin, Hodges, Emily, Karijolich, John

“…Higher-order genome structure influences the transcriptional regulation of cellular genes through the juxtaposition of regulatory elements, such as enhancers,…”
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Opposite modulation of functional recovery following contusive spinal cord injury in mice with oligodendrocyte-selective deletions of Atf4 and Chop/Ddit3 by Gao, Yonglin, Wei, George Z., Forston, Michael D., Rood, Benjamin, Hodges, Emily R., Burke, Darlene, Andres, Kariena, Morehouse, Johnny, Armstrong, Christine, Glover, Charles, Slomnicki, Lukasz P., Ding, Jixiang, Chariker, Julia H., Rouchka, Eric C., Saraswat Ohri, Sujata, Whittemore, Scott R., Hetman, Michal

“…The integrated stress response (ISR)-activated transcription factors ATF4 and CHOP/DDIT3 may regulate oligodendrocyte (OL) survival, tissue damage and…”
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Two waves of de novo methylation during mouse germ cell development by Molaro, Antoine, Falciatori, Ilaria, Hodges, Emily, Aravin, Alexei A, Marran, Krista, Rafii, Shahin, McCombie, W Richard, Smith, Andrew D, Hannon, Gregory J

“…During development, mammalian germ cells reprogram their epigenomes via a genome-wide erasure and de novo rewriting of DNA methylation marks. We know little of…”
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Genomic landscape of human allele-specific DNA methylation by Fang, Fang, Hodges, Emily, Molaro, Antoine, Dean, Matthew, Hannon, Gregory J, Smith, Andrew D

“…DNA methylation mediates imprinted gene expression by passing an epigenomic state across generations and differentially marking specific regulatory regions on…”
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Genomic dissection and mutation-specific target discovery for breast cancer PIK3CA hotspot mutations by Miranda, Adam X, Kemp, Justin, Davidson, Brad A, Bellomo, Sara Erika, Miranda, Verda E, Manoni, Alexandra, Marchiò, Caterina, Croessmann, Sarah, Park, Ben H, Hodges, Emily

“…Recent advancements in high-throughput genomics and targeted therapies have provided tremendous potential to identify and therapeutically target distinct…”
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An Epigenetic Memory of Pregnancy in the Mouse Mammary Gland by dos Santos, Camila O., Dolzhenko, Egor, Hodges, Emily, Smith, Andrew D., Hannon, Gregory J.

“…Pregnancy is the major modulator of mammary gland activity. It induces a tremendous expansion of the mammary epithelium and the generation of alveolar…”
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Evolutionary expansion of DNA hypomethylation in the mammalian germline genome by Qu, Jianghan, Hodges, Emily, Molaro, Antoine, Gagneux, Pascal, Dean, Matthew D, Hannon, Gregory J, Smith, Andrew D

“…DNA methylation in the germline is among the most important factors influencing the evolution of mammalian genomes. Yet little is known about its evolutionary…”
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High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing by Hodges, Emily, Smith, Andrew D, Kendall, Jude, Xuan, Zhenyu, Ravi, Kandasamy, Rooks, Michelle, Zhang, Michael Q, Ye, Kenny, Bhattacharjee, Arindam, Brizuela, Leonardo, McCombie, W Richard, Wigler, Michael, Hannon, Gregory J, Hicks, James B

“…DNA methylation stabilizes developmentally programmed gene expression states. Aberrant methylation is associated with disease progression and is a common…”
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Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity by Liu, Jing, Banerjee, Amrita, Herring, Charles A., Attalla, Jonathan, Hu, Ruiying, Xu, Yanwen, Shao, Qiujia, Simmons, Alan J., Dadi, Prasanna K., Wang, Sui, Jacobson, David A., Liu, Bindong, Hodges, Emily, Lau, Ken S., Gu, Guoqiang

“…In the developing pancreas, transient Neurog3-expressing progenitors give rise to four major islet cell types: α, β, δ, and γ; when and how the Neurog3+ cells…”
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Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes by Stark, Alexander, Kheradpour, Pouya, Parts, Leopold, Brennecke, Julius, Hodges, Emily, Hannon, Gregory J, Kellis, Manolis

“…MicroRNAs (miRNAs) are short regulatory RNAs that inhibit target genes by complementary binding in 3' untranslated regions (3' UTRs). They are one of the most…”
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A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands by Stark, Alexander, Bushati, Natascha, Jan, Calvin H, Kheradpour, Pouya, Hodges, Emily, Brennecke, Julius, Bartel, David P, Cohen, Stephen M, Kellis, Manolis

“…MicroRNAs (miRNAs) are approximately 22-nucleotide RNAs that are processed from characteristic precursor hairpins and pair to sites in messages of…”
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Updates to the RMAP short-read mapping software by Smith, Andrew D., Chung, Wen-Yu, Hodges, Emily, Kendall, Jude, Hannon, Greg, Hicks, James, Xuan, Zhenyu, Zhang, Michael Q.

“…We report on a major new version of the RMAP software for mapping reads from short-read sequencing technology. General improvements to accuracy and space…”
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Transcriptional Silencing of ALDH2 Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia by Yang, Zhaolin, Wu, Xiaoli S, Wei, Yiliang, Polyanskaya, Sofya A, Iyer, Shruti V, Jung, Moonjung, Lach, Francis P, Adelman, Emmalee R, Klingbeil, Olaf, Milazzo, Joseph P, Kramer, Melissa, Demerdash, Osama E, Chang, Kenneth, Goodwin, Sara, Hodges, Emily, McCombie, W Richard, Figueroa, Maria E, Smogorzewska, Agata, Vakoc, Christopher R

“…Hundreds of genes become aberrantly silenced in acute myeloid leukemia (AML), with most of these epigenetic changes being of unknown functional consequence…”
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