Search Results - "HOCKINGS, Jennifer K"
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Impact of recommended weight-based dosing of granulocyte-colony stimulating factors in acute leukemia and stem cell transplant patients
Published in Supportive care in cancer (01-06-2017)“…Purpose Febrile neutropenia (FN) is a major risk factor for infection-related morbidity and mortality. The National Comprehensive Cancer Network recommends the…”
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The ligand status of the aromatic hydrocarbon receptor modulates transcriptional activation of BRCA-1 promoter by estrogen
Published in Cancer research (Chicago, Ill.) (15-02-2006)“…In sporadic breast cancers, BRCA-1 expression is down-regulated in the absence of mutations in the BRCA-1 gene. This suggests that disruption of BRCA-1…”
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Pharmacogenomics meets precision cardio-oncology: is there synergistic potential?
Published in Human molecular genetics (20-10-2020)“…An individual's inherited genetic makeup and acquired genomic variants may account for a significant portion of observable variability in therapy efficacy and…”
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Cyclooxygenase-2 Promoter Activation by the Aromatic Hydrocarbon Receptor in Breast Cancer MCF-7 Cells: Repressive Effects of Conjugated Linoleic Acid
Published in Nutrition and cancer (01-01-2007)“…The role of the aromatic hydrocarbon receptor (AhR) in transcriptional regulation of the human cyclooxygenase-2 (COX-2) gene remains elusive. We report that…”
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An Estrogen Receptor-α/p300 Complex Activates the BRCA-1 Promoter at an AP-1 Site That Binds Jun/Fos Transcription Factors: Repressive Effects of p53 on BRCA-1 Transcription
Published in Neoplasia (New York, N.Y.) (01-09-2005)“…One of the puzzles in cancer predisposition is that women carrying BRCA-1 mutations preferentially develop tumors in epithelial tissues of the breast, ovary…”
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Pharmacogenomics: An evolving clinical tool for precision medicine
Published in Cleveland Clinic journal of medicine (01-02-2020)“…Pharmacogenomics, ie, the study of how an individual's genomic profile influences his or her response to drugs, has emerged as a clinical tool to optimize drug…”
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Critical evaluation of the current landscape of pharmacogenomics in Parkinson's disease - What is missing? A systematic review
Published in Parkinsonism & related disorders (13-11-2024)“…The first-line treatment for Parkinson's disease (PD) involves dopamine-replacement therapies; however, significant variability exists in patient responses…”
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Altered mental status in a man with metabolic syndrome
Published in Cleveland Clinic journal of medicine (01-08-2022)Get full text
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Integration of a pharmacist-led pharmacogenomic service in a geriatric clinic: Barriers and outcomes
Published in Journal of the American Pharmacists Association (01-05-2023)“…The primary objective was to identify the proportion of patients who successfully completed PGx testing. Secondary objectives included determining the…”
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Involvement of a specificity proteins-binding element in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene
Published in Breast cancer research : BCR (01-01-2008)“…Increased estrogen level has been regarded to be a risk factor for breast cancer. However, estrogen has also been shown to induce the expression of the tumor…”
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An Estrogen Receptor-α/p300 Complex Activates the BRCA-1 Promoter at an AP-1 Site That Binds Jun/Fos Transcription Factors: Repressive Effects of p53 on BRCA-1 Transcription1
Published in Neoplasia (New York, N.Y.) (01-09-2005)“…One of the puzzles in cancer predisposition is that women carrying BRCA-1 mutations preferentially develop tumors in epithelial tissues of the breast and…”
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