Search Results - "HOCHKEPPEL, H. K"

MxA Gene Expression after Live Virus Vaccination: A Sensitive Marker for Endogenous Type I Interferon by Roers, A., Hochkeppel, H. K., Horisberger, M. A., Hovanessian, A., Haller, O.

“…MxA gene expression is known to be regulated tightly and exclusively by type I interferons (IFNs). The kinetics of MxA gene expression was analyzed in…”
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Identification of novel mdm2 binding peptides by phage display by Böttger, V, Böttger, A, Howard, S F, Picksley, S M, Chène, P, Garcia-Echeverria, C, Hochkeppel, H K, Lane, D P

“…The oncogene mdm2 and its human homologue hdm2 bind to the tumour suppressor protein p53 and inactivate its function as a transcription factor. This has been…”
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The human intracellular Mx-homologous protein is specifically induced by type I interferons by von Wussow, P, Jakschies, D, Hochkeppel, H K, Fibich, C, Penner, L, Deicher, H

“…The murine Mx-1 protein is one of the best biochemically and functionally characterized interferon (IFN)-induced proteins that is necessary, and sufficient,…”
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9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections by GANGEMI, J. D, COZENS, R. M, DE CLERCQ, E, BALZARINI, J, HOCHKEPPEL, H.-K

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Effective Natural Interferon-α Therapy in Recombinant Interferon-α-Resistant Patients With Hairy Cell Leukemia by Wussow, P. von, Pralle, H., Hochkeppel, H.-K., Jakschies, D., Sonnen, S., Schmidt, H., Miiller-Rosenau, D., Franke, M., Haferlach, T., Zwingers, T., Rapp, U., Deicher, H.

“…To explore the relationship between anti-interferon-α (anti-IFN-α) antibodies and loss of clinical responsiveness to IFN-α treatment, we examined sera from 59…”
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IFN-tau exhibits potent suppression of human papillomavirus E6/E7 oncoprotein expression by Johnson, J A, Hochkeppel, H K, Gangemi, J D

“…The effects of interferon-tau (IFN-tau) on tumor suppressor factors and virus oncoprotein expression were compared with two other type I IFN in human…”
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Serotyping and electron microscopy studies of Staphylococcus aureus clinical isolates with monoclonal antibodies to capsular polysaccharide types 5 and 8 by HOCHKEPPEL, H. K, BRAUN, D. G, VISCHER, W, IMM, A, SUTTER, S, STAEUBLI, U, GUGGENHEIM, R, KAPLAN, E. L, BOUTONNIER, A, FOURNIER, J. M

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Molecular characterization of the hdm2-p53 interaction by Böttger, A, Böttger, V, Garcia-Echeverria, C, Chène, P, Hochkeppel, H K, Sampson, W, Ang, K, Howard, S F, Picksley, S M, Lane, D P

“…A number of viral oncogenes target the tumour suppressor protein p53 and inactivate its function. This is an important step in tumourogenesis. The cellular…”
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Predominance of capsular polysaccharide type 5 among oxacillin-resistant Staphylococcus aureus by FOURNIER, J. M, BOUVET, A, BOUTONNIER, A, AUDURIER, A, GOLDSTEIN, F, PIERRE, J, BURE, A, LEBRUN, L, HOCHKEPPEL, H. K

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Cross-species antiviral activity of a recombinant human alpha-interferon hybrid by Ghaffar, A, Mayer, E P, Barnhart, D C, Pyo, S, Szymaniec, S, Hochkeppel, H K, Gangemi, J D

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An interferon-induced mouse protein involved in the mechanism of resistance to influenza viruses. Its purification to homogeneity and characterization by polyclonal antibodies by Horisberger, M A, Hochkeppel, H K

“…Interferon-alpha + beta (IFN-alpha + beta) plays a central role in the specific resistance to influenza virus infection of those mice carrying the gene Mx (for…”
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IFN-alpha induced human 78 kD protein: purification and homologies with the mouse Mx protein, production of monoclonal antibodies, and potentiation effect of IFN-gamma by Horisberger, M A, Hochkeppel, H K

“…A 78-kD protein (p78) is induced in human cells in response to interferon (IFN). It appeared as a radioactive spot when newly synthesized proteins from…”
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Monoclonal antibody against human IFN- γ by Hochkeppel, H. K, de Ley, M

“…Since the discovery that mouse spleen B lymphocytes can be fused with mouse B-myeloma cells to yield hybrid cells (hybridomas) secreting specific antibodies…”
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Monoclonal antibodies against human fibroblast interferon by Hochkeppel, H. K, Menge, U, Collins, J

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Antiviral activity of a novel recombinant human interferon-alpha B/D hybrid by Gangemi, J D, Lazdins, J, Dietrich, F M, Matter, A, Poncioni, B, Hochkeppel, H K

“…The antiviral potential of a novel cross-species active, recombinant human interferon-alpha B/D hybrid (rHuIFN-alpha B/D), was evaluated for its efficiacy in…”
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Correlation of the Antiproliferative Effect and the Mx-Homologous Protein Induction by IFN in Patients with Malignant Melanoma by Jakschies, Detlef, Hochkeppel, Heinz-Kurt, Horisberger, Michel Andre, Deicher, Helmuth, Wussow, Peter Von

“…The human interferon-induced intracellular protein homologous to the murine Mx-protein has recently been identified by means of a specific monoclonal antibody…”
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Biological activities of human recombinant interferon α/β targeted by anti-Epstein-Barr virus monoclonal antibodies by Miescher-Granger, S., Hochkeppel, H.K., Braun, D.G., Alkan, S.S.

“…The requirement of high doses of interferon (IFN) during therapy severely restrict its application. Thus a model using an Epstein-Barr virus (EBV) membrane…”
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Strong transient expression of the type I interferon-induced MxA protein in hepatitis A but not in acute hepatitis B and C by Jakschies, D, Zachoval, R, Müller, R, Manns, M, Nolte, K U, Hochkeppel, H K, Horisberger, M A, Deicher, H, Von Wussow, P

“…The human MxA protein is a new specific marker for type I interferon activity both in vitro and in vivo. In the study presented here, this interferon-induced…”
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Significant differences in therapeutic responses to a human interferon-alpha B/D hybrid in Rauscher or Friend murine leukemia virus infections by Gangemi, J D, Matter, A, Poncioni, B, Hochkeppel, H K

“…Treatment of mice infected with Rauscher (RMLV) or Friend (FMLV) murine leukemia viruses at an early stage of disease (beginning at day 0 and continuing every…”
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Demonstration of HIFN-β in the liver of patients undergoing HIFN-β treatment by Müller, R., Hochkeppel, H.K., Klein, H.

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