Search Results - "HOBBS, Robert F"

Generalized methods for predicting biological response to mixed radiation types and calculating equieffective doses (EQDX) by Katugampola, Sumudu, Hobbs, Robert F., Howell, Roger W.

“…Background Predicting biological responses to mixed radiation types is of considerable importance when combining radiation therapies that use multiple…”
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Whole-Body and Microenvironmental Localization of Radium-223 in Naïve and Mouse Models of Prostate Cancer Metastasis by Abou, Diane S, Ulmert, David, Doucet, Michele, Hobbs, Robert F, Riddle, Ryan C, Thorek, Daniel L J

“…Bone-metastatic, castration-resistant prostate cancer (bmCRPC) represents a lethal stage of the most common noncutaneous cancer in men. The recent introduction…”
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Large-scale in vitro microdosimetry via live cell microscopy imaging: implications for radiosensitivity and RBE evaluations in alpha-emitter radiopharmaceutical therapy by Bastiaannet, Remco, Liatsou, Ioanna, F Hobbs, Robert, Sgouros, George

“…Alpha-emitter radiopharmaceutical therapy (αRPT) has shown promising outcomes in metastatic disease. However, the short range of the alpha particles…”
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Dosimetry for Radiopharmaceutical Therapy by Sgouros, George, PhD, Hobbs, Robert F., PhD

“…Radiopharmaceutical therapy (RPT) involves the use of radionuclides that are either conjugated to tumor-targeting agents (e.g., nanoscale constructs,…”
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Preclinical Evaluation of a New Series of Albumin-Binding 177Lu-Labeled PSMA-Based Low-Molecular-Weight Radiotherapeutics by Boinapally, Srikanth, Alati, Suresh, Jiang, Zirui, Yan, Yu, Lisok, Alla, Singh, Rajan, Lofland, Gabriela, Minn, Il, Hobbs, Robert F., Pomper, Martin G., Banerjee, Sangeeta Ray

“…Prostate-specific membrane antigen (PSMA)-based low-molecular-weight agents using beta(β)-particle-emitting radiopharmaceuticals is a new treatment paradigm…”
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I-124 PET/CT image-based dosimetry in patients with differentiated thyroid cancer treated with I-131: correlation of patient-specific lesional dosimetry to treatment response by Plyku, Donika, Hobbs, Robert F., Wu, Di, Garcia, Carlos, Sgouros, George, Van Nostrand, Douglas

“…Purpose The objective of this study is to evaluate the lesion absorbed dose (AD), biological effective dose (BED), and equivalent uniform dose (EUD) to…”
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Mapping Patterns of Local Recurrence After Pancreaticoduodenectomy for Pancreatic Adenocarcinoma: A New Approach to Adjuvant Radiation Field Design by Dholakia, Avani S., BS, Kumar, Rachit, MD, Raman, Siva P., MD, Moore, Joseph A., PhD, Ellsworth, Susannah, MD, McNutt, Todd, PhD, Laheru, Daniel A., MD, Jaffee, Elizabeth, MD, Cameron, John L., MD, Tran, Phuoc T., MD, PhD, Hobbs, Robert F., PhD, Wolfgang, Christopher L., MD, PhD, Herman, Joseph M., MD, MSc

“…Purpose To generate a map of local recurrences after pancreaticoduodenectomy (PD) for patients with resectable pancreatic ductal adenocarcinoma (PDA) and to…”
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Redefining Relative Biological Effectiveness in the Context of the EQDX Formalism: Implications for Alpha-Particle Emitter Therapy by Hobbs, Robert F., Howell, Roger W., Song, Hong, Baechler, Sébastien, Sgouros, George

“…Alpha-particle radiopharmaceutical therapy (αRPT) is currently enjoying increasing attention as a viable alternative to chemotherapy for targeting of…”
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CD38‐Specific Gallium‐68 Labeled Peptide Radiotracer Enables Pharmacodynamic Monitoring in Multiple Myeloma with PET by Sharma, Ajay Kumar, Gupta, Kuldeep, Mishra, Akhilesh, Lofland, Gabriela, Marsh, Ian, Kumar, Dhiraj, Ghiaur, Gabriel, Imus, Philip, Rowe, Steven P., Hobbs, Robert F., Gocke, Christian B., Nimmagadda, Sridhar

“…The limited availability of molecularly targeted low‐molecular‐weight imaging agents for monitoring multiple myeloma (MM)‐targeted therapies has been a…”
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177Lu-labeled low-molecular-weight agents for PSMA-targeted radiopharmaceutical therapy by Banerjee, Sangeeta Ray, Kumar, Vivek, Lisok, Ala, Chen, Jian, Minn, Il, Brummet, Mary, Boinapally, Srikanth, Cole, Michael, Ngen, Ethel, Wharram, Bryan, Brayton, Cory, Hobbs, Robert F., Pomper, Martin G.

“…Purpose To develop a prostate-specific membrane antigen (PSMA)-targeted radiotherapeutic for metastatic castration-resistant prostate cancer (mCRPC) with…”
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Pharmacokinetics, microscale distribution, and dosimetry of alpha-emitter-labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model by Nedrow, Jessie R., Josefsson, Anders, Park, Sunju, Bäck, Tom, Hobbs, Robert F., Brayton, Cory, Bruchertseifer, Frank, Morgenstern, Alfred, Sgouros, George

“…Background Studies combining immune checkpoint inhibitors with external beam radiation have shown a therapeutic advantage over each modality alone. The purpose…”
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Smart Radiotherapy Biomaterials for Image-Guided In Situ Cancer Vaccination by Ainsworth, Victoria, Moreau, Michele, Guthier, Romy, Zegeye, Ysaac, Kozono, David, Swanson, William, Jandel, Marian, Oh, Philmo, Quon, Harry, Hobbs, Robert F, Yasmin-Karim, Sayeda, Sajo, Erno, Ngwa, Wilfred

“…Recent studies have highlighted the potential of smart radiotherapy biomaterials (SRBs) for combining radiotherapy and immunotherapy. These SRBs include smart…”
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A Treatment Planning Method for Sequentially Combining Radiopharmaceutical Therapy and External Radiation Therapy by Hobbs, Robert F., Ph.D, McNutt, Todd, Ph.D, Baechler, Sébastien, Ph.D, He, Bin, Ph.D, Esaias, Caroline E., B.S, Frey, Eric C., Ph.D, Loeb, David M., M.D., Ph.D, Wahl, Richard L., M.D, Shokek, Ori, M.D, Sgouros, George, Ph.D

“…Purpose Effective cancer treatment generally requires combination therapy. The combination of external beam therapy (XRT) with radiopharmaceutical therapy…”
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Modelling and dosimetry for alpha-particle therapy by Sgouros, George, Hobbs, Robert F, Song, Hong

“…As a consequence of the high potency and short range of alpha-particles, radiopharmaceutical therapy with alpha- particle emitting radionuclides is a promising…”
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Dosimetry for Optimized, Personalized Radiopharmaceutical Therapy by Graves, Stephen A., Hobbs, Robert F.

“…Radiopharmaceutical therapy (RPT) has grown rapidly over the last decade for treatment of numerous cancer types. Dosimetric guidance, as with other…”
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Factors affecting the stability and repeatability of gamma camera calibration for quantitative imaging applications based on a retrospective review of clinical data by Anizan, Nadège, Wang, Hao, Zhou, Xian C, Hobbs, Robert F, Wahl, Richard L, Frey, Eric C

“…Background Absolute quantitative single-photon emission computed tomography (SPECT) has several important applications including monitoring tumor response…”
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ASTRO's Framework for Radiopharmaceutical Therapy Curriculum Development for Trainees by Kiess, Ana P., Hobbs, Robert F., Bednarz, Bryan, Knox, Susan J., Meredith, Ruby, Escorcia, Freddy E.

“…In 2017, the ASTRO Board of Directors prioritized radiopharmaceutical therapy (RPT) as a leading area for new therapeutic development, and the ASTRO RPT…”
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Early Normal Tissue Effects and Bone Marrow Relative Biological Effectiveness for an Actinium 225-Labeled HER2/neu-Targeting Antibody by Liatsou, Ioanna, Josefsson, Anders, Yu, Jing, Li, Zhi, Davis, Kaori, Brayton, Cory, Wang, Hao, Hobbs, Robert F., Sgouros, George

“…In this study we determined the dose-independent relative biological effectiveness (RBE2) of bone marrow for an anti-HER2/neu antibody labeled with the…”
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212Pb-conjugated anti-rat HER2/neu antibody against a neu-N derived murine mammary carcinoma cell line: cell kill and RBE in vitro by Liatsou, Ioanna, Yu, Jing, Bastiaannet, Remco, Li, Zhi, Hobbs, Robert F., Torgue, Julien, Sgouros, George

“…In the current work, the RBE of a 212 Pb-conjugated anti-HER2/neu antibody construct has been evaluated, in vitro, by colony formation assay. The RBE was…”
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Gallium-68-labeled Peptide PET Quantifies Tumor Exposure of PD-L1 Therapeutics by Mishra, Akhilesh, Kumar, Dhiraj, Gupta, Kuldeep, Lofland, Gabriela, Sharma, Ajay Kumar, Banka, Dhanush S, Hobbs, Robert F, Dannals, Robert F, Rowe, Steven P, Gabrielson, Edward, Nimmagadda, Sridhar

“…Immune checkpoint therapy (ICT) is currently ineffective in a majority of patients. Tumor drug exposure measurements can provide vital insights into mechanisms…”
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