Search Results - "HOBBS, Nicola"

Are behavioral interventions effective in increasing physical activity at 12 to 36 months in adults aged 55 to 70 years? A systematic review and meta-analysis by Hobbs, Nicola, Godfrey, Alan, Lara, Jose, Errington, Linda, Meyer, Thomas D, Rochester, Lynn, White, Martin, Mathers, John C, Sniehotta, Falko F

“…Retirement represents a major transitional life stage in middle to older age. Changes in physical activity typically accompany this transition, which has…”
Get full text

An event-based model for disease progression and its application in familial Alzheimer's disease and Huntington's disease by Fonteijn, Hubert M., Modat, Marc, Clarkson, Matthew J., Barnes, Josephine, Lehmann, Manja, Hobbs, Nicola Z., Scahill, Rachael I., Tabrizi, Sarah J., Ourselin, Sebastien, Fox, Nick C., Alexander, Daniel C.

“…Understanding the progression of neurological diseases is vital for accurate and early diagnosis and treatment planning. We introduce a new characterization of…”
Get full text

Cerebellar abnormalities in Huntington's disease: A role in motor and psychiatric impairment? by Rees, Elin M., Farmer, Ruth, Cole, James H., Haider, Salman, Durr, Alexandra, Landwehrmeyer, Bernhard, Scahill, Rachael I., Tabrizi, Sarah J., Hobbs, Nicola Z.

“…The cerebellum has received limited attention in Huntington's disease (HD), despite signs of possible cerebellar dysfunction, including motor incoordination…”
Get full text

The impact of occipital lobe cortical thickness on cognitive task performance: An investigation in Huntington's Disease by Johnson, Eileanoir B., Rees, Elin M., Labuschagne, Izelle, Durr, Alexandra, Leavitt, Blair R., Roos, Raymund A.C., Reilmann, Ralf, Johnson, Hans, Hobbs, Nicola Z., Langbehn, Douglas R., Stout, Julie C., Tabrizi, Sarah J., Scahill, Rachael I.

“…The occipital lobe is an important visual processing region of the brain. Following consistent findings of early neural changes in the occipital lobe in…”
Get full text

Clinical impairment in premanifest and early Huntington's disease is associated with regionally specific atrophy by Scahill, Rachael I., Hobbs, Nicola Z., Say, Miranda J., Bechtel, Natalie, Henley, Susie M.D., Hyare, Harpreet, Langbehn, Douglas R., Jones, Rebecca, Leavitt, Blair R., Roos, Raymund A.C., Durr, Alexandra, Johnson, Hans, Lehéricy, Stéphane, Craufurd, David, Kennard, Christopher, Hicks, Stephen L., Stout, Julie C., Reilmann, Ralf, Tabrizi, Sarah J.

“…TRACK‐HD is a multicentre longitudinal observational study investigating the use of clinical assessments and 3‐Tesla magnetic resonance imaging as potential…”
Get full text

Testing Self-Regulation Interventions to Increase Walking Using Factorial Randomized N-of-1 Trials by SNIEHOTTA, Falko F, PRESSEAU, Justin, HOBBS, Nicola, ARAUJO-SOARES, Vera

“…To investigate the suitability of N-of-1 randomized controlled trials (RCTs) as a means of testing the effectiveness of behavior change techniques based on…”
Get full text

Assessment of Perivascular Space Morphometry Across the White Matter in Huntington's Disease Using MRI by Coleman, Annabelle, Langan, Mackenzie T, Verma, Gaurav, Knights, Harry, Sturrock, Aaron, Leavitt, Blair R, Tabrizi, Sarah J, Scahill, Rachael I, Hobbs, Nicola Z

“…Perivascular spaces (PVS) are fluid-filled cavities surrounding small cerebral blood vessels. There are limited reports of enlarged PVS across the grey matter…”
Get more information

Progressive alterations in white matter microstructure across the timecourse of Huntington's disease by Estevez‐Fraga, Carlos, Elmalem, Michael S., Papoutsi, Marina, Durr, Alexandra, Rees, Elin M., Hobbs, Nicola Z., Roos, Raymund A. C., Landwehrmeyer, Bernhard, Leavitt, Blair R., Langbehn, Douglas R., Scahill, Rachael I., Rees, Geraint, Tabrizi, Sarah J., Gregory, Sarah

“…Background Whole‐brain longitudinal diffusion studies are crucial to examine changes in structural connectivity in neurodegeneration. Here, we investigated the…”
Get full text

Neuroimaging to Facilitate Clinical Trials in Huntington's Disease: Current Opinion from the EHDN Imaging Working Group by Hobbs, Nicola Z, Papoutsi, Marina, Delva, Aline, Kinnunen, Kirsi M, Nakajima, Mitsuko, Van Laere, Koen, Vandenberghe, Wim, Herath, Priyantha, Scahill, Rachael I

“… Neuroimaging is increasingly being included in clinical trials of Huntington's disease (HD) for a wide range of purposes from participant selection and safety…”
Get more information

Cerebrospinal fluid flow dynamics in Huntington's disease evaluated by phase contrast MRI by Rodrigues, Filipe B., Byrne, Lauren M., De Vita, Enrico, Johnson, Eileanoir B., Hobbs, Nicola Z., Thornton, John S., Scahill, Rachael I., Wild, Edward J.

“…Multiple targeted therapeutics for Huntington's disease are now in clinical trials, including intrathecally delivered compounds. Previous research suggests…”
Get full text

Validating Automated Segmentation Tools in the Assessment of Caudate Atrophy in Huntington's Disease by Mansoor, Nina M, Vanniyasingam, Tishok, Malone, Ian, Hobbs, Nicola Z, Rees, Elin, Durr, Alexandra, Roos, Raymund A C, Landwehrmeyer, Bernhard, Tabrizi, Sarah J, Johnson, Eileanoir B, Scahill, Rachael I

“…Neuroimaging shows considerable promise in generating sensitive and objective outcome measures for therapeutic trials across a range of neurodegenerative…”
Get full text

White matter integrity in premanifest and early Huntington's disease is related to caudate loss and disease progression by Novak, Marianne J.U., Seunarine, Kiran K., Gibbard, Clare R., Hobbs, Nicola Z., Scahill, Rachael I., Clark, Chris A., Tabrizi, Sarah J.

“…Huntington's disease (HD) is associated with progressive loss of caudate and white matter volume and integrity. Our aim was to systematically assess…”
Get full text

The progression of regional atrophy in premanifest and early Huntington's disease: a longitudinal voxel-based morphometry study by Hobbs, Nicola Z, Henley, Susie M D, Ridgway, Gerard R, Wild, Edward J, Barker, Roger A, Scahill, Rachael I, Barnes, Josephine, Fox, Nick C, Tabrizi, Sarah J

“…BackgroundUnbiased longitudinal studies are needed to understand the distributed neurodegenerative changes of Huntington's disease (HD). They may also provide…”
Get full text

Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease by Leoni, Valerio, Mariotti, Caterina, Tabrizi, Sarah J., Valenza, Marta, Wild, Edward J., Henley, Susie M. D., Hobbs, Nicola Z., Mandelli, Maria Luisa, Grisoli, Marina, Björkhem, Ingemar, Cattaneo, Elena, Di Donato, Stefano

“…Huntington's disease (HD) is a hereditary neurodegenerative disorder for which biological indicators of disease progression, or disease stage, would be…”
Get full text

The structural involvement of the cingulate cortex in premanifest and early Huntington's disease by Hobbs, Nicola Z., Pedrick, Amy V., Say, Miranda J., Frost, Chris, Dar Santos, Rachelle, Coleman, Allison, Sturrock, Aaron, Craufurd, David, Stout, Julie C., Leavitt, Blair R., Barnes, Josephine, Tabrizi, Sarah J., Scahill, Rachael I.

“…The impact of Huntington's disease neuropathology on the structure of the cingulate is uncertain, with evidence of both cortical enlargement and atrophy in…”
Get full text

Short-interval observational data to inform clinical trial design in Huntington's disease by Hobbs, Nicola Z, Farmer, Ruth E, Rees, Elin M, Cole, James H, Haider, Salman, Malone, Ian B, Sprengelmeyer, Reiner, Johnson, Hans, Mueller, Hans-Peter, Sussmuth, Sigurd D, Roos, Raymund A C, Durr, Alexandra, Frost, Chris, Scahill, Rachael I, Landwehrmeyer, Bernhard, Tabrizi, Sarah J

“…ObjectivesTo evaluate candidate outcomes for disease-modifying trials in Huntington's disease (HD) over 6-month, 9-month and 15-month intervals, across…”
Get full text

Inconsistent emotion recognition deficits across stimulus modalities in Huntington's disease by REES, Elin M, FARMER, Ruth, COLE, James H, HENLEY, Susie M. D, SPRENGELMEYER, Reiner, FROST, Chris, SCAHILL, Rachael I, HOBBS, Nicola Z, TABRIZI, Sarah J

“…Background: Recognition of negative emotions is impaired in Huntington's Disease (HD). It is unclear whether these emotion-specific problems are driven by…”
Get full text

Defective emotion recognition in early HD is neuropsychologically and anatomically generic by Henley, Susie M.D., Wild, Edward J., Hobbs, Nicola Z., Warren, Jason D., Frost, Chris, Scahill, Rachael I., Ridgway, Gerard R., MacManus, David G., Barker, Roger A., Fox, Nick C., Tabrizi, Sarah J.

“…Huntington's disease (HD) is an inherited neurodegenerative disorder that classically presents with motor, cognitive and psychiatric symptoms. However, other…”
Get full text

Automated quantification of caudate atrophy by local registration of serial MRI: Evaluation and application in Huntington's disease by Hobbs, Nicola Z., Henley, Susie M.D., Wild, Edward J., Leung, Kelvin K., Frost, Chris, Barker, Roger A., Scahill, Rachael I., Barnes, Josephine, Tabrizi, Sarah J., Fox, Nick C.

“…Objective: Caudate atrophy rate measured from serial MRI is proposed as a biomarker of HD progression that may be of use in assessing putative…”
Get full text

Longitudinal Diffusion Tensor Imaging Shows Progressive Changes in White Matter in Huntington's Disease by Gregory, Sarah, Cole, James H, Farmer, Ruth E, Rees, Elin M, Roos, Raymund A C, Sprengelmeyer, Reiner, Durr, Alexandra, Landwehrmeyer, Bernhard, Zhang, Hui, Scahill, Rachael I, Tabrizi, Sarah J, Frost, Chris, Hobbs, Nicola Z

“…Huntington's disease is marked by progressive neuroanatomical changes, assumed to underlie the development of the disease's characteristic symptoms. Previous…”
Get more information