Search Results - "HO KEUNG NG"

International Society of Neuropathology-Haarlem Consensus Guidelines for Nervous System Tumor Classification and Grading by Louis, David N., Perry, Arie, Burger, Peter, Ellison, David W., Reifenberger, Guido, von Deimling, Andreas, Aldape, Kenneth, Brat, Daniel, Collins, V. Peter, Eberhart, Charles, Figarella-Branger, Dominique, Fuller, Gregory N., Giangaspero, Felice, Giannini, Caterina, Hawkins, Cynthia, Kleihues, Paul, Korshunov, Andrey, Kros, Johan M., Beatriz Lopes, M., Ng, Ho-Keung, Ohgaki, Hiroko, Paulus, Werner, Pietsch, Torsten, Rosenblum, Marc, Rushing, Elisabeth, Soylemezoglu, Figen, Wiestler, Otmar, Wesseling, Pieter

“…Major discoveries in the biology of nervous system tumors have raised the question of how non‐histological data such as molecular information can be…”
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IDH mutant lower grade (WHO Grades II/III) astrocytomas can be stratified for risk by CDKN2A, CDK4 and PDGFRA copy number alterations by Yang, Rui Ryan, Shi, Zhi‐feng, Zhang, Zhen‐yu, Chan, Aden Ka‐Yin, Aibaidula, Abudumijiti, Wang, Wei‐wei, Kwan, Johnny Sheung Him, Poon, Wai Sang, Chen, Hong, Li, Wen‐cai, Chung, Nellie Yuk‐Fei, Punchhi, Gopika, Chu, William Ching‐Yuen, Chan, Ivan Sik‐Hei, Liu, Xian‐zhi, Mao, Ying, Li, Kay Ka‐Wai, Ng, Ho‐Keung

“…In the 2016, WHO classification of tumors of the central nervous system, isocitrate dehydrogenase (IDH) mutation is a main classifier for lower grade…”
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Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells by Vinci, Mara, Burford, Anna, Molinari, Valeria, Kessler, Ketty, Popov, Sergey, Clarke, Matthew, Taylor, Kathryn R., Pemberton, Helen N., Lord, Christopher J., Gutteridge, Alice, Forshew, Tim, Carvalho, Diana, Marshall, Lynley V., Qin, Elizabeth Y., Ingram, Wendy J., Moore, Andrew S., Ng, Ho-Keung, Trabelsi, Saoussen, H’mida-Ben Brahim, Dorra, Entz-Werle, Natacha, Zacharoulis, Stergios, Vaidya, Sucheta, Mandeville, Henry C., Bridges, Leslie R., Martin, Andrew J., Al-Sarraj, Safa, Chandler, Christopher, Sunol, Mariona, Mora, Jaume, de Torres, Carmen, Cruz, Ofelia, Carcaboso, Angel M., Monje, Michelle, Mackay, Alan, Jones, Chris

“…The failure to develop effective therapies for pediatric glioblastoma (pGBM) and diffuse intrinsic pontine glioma (DIPG) is in part due to their intrinsic…”
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TP53 and Histone H3.3 Mutations in Triple-Negative Lower-Grade Gliomas by Chan, Aden K, Mao, Ying, Ng, Ho-Keung

“…Deletion of chromosome arms 1p and 19q and mutations in IDH and TERT define prognostic subgroups of low-grade gliomas. Gliomas without these lesions…”
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Prognostic impact of distinct genetic entities in pediatric diffuse glioma WHO‐grade II—Report from the German/Swiss SIOP‐LGG 2004 cohort by Falkenstein, Fabian, Gessi, Marco, Kandels, Daniela, Ng, Ho‐Keung, Schmidt, René, Warmuth‐Metz, Monika, Bison, Brigitte, Krauss, Juergen, Kortmann, Rolf‐Dieter, Timmermann, Beate, Thomale, Ulrich‐Wilhelm, Albert, Michael H., Pekrun, Arnulf, Maaß, Eberhard, Gnekow, Astrid K., Pietsch, Torsten

“…Reports on pediatric low‐grade diffuse glioma WHO‐grade II (DG2) suggest an impaired survival rate, but lack conclusive results for genetically defined…”
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Molecular landscape of IDH‐wild‐type, H3‐wild‐type glioblastomas of adolescents and young adults by Shi, Zhi‐Feng, Li, Kay Ka‐Wai, Huang, Queenie Jun‐Qi, Wang, Wei‐Wei, Kwan, Johnny Sheung‐Him, Chen, Hong, Liu, Xiang‐Zhi, Li, Wen‐Cai, Chan, Danny Tat‐Ming, Zhang, Zhen‐Yu, Mao, Ying, Ng, Ho‐Keung

“…Objective We aimed to characterise glioblastomas of adolescents and young adults (AYAs) that were isocitrate dehydrogenase (IDH) wild type (wt) and H3wt…”
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Whole‐exome sequencing revealed mutational profiles of giant cell glioblastomas by Shi, Zhi‐feng, Li, Kay Ka‐Wai, Kwan, Johnny Sheung Him, Yang, Rui Ryan, Aibaidula, Abudumijiti, Tang, Qisheng, Bao, Yifeng, Mao, Ying, Chen, Hong, Ng, Ho‐Keung

“…Giant cell glioblastoma (gcGBM) is a rare histological variant of GBM, accounting for about 1% of all GBM. The prognosis is poor generally though gcGBM does…”
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MiR-383 is Downregulated in Medulloblastoma and Targets Peroxiredoxin 3 (PRDX3) by Li, Kay Ka-Wai, Pang, Jesse Chung-Sean, Lau, Kin-Mang, Zhou, Liangfu, Mao, Ying, Wang, Yin, Poon, Wai-Sang, Ng, Ho-Keung

“…Accumulating evidence suggests that microRNAs (miRNAs) are over‐ or under‐expressed in tumors, and abnormalities in miRNA expression may contribute to…”
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Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study by Liu, Anthony P. Y., Li, Bryan K., Pfaff, Elke, Gudenas, Brian, Vasiljevic, Alexandre, Orr, Brent A., Dufour, Christelle, Snuderl, Matija, Karajannis, Matthias A., Rosenblum, Marc K., Hwang, Eugene I., Ng, Ho-Keung, Hansford, Jordan R., Szathmari, Alexandru, Faure-Conter, Cécile, Merchant, Thomas E., Levine, Max, Bouvier, Nancy, von Hoff, Katja, Mynarek, Martin, Rutkowski, Stefan, Sahm, Felix, Kool, Marcel, Hawkins, Cynthia, Onar-Thomas, Arzu, Robinson, Giles W., Gajjar, Amar, Pfister, Stefan M., Bouffet, Eric, Northcott, Paul A., Jones, David T. W., Huang, Annie

“…Recent genomic studies have shed light on the biology and inter-tumoral heterogeneity underlying pineal parenchymal tumors, in particular pineoblastomas (PBs)…”
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Molecular landscape of IDH-mutant primary astrocytoma Grade IV/glioblastomas by Wong, Queenie Hoi-Wing, Li, Kay Ka-Wai, Wang, Wei-Wei, Malta, Tathiane M., Noushmehr, Houtan, Grabovska, Yura, Jones, Chris, Chan, Aden Ka-Yin, Kwan, Johnny Sheung-Him, Huang, Queenie Jun-Qi, Wong, Gabriel Chun-Hei, Li, Wen-Cai, Liu, Xian-Zhi, Chen, Hong, Chan, Danny Tat-Ming, Mao, Ying, Zhang, Zhen-Yu, Shi, Zhi-Feng, Ng, Ho-Keung

“…WHO 2016 classified glioblastomas into IDH-mutant and IDH-wildtype with the former having a better prognosis but there was no study on IDH-mutant primary…”
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Molecular landscape of IDH‐wild type, pTERT‐wild type adult glioblastomas by Liu, Emma Munan, Shi, Zhi‐Feng, Li, Kay Ka‐Wai, Malta, Tathiane M., Chung, Nellie Yuk‐Fei, Chen, Hong, Chan, Janice Yuen‐Tung, Poon, Manix Fung‐Man, Kwan, Johnny Sheung‐Him, Chan, Danny Tat‐Ming, Noushmehr, Houtan, Mao, Ying, Ng, Ho‐Keung

“…Telomerase reverse transcriptase (TERT) promoter (pTERT) mutation has often been described as a late event in gliomagenesis and it has been suggested as a…”
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miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1 by Li, Kay Ka Wai, MPhil, Pang, Jesse Chung-sean, MSc, Ching, Arthur Ka-keung, PhD, Wong, Chun Kwok, PhD, Kong, Xiangyin, PhD, Wang, Yin, MD, Zhou, Liangfu, MD, Chen, Zhongping, MD, Ng, Ho-keung, MD

“…Summary Given that miR-124 is preferentially expressed in differentiating and mature neurons and external granule cells of cerebellum are thought to be…”
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Expanding the clinical and molecular spectrum of pituitary blastoma by Liu, Anthony Pak-Yin, Li, Kay Ka-Wai, Chow, Chit, Chan, Shing, Leung, Alex Wing-Kwan, Shing, Matthew Ming-Kong, To, Ka-Fai, Chan, Danny Tat-Ming, Chan, Godfrey Chi-Fung, Ng, Ho-Keung

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Clinical and mutational profiles of adult medulloblastoma groups by Wong, Gabriel Chun-Hei, Li, Kay Ka-Wai, Wang, Wei-Wei, Liu, Anthony Pak-Yin, Huang, Queenie Junqi, Chan, Aden Ka-Yin, Poon, Manix Fung-Man, Chung, Nellie Yuk-Fei, Wong, Queenie Hoi-Wing, Chen, Hong, Chan, Danny Tat Ming, Liu, Xian-Zhi, Mao, Ying, Zhang, Zhen-Yu, Shi, Zhi-Feng, Ng, Ho-Keung

“…Adult medulloblastomas are clinically and molecularly understudied due to their rarity. We performed molecular grouping, targeted sequencing, and TERT promoter…”
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Non-mitotic proliferation of malignant cancer cells revealed through live-cell imaging of primary and cell-line cultures by Tyagi, Iram Shazia, Tsui, Ho Yin Calvin, Chen, Si, Li, Xinyi, Mat, Wai-Kin, Khan, Muhammad A, Choy, Lucas Brendan, Chan, Ka-Yin Aden, Chan, Tat-Ming Danny, Ng, Chi-Ping Stephanie, Ng, Ho-Keung, Poon, Wai Sang, Xue, Hong

“…Anti-mitosis has been a key strategy of anti-cancer therapies, targeting at a fundamental property of cancer cells, their non-controllable proliferation due to…”
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Molecular landscapes of longitudinal NF2/22q and non‐NF2/22q meningiomas show different life histories by Ng, Ho‐Keung, Li, Kay Ka‐Wai, Chung, Nellie Yuk‐Fei, Chan, Janice Yuen‐Tung, Poon, Manix Fung‐Man, Wong, Queenie Hoi‐Wing, Kwan, Johnny Sheung‐Him, Poon, Wai‐Sang, Chen, Hong, Chan, Danny Tat‐Ming, Shi, Zhi‐Feng, Mao, Ying

“…Recurrence is a major complication of some meningiomas. Although there were many studies on biomarkers associated with higher grades or increased…”
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Pediatric low-grade gliomas can be molecularly stratified for risk by Yang, Rui Ryan, Aibaidula, Abudumijiti, Wang, Wei-wei, Chan, Aden Ka-Yin, Shi, Zhi-feng, Zhang, Zhen-yu, Chan, Danny Tat Ming, Poon, Wai Sang, Liu, Xian-zhi, Li, Wen-cai, Zhang, Rui-qi, Li, Yan-Xi, Chung, Nellie Yuk-Fei, Chen, Hong, Wu, Jingsong, Zhou, Liangfu, Li, Kay Ka-Wai, Ng, Ho-Keung

“…Pediatric low-grade gliomas (PLGGs) consist of a number of entities with overlapping histological features. PLGGs have much better prognosis than the adult…”
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Clinical significance of vasculogenic mimicry in human gliomas by Liu, Xiao-mei, Zhang, Qing-ping, Mu, Yong-gao, Zhang, Xiang-hen, Sai, Ke, Pang, Jesse Chung-Sean, Ng, Ho-Keung, Chen, Zhong-ping

“…Vasculogenic mimicry (VM) is known as non-endothelial tumor cell-lined microvascular channels in aggressive tumors. We have previously found the presence of VM…”
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Radiomic Features From Multi-Parameter MRI Combined With Clinical Parameters Predict Molecular Subgroups in Patients With Medulloblastoma by Yan, Jing, Liu, Lei, Wang, Weiwei, Zhao, Yuanshen, Li, Kay Ka-Wai, Li, Ke, Wang, Li, Yuan, Binke, Geng, Haiyang, Zhang, Shenghai, Liu, Zhen, Duan, Wenchao, Zhan, Yunbo, Pei, Dongling, Zhao, Haibiao, Sun, Tao, Sun, Chen, Wang, Wenqing, Hong, Xuanke, Wang, Xiangxiang, Guo, Yu, Li, Wencai, Cheng, Jingliang, Liu, Xianzhi, Ng, Ho-Keung, Li, Zhicheng, Zhang, Zhenyu

“…The 2016 WHO classification of central nervous system tumors has included four molecular subgroups under medulloblastoma (MB) as sonic hedgehog (SHH), wingless…”
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High Signal on T1 Sequence of Magnetic Resonance Imaging Confirmed to Be Intraplaque Haemorrhage by Histology in Middle Cerebral Artery by Chen, Xiang Yan, Wong, Ka Sing, Lam, Wynnie Wai Man, Ng, Ho-Keung

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