Search Results - "HISCOTT, John"

Triggering the Innate Antiviral Response through IRF-3 Activation by Hiscott, John

“…Rapid induction of type I interferon (IFN) expression is a central event in the establishment of the innate immune response against viral infection and…”
Get full text

Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists by Metcalf, Talibah U, Wilkinson, Peter A, Cameron, Mark J, Ghneim, Khader, Chiang, Cindy, Wertheimer, Anne M, Hiscott, John B, Nikolich-Zugich, Janko, Haddad, Elias K

“…Age-related alterations in immunity have been linked to increased incidence of infections and decreased responses to vaccines in the aging population. Human…”
Get full text

Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter by Belgnaoui, S Mehdi, Paz, Suzanne, Hiscott, John

“…Highlights ► Overview of RIG-I mediated signaling to the IFN antiviral response: specificity, complexity and diversity. ► Overview of the recent findings…”
Get full text

Cellular oxidative stress response controls the antiviral and apoptotic programs in dengue virus-infected dendritic cells by Olagnier, David, Peri, Suraj, Steel, Courtney, van Montfoort, Nadine, Chiang, Cindy, Beljanski, Vladimir, Slifker, Michael, He, Zhong, Nichols, Carmen N, Lin, Rongtuan, Balachandran, Siddharth, Hiscott, John

“…Dengue virus (DENV) is a re-emerging arthropod borne flavivirus that infects more than 300 million people worldwide, leading to 50,000 deaths annually. Because…”
Get full text

Introduction to Innate Sensing and Response to Pathogens (Part 2) by Hiscott, John, PhD

Get full text

Introduction to Innate Sensing and Response to Pathogens by Hiscott, John, PhD

Get full text

Type I Interferons in COVID-19 Pathogenesis by Palermo, Enrico, Di Carlo, Daniele, Sgarbanti, Marco, Hiscott, John

“…Among the many activities attributed to the type I interferon (IFN) multigene family, their roles as mediators of the antiviral immune response have emerged as…”
Get full text

Dengue Virus Targets Nrf2 for NS2B3-Mediated Degradation Leading to Enhanced Oxidative Stress and Viral Replication by Ferrari, Matteo, Zevini, Alessandra, Palermo, Enrico, Muscolini, Michela, Alexandridi, Magdalini, Etna, Marilena P, Coccia, Eliana M, Fernandez-Sesma, Ana, Coyne, Carolyn, Zhang, Donna D, Marques, Ernesto T A, Olagnier, David, Hiscott, John

“…Dengue virus (DENV) is a mosquito-borne virus that infects upward of 300 million people annually and has the potential to cause fatal hemorrhagic fever and…”
Get full text

Editorial: Insights in virus and host: 2021 by Hiscott, John, Brandt, Curtis R

Get full text

Global analyses revealed age‐related alterations in innate immune responses after stimulation of pathogen recognition receptors by Metcalf, Talibah U., Cubas, Rafael A., Ghneim, Khader, Cartwright, Michael J., Grevenynghe, Julien Van, Richner, Justin M., Olagnier, David P., Wilkinson, Peter A., Cameron, Mark J., Park, Byung S., Hiscott, John B., Diamond, Michael S., Wertheimer, Anne M., Nikolich‐Zugich, Janko, Haddad, Elias K.

“…Summary Aging leads to dysregulation of multiple components of the immune system that results in increased susceptibility to infections and poor response to…”
Get full text

A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response by Paz, Suzanne, Vilasco, Myriam, Werden, Steven J, Arguello, Meztli, Joseph-Pillai, Deshanthe, Zhao, Tiejun, Nguyen, Thi Lien-Anh, Sun, Qiang, Meurs, Eliane F, Lin, Rongtuan, Hiscott, John

“…Recognition of viral RNA structures by the cytosolic sensor retinoic acid-inducible gene-I （RIG-l） results in the activation of signaling cascades that…”
Get full text

Activation of Nrf2 Signaling Augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity by Olagnier, David, Lababidi, Rassin R., Hadj, Samar Bel, Sze, Alexandre, Liu, Yiliu, Naidu, Sharadha Dayalan, Ferrari, Matteo, Jiang, Yuan, Chiang, Cindy, Beljanski, Vladimir, Goulet, Marie-Line, Knatko, Elena V., Dinkova-Kostova, Albena T., Hiscott, John, Lin, Rongtuan

“…Oncolytic viruses (OVs) offer a promising therapeutic approach to treat multiple types of cancer. In this study, we show that the manipulation of the…”
Get full text

Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists by Chiang, Cindy, Beljanski, Vladimir, Yin, Kevin, Olagnier, David, Ben Yebdri, Fethia, Steel, Courtney, Goulet, Marie-Line, DeFilippis, Victor R, Streblow, Daniel N, Haddad, Elias K, Trautmann, Lydie, Ross, Ted, Lin, Rongtuan, Hiscott, John

“…The cytosolic RIG-I (retinoic acid-inducible gene I) receptor plays a pivotal role in the initiation of the immune response against RNA virus infection by…”
Get full text

RIG-I-Mediated Antiviral Signaling Is Inhibited in HIV-1 Infection by a Protease-Mediated Sequestration of RIG-I by SOLIS, Mayra, NAKHAEI, Peyman, JALALIRAD, Mohammad, LACOSTE, Judith, DOUVILLE, Renée, ARGUELLO, Meztli, TIEJUN ZHAO, LAUGHREA, Michael, WAINBERG, Mark A, HISCOTT, John

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Influenza Virus Down-Modulates G6PD Expression and Activity to Induce Oxidative Stress and Promote Its Replication by De Angelis, Marta, Amatore, Donatella, Checconi, Paola, Zevini, Alessandra, Fraternale, Alessandra, Magnani, Mauro, Hiscott, John, De Chiara, Giovanna, Palamara, Anna Teresa, Nencioni, Lucia

“…Influenza virus infection induces oxidative stress in host cells by decreasing the intracellular content of glutathione (GSH) and increasing reactive oxygen…”
Get full text

Virus-like particle - mediated delivery of the RIG-I agonist M8 induces a type I interferon response and protects cells against viral infection by Palermo, Enrico, Alexandridi, Magdalini, Di Carlo, Daniele, Muscolini, Michela, Hiscott, John

“…Virus-Like Particles (VLPs) are nanostructures that share conformation and self-assembly properties with viruses, but lack a viral genome and therefore the…”
Get full text

Triggering the Interferon Antiviral Response through an IKK-Related Pathway by Sharma, Sonia, tenOever, Benjamin R., Grandvaux, Nathalie, Zhou, Guo-Ping, Lin, Rongtuan, Hiscott, John

“…Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous…”
Get full text

Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon by Zhou, Qinjie, Lavorgna, Alfonso, Bowman, Melissa, Hiscott, John, Harhaj, Edward W.

“…The transcription factor IRF7 (interferon regulatory factor 7) is a key regulator of type I interferon and plays essential roles in restricting virus infection…”
Get full text

Linear Ubiquitination of NEMO Negatively Regulates the Interferon Antiviral Response through Disruption of the MAVS-TRAF3 Complex by Belgnaoui, S. Mehdi, Paz, Suzanne, Samuel, Sara, Goulet, Marie-Line, Sun, Qiang, Kikkert, Marjolein, Iwai, Kazuhiro, Dikic, Ivan, Hiscott, John, Lin, Rongtuan

“…The RIG-I/Mda5 sensors recognize viral intracellular RNA and trigger host antiviral responses. RIG-I signals through the adaptor protein MAVS, which engages…”
Get full text

Differential Regulation of Human Interferon A Gene Expression by Interferon Regulatory Factors 3 and 7 by Génin, Pierre, Lin, Rongtuan, Hiscott, John, Civas, Ahmet

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text