Search Results - "HIRST, David G"

Cell-Specific Radiosensitization by Gold Nanoparticles at Megavoltage Radiation Energies by Jain, Suneil, M.B., B.Ch, Coulter, Jonathan A., Ph.D, Hounsell, Alan R., Ph.D, Butterworth, Karl T., Ph.D, McMahon, Stephen J., Ph.D, Hyland, Wendy B., B.Sc. Hons, Muir, Mark F., B.Sc, Dickson, Glenn R., Ph.D, Prise, Kevin M., Ph.D, Currell, Fred J., Ph.D, O’Sullivan, Joe M., M.D, Hirst, David G., Ph.D

“…Purpose Gold nanoparticles (GNPs) have been shown to cause sensitization with kilovoltage (kV) radiation. Differences in the absorption coefficient between…”
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Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft by Senra, Joana M, Telfer, Brian A, Cherry, Kim E, McCrudden, Cian M, Hirst, David G, O'Connor, Mark J, Wedge, Stephen R, Stratford, Ian J

“…PARP-1 is a critical enzyme in the repair of DNA strand breaks. Inhibition of PARP-1 increases the effectiveness of radiation in killing tumor cells. However,…”
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Nanodosimetric effects of gold nanoparticles in megavoltage radiation therapy by McMahon, Stephen J, Hyland, Wendy B, Muir, Mark F, Coulter, Jonathan A, Jain, Suneil, Butterworth, Karl T, Schettino, Giuseppe, Dickson, Glenn R, Hounsell, Alan R, O’Sullivan, Joe M, Prise, Kevin M, Hirst, David G, Currell, Fred J

“…Abstract Background and purpose The addition of gold nanoparticles (GNPs) to tumours leads to an increase in dose due to their high density and energy…”
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Nitrosative stress in cancer therapy by Hirst, David G, Robson, Tracy

“…Reactive nitrogen species play important roles in cell signalling, but when present at high concentrations they can subject cells to nitrosative stress, which…”
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Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles by McMahon, Stephen J., Hyland, Wendy B., Muir, Mark F., Coulter, Jonathan A., Jain, Suneil, Butterworth, Karl T., Schettino, Giuseppe, Dickson, Glenn R., Hounsell, Alan R., O'Sullivan, Joe M., Prise, Kevin M., Hirst, David G., Currell, Fred J.

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The anti-migratory effects of FKBPL and its peptide derivative, AD-01: regulation of CD44 and the cytoskeletal pathway by Yakkundi, Anita, McCallum, Lynn, O'Kane, Anthony, Dyer, Hayder, Worthington, Jenny, McKeen, Hayley D, McClements, Lana, Elliott, Christopher, McCarthy, Helen O, Hirst, David G, Robson, Tracy

“…FK506 binding protein-like (FKBPL) and its peptide derivatives exert potent anti-angiogenic activity in vitro and in vivo and control tumour growth in…”
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Vasoactivity of rucaparib, a PARP-1 inhibitor, is a complex process that involves myosin light chain kinase, P2 receptors, and PARP itself by McCrudden, Cian M, O'Rourke, Martin G, Cherry, Kim E, Yuen, Hiu-Fung, O'Rourke, Declan, Babur, Muhammad, Telfer, Brian A, Thomas, Huw D, Keane, Patrick, Nambirajan, Thiagarajan, Hagan, Chris, O'Sullivan, Joe M, Shaw, Chris, Williams, Kaye J, Curtin, Nicola J, Hirst, David G, Robson, Tracy

“…Therapeutic inhibition of poly(ADP-ribose) polymerase (PARP), as monotherapy or to supplement the potencies of other agents, is a promising strategy in cancer…”
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Vasoactivity of AG014699, a Clinically Active Small Molecule Inhibitor of Poly(ADP-ribose) Polymerase: a Contributory Factor to Chemopotentiation In vivo? by ALI, Majid, TELFER, Brian A, CURTIN, Nicola J, WILLIAMS, Kaye J, MCCRUDDEN, Cian, O'ROURKE, Martin, THOMAS, Huw D, KAMJOO, Marzieh, KYLE, Suzanne, ROBSON, Tracy, SHAW, Chris, HIRST, David G

“…Purpose: Poly(ADP-ribose) polymerase (PARP) plays an important role in DNA repair, and PARP inhibitors can enhance the activity of DNA-damaging agents in vitro…”
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Electrical events underlying organized myogenic contractions of the guinea pig stomach by Hirst, G. David S., Edwards, Frank R.

“…The stomach generates a characteristic pattern of coordinated activity whereby rings of contraction regularly start in the corpus and migrate slowly down the…”
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Transcriptional Targeting in Cancer Gene Therapy by Robson, Tracy, Hirst, David G.

“…Cancer gene therapy has been one of the most exciting areas of therapeutic research in the past decade. In this review, we discuss strategies to restrict…”
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The contribution of N₂O₃ to the cytotoxicity of the nitric oxide donor DETA/NO: an emerging role for S-nitrosylation by Ali, Ahlam A, Coulter, Jonathan A, Ogle, Claire H, Migaud, Marie M, Hirst, David G, Robson, Tracy, McCarthy, Helen O

“…The relationship between the biological activity of NO and its chemistry is complex. The objectives of this study were to investigate the influence of oxygen…”
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Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles by McMahon, Stephen J., Hyland, Wendy B., Muir, Mark F., Coulter, Jonathan A., Jain, Suneil, Butterworth, Karl T., Schettino, Giuseppe, Dickson, Glenn R., Hounsell, Alan R., O'Sullivan, Joe M., Prise, Kevin M., Hirst, David G., Currell, Fred J.

“…Gold nanoparticles (GNPs) are being proposed as contrast agents to enhance X-ray imaging and radiotherapy, seeking to take advantage of the increased X-ray…”
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Role of Interstitial Cells of Cajal in the Control of Gastric Motility by Hirst, G. David S., Edwards, Frank R.

“…Most regions of the gastrointestinal tract generate spontaneous electrical and mechanical activity in the absence of stimulation. When electrical recordings…”
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Propagation of slow waves in the guinea-pig gastric antrum by Hirst, G. David S., Garcia‐Londoño, A. Pilar, Edwards, Frank R.

“…Intracellular recordings were made from the circular layer of the intact muscular wall of the guinea-pig gastric antrum in preparations where much of the…”
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Imaging and radiation effects of gold nanoparticles in tumour cells by McQuaid, Harold N., Muir, Mark F., Taggart, Laura E., McMahon, Stephen J., Coulter, Jonathan A., Hyland, Wendy B., Jain, Suneil, Butterworth, Karl T., Schettino, Giuseppe, Prise, Kevin M., Hirst, David G., Botchway, Stanley W., Currell, Fred J.

“…Gold nanoparticle radiosensitization represents a novel technique in enhancement of ionising radiation dose and its effect on biological systems. Variation…”
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Evaluation of the Antiangiogenic Potential of AQ4N by O'ROURKE, Martin, WARD, Claire, WORTHINGTON, Jenny, MCKENNA, Julie, VALENTINE, Andrea, ROBSON, Tracy, HIRST, David G, MCKEOWN, Stephanie R

“…Purpose: A number of cytotoxic chemotherapy agents tested at low concentrations show antiangiogenic properties with limited cytotoxicity, e.g.,…”
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Use of the radiation-inducible WAF1 promoter to drive iNOS gene therapy as a novel anti-cancer treatment by Worthington, Jenny, McCarthy, Helen O., Barrett, Eimear, Adams, Catherine, Robson, Tracy, Hirst, David G

“…Background Inducible nitric oxide synthase (iNOS) gene therapy has been identified as a potential anti‐tumour strategy. A major problem common to most gene…”
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An electrical analysis of slow wave propagation in the guinea-pig gastric antrum by Edwards, Frank R., Hirst, G. David S.

“…This paper provides an electrical description of the propagation of slow waves and pacemaker potentials in the guinea-pig gastric antrum in anal and…”
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Atypical slow waves generated in gastric corpus provide dominant pacemaker activity in guinea pig stomach by Hashitani, Hikaru, Garcia‐Londoño, A. Pilar, Hirst, G. David S., Edwards, Frank R.

“…When intracellular recordings were made from the circular layer of the intact muscular wall of the isolated guinea pig gastric corpus, an ongoing regular high…”
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Gold nanoparticle cellular uptake, toxicity and radiosensitisation in hypoxic conditions by Jain, Suneil, Coulter, Jonathan A, Butterworth, Karl T, Hounsell, Alan R, McMahon, Stephen J, Hyland, Wendy B, Muir, Mark F, Dickson, Glenn R, Prise, Kevin M, Currell, Fred J, Hirst, David G, O’Sullivan, Joe M

“…Abstract Background and purpose Gold nanoparticles (GNPs) are novel agents that have been shown to cause radiosensitisation in vitro and in vivo . Tumour…”
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