Search Results - "HIRSCH, Vanessa"

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers by Fukazawa, Yoshinori, Lum, Richard, Okoye, Afam A, Park, Haesun, Matsuda, Kenta, Bae, Jin Young, Hagen, Shoko I, Shoemaker, Rebecca, Deleage, Claire, Lucero, Carissa, Morcock, David, Swanson, Tonya, Legasse, Alfred W, Axthelm, Michael K, Hesselgesser, Joseph, Geleziunas, Romas, Hirsch, Vanessa M, Edlefsen, Paul T, Piatak, Michael, Estes, Jacob D, Lifson, Jeffrey D, Picker, Louis J

“…Fukazawa et al . report that SIV persists in follicular helper T cells in elite controller macaques, evading clearance by CD8+ T cells Chronic-phase HIV and…”
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The Host Restriction Factor APOBEC3G and Retroviral Vif Protein Coevolve due to Ongoing Genetic Conflict by Compton, Alex A., Hirsch, Vanessa M., Emerman, Michael

“…APOBEC3G (A3G) is a host cytidine deaminase that inhibits retroviruses. HIV and related primate lentiviruses encode Vif, which counteracts A3G by inducing its…”
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TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species by Kirmaier, Andrea, Wu, Fan, Newman, Ruchi M, Hall, Laura R, Morgan, Jennifer S, O'Connor, Shelby, Marx, Preston A, Meythaler, Mareike, Goldstein, Simoy, Buckler-White, Alicia, Kaur, Amitinder, Hirsch, Vanessa M, Johnson, Welkin E

“…Simian immunodeficiency viruses of sooty mangabeys (SIVsm) are the source of multiple, successful cross-species transmissions, having given rise to HIV-2 in…”
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Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections by Estes, Jacob D, Harris, Levelle D, Klatt, Nichole R, Tabb, Brian, Pittaluga, Stefania, Paiardini, Mirko, Barclay, G Robin, Smedley, Jeremy, Pung, Rhonda, Oliveira, Kenneth M, Hirsch, Vanessa M, Silvestri, Guido, Douek, Daniel C, Miller, Christopher J, Haase, Ashley T, Lifson, Jeffrey, Brenchley, Jason M

“…The chronic phase of HIV infection is marked by pathological activation of the immune system, the extent of which better predicts disease progression than…”
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Macrophages in Progressive Human Immunodeficiency Virus/Simian Immunodeficiency Virus Infections by DiNapoli, Sarah R, Hirsch, Vanessa M, Brenchley, Jason M

“…The cells that are targeted by primate lentiviruses (HIV and simian immunodeficiency virus [SIV]) are of intense interest given the renewed effort to identify…”
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Budding of a Retrovirus: Some Assemblies Required by Rose, Kevin M, Hirsch, Vanessa M, Bouamr, Fadila

“…One of the most important steps in any viral lifecycle is the production of progeny virions. For retroviruses as well as other viruses, this step is a highly…”
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Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques by Hessell, Ann J, Jaworski, J Pablo, Epson, Erin, Matsuda, Kenta, Pandey, Shilpi, Kahl, Christoph, Reed, Jason, Sutton, William F, Hammond, Katherine B, Cheever, Tracy A, Barnette, Philip T, Legasse, Alfred W, Planer, Shannon, Stanton, Jeffrey J, Pegu, Amarendra, Chen, Xuejun, Wang, Keyun, Siess, Don, Burke, David, Park, Byung S, Axthelm, Michael K, Lewis, Anne, Hirsch, Vanessa M, Graham, Barney S, Mascola, John R, Sacha, Jonah B, Haigwood, Nancy L

“…Hessell et al . report that post-exposure treatment with HIV-1–specific neutralizing antibodies clears SHIV infection from the blood and tissues of infant…”
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Tissue Myeloid Cells in SIV-Infected Primates Acquire Viral DNA through Phagocytosis of Infected T Cells by Calantone, Nina, Wu, Fan, Klase, Zachary, Deleage, Claire, Perkins, Molly, Matsuda, Kenta, Thompson, Elizabeth A., Ortiz, Alexandra M., Vinton, Carol L., Ourmanov, Ilnour, Loré, Karin, Douek, Daniel C., Estes, Jacob D., Hirsch, Vanessa M., Brenchley, Jason M.

“…The viral accessory protein Vpx, expressed by certain simian and human immunodeficiency viruses (SIVs and HIVs), is thought to improve viral infectivity of…”
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A SIV molecular clone that targets the CNS and induces neuroAIDS in rhesus macaques by Matsuda, Kenta, Riddick, Nadeene E, Lee, Cheri A, Puryear, Sarah B, Wu, Fan, Lafont, Bernard A P, Whitted, Sonya, Hirsch, Vanessa M

“…Despite effective control of plasma viremia with the use of combination antiretroviral therapies (cART), minor cognitive and motor disorders (MCMD) persist as…”
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TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation by Chiramel, Abhilash I, Meyerson, Nicholas R, McNally, Kristin L, Broeckel, Rebecca M, Montoya, Vanessa R, Méndez-Solís, Omayra, Robertson, Shelly J, Sturdevant, Gail L, Lubick, Kirk J, Nair, Vinod, Youseff, Brian H, Ireland, Robin M, Bosio, Catharine M, Kim, Kyusik, Luban, Jeremy, Hirsch, Vanessa M, Taylor, R Travis, Bouamr, Fadila, Sawyer, Sara L, Best, Sonja M

“…Tripartite motif-containing protein 5α (TRIM5α) is a cellular antiviral restriction factor that prevents early events in retrovirus replication. The activity…”
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SIV infection duration largely determines broadening of neutralizing antibody response in macaques by Wu, Fan, Ourmanov, Ilnour, Kirmaier, Andrea, Leviyang, Sivan, LaBranche, Celia, Huang, Jinghe, Whitted, Sonya, Matsuda, Kenta, Montefiori, David, Hirsch, Vanessa M

“…The development of broadly neutralizing antibodies (BNAbs) in HIV infection is a result of long-term coevolutionary interaction between viruses and antibodies…”
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The Canarypox Virus Vector ALVAC Induces Distinct Cytokine Responses Compared to the Vaccinia Virus-Based Vectors MVA and NYVAC in Rhesus Monkeys by Teigler, Jeffrey E, Phogat, Sanjay, Franchini, Genoveffa, Hirsch, Vanessa M, Michael, Nelson L, Barouch, Dan H

“…OA  Classifications Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts by Silvestri, Guido, Sodora, Donald L, Allan, Jonathan S, Apetrei, Cristian, Brenchley, Jason M, Douek, Daniel C, Else, James G, Estes, Jacob D, Hahn, Beatrice H, Hirsch, Vanessa M, Kaur, Amitinder, Kirchhoff, Frank, Muller-Trutwin, Michaela, Pandrea, Ivona, Schmitz, Jörn E

“…The design of an effective AIDS vaccine has eluded the efforts of the scientific community to the point that alternative approaches to classic vaccine…”
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Mutation in the Disordered Linker Region of Capsid Disrupts Viral Kinetics of a Neuropathogenic SIV in Rhesus Macaques by Lee, Cheri A, Hirsch, Vanessa M

“…TRIM5α polymorphism in rhesus macaques (RM) limits the genetic pool of animals in which we can perform simian immunodeficiency virus (SIV) studies without…”
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A Potent Anti-Simian Immunodeficiency Virus Neutralizing Antibody Induction Associated with a Germ Line Immunoglobulin Gene Polymorphism in Rhesus Macaques by Matsuoka, Saori, Kuwata, Takeo, Ishii, Hiroshi, Sekizuka, Tsuyoshi, Kuroda, Makoto, Sano, Masato, Okazaki, Midori, Yamamoto, Hiroyuki, Shimizu, Mikiko, Matsushita, Shuzo, Seki, Yohei, Saito, Akatsuki, Sakawaki, Hiromi, Hirsch, Vanessa M, Miura, Tomoyuki, Akari, Hirofumi, Matano, Tetsuro

“…Virus infection induces B cells with a wide variety of B-cell receptor (BCR) repertoires. Patterns of induced BCR repertoires are different in individuals,…”
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TRIM5 alpha drives SIVsmm evolution in rhesus macaques by Wu, Fan, Kirmaier, Andrea, Goeken, Robert, Ourmanov, Ilnour, Hall, Laura, Morgan, Jennifer S, Matsuda, Kenta, Buckler-White, Alicia, Tomioka, Keiko, Plishka, Ronald, Whitted, Sonya, Johnson, Welkin, Hirsch, Vanessa M

“…The antagonistic interaction with host restriction proteins is a major driver of evolutionary change for viruses. We previously reported that polymorphisms of…”
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Truncating the gp41 Cytoplasmic Tail of Simian Immunodeficiency Virus Decreases Sensitivity to Neutralizing Antibodies without Increasing the Envelope Content of Virions by White, Ellen, Wu, Fan, Chertova, Elena, Bess, Julian, Roser, James D, Lifson, Jeffrey D, Hirsch, Vanessa M

“…An incomplete understanding of native human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) envelope glycoproteins (Envs) impedes the…”
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Simian Immunodeficiency Virus-Infected Memory CD4 + T Cells Infiltrate to the Site of Infected Macrophages in the Neuroparenchyma of a Chronic Macaque Model of Neurological Complications of AIDS by Lee, Cheri A, Beasley, Erin, Sundar, Karthikeyan, Smelkinson, Margery, Vinton, Carol, Deleage, Claire, Matsuda, Kenta, Wu, Fan, Estes, Jake D, Lafont, Bernard A P, Brenchley, Jason M, Hirsch, Vanessa M

“…Simian immunodeficiency virus (SIV)-infected nonhuman primates can serve as a relevant model for AIDS neuropathogenesis. Current SIV-induced encephalitis…”
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CD4 downregulation by memory CD4 + T cells in vivo renders African green monkeys resistant to progressive SIVagm infection by Beaumier, Coreen M, Harris, Levelle D, Klatt, Nichole R, Apetrei, Cristian, Pandrea, Ivona, Brenchley, Jason M, Goldstein, Simoy, Whitted, Sonya, McGinty, John, Hirsch, Vanessa M

“…Natural hosts of simian immunodeficiency virus (SIV)—such as African green monkeys—have evolved to tolerate SIV infection without developing immune deficiency…”
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Erratum: Rose et al. When in Need of an ESCRT: The Nature of Virus Assembly Sites Suggests Mechanistic Parallels between Nuclear Virus Egress and Retroviral Budding. Viruses 2021, 13 , 1138 by Rose, Kevin M, Spada, Stephanie J, Hirsch, Vanessa M, Bouamr, Fadila

“…The authors wish to make the following erratum to this paper [...]…”
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