Search Results - "HIRSCH, C"

Ten Unsolved Questions About Neuroinflammation in Parkinson's Disease by Hirsch, Etienne C., Standaert, David G.

“…Parkinson's disease is a progressive and debilitating disorder that has so far eluded attempts to develop disease‐modifying treatment. Both epidemiological and…”
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Neuroinflammation in Parkinson's disease: a target for neuroprotection? by Hirsch, Etienne C, PhD, Hunot, Stéphane, PhD

“…Summary Parkinson's disease is characterised by a slow and progressive degeneration of dopaminergic neurons in the substantia nigra. Despite intensive…”
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Pathogenesis of Parkinson's disease by Hirsch, Etienne C., Jenner, Peter, Przedborski, Serge

“…Parkinson's disease is a common adult‐onset neurodegenerative disorder whose pathogenesis remains essentially unknown. Currently, it is believed that the…”
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Missing pieces in the Parkinson's disease puzzle by Obeso, Jose A, Rodriguez-Oroz, Maria C, Goetz, Christopher G, Marin, Concepcion, Kordower, Jeffrey H, Rodriguez, Manuel, Hirsch, Etienne C, Farrer, Matthew, Schapira, Anthony H V, Halliday, Glenda

“…Parkinson's disease is a neurodegenerative process characterized by numerous motor and nonmotor clinical manifestations for which effective, mechanism-based…”
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Can a decision support system accelerate rare disease diagnosis? Evaluating the potential impact of Ada DX in a retrospective study by Ronicke, Simon, Hirsch, Martin C, Türk, Ewelina, Larionov, Katharina, Tientcheu, Daphne, Wagner, Annette D

“…Rare disease diagnosis is often delayed by years. A primary factor for this delay is a lack of knowledge and awareness regarding rare diseases. Probabilistic…”
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Genomic determinants of chronic myelomonocytic leukemia by Patel, B J, Przychodzen, B, Thota, S, Radivoyevitch, T, Visconte, V, Kuzmanovic, T, Clemente, M, Hirsch, C, Morawski, A, Souaid, R, Saygin, C, Nazha, A, Demarest, B, LaFramboise, T, Sakaguchi, H, Kojima, S, Carraway, H E, Ogawa, S, Makishima, H, Sekeres, M A, Maciejewski, J P

“…The biology, clinical phenotype and progression rate of chronic myelomonocytic leukemia (CMML) are highly variable due to diverse initiating and secondary…”
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Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model by Alvarez-Fischer, Daniel, Noelker, Carmen, Vulinović, Franca, Grünewald, Anne, Chevarin, Caroline, Klein, Christine, Oertel, Wolfgang H, Hirsch, Etienne C, Michel, Patrick P, Hartmann, Andreas

“…Bee venom has recently been suggested to possess beneficial effects in the treatment of Parkinson disease (PD). For instance, it has been observed that…”
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Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass by Gaies, Michael G, Gurney, James G, Yen, Alberta H, Napoli, Michelle L, Gajarski, Robert J, Ohye, Richard G, Charpie, John R, Hirsch, Jennifer C

“…Inotrope score has been proposed as a marker of illness severity after pediatric cardiac surgery despite a lack of data to support its use as such. The goal of…”
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The iron-binding protein lactoferrin protects vulnerable dopamine neurons from degeneration by preserving mitochondrial calcium homeostasis by Rousseau, Erwann, Michel, Patrick P, Hirsch, Etienne C

“…Previous studies on postmortem human brain tissue have shown that the iron-binding glycoprotein lactoferrin is upregulated in dopamine (DA) neurons resistant…”
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Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease by Karachi, Carine, Grabli, David, Bernard, Frédéric A, Tandé, Dominique, Wattiez, Nicolas, Belaid, Hayat, Bardinet, Eric, Prigent, Annick, Nothacker, Hans-Peter, Hunot, Stéphane, Hartmann, Andreas, Lehéricy, Stéphane, Hirsch, Etienne C, François, Chantal

“…Gait disorders and postural instability, which are commonly observed in elderly patients with Parkinson disease (PD), respond poorly to dopaminergic agents…”
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Understanding Dopaminergic Cell Death Pathways in Parkinson Disease by Michel, Patrick P., Hirsch, Etienne C., Hunot, Stéphane

“…Parkinson disease (PD) is a multifactorial neurodegenerative disorder, the etiology of which remains largely unknown. Progressive impairment of voluntary motor…”
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Multi-objective optimization of turbomachinery using improved NSGA-II and approximation model by Wang, X.D., Hirsch, C., Kang, Sh, Lacor, C.

“…Coupled optimization methods based on multi-objective genetic algorithms and approximation models are widely used in engineering optimizations. In the present…”
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The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease by DAMIER, P, HIRSCH, E. C, AGID, Y, GRAYBIEL, A. M

“…To achieve accuracy in studying the patterns of loss of midbrain dopamine-containing neurons in Parkinson's disease, we used compartmental patterns of…”
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Identification of an optimal dose of intravenous ketamine for late-life treatment-resistant depression: a Bayesian adaptive randomization trial by Lijffijt, Marijn, Murphy, Nicholas, Iqbal, Sidra, Green, Charles E, Iqbal, Tabish, Chang, Lee C, Haile, Colin N, Hirsch, Lorna C, Ramakrishnan, Nithya, Fall, Dylan A, Swann, Alan C, Al Jurdi, Rayan K, Mathew, Sanjay J

“…Evidence supporting specific therapies for late-life treatment-resistant depression (LL-TRD) is necessary. This study used Bayesian adaptive randomization to…”
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JNK-Mediated Induction of Cyclooxygenase 2 Is Required for Neurodegeneration in a Mouse Model of Parkinson's Disease by Hunot, Stéphane, Vila, Miquel, Teismann, Peter, Davis, Roger J., Hirsch, Etienne C., Przedborski, Serge, Rakic, Pasko, Flavell, Richard A.

“…Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopamine-containing neurons, but the molecular pathways underlying its…”
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Adoption and perception of prescribable digital health applications (DiGA) and the advancing digitalization among German internal medicine physicians: a cross-sectional survey study by Cirkel, Lasse, Lechner, Fabian, Schlicker, Nadine, Leipe, Jan, Mühlensiepen, Felix, Grgic, Ivica, Hirsch, Martin C., Kuhn, Sebastian, Knitza, Johannes

“…Abstract Background Therapeutic digital health applications (DiGAs) are expected to significantly enhance access to evidence-based care. Since 2020, German…”
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Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease by Salazar, Julio, Mena, Natalia, Hunot, Stephane, Prigent, Annick, Alvarez-Fischer, Daniel, Arredondo, Miguel, Duyckaerts, Charles, Sazdovitch, Veronique, Zhao, Lin, Garrick, Laura M, Nuñez, Marco T, Garrick, Michael D, Raisman-Vozari, Rita, Hirsch, Etienne C

“…Dopaminergic cell death in the substantia nigra (SN) is central to Parkinson's disease (PD), but the neurodegenerative mechanisms have not been completely…”
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Dysfunction of mitochondrial Lon protease and identification of oxidized protein in mouse brain following exposure to MPTP: Implications for Parkinson disease by Bulteau, Anne-Laure, Mena, Natalia P., Auchère, Françoise, Lee, Irene, Prigent, Annick, Lobsiger, Christian S., Camadro, Jean-Michel, Hirsch, Etienne C.

“…Compelling evidence suggests that mitochondrial dysfunction leading to reactive oxygen species (ROS) production and protein oxidation could represent a…”
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Health economic benefits through the use of diagnostic support systems and expert knowledge by Willmen, Tina, Völkel, Lukas, Ronicke, Simon, Hirsch, Martin C, Kaufeld, Jessica, Rychlik, Reinhard P, Wagner, Annette D

“…Rare diseases are difficult to diagnose. Due to their rarity, heterogeneity, and variability, rare diseases often result not only in extensive diagnostic tests…”
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A role for CD4+CD25+ T cells in regulation of the immune response during human tuberculosis by Ribeiro‐Rodrigues, R., Resende Co, T., Rojas, R., Toossi, Z., Dietze, R., Boom, W. H., Maciel, E., Hirsch, C. S.

“…Summary Active tuberculosis (TB) is associated with prolonged suppression of Mycobacterium tuberculosis (MTB)‐specific immune responses, but mechanisms…”
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