Search Results - "HIROYUKI SASAKI"

The UHRF protein family in epigenetics, development, and carcinogenesis by UNOKI, Motoko, SASAKI, Hiroyuki

“…The UHRF protein family consists of multidomain regulatory proteins that sense modification status of DNA and/or proteins and catalyze the ubiquitylation of…”
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Generation of human oogonia from induced pluripotent stem cells in vitro by Yamashiro, Chika, Sasaki, Kotaro, Yabuta, Yukihiro, Kojima, Yoji, Nakamura, Tomonori, Okamoto, Ikuhiro, Yokobayashi, Shihori, Murase, Yusuke, Ishikura, Yukiko, Shirane, Kenjiro, Sasaki, Hiroyuki, Yamamoto, Takuya, Saitou, Mitinori

“…Human in vitro gametogenesis may transform reproductive medicine. Human pluripotent stem cells (hPSCs) have been induced into primordial germ cell-like cells…”
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Reprogramming of the histone H3.3 landscape in the early mouse embryo by Ishiuchi, Takashi, Abe, Shusaku, Inoue, Kimiko, Yeung, Wan Kin Au, Miki, Yuka, Ogura, Atsuo, Sasaki, Hiroyuki

“…Epigenetic reprogramming of the zygote involves dynamic incorporation of histone variant H3.3. However, the genome-wide distribution and dynamics of H3.3…”
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CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome by Unoki, Motoko, Funabiki, Hironori, Velasco, Guillaume, Francastel, Claire, Sasaki, Hiroyuki

“…Mutations in CDCA7 and HELLS that respectively encode a CXXC-type zinc finger protein and an SNF2 family chromatin remodeler cause immunodeficiency,…”
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Gut Microbiota-Derived Short Chain Fatty Acids Induce Circadian Clock Entrainment in Mouse Peripheral Tissue by Tahara, Yu, Yamazaki, Mayu, Sukigara, Haruna, Motohashi, Hiroaki, Sasaki, Hiroyuki, Miyakawa, Hiroki, Haraguchi, Atsushi, Ikeda, Yuko, Fukuda, Shinji, Shibata, Shigenobu

“…Microbiota-derived short-chain fatty acids (SCFAs) and organic acids produced by the fermentation of non-digestible fibre can communicate from the microbiome…”
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Genomic imprinting in mammals： its life cycle, molecular mechanisms and reprogramming by Li, Yufeng, Sasaki, Hiroyuki

“…Genomic imprinting, an epigenetic gene-marking phenomenon that occurs in the germline, leads to parental-origin-specific expression of a small subset of genes…”
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Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence by Sasaki, Hiroyuki, Hamatani, Toshio, Kamijo, Shintaro, Iwai, Maki, Kobanawa, Masato, Ogawa, Seiji, Miyado, Kenji, Tanaka, Mamoru

“…Reproductive capacity in women starts to decline beyond their mid-30s and pregnancies in older women result in higher rates of miscarriage with aneuploidy…”
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Genomic Imprinting and Physiological Processes in Mammals by Tucci, Valter, Isles, Anthony R., Kelsey, Gavin, Ferguson-Smith, Anne C., Tucci, Valter, Bartolomei, Marisa S., Benvenisty, Nissim, Bourc’his, Déborah, Charalambous, Marika, Dulac, Catherine, Feil, Robert, Glaser, Juliane, Huelsmann, Lisa, John, Rosalind M., McNamara, Gráinne I., Moorwood, Kim, Muscatelli, Francoise, Sasaki, Hiroyuki, Strassmann, Beverly I., Vincenz, Claudius, Wilkins, Jon, Isles, Anthony R., Kelsey, Gavin, Ferguson-Smith, Anne C.

“…Complex multicellular organisms, such as mammals, express two complete sets of chromosomes per nucleus, combining the genetic material of both parents…”
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Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos by Maenohara, Shoji, Unoki, Motoko, Toh, Hidehiro, Ohishi, Hiroaki, Sharif, Jafar, Koseki, Haruhiko, Sasaki, Hiroyuki

“…The methylation of cytosine at CG sites in the mammalian genome is dynamically reprogrammed during gametogenesis and preimplantation development. It was…”
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The DNMT3A ADD domain is required for efficient de novo DNA methylation and maternal imprinting in mouse oocytes by Uehara, Ryuji, Au Yeung, Wan Kin, Toriyama, Keisuke, Ohishi, Hiroaki, Kubo, Naoki, Toh, Hidehiro, Suetake, Isao, Shirane, Kenjiro, Sasaki, Hiroyuki

“…Establishment of a proper DNA methylation landscape in mammalian oocytes is important for maternal imprinting and embryonic development. De novo DNA…”
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Mouse oocyte methylomes at base resolution reveal genome-wide accumulation of non-CpG methylation and role of DNA methyltransferases by Shirane, Kenjiro, Toh, Hidehiro, Kobayashi, Hisato, Miura, Fumihito, Chiba, Hatsune, Ito, Takashi, Kono, Tomohiro, Sasaki, Hiroyuki

“…DNA methylation is an epigenetic modification that plays a crucial role in normal mammalian development, retrotransposon silencing, and cellular reprogramming…”
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An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence by Liu, Yiwei, Toh, Hidehiro, Sasaki, Hiroyuki, Zhang, Xing, Cheng, Xiaodong

“…Zinc finger transcription factor Zfp57 recognizes the methylated CpG within the TGCCGC element. We determined the structure of the DNA-binding domain of Zfp57,…”
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Production of functional oocytes requires maternally expressed PIWI genes and piRNAs in golden hamsters by Hasuwa, Hidetoshi, Iwasaki, Yuka W., Au Yeung, Wan Kin, Ishino, Kyoko, Masuda, Harumi, Sasaki, Hiroyuki, Siomi, Haruhiko

“…Many animals have a conserved adaptive genome defence system known as the Piwi-interacting RNA (piRNA) pathway, which is essential for germ cell development…”
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Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes by Yano, Seiichi, Ishiuchi, Takashi, Abe, Shusaku, Namekawa, Satoshi H., Huang, Gang, Ogawa, Yoshihiro, Sasaki, Hiroyuki

“…Establishment of the DNA methylation landscape of mammalian oocytes, mediated by the DNMT3A-DNMT3L complex, is crucial for reproduction and development. In…”
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Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development by Hirasawa, Ryutaro, Chiba, Hatsune, Kaneda, Masahiro, Tajima, Shoji, Li, En, Jaenisch, Rudolf, Sasaki, Hiroyuki

“…Parental origin-specific DNA methylation regulates the monoallelic expression of the mammalian imprinted genes. The methylation marks or imprints are…”
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Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells by Kubo, Naoki, Uehara, Ryuji, Uemura, Shuhei, Ohishi, Hiroaki, Shirane, Kenjiro, Sasaki, Hiroyuki

“…DNA methyltransferase 3A (DNMT3A) and its catalytically inactive cofactor DNA methyltransferase 3-Like (DNMT3L) proteins form functional heterotetramers to…”
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Genomic imprinting and its relevance to congenital disease, infertility, molar pregnancy and induced pluripotent stem cell by Tomizawa, Shin-ichi, Sasaki, Hiroyuki

“…Genomic imprinting is an epigenetic gene-marking phenomenon that occurs in the germline, whereby genes are expressed from only one of the two parental copies…”
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The Sendai Framework for Disaster Risk Reduction: Renewing the Global Commitment to People’s Resilience, Health, and Well-being by Aitsi-Selmi, Amina, Egawa, Shinichi, Sasaki, Hiroyuki, Wannous, Chadia, Murray, Virginia

“…The Sendai Framework for Disaster Risk Reduction 2015–2030 (SFDRR) is the first global policy framework of the United Nations’ post-2015 agenda. It represents…”
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Defects in dosage compensation impact global gene regulation in the mouse trophoblast by Sakata, Yuka, Nagao, Koji, Hoki, Yuko, Sasaki, Hiroyuki, Obuse, Chikashi, Sado, Takashi

“…RNA, which is responsible for X inactivation, is a key epigenetic player in the embryogenesis of female mammals. Of the several repeats conserved in RNA, the…”
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Setdb1 is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells by Liu, Sheng, Brind'Amour, Julie, Karimi, Mohammad M, Shirane, Kenjiro, Bogutz, Aaron, Lefebvre, Louis, Sasaki, Hiroyuki, Shinkai, Yoichi, Lorincz, Matthew C

“…Transcription of endogenous retroviruses (ERVs) is inhibited by de novo DNA methylation during gametogenesis, a process initiated after birth in oocytes and at…”
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