Search Results - "HIROTA, Keiji"

The pathogenicity of Th17 cells in autoimmune diseases by Yasuda, Keiko, Takeuchi, Yusuke, Hirota, Keiji

“…IL-17-producing T helper (Th17) cells have been implicated in the pathogenesis of many inflammatory and autoimmune diseases. Targeting the effector cytokines…”
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An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation by Wilhelm, Christoph, Hirota, Keiji, Stieglitz, Benjamin, Van Snick, Jacques, Tolaini, Mauro, Lahl, Katharina, Sparwasser, Tim, Helmby, Helena, Stockinger, Brigitta

“…The cellular sources of IL-9 in lung inflammation remain unknown. Stockinger and colleagues use an IL-9 reporter to show IL-9 production is restricted to…”
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Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis by Hirota, Keiji, Hashimoto, Motomu, Ito, Yoshinaga, Matsuura, Mayumi, Ito, Hiromu, Tanaka, Masao, Watanabe, Hitomi, Kondoh, Gen, Tanaka, Atsushi, Yasuda, Keiko, Kopf, Manfred, Potocnik, Alexandre J., Stockinger, Brigitta, Sakaguchi, Noriko, Sakaguchi, Shimon

“…Despite the importance of Th17 cells in autoimmune diseases, it remains unclear how they control other inflammatory cells in autoimmune tissue damage. Using a…”
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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins by Veldhoen, Marc, Hirota, Keiji, Westendorf, Astrid M., Buer, Jan, Dumoutier, Laure, Renauld, Jean-Christophe, Stockinger, Brigitta

“…Toxins and autoimmunity The aryl hydrocarbon receptor (AHR) is a transcription factor best known for mediating the toxicity of aromatic hydrocarbons such as…”
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Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation by Yasuda, Keiko, Kitagawa, Yohko, Kawakami, Ryoji, Isaka, Yoshitaka, Watanabe, Hitomi, Kondoh, Gen, Kohwi-Shigematsu, Terumi, Sakaguchi, Shimon, Hirota, Keiji

“…The genome organizer, special AT-rich sequence-binding protein-1 (Satb1), plays a pivotal role in the regulation of global gene networks in a cell…”
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Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions by Di Meglio, Paola, Duarte, João H., Ahlfors, Helena, Owens, Nick D.L., Li, Ying, Villanova, Federica, Tosi, Isabella, Hirota, Keiji, Nestle, Frank O., Mrowietz, Ulrich, Gilchrist, Michael J., Stockinger, Brigitta

“…Environmental stimuli are known to contribute to psoriasis pathogenesis and that of other autoimmune diseases, but the mechanisms are largely unknown. Here we…”
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Uniformity and Efficacy of Dry Powders Delivered to the Lungs of a Mycobacterial-Surrogate Rat Model of Tuberculosis by Hirota, Keiji, Hirai, Yutaka, Nakajima, Takehisa, Goto, Satoru, Makino, Kimiko, Terada, Hiroshi

“…Purpose Pulmonary administration of dry drug powder is a considered promising strategy in the treatment of various lung diseases such as tuberculosis and is…”
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Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo by Duarte, João H, Di Meglio, Paola, Hirota, Keiji, Ahlfors, Helena, Stockinger, Brigitta

“…The aryl hydrocarbon receptor (AhR) has been attributed with anti-inflammatory effects in the development of pathological immune responses leading to…”
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Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model by Hirota, Keiji, Yoshitomi, Hiroyuki, Hashimoto, Motomu, Maeda, Shinji, Teradaira, Shin, Sugimoto, Naoshi, Yamaguchi, Tomoyuki, Nomura, Takashi, Ito, Hiromu, Nakamura, Takashi, Sakaguchi, Noriko, Sakaguchi, Shimon

“…This report shows that interleukin (IL) 17-producing T helper type 17 (Th17) cells predominantly express CC chemokine receptor (CCR) 6 in an animal model of…”
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Synovial Tissue Inflammation Mediated by Autoimmune T Cells by Takeuchi, Yusuke, Hirota, Keiji, Sakaguchi, Shimon

“…In rheumatoid arthritis (RA), various hematopoietic and non-hematopoietic cells present in the synovial tissue secrete numerous inflammatory mediators…”
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Foxp3+ Regulatory T Cells Inhibit CCl4-Induced Liver Inflammation and Fibrosis by Regulating Tissue Cellular Immunity by Ikeno, Yoshinobu, Ohara, Daiya, Takeuchi, Yusuke, Watanabe, Hitomi, Kondoh, Gen, Taura, Kojiro, Uemoto, Shinji, Hirota, Keiji

“…Foxp3+ regulatory T (Treg) cells are pivotal in maintaining immunological self-tolerance and tissue homeostasis; however, it remains unclear how tissue Treg…”
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Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis by Sugimoto, Naoshi, Oida, Takatoku, Hirota, Keiji, Nakamura, Kyoko, Nomura, Takashi, Uchiyama, Takashi, Sakaguchi, Shimon

“…Naturally occurring CD25+CD4+ regulatory T cells (Tregs) actively engage in the maintenance of immunologic self-tolerance and immunoregulation. They…”
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Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis by Takeuchi, Yusuke, Ohara, Daiya, Watanabe, Hitomi, Sakaguchi, Noriko, Sakaguchi, Shimon, Kondoh, Gen, Morinobu, Akio, Mimori, Tsuneyo, Hirota, Keiji

“…Programmed necrosis, such as necroptosis and pyroptosis, is a highly pro-inflammatory cellular event that is associated with chronic inflammation. Although…”
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Lipid raft dynamics linked to sperm competency for fertilization in mice by Watanabe, Hitomi, Takeda, Rie, Hirota, Keiji, Kondoh, Gen

“…It is well known that mammalian sperm acquires fertilization ability after several maturation processes, particularly within the female reproductive tract. In…”
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Complement drives Th17 cell differentiation and triggers autoimmune arthritis by Hashimoto, Motomu, Hirota, Keiji, Yoshitomi, Hiroyuki, Maeda, Shinji, Teradaira, Shin, Akizuki, Shuji, Prieto-Martin, Paz, Nomura, Takashi, Sakaguchi, Noriko, Köhl, Jörg, Heyman, Birgitta, Takahashi, Minoru, Fujita, Teizo, Mimori, Tsuneyo, Sakaguchi, Shimon

“…Activation of serum complement triggers Th17 cell-dependent spontaneous autoimmune disease in an animal model. In genetically autoimmune-prone SKG mice,…”
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Correction to: The pathogenicity of Th17 cells in autoimmune diseases by Yasuda, Keiko, Takeuchi, Yusuke, Hirota, Keiji

“…Unfortunately, an error occurred in the following passus of the article. The word “receptor” was missing in the sentence “Because T cells do not express GM-CSF…”
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Regulation and function of innate and adaptive interleukin-17-producing cells by Hirota, Keiji, Ahlfors, Helena, Duarte, João H, Stockinger, Brigitta

“…Interleukin‐17 (IL‐17)‐mediated immune responses play a crucial role in the mucosal host defence against microbial and fungal pathogens. However, the chronic…”
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Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection by Hojo, Miki Arai, Masuda, Kyoko, Hojo, Hiroaki, Nagahata, Yosuke, Yasuda, Keiko, Ohara, Daiya, Takeuchi, Yusuke, Hirota, Keiji, Suzuki, Yutaka, Kawamoto, Hiroshi, Kawaoka, Shinpei

“…During thymic negative selection, autoreactive thymocytes carrying T cell receptor (TCR) with overtly strong affinity to self-MHC/self-peptide are removed by…”
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Optimum conditions for efficient phagocytosis of rifampicin-loaded PLGA microspheres by alveolar macrophages by Hirota, Keiji, Hasegawa, Taizo, Hinata, Hideyuki, Ito, Fuminori, Inagawa, Hiroyuki, Kochi, Chie, Soma, Gen-Ichiro, Makino, Kimiko, Terada, Hiroshi

“…We examined the phagocytic activities of alveolar macrophages (NR8383 cells) toward poly(lactic-co-glycolic) acid (PLGA) microspheres (MS) loaded with the…”
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Targeting abatacept-resistant T-helper-17 cells by aldehyde dehydrogenase inhibition by Tokifuji, Yukiko, Hayabuchi, Hodaka, Sasaki, Takashi, Hara-Chikuma, Mariko, Hirota, Keiji, Takahashi, Hayato, Amagai, Masayuki, Yoshimura, Akihiko, Chikuma, Shunsuke

“…IL-17-producing helper T (Th17) cells are long-lived and serve as central effector cells in chronic autoimmune diseases. The underlying mechanisms of Th17…”
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