Search Results - "HIROSHI MAEJIMA"

Exercise enhances cognitive function and neurotrophin expression in the hippocampus accompanied by changes in epigenetic programming in senescence-accelerated mice by Maejima, Hiroshi, Kanemura, Naohiko, Kokubun, Takanori, Murata, Kenji, Takayanagi, Kiyomi

“…•Long term exercise improves cognitive function in the senescence-accelerated mice.•Long term exercise enhances the expression of BDNF in the hippocampus.•Long…”
Get full text

Effects of exercise and pharmacological inhibition of histone deacetylases (HDACs) on epigenetic regulations and gene expressions crucial for neuronal plasticity in the motor cortex by Maejima, Hiroshi, Kitahara, Mika, Takamatsu, Yasuyuki, Mani, Hiroki, Inoue, Takahiro

“…•HDAC inhibition decreased total HDAC activity in the motor cortex.•HDAC inhibition increased acetylation level of histone H4 and H3 in the motor…”
Get full text

Epigenetic modifications in the motor cortex caused by exercise or pharmacological inhibition of histone deacetylases (HDACs) after intracerebral hemorrhage (ICH) by Maejima, Hiroshi, Okamura, Misato, Inoue, Takahiro, Takamatsu, Yasuyuki, Nishio, Taichi, Liu, Yushan

“…[Display omitted] •ICH decreased acetylation of histone H4 in the ipsilateral cortex.•HDAC inhibitor removed the attenuated acetylation after ICH improving…”
Get full text

Exercise enhances the expression of brain-derived neurotrophic factor in the hippocampus accompanied by epigenetic alterations in senescence-accelerated mice prone 8 by Li, Xiang, Inoue, Takahiro, Hayashi, Masataka, Maejima, Hiroshi

“…•Exercise enhanced the expression of hippocampal BDNF in SAM mice.•Exercise down-regulated hippocampal p75 in SAM mice.•Aging decreased the activity of histone…”
Get full text

Temporal dynamics of brain BDNF expression following a single bout of exercise: A bioluminescence imaging study by Inoue, Takahiro, Ikegami, Ryo, Takamatsu, Yasuyuki, Fukuchi, Mamoru, Haga, Sanae, Ozaki, Michitaka, Maejima, Hiroshi

“…[Display omitted] •This study examined how BDNF expression changes after exercise using in vivo bioluminescence imaging.•Relative luminescence signal…”
Get full text

Exercise and pharmacological inhibition of histone deacetylase improves cognitive function accompanied by an increase of gene expressions crucial for neuronal plasticity in the hippocampus by Kitahara, Mika, Inoue, Takahiro, Mani, Hiroki, Takamatsu, Yasuyuki, Ikegami, Ryo, Tohyama, Harukazu, Maejima, Hiroshi

“…•HDAC inhibition improved cognitive function.•Exercise in the presence of HDAC inhibition improved cognitive function.•HDAC inhibition enhanced hippocampal…”
Get full text

Effects of detraining on preconditioning exercise-induced neuroprotective potential after ischemic stroke in rats by Otsuka, Shotaro, Sakakima, Harutoshi, Tani, Akira, Nakanishi, Kazuki, Takada, Seiya, Norimatsu, Kosuke, Maejima, Hiroshi, Maruyama, Ikuro

“…Preconditioning exercise prior to stroke exerts neuroprotection, which is an endogenous strategy that leads the brain cells to express several intrinsic…”
Get full text

Exercise Plus Pharmacological Neuromodulation of Synaptic Inhibition Enhance Motor Function Recovery After Ischemic Stroke by Inoue, Takahiro, Okamura, Misato, Kitahara, Mika, Takamatsu, Yasuyuki, Sakakima, Harutoshi, Maejima, Hiroshi

“…•Co-application of exercise and a low-level GABAA antagonist facilitated motor functional recovery after stroke.•Co-application of exercise and a low-level…”
Get full text

Low-Level Inhibition of GABAergic Synapses Enhances Gene Expressions Crucial for Neuronal Plasticity in the Hippocampus After Ischemic Stroke by Okamura, Misato, Inoue, Takahiro, Takamatsu, Yasuyuki, Maejima, Hiroshi

“…•Ischemic stroke increases the expression of BDNF receptor in the hippocampus.•Inhibition of GABAergic synapses increases hippocampal synaptophysin after…”
Get full text

Learning effects of dynamic postural control by auditory biofeedback versus visual biofeedback training by Hasegawa, Naoya, Takeda, Kenta, Sakuma, Moe, Mani, Hiroki, Maejima, Hiroshi, Asaka, Tadayoshi

“…•Learning effects of auditory BF versus visual BF training were investigated.•Sensory BF changed according to the distance between the real-time COP and…”
Get full text

Exercise and low-level GABAA receptor inhibition modulate locomotor activity and the expression of BDNF accompanied by changes in epigenetic regulation in the hippocampus by Maejima, Hiroshi, Ninuma, Shuta, Okuda, Akane, Inoue, Takahiro, Hayashi, Masataka

“…•Long-term exercise enhances the expression of BDNF in the hippocampus.•Long-term exercise activates acetyltransferase in the hippocampus.•Inhibition of…”
Get full text

Effects of long-term exercise and low-level inhibition of GABAergic synapses on motor control and the expression of BDNF in the motor related cortex by Inoue, Takahiro, Ninuma, Shuta, Hayashi, Masataka, Okuda, Akane, Asaka, Tadayoshi, Maejima, Hiroshi

“…Brain-derived neurotrophic factor (BDNF) plays important roles in neuroplasticity in the brain. The objective of this study was to examine the effects of…”
Get full text

Specific inhibition of α5 subunit-containing GABAA receptors enhances locomotor activity and neuronal activity in the motor cortex by INOUE, Takahiro, TAKAMATSU, Yasuyuki, OKAMURA, Misato, MANI, Hiroki, HASEGAWA, Naoya, MAEJIMA, Hiroshi

“…Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the central nervous system (CNS). This study examined the effect of specific…”
Get full text

Epigenetic modification of histone acetylation in the sensorimotor cortex after intracerebral hemorrhage by Nishio, Taichi, Inoue, Takahiro, Takamatsu, Yasuyuki, Mishima, Taiga, Takamura, Hana, Soma, Kiho, Kondo, Yuki, Okamura, Misato, Ikegami, Ryo, Maejima, Hiroshi

“…Epigenetic regulation is involved in post-stroke neuroplasticity. We investigated the effects of intracerebral hemorrhage (ICH) on histone acetylation and gene…”
Get more information

Effects of aging and treadmill exercise on cognitive function and the expression of BDNF in the hippocampus by Maejima, Hiroshi, Kanemura, Naohiko, Kokubun, Takanori, Murata, Kenji, Takayanagi, Kiyomi

“…Abstract only Neurotrophins play a crucial role in neuroplasticity, neurogenesis, and neuroprotection in the central nervous system. Aerobic exercise is known…”
Get full text

Decline of Hip Joint Movement Relates to Overestimation of Maximum Forward Reach in Elderly Persons by Okimoto, Atsushi, Toriyama, Minoru, Deie, Masataka, Maejima, Hiroshi

“…The authors aimed to characterize age-related changes in the performance of maximum reach and identify kinematic parameters that explain the age-related…”
Get full text

Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii by Nakamura, Fumiaki, Maejima, Hiroshi, Kawamura, Midori, Arai, Daisuke, Okino, Tatsufumi, Zhao, Meng, Ye, Tao, Lee, Jungyeol, Chang, Young-Tae, Fusetani, Nobuhiro, Nakao, Yoichi

“…[Display omitted] •A new cyclic pentapeptide isolated from the marine cyanobacterium.•Moderately cytotoxic against HeLa cells.•Induced differentiation of…”
Get full text

Adaptation effects in static postural control by providing simultaneous visual feedback of center of pressure and center of gravity by Takeda, Kenta, Mani, Hiroki, Hasegawa, Naoya, Sato, Yuki, Tanaka, Shintaro, Maejima, Hiroshi, Asaka, Tadayoshi

“…The benefit of visual feedback of the center of pressure (COP) on quiet standing is still debatable. This study aimed to investigate the adaptation effects of…”
Get full text

Distinct Sites Regulating Grayanotoxin Binding and Unbinding to D4S6 of Nav1.4 Sodium Channel as Revealed by Improved Estimation of Toxin Sensitivity by Maejima, Hiroshi, Kinoshita, Eiji, Seyama, Issei, Yamaoka, Kaoru

“…Grayanotoxin (GTX) exerts selective effects on voltage-dependent sodium channels by eliminating fast sodium inactivation and causing a hyperpolarizing shift in…”
Get full text

Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells by Nakao, Yoichi, Narazaki, Genta, Hoshino, Takuhiro, Maeda, Satoko, Yoshida, Minoru, Maejima, Hiroshi, Yamashita, Jun K.

“…Evaluation of antiangiogenic activity of azumamide E is reported. Evaluation of antiangiogenic activity of marine sponge derived azumamides by the in vitro…”
Get full text