Search Results - "HIROSE, Tomoyasu"

Afidopyropen, a novel insecticide originating from microbial secondary extracts by Horikoshi, Ryo, Goto, Kimihiko, Mitomi, Masaaki, Oyama, Kazuhiko, Hirose, Tomoyasu, Sunazuka, Toshiaki, Ōmura, Satoshi

“…Afidopyropen, a novel insecticide, is a derivative of pyripyropene A, which is produced by the filamentous fungus Penicillium coprobium. Afidopyropen has…”
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Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A(H1N1)pdm09 virus infection by interfering with virus internalization process by Tran, Dat Huu, Sugamata, Ryuichi, Hirose, Tomoyasu, Suzuki, Shoichi, Noguchi, Yoshihiko, Sugawara, Akihiro, Ito, Fuyu, Yamamoto, Tomoko, Kawachi, Shoji, Akagawa, Kiyoko S., Ōmura, Satoshi, Sunazuka, Toshiaki, Ito, Naoki, Mimaki, Masakazu, Suzuki, Kazuo

“…The pandemic influenza 2009 (A(H1N1)pdm09) virus currently causes seasonal and annual epidemic outbreaks. The widespread use of anti-influenza drugs such as…”
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Discoveries and Syntheses of Highly Potent Antimalarial Troponoids by Saito, Ryo, Sennari, Goh, Nakajima, Asuka, Kimishima, Aoi, Iwatsuki, Masato, Ishiyama, Aki, Hokari, Rei, Hirose, Tomoyasu, Sunazuka, Toshiaki

“…Novel derivatives of puberulic acid were synthesized and their antimalarial properties were evaluated in vitro against the Plasmodium falciparum K1 parasite…”
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Studies on the Catechin Constituents of Bark of Cinnamomum sieboldii by Hirose, Tomoyasu, Ozaki, Kaori, Saito, Yukiko, Takai-Todaka, Reiko, Matsui, Hidehito, Honsho, Masako, Iwatsuki, Masato, Asami, Yukihiro, Katayama, Kazuhiko, Sunazuka, Toshiaki, Hanaki, Hideaki, Teruya, Toshiaki

“…Screening for bioactivity related to anti-infective, anti-methicillin-resistant Staphylococcus aureus (MRSA) and anti-viral activity, led us to identify active…”
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Synthesis of the Antimalarial Peptide Aldehyde, a Precursor of Kozupeptin A, Utilizing a Designed Hydrophobic Anchor Molecule by Hayashi, Yumi, Hirose, Tomoyasu, Iwatsuki, Masato, O̅mura, Satoshi, Sunazuka, Toshiaki

“…This Letter describes an efficient method of synthesizing highly bioactive peptide aldehydes without any concern about epimerization by liquid-phase peptide…”
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Medermycin Inhibits TNFα-Promoted Inflammatory Reaction in Human Synovial Fibroblasts by Inoue, Sho, Inahashi, Yuki, Itakura, Makoto, Inoue, Gen, Muneshige, Kyoko, Hirose, Tomoyasu, Iwatsuki, Masato, Takaso, Masashi, Miyagi, Masayuki, Uchida, Kentaro

“…Synovial inflammation plays a crucial role in the destruction of joints and the experience of pain in osteoarthritis (OA). Emerging evidence suggests that…”
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Pot-economical synthesis of cyclic depsipeptides using a hydrophobic anchor molecule toward the construction of an unnatural peptide library by Noguchi, Yoshihiko, Sekikawa, Shogo, Nogaki, Yutaka, Satake, Yudai, Murashima, Norifumi, Kirisawa, Takashi, Schiffer, Guido, Köebberling, Johannes, Hirose, Tomoyasu, Sunazuka, Toshiaki

“…Cyclic peptides and cyclic depsipeptides are important sources of novel lead compounds in drug discovery research. However, solid phase peptide synthesis…”
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Towards the total synthesis of aurodox: Preparation of the key hemiacetal-lactone by Ohara, Motoyoshi, Ikeda, Akari, Nakajima, Asuka, Ōno, Takanori, Noguchi, Yoshihiko, Watanabe, Akito, Hirose, Tomoyasu, Sunazuka, Toshiaki

“…[Display omitted] •Toward the total synthesis of aurodox.•Chemo- and stereo-selective epoxidation.•Construction of 5-membered lactone in cascade sequence. We…”
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Pd-catalyzed Regio- and Stereoselective Hydrostannylation of an Alkyl Ethynyl Ether/One-Pot Stille Coupling Enables the Synthesis of 14-Membered Macrolactone of Luminamicin by Sugawara, Akihiro, Takada, Hirokazu, Hirose, Tomoyasu, Kimishima, Aoi, Yamada, Takeshi, Toda, Masaki, Kojima, Toru, Matsumaru, Takanori, Sunazuka, Toshiaki

“…Regio- and stereoselective hydrostannylation of alkyl ethynyl ethers generates alkenyl ethers, which are useful building blocks in organic synthesis. This…”
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A new analog of dihydroxybenzoic acid from Saccharopolyspora sp. KR21-0001 by Janthanom, Rattiya, Kikuchi, Yuta, Kanto, Hiroki, Hirose, Tomoyasu, Tahara, Arisu, Ishii, Takahiro, Thamchaipenet, Arinthip, Inahashi, Yuki

“…Actinomycetes are well-known as the main producers of bioactive compounds such as antibiotics, anticancers, and immunosuppressants. Screening of natural…”
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Koshidacins A and B, Antiplasmodial Cyclic Tetrapeptides from the Okinawan Fungus Pochonia boninensis FKR-0564 by Watanabe, Yoshihiro, Hachiya, Kodai, Ikeda, Akari, Nonaka, Kenichi, Higo, Mayuka, Muramatsu, Reiko, Noguchi, Chikako, Honsho, Masako, Asami, Yukihiro, Inahashi, Yuki, Hirose, Tomoyasu, Matsui, Hidehito, Sunazuka, Toshiaki, Hanaki, Hideaki, Ishii, Takahiro, Teruya, Toshiaki, Hokari, Rei, Ishiyama, Aki, Iwatsuki, Masato

“…Two new antiplasmodial peptides, named koshidacins A (1) and B (2), were discovered from the culture broth of the Okinawan fungus Pochonia boninensis FKR-0564…”
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Synthesis and Evaluation of Antibacterial Activity of Bottromycins by Yamada, Takeshi, Yagita, Miu, Kobayashi, Yutaka, Sennari, Goh, Shimamura, Hiroyuki, Matsui, Hidehito, Horimatsu, Yuki, Hanaki, Hideaki, Hirose, Tomoyasu, O̅mura, Satoshi, Sunazuka, Toshiaki

“…Total synthesis of bottromycin A2 can be accomplished through a diastereoselective Mannich reaction of a chiral sulfinamide, mercury-mediated intermolecular…”
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Fusaramin, an antimitochondrial compound produced by Fusarium sp., discovered using multidrug-sensitive Saccharomyces cerevisiae by Sakai, Katsuyuki, Unten, Yufu, Iwatsuki, Masato, Matsuo, Hirotaka, Fukasawa, Wataru, Hirose, Tomoyasu, Chinen, Takumi, Nonaka, Kenichi, Nakashima, Takuji, Sunazuka, Toshiaki, Usui, Takeo, Murai, Masatoshi, Miyoshi, Hideto, Asami, Yukihiro, Ōmura, Satoshi, Shiomi, Kazuro

“…A new compound, fusaramin ( 1 ), along with three known compounds, sambutoxin ( 2 ), N -demethylsambutoxin ( 3 ) and (−)-6-deoxyoxysporidinone ( 4 ), was…”
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Synthesis and insecticidal efficacy of pyripyropene derivatives. Part II—Invention of afidopyropen by Goto, Kimihiko, Horikoshi, Ryo, Mitomi, Masaaki, Oyama, Kazuhiko, Hirose, Tomoyasu, Sunazuka, Toshiaki, Ōmura, Satoshi

“…The synthesis and insecticidal activity of a series of pyripyropene derivatives with cyclopropanecarbonyloxy group(s) at the C-1, C-7 and/or C-11 position(s)…”
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Actinoallolides A–E, New Anti-trypanosomal Macrolides, Produced by an Endophytic Actinomycete, Actinoallomurus fulvus MK10-036 by Inahashi, Yuki, Iwatsuki, Masato, Ishiyama, Aki, Matsumoto, Atsuko, Hirose, Tomoyasu, Oshita, Jun, Sunazuka, Toshiaki, Panbangred, Watanalai, Takahashi, Yoko, Kaiser, Marcel, Otoguro, Kazuhiko, O̅mura, Satoshi

“…Five new anti-trypanosomal macrolides, actinoallolides A–E (1–5), were discovered from the cultured broth of Actinoallomurus fulvus MK10-036. The structures of…”
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Unified enantioselective total synthesis of 3,6-dioxygenated diketopiperazine natural products, diatretol and lepistamides A, B and C by Takahashi, Shu, Kimishima, Aoi, Hirose, Tomoyasu, Yamada, Takeshi, Sugawara, Akihiro, Shirahata, Tatsuya, Noguchi, Yoshihiko, Iwatsuki, Masato, Hokari, Rei, Ishiyama, Aki, Kobayashi, Yoshinori, Sunazuka, Toshiaki

“…[Display omitted] •Total synthesis and determination of the absolute configuration of Dietretol was accomplished.•This synthetic approach involves the use of a…”
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Synthesis and insecticidal efficacy of pyripyropene derivatives focusing on the C-1, C-7, and C-11 positions’ substituent groups by Goto, Kimihiko, Horikoshi, Ryo, Mitomi, Masaaki, Oyama, Kazuhiko, Hirose, Tomoyasu, Sunazuka, Toshiaki, Ōmura, Satoshi

“…The C-1, C-7, and C-11 positions of pyripyropene A were chemically modified to improve the insecticidal activity. Some derivatives showed higher insecticidal…”
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Efficient synthesis of a ryanodine binding inhibitor verticilide using two practical approaches by Watanabe, Akito, Noguchi, Yoshihiko, Hirose, Tomoyasu, Monma, Souichi, Satake, Yudai, Arai, Takahiro, Masuda, Kei, Murashima, Norifumi, Shiomi, Kazuro, Ōmura, Satoshi, Sunazuka, Toshiaki

“…[Display omitted] •Total synthesis of symmetrical 24 membered cyclicdepsipeptide.•Solid support and hydrophobic anchor molecule are practical and efficient…”
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Fungal Secondary Metabolite Exophillic Acid Selectively Inhibits the Entry of Hepatitis B and D Viruses by Kobayashi, Chisa, Watanabe, Yoshihiro, Oshima, Mizuki, Hirose, Tomoyasu, Yamasaki, Masako, Iwamoto, Masashi, Iwatsuki, Masato, Asami, Yukihiro, Kuramochi, Kouji, Wakae, Kousho, Aizaki, Hideki, Muramatsu, Masamichi, Sureau, Camille, Sunazuka, Toshiaki, Watashi, Koichi

“…Current anti-hepatitis B virus (HBV) drugs are suppressive but not curative for HBV infection, so there is considerable demand for the development of new…”
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Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2 by Nakanishi, Anna, Okumura, Hiroki, Hashita, Tadahiro, Yamashita, Aya, Nishimura, Yuka, Watanabe, Chihiro, Kamimura, Sakina, Hayashi, Sanae, Murakami, Shuko, Ito, Kyoko, Iwao, Takahiro, Ikeda, Akari, Hirose, Tomoyasu, Sunazuka, Toshiaki, Tanaka, Yasuhito, Matsunaga, Tamihide

“…Hepatitis B virus (HBV) specifically infects human hepatocytes and increases the risks of cirrhosis and liver cancer. Currently, nucleic acid analogs are the…”
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