Search Results - "HIROHASHI, S"

Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma by Yoshikawa, D, Ojima, H, Iwasaki, M, Hiraoka, N, Kosuge, T, Kasai, S, Hirohashi, S, Shibata, T

“…Epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), and human epidermal growth factor receptor 2 (HER2) have been considered as…”
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Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma by Yoshikawa, D, Ojima, H, Kokubu, A, Ochiya, T, Kasai, S, Hirohashi, S, Shibata, T

“…Cholangiocarcinoma is an intractable cancer, with no effective therapy other than surgical resection. Elevated vascular endothelial growth factor (VEGF) and…”
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Diffusion Anisotropy and Diffusivity of White Matter Tracts Within the Temporal Stem in Alzheimer Disease: Evaluation of the "Tract of Interest" by Diffusion Tensor Tractography by Taoka, T, Iwasaki, S, Sakamoto, M, Nakagawa, H, Fukusumi, A, Myochin, K, Hirohashi, S, Hoshida, T, Kichikawa, K

“…Our aim was to determine whether diffusion anisotropy and diffusivity of white matter tracts of the temporal stem in patients with Alzheimer (AD) can be…”
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DEK oncoprotein regulates transcriptional modifiers and sustains tumor initiation activity in high-grade neuroendocrine carcinoma of the lung by Shibata, T, Kokubu, A, Miyamoto, M, Hosoda, F, Gotoh, M, Tsuta, K, Asamura, H, Matsuno, Y, Kondo, T, Imoto, I, Inazawa, J, Hirohashi, S

“…Lung cancer shows diverse histological subtypes. Large-cell neuroendocrine cell carcinoma and small-cell lung carcinoma show similar histological features and…”
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Transactivation of the multidrug resistance 1 gene by T-cell factor 4/β-catenin complex in early colorectal carcinogenesis by YAMADA, Tesshi, TAKAOKA, Asako S, NAISHIRO, Yasuyoshi, HAYASHI, Reiko, MARUYAMA, Keiji, MAESAWA, Chihaya, OCHIAI, Atsushi, HIROHASHI, Setsuo

“…The mutational inactivation of a tumor suppressor gene, adenomatous polyposis coli (APC), results in the accumulation of cytoplasmic beta-catenin protein and…”
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Silencing of the E-Cadherin Invasion-Suppressor Gene by CpG Methylation in Human Carcinomas by Yoshiura, Kenta, Kanai, Yae, Ochiai, Atsushi, Shimoyama, Yutaka, Sugimura, Takashi, Hirohashi, Setsuo

“…E-Cadherin, a cell adhesion molecule, which plays a key role in maintaining the epithelial phenotype, is regarded as an invasion-suppressor gene in light of…”
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Expression profile of early lung adenocarcinoma: identification of MRP3 as a molecular marker for early progression by Hanada, S, Maeshima, A, Matsuno, Y, Ohta, T, Ohki, M, Yoshida, T, Hayashi, Y, Yoshizawa, Y, Hirohashi, S, Sakamoto, M

“…Early lung adenocarcinoma is well-recognized as a small-sized non-invasive adenocarcinoma or localized non-mucinous bronchioloalveolar carcinoma (LNMBAC);…”
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Expression of enamel proteins and LEF1 in adamantinomatous craniopharyngioma: evidence for its odontogenic epithelial differentiation by Sekine, S, Takata, T, Shibata, T, Mori, M, Morishita, Y, Noguchi, M, Uchida, T, Kanai, Y, Hirohashi, S

“…Aims:  Adamantinomatous craniopharyngioma (ACP) resembles histologically some odontogenic tumours, such as ameloblastoma and calcifying odontogenic cyst…”
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Aberrant O-glycosylation inhibits stable expression of dysadherin, a carcinoma-associated antigen, and facilitates cell–cell adhesion by Tsuiji, Hitomi, Takasaki, Seiichi, Sakamoto, Michiie, Irimura, Tatsuro, Hirohashi, Setsuo

“…Recently, we identified dysadherin, a novel carcinoma-associated glycoprotein, and showed that overexpression of dysadherin in human hepatocarcinoma PLC/PRF/5…”
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Genomic loss and epigenetic silencing of very-low-density lipoprotein receptor involved in gastric carcinogenesis by TAKADA, H, IMOTO, I, TSUDA, H, NAKANISHI, Y, SAKAKURA, C, MITSUFUJI, S, HIROHASHI, S, INAZAWA, J

“…Homozygous loss in the genomic sequence, a mechanism for inactivating tumor-suppressor genes (TSGs) in cancer, has been used as a tag for the identification of…”
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Prognostic significance of dysadherin expression in advanced colorectal carcinoma by AOKI, S, SHIMAMURA, T, SHIBATA, T, NAKANISHI, Y, MORIYA, Y, SATO, Y, KITAJIMA, M, SAKAMOTO, M, HIROHASHI, S

“…A novel glycoprotein, dysadherin, has an anti-cell - cell adhesion function through downregulating E-cadherin. In this study, we investigated the expressions…”
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Implications of peritoneal washing cytology in patients with potentially resectable pancreatic cancer by Yachida, S., Fukushima, N., Sakamoto, M., Matsuno, Y., Kosuge, T., Hirohashi, S.

“…Background: The aim of this study was to assess the implications of positive peritoneal washing cytology for management of patients with potentially resectable…”
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Actinin-4 is preferentially involved in circular ruffling and macropinocytosis in mouse macrophages: analysis by fluorescence ratio imaging by Araki, N, Hatae, T, Yamada, T, Hirohashi, S

“…We have applied fluorescence ratio imaging to the analysis of an actin-binding protein concentration relative to F-actin in macrophages, in order to explore…”
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In breast carcinoma dysadherin expression is correlated with invasiveness but not with E-cadherin by BATISTATOU, A, PESCHOS, D, TSANOU, H, CHARALABOPOULOS, A, NAKANISHI, Y, HIROHASHI, S, AGNANTIS, N. J, CHARALABOPOULOS, K

“…Reduction/loss of E-cadherin is associated with the development and progression of many epithelial tumours. Dysadherin, recently characterised by members of…”
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Expression of Dysadherin and E-Cadherin in Trophoblastic Tissue in Normal and Abnormal Pregnancies by Batistatou, A, Makrydimas, G, Zagorianakou, N, Zagorianakou, P, Nakanishi, Y, Agnantis, N.J, Hirohashi, S, Charalabopoulos, K

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Involvement of dysadherin and E-cadherin in the development of testicular tumours by BATISTATOU, A, SCOPA, C. D, RAVAZOULA, P, NAKANISHI, Y, PESCHOS, D, AGNANTIS, N. J, HIROHASHI, S, CHARALABOPOULOS, K. A

“…Testicular neoplasms are comprised of a variety of histologically different forms, and their pathogenesis has not been elucidated. Dysadherin is a recently…”
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Pfetin as a Prognostic Biomarker in Gastrointestinal Stromal Tumor: Novel Monoclonal Antibody and External Validation Study in Multiple Clinical Facilities by Kikuta, Kazutaka, Gotoh, Masahiro, Kanda, Tatsuo, Tochigi, Naobumi, Shimoda, Tadakazu, Hasegawa, Tadashi, Katai, Hitoshi, Shimada, Yasuhiro, Suehara, Yoshiyuki, Kawai, Akira, Hirohashi, Setsuo, Kondo, Tadashi

“…Objective The clinical course of gastrointestinal stromal tumor (GIST) spans a wide spectrum from a curable disorder to a highly malignant disease that leads…”
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Natural History and Prognosis of Adenomatous Hyperplasia and Early Hepatocellular Carcinoma: Multi-institutional Analysis of 53 Nodules Followed Up for More Than 6 Months and 141 Patients with Single Early Hepatocellular Carcinoma Treated by Surgical Resection or Percutaneous Ethanol Injection by Sakamoto, Michiie, Hirohashi, Setsuo

“…Background: The natural history and posttherapeutic outcome of adenomatous hyperplasia and early hepatocellular carcinoma have rarely been analyzed. Methods:…”
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Cadherin intercellular adhesion molecule in hepatocellular carcinomas: loss of E-cadherin expression in an undifferentiated carcinoma by Shimoyama, Y, Hirohashi, S

“…Expression of E- and P-cadherin in 24 primary hepatocellular carcinomas, together with the non-cancerous liver tissue from each case, was examined by…”
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E-Cadherin Gene Mutations in Human Gastric Carcinoma Cell Lines by Oda, Tatsuya, Kanai, Yae, Oyama, Tsukasa, Yoshiura, Kenta, Shimoyama, Yutaka, Birchmeier, Walter, Sugimura, Takashi, Hirohashi, Setsuo

“…Reduced expression of E-cadherin has been regarded as one of the main molecular events involved in dysfunction of the cell-cell adhesion system, triggering…”
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