Search Results - "HIRBE, Angela C"

Neurofibromatosis type 1: a multidisciplinary approach to care by Hirbe, Angela C, MD, Gutmann, David H, Dr

“…Summary Neurofibromatosis type 1 is a relatively common inherited disorder. Patients have a high predisposition to develop both benign and malignant tumours…”
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Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas by Pekmezci, Melike, Reuss, David E, Hirbe, Angela C, Dahiya, Sonika, Gutmann, David H, von Deimling, Andreas, Horvai, Andrew E, Perry, Arie

“…Cellular schwannoma is an uncommon, but well-recognized, benign peripheral nerve sheath tumor, which can be misdiagnosed as malignant peripheral nerve sheath…”
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Cell-free DNA ultra-low-pass whole genome sequencing to distinguish malignant peripheral nerve sheath tumor (MPNST) from its benign precursor lesion: A cross-sectional study by Szymanski, Jeffrey J, Sundby, R Taylor, Jones, Paul A, Srihari, Divya, Earland, Noah, Harris, Peter K, Feng, Wenjia, Qaium, Faridi, Lei, Haiyan, Roberts, David, Landeau, Michele, Bell, Jamie, Huang, Yi, Hoffman, Leah, Spencer, Melissa, Spraker, Matthew B, Ding, Li, Widemann, Brigitte C, Shern, Jack F, Hirbe, Angela C, Chaudhuri, Aadel A

“…The leading cause of mortality for patients with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome is the development of malignant peripheral…”
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Treatment decisions and the use of MEK inhibitors for children with neurofibromatosis type 1-related plexiform neurofibromas by Armstrong, Amy E, Belzberg, Allan J, Crawford, John R, Hirbe, Angela C, Wang, Zhihong J

“…Neurofibromatosis type 1 (NF1), the most common tumor predisposition syndrome, occurs when NF1 gene variants result in loss of neurofibromin, a negative…”
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A Retrospective Analysis of the Efficacy of Immunotherapy in Metastatic Soft-Tissue Sarcomas by Monga, Varun, Skubitz, Keith M, Maliske, Seth, Mott, Sarah L, Dietz, Hilary, Hirbe, Angela C, Van Tine, Brian A, Oppelt, Peter, Okuno, Scott, Robinson, Steven, O'Connor, Madeline, Seetharam, Mahesh, Attia, Steven, Charlson, John, Agulnik, Mark, Milhem, Mohammed

“…Although checkpoint inhibitors have been approved in multiple cancers, they are still under investigation in soft tissue sarcoma (STS). We conducted a…”
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The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling by Su, Xinming, Floyd, Desiree H, Hughes, Alun, Xiang, Jingyu, Schneider, Jochen G, Uluckan, Ozge, Heller, Emanuela, Deng, Hongju, Zou, Wei, Craft, Clarissa S, Wu, Kaiming, Hirbe, Angela C, Grabowska, Dorota, Eagleton, Mark C, Townsley, Sarah, Collins, Lynne, Piwnica-Worms, David, Steinberg, Thomas H, Novack, Deborah V, Conley, Pamela B, Hurchla, Michelle A, Rogers, Michael, Weilbaecher, Katherine N

“…The adenosine diphosphate (ADP) receptor P2RY12 (purinergic receptor P2Y, G protein coupled, 12) plays a critical role in platelet aggregation, and P2RY12…”
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RelB is the NF-κB subunit downstream of NIK responsible for osteoclast differentiation by Vaira, Sergio, Johnson, Trevor, Hirbe, Angela C, Alhawagri, Muhammad, Anwisye, Imani, Sammut, Benedicte, O'Neal, Julie, Zou, Wei, Weilbaecher, Katherine N, Faccio, Roberta, Novack, Deborah Veis

“…NF-κB inducing kinase (NIK) is required for osteoclastogenesis in response to pathologic stimuli, and its loss leads to functional blockade of both alternative…”
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Targeting Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors (MPNST) in a Phase II Study of Everolimus in Combination with Bevacizumab (SARC016) by Hirbe, Angela C., Kim, AeRang, Turpin, Brian, Dombi, Eva, Jayaprakash, Nalini, Helman, Lee J., Onwudiwe, Ndidi, Cichowski, Karen, Perentesis, John, Milhem, Mohammed, Chugh, Rashmi, Cote, Gregory M., Meyer, Christian F., Okuno, Scott H., Reinke, Denise, Lu, Yao, Widemann, Brigitte C., Pressey, Joseph G.

“…Purpose. There are no known effective medical treatments for refractory MPNST. Inactivation of the NF1 tumor suppressor in MPNST results in upregulation of…”
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Yoga Therapy During Chemotherapy for Early-Stage and Locally Advanced Breast Cancer by Greaney, Samantha K., Amin, Neha, Prudner, Bethany C., Compernolle, Maggie, Sandell, Linda J., Tebb, Susan C., Weilbaecher, Katherine N., Abeln, Peri, Luo, Jingqin, Tao, Yu, Hirbe, Angela C., Peterson, Lindsay L.

“…Background: Chemotherapy is associated with decreased quality of life (QOL), fatigue, depression, and weight gain in patients with breast cancer. Weight gain…”
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TYK2 promotes malignant peripheral nerve sheath tumor progression through inhibition of cell death by Qin, Wenjing, Godec, Abigail, Zhang, Xiaochun, Zhu, Cuige, Shao, Jieya, Tao, Yu, Bu, Xianzhang, Hirbe, Angela C.

“…Background Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that arise most commonly in the setting of the Neurofibromatosis Type 1…”
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Neoadjuvant Ifosfamide and Epirubicin in the Treatment of Malignant Peripheral Nerve Sheath Tumors by Van Tine, Brian A., Dahiya, Sonika, Cosper, Pippa F., Hirbe, Angela C.

“…Background and Objectives. Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas with poor overall survival. Response to…”
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Pregnancy outcomes related to the treatment of sarcomas with anthracyclines and/or ifosfamide during pregnancy by Miller, Devon, Livingston, John A., Park, Yeonhee, Posey, Kristi, Godbole, Sonia, Skubitz, Keith, Robinson, Steven I., Agulnik, Mark, Davis, Lara E., Van Tine, Brian A., Hirbe, Angela C., Parkes, Amanda

“…Background Sarcomas are rare diagnoses but are seen with relative frequency in adolescents and young adults and thus can present in pregnancy. We sought to…”
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Chromosome 8 gain is associated with high-grade transformation in MPNST by Dehner, Carina, Moon, Chang In, Zhang, Xiyuan, Zhou, Zhaohe, Miller, Chris, Xu, Hua, Wan, Xiaodan, Yang, Kuangying, Mashl, Jay, Gosline, Sara Jc, Wang, Yuxi, Zhang, Xiaochun, Godec, Abigail, Jones, Paul A, Dahiya, Sonika, Bhatia, Himanshi, Primeau, Tina, Li, Shunqiang, Pollard, Kai, Rodriguez, Fausto J, Ding, Li, Pratilas, Christine A, Shern, Jack F, Hirbe, Angela C

“…One of the most common malignancies affecting adults with Neurofibromatosis type 1 (NF1) is the malignant peripheral nerve sheath tumor (MPNST), an aggressive…”
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Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner by Hirbe, Angela C., Uluçkan, Özge, Morgan, Elizabeth A., Eagleton, Mark C., Prior, Julie L., Piwnica-Worms, David, Trinkaus, Kathryn, Apicelli, Anthony, Weilbaecher, Katherine

“…Inhibition of osteoclast (OC) activity has been associated with decreased tumor growth in bone in animal models. Increased recognition of factors that promote…”
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Phase II study of dacarbazine given with modern prophylactic anti-emetics and growth factor support to patients with metastatic, resistant soft tissue, and bone sarcoma by Van Tine, Brian A, Weiss, Mia C, Hirbe, Angela C, Oppelt, Peter J, Abaricia, Sarah, Trinkaus, Kathryn, Luo, Jingqin, Berry, Shellie, Ruff, Tyler, Callahan, Cheryl, Toensikoetter, Jacqui, Ley, Jessica, Siegel, Marilyn J, Dehdashti, Farrokh, Siegel, Barry A, Adkins, Douglas R

“…Historically, administration of dacarbazine to sarcoma patients was limited by frequent treat-ment-related nausea/vomiting and neutropenia. These toxicities…”
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Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone by Hirbe, Angela C, Rubin, Jessica, Uluçkan, Özge, Morgan, Elizabeth A, Eagleton, Mark C, Prior, Julie L, Piwnica-Worms, David, Weilbaecher, Katherine N

“…CXCR4 regulates hematopoietic and tumor cell homing to bone, but its role during osteoclast (OC) development is unknown. We investigated the role of CXCR4 in…”
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Diagnosis and Treatment of Myxoid Liposarcomas: Histology Matters by Abaricia, Sarah, Hirbe, Angela C.

“…Opinion statement Sarcomas are a heterogeneous group of rare malignancies that arise from mesenchymal cells and can occur anywhere in the body. Herein, the…”
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Diagnosis and management of malignant peripheral nerve sheath tumors: Current practice and future perspectives by Prudner, Bethany C, Ball, Tyler, Rathore, Richa, Hirbe, Angela C

“…One of the most common malignancies affecting adults with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome is the malignant peripheral nerve…”
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Plexiform neurofibroma: shedding light on the investigational agents in clinical trials by Acar, Simge, Armstrong, Amy E, Hirbe, Angela C

“…Neurofibromatosis Type 1 (NF1) is an autosomal dominant genetic condition, which predisposes individuals to the development of plexiform neurofibromas (PN),…”
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A Phase I Study of the Combination of Pexidartinib and Sirolimus to Target Tumor-Associated Macrophages in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors by Manji, Gulam A, Van Tine, Brian A, Lee, Shing M, Raufi, Alexander G, Pellicciotta, Ilenia, Hirbe, Angela C, Pradhan, Jaya, Chen, Andrew, Rabadan, Raul, Schwartz, Gary K

“…To evaluate the safety and tolerability in phase I first-in-human combination therapy with pexidartinib, an inhibitor of colony-stimulating factor-1 receptor,…”
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