Search Results - "HIRAO, Atsushi"

The Role of Nutrients in Maintaining Hematopoietic Stem Cells and Healthy Hematopoiesis for Life by Tadokoro, Yuko, Hirao, Atsushi

“…Nutrients are converted by the body to smaller molecules, which are utilized for both anabolic and catabolic metabolic reactions. Cooperative regulation of…”
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Guest editorial: Cooperative networks for stem cell homeostasis in normal and malignant hematopoiesis: from metabolism to epigenetics by Hirao, Atsushi

“…Issue Title: Including PIH Articles on Epigenetic and metabolic regulation in hematopoiesis/leukemogenesis…”
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Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1 by Hasegawa, Tetsuo, Kikuta, Junichi, Sudo, Takao, Matsuura, Yoshinobu, Matsui, Takahiro, Simmons, Szandor, Ebina, Kosuke, Hirao, Makoto, Okuzaki, Daisuke, Yoshida, Yuichi, Hirao, Atsushi, Kalinichenko, Vladimir V., Yamaoka, Kunihiro, Takeuchi, Tsutomu, Ishii, Masaru

“…Osteoclasts have a unique bone-destroying capacity, playing key roles in steady-state bone remodeling and arthritic bone erosion. Whether the osteoclasts in…”
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Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy by Ichimura, Yoshinobu, Waguri, Satoshi, Sou, Yu-shin, Kageyama, Shun, Hasegawa, Jun, Ishimura, Ryosuke, Saito, Tetsuya, Yang, Yinjie, Kouno, Tsuguka, Fukutomi, Toshiaki, Hoshii, Takayuki, Hirao, Atsushi, Takagi, Kenji, Mizushima, Tsunehiro, Motohashi, Hozumi, Lee, Myung-Shik, Yoshimori, Tamotsu, Tanaka, Keiji, Yamamoto, Masayuki, Komatsu, Masaaki

“…The Keap1-Nrf2 system and autophagy are both involved in the oxidative-stress response, metabolic pathways, and innate immunity, and dysregulation of these…”
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Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells by Takubo, Keiyo, Nagamatsu, Go, Kobayashi, Chiharu I., Nakamura-Ishizu, Ayako, Kobayashi, Hiroshi, Ikeda, Eiji, Goda, Nobuhito, Rahimi, Yasmeen, Johnson, Randall S., Soga, Tomoyoshi, Hirao, Atsushi, Suematsu, Makoto, Suda, Toshio

“…Defining the metabolic programs that underlie stem cell maintenance will be essential for developing strategies to manipulate stem cell capacity. Mammalian…”
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Metabolic regulation of osteoclast differentiation and function by Indo, Yoriko, Takeshita, Sunao, Ishii, Kiyo‐Aki, Hoshii, Takayuki, Aburatani, Hiroyuki, Hirao, Atsushi, Ikeda, Kyoji

“…ABSTRACT The osteoclast is a giant cell that resorbs calcified matrix by secreting acids and collagenolytic enzymes. The molecular mechanisms underlying…”
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Therapeutic advantage of targeting lysosomal membrane integrity supported by lysophagy in malignant glioma by Jing, Yongwei, Kobayashi, Masahiko, Vu, Ha Thi, Kasahara, Atsuko, Chen, Xi, Pham, Loc Thi, Kurayoshi, Kenta, Tadokoro, Yuko, Ueno, Masaya, Todo, Tomoki, Nakada, Mitsutoshi, Hirao, Atsushi

“…Lysosomes function as the digestive system of a cell and are involved in macromolecular recycling, vesicle trafficking, metabolic reprogramming, and progrowth…”
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Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells by Naka, Kazuhito, Muraguchi, Teruyuki, Hoshii, Takayuki, Hirao, Atsushi

“…Hematopoietic stem cells (HSCs) are defined by their ability both to self-renew and to give rise to fresh blood cells throughout the lifetime of an animal. The…”
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PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ by Kurebayashi, Yutaka, Nagai, Shigenori, Ikejiri, Ai, Ohtani, Masashi, Ichiyama, Kenji, Baba, Yukiko, Yamada, Taketo, Egami, Shohei, Hoshii, Takayuki, Hirao, Atsushi, Matsuda, Satoshi, Koyasu, Shigeo

“…The PI3K-Akt-mTORC1 axis contributes to the activation, survival, and proliferation of CD4+ T cells upon stimulation through TCR and CD28. Here, we demonstrate…”
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Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells by Hirao, Atsushi, Suda, Toshio, Ito, Keisuke, Arai, Fumio, Takubo, Keiyo, Matsuoka, Sahoko, Miyamoto, Kana, Ohmura, Masako, Naka, Kazuhito, Hosokawa, Kentaro, Ikeda, Yasuo

“…Hematopoietic stem cells (HSCs) undergo self-renewing cell divisions and maintain blood production for their lifetime. Appropriate control of HSC self-renewal…”
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Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway by Baba, Tomohisa, Yoshida, Takeshi, Tanabe, Yamato, Nishimura, Tatsunori, Morishita, Soji, Gotoh, Noriko, Hirao, Atsushi, Hanayama, Rikinari, Mukaida, Naofumi

“…Accumulating evidence indicates the presence of cytoplasmic DNAs in various types of malignant cells, and its involvement in anti-cancer drug- or…”
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Essential role of autophagy in protecting neonatal haematopoietic stem cells from oxidative stress in a p62-independent manner by Nomura, Naho, Ito, Chiaki, Ooshio, Takako, Tadokoro, Yuko, Kohno, Susumu, Ueno, Masaya, Kobayashi, Masahiko, Kasahara, Atsuko, Takase, Yusuke, Kurayoshi, Kenta, Si, Sha, Takahashi, Chiaki, Komatsu, Masaaki, Yanagawa, Toru, Hirao, Atsushi

“…Autophagy is a cellular degradation system contributing to homeostasis of tissue stem cells including haematopoietic stem cells (HSCs). It plays pleiotropic…”
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Maintenance of genomic integrity in hematopoietic stem cells by Naka, Kazuhito, Hirao, Atsushi

“…Hematopoietic stem cells (HSCs) maintain hematopoietic homeostasis throughout a mammal’s lifespan through self-renewal and differentiation into mature blood…”
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Cutting edge: mTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production by Ohtani, Masashi, Hoshii, Takayuki, Fujii, Hideki, Koyasu, Shigeo, Hirao, Atsushi, Matsuda, Satoshi

“…The mammalian target of rapamycin (mTOR) controls cell growth and survival through two distinct complexes called mTOR complex 1 (mTORC1) and mTOR complex 2…”
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The GPI-anchored protein CD109 protects hematopoietic progenitor cells from undergoing erythroid differentiation induced by TGF-β by Tanabe, Mikoto, Hosokawa, Kohei, Nguyen, Mai Anh Thi, Nakagawa, Noriharu, Maruyama, Kana, Tsuji, Noriaki, Urushihara, Ryota, Espinoza, Luis, Elbadry, Mahmoud I., Mohiuddin, Md, Katagiri, Takamasa, Ono, Masanori, Fujiwara, Hiroshi, Chonabayashi, Kazuhisa, Yoshida, Yoshinori, Yamazaki, Hirohito, Hirao, Atsushi, Nakao, Shinji

“…Although a glycosylphosphatidylinositol-anchored protein (GPI-AP) CD109 serves as a TGF-β co-receptor and inhibits TGF-β signaling in keratinocytes, the role…”
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Foxo3a Is Essential for Maintenance of the Hematopoietic Stem Cell Pool by Miyamoto, Kana, Araki, Kiyomi Y., Naka, Kazuhito, Arai, Fumio, Takubo, Keiyo, Yamazaki, Satoshi, Matsuoka, Sahoko, Miyamoto, Takeshi, Ito, Keisuke, Ohmura, Masako, Chen, Chen, Hosokawa, Kentaro, Nakauchi, Hiromitsu, Nakayama, Keiko, Nakayama, Keiichi I., Harada, Mine, Motoyama, Noboru, Suda, Toshio, Hirao, Atsushi

“…Hematopoietic stem cells (HSCs) are maintained in an undifferentiated quiescent state within a bone marrow niche. Here we show that Foxo3a, a forkhead…”
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B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells by Jin, Guihua, MD, Hamaguchi, Yasuhito, MD, PhD, Matsushita, Takashi, MD, PhD, Hasegawa, Minoru, MD, PhD, Le Huu, Doanh, MD, Ishiura, Nobuko, MD, PhD, Naka, Kazuhito, PhD, Hirao, Atsushi, MD, Takehara, Kazuhiko, MD, PhD, Fujimoto, Manabu, MD

“…Background Regulatory B cells that exhibit the cell-surface CD1dhi CD5+ phenotype and produce IL-10 are termed B10 cells. Although B10 cells exert potent…”
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A novel splenic B1 regulatory cell subset suppresses allergic disease through phosphatidylinositol 3-kinase–Akt pathway activation by Matsushita, Takashi, MD, PhD, Le Huu, Doanh, MD, PhD, Kobayashi, Tadahiro, MD, PhD, Hamaguchi, Yasuhito, MD, PhD, Hasegawa, Minoru, MD, PhD, Naka, Kazuhito, PhD, Hirao, Atsushi, MD, Muramatsu, Masamichi, MD, PhD, Takehara, Kazuhiko, MD, PhD, Fujimoto, Manabu, MD

“…Background IL-10–producing regulatory B (B10) cells potently suppress allergic diseases, such as contact hypersensitivity (CHS). Splenic B10 cells share…”
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Therapeutic potential of pentamidine for glioma‐initiating cells and glioma cells through multimodal antitumor effects by Tamai, Sho, Ichinose, Toshiya, Jiapaer, Shabierjiang, Hirai, Nozomi, Sabit, Hemragul, Tanaka, Shingo, Kinoshita, Masashi, Kobayashi, Masahiko, Hirao, Atsushi, Nakada, Mitsutoshi

“…Glioma‐initiating cells, which comprise a heterogeneous population of glioblastomas, contribute to resistance against aggressive chemoradiotherapy. Using drug…”
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Mechanistic / mammalian target protein of rapamycin signaling in hematopoietic stem cells and leukemia by Hirao, Atsushi, Hoshii, Takayuki

“…Mechanistic/mammalian target protein of rapamycin (mTOR) is an evolutionarily conserved kinase that plays a critical role in sensing and responding to…”
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